Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Membrane-anchored lipid-binding protein SIP3

Gene

SIP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in sterol transfer between intracellular membranes.1 Publication

GO - Molecular functioni

  • transcription cofactor activity Source: SGD

GO - Biological processi

  • intracellular sterol transport Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33253-MONOMER.

Protein family/group databases

TCDBi9.B.198.1.2. the membrane-anchored lipid-binding protein (lam) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-anchored lipid-binding protein SIP31 Publication
Alternative name(s):
Lipid transfer protein anchored at membrane contact sites 31 Publication
SNF1-interacting protein 31 Publication
Gene namesi
Name:SIP31 Publication
Synonyms:LAM31 Publication
Ordered Locus Names:YNL257CImported
ORF Names:N0844
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL257C.
SGDiS000005201. SIP3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 1066Cytoplasmic2 PublicationsAdd BLAST1066
Transmembranei1067 – 1087HelicalSequence analysisAdd BLAST21
Topological domaini1088 – 1229Lumenal1 PublicationAdd BLAST142

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977651 – 1229Membrane-anchored lipid-binding protein SIP3Add BLAST1229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi1206N-linked (GlcNAc...)PROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP38717.
PRIDEiP38717.

PTM databases

iPTMnetiP38717.

Interactioni

Subunit structurei

Interacts with SNF1.1 Publication

Protein-protein interaction databases

BioGridi35582. 54 interactors.
DIPiDIP-780N.

Structurei

3D structure databases

ProteinModelPortaliP38717.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 423PHPROSITE-ProRule annotationAdd BLAST115
Domaini771 – 976VAStPROSITE-ProRule annotationAdd BLAST206

Domaini

The VASt domain bind sterols.By similarity

Sequence similaritiesi

Belongs to the SIP3 family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 VASt domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000016474.
HOGENOMiHOG000057112.
InParanoidiP38717.
OMAiNEDRRFC.
OrthoDBiEOG092C0B9T.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR031968. DUF4782.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF16016. DUF4782. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS51778. VAST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVHGRDPKK RQLRLISVAF KEASIDSPSF RASVNFFQTR VDALEDWIEK
60 70 80 90 100
TVDFFDQKYK VSFEDFRRAK ETLLSQLLPP PALLSNGFVS NQSFTPRLID
110 120 130 140 150
SFNKDYYDFS MKLLQIVKGD DSSHSTALLE LMTTAIEPYR NVRKNFDFYQ
160 170 180 190 200
GKYDSMLASY QAIRISKTSL EPSSIKSDAL QLFEVQKNYL KASLDLISAI
210 220 230 240 250
SAVKLSLDKF ILESMKVLKS RSIFITKDSG RKIDLSPCIN EYLDNYAIWV
260 270 280 290 300
ENSIEGSKVL DSDISNAKKQ AYRYTLKRIT PSSDTSDYNI RSIHSSKLLS
310 320 330 340 350
KDTQVPPKSP EKSGWLYMKT QVGKPTREIW VRRWCFLKNA VFGMFLLSPS
360 370 380 390 400
KTYVEETDKF GVFLTNVRYD PEEDRKFCFE VKIFGNKVTE AHDNMSKDIT
410 420 430 440 450
LVFQTSNYLD LKSWLIAFEA TKKYVMSIQH DSLEYELAFK RFSPKFFEFA
460 470 480 490 500
SSTTTSIDQL ITTFDKETES LYETLNCSIS EYDILTLGEE KVFQFQMPTT
510 520 530 540 550
PISTKMTQLA ILSNFLTKGS WFPNAVLANI WGTTDWSEYT ILPGKGKKPS
560 570 580 590 600
SLLTIDGKRL PIRNSTIYPQ YYSNELKVLD LQFKSLVFSP DQRLEKLPEE
610 620 630 640 650
LLLFKFEALW CPNKKQKFSA TCFCTKDYIY CYMNSMEFIC LTKISLSEIV
660 670 680 690 700
SVEADRSSKK TLKLYDASGL QMKAIVLFSD YKLIASKLQY LLENKAIKNP
710 720 730 740 750
NSNEEILVKF EQMEKESQEK KQEELYKIEQ ENSFDRKATS VSKIIKSRVT
760 770 780 790 800
FWEMSDDAST LLNRLKKLQT EYSITYNHEY EISSKGLAHI LFGDKSNAFP
810 820 830 840 850
KCLFLARKDG EEHGKRFWYK NKDINGKSQL VRKIPFRLDM TGNFLNTGKY
860 870 880 890 900
HRDKESKMIF ATQRIVKIVD NKYYEVDLDP FFVKVPFCHL LKLSIKFVIT
910 920 930 940 950
ESYDVDNHLE IKLNMTASSS SLHVLYKLEY IDSRTGKTIE KLSLAEIICQ
960 970 980 990 1000
TWALKFAHSE FLLIRRVLRY YLEKIGKHGK VIKAIKLCGI LGVLSNKSEE
1010 1020 1030 1040 1050
PATEKNGNSK ESESMQYDIR YSCTILFLVF IKLMVYRVTN LTFVFFRILI
1060 1070 1080 1090 1100
GILLLCAEKF SRINRMMVVG LLASIMINIL LSEKASVPYW SIKRAEKLFH
1110 1120 1130 1140 1150
DRLGSDKFTM QRAIYISDSD LLSSQLSVPS NNPIFEKFSE DNFNKDYQYS
1160 1170 1180 1190 1200
ETRKQLAMRR NELLIELRIL QDMEKQLVHD DYEKFLLEEV NKCSMVSIEM
1210 1220
TDLWFNDTQL QNYCSICNEE LEKLRPPIT
Length:1,229
Mass (Da):142,820
Last modified:February 1, 1995 - v1
Checksum:i977995219282CD65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03376 Genomic DNA. Translation: AAA17885.1.
X96722 Genomic DNA. Translation: CAA65487.1.
Z71533 Genomic DNA. Translation: CAA96164.1.
BK006947 Genomic DNA. Translation: DAA10302.1.
PIRiS42391.
RefSeqiNP_014142.1. NM_001183095.1.

Genome annotation databases

EnsemblFungiiYNL257C; YNL257C; YNL257C.
GeneIDi855464.
KEGGisce:YNL257C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03376 Genomic DNA. Translation: AAA17885.1.
X96722 Genomic DNA. Translation: CAA65487.1.
Z71533 Genomic DNA. Translation: CAA96164.1.
BK006947 Genomic DNA. Translation: DAA10302.1.
PIRiS42391.
RefSeqiNP_014142.1. NM_001183095.1.

3D structure databases

ProteinModelPortaliP38717.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35582. 54 interactors.
DIPiDIP-780N.

Protein family/group databases

TCDBi9.B.198.1.2. the membrane-anchored lipid-binding protein (lam) family.

PTM databases

iPTMnetiP38717.

Proteomic databases

MaxQBiP38717.
PRIDEiP38717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL257C; YNL257C; YNL257C.
GeneIDi855464.
KEGGisce:YNL257C.

Organism-specific databases

EuPathDBiFungiDB:YNL257C.
SGDiS000005201. SIP3.

Phylogenomic databases

GeneTreeiENSGT00390000016474.
HOGENOMiHOG000057112.
InParanoidiP38717.
OMAiNEDRRFC.
OrthoDBiEOG092C0B9T.

Enzyme and pathway databases

BioCyciYEAST:G3O-33253-MONOMER.

Miscellaneous databases

PROiP38717.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR031968. DUF4782.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF16016. DUF4782. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS51778. VAST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIP3_YEAST
AccessioniPrimary (citable) accession number: P38717
Secondary accession number(s): D6W0T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 432 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.