Reviewed, UniProtKB/Swiss-Prot P38716 (YHR2_YEAST)

Names and origin

Protein names

Recommended name:
    Uncharacterized trans-sulfuration enzyme YHR112C

Gene names

Ordered Locus Names:

YHR112C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Cofactor	Pyridoxal phosphate By similarity.
Miscellaneous	Present with 1360 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the trans-sulfuration enzymes family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from direct assay. Source: SGD
Molecular function	lyase activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PRP40	P33203	1	EBI-24682,EBI-701
RSP5	P39940	1	EBI-24682,EBI-16219
SSM4	P40318	1	EBI-24682,EBI-18208

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	Uncharacterized trans-sulfuration enzyme YHR112C		PRO_0000114766
Sites
	Binding site	198	1	Pyridoxal phosphate (covalent) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P38716-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 3300336DCC20EE5E	FASTA	378	42,445
	10 20 30 40 50 60 MVDLSTALIH GDDKDNRVTD VAPPINVSTT FRYDDDDLIP WTERENLDFM EKKPVYSRLA 70 80 90 100 110 120 HPNSTRLESI FSEILDGYAV IYSSGLAAFY AAMVHYNPKK IFIGQSYHGV RAIANILTRN 130 140 150 160 170 180 YGIEQHPLED IEKCASEGDI VHLESPVNPY GTSSDIESLA RRAHAKGALL IVDSTFASPP 190 200 210 220 230 240 LQYAWNFGAD IVLYSATKYF GGHSDLLSGV LVVKEEATSR QLKDDRIYLG TNVANLESFM 250 260 270 280 290 300 LLRSLRTYEM RITKQSENAT KLVRFLSDHQ SEFDKVLKTI YHSSLQTEEF VKKQLVGGYG 310 320 330 340 350 360 PVFAITLYTK EQCKQLPLKL KYFHHATSLG GIESLVEWRA MTDPYIDQTL IRVSVGCESA 370 NDLIKDLASA LKELQDAA

References

[1]

"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.

[2]

"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00059 Genomic DNA. Translation: AAB68864.1.
PIR	S48954.
RefSeq	NP_011980.1.
3D structure databases
HSSP	HSSP built from PDB template 1GC0 based on UniProtKB P13254.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:2850N.
IntAct	P38716.
Proteomic databases
PeptideAtlas	P38716.
Genome annotation databases
Ensembl	YHR112C. Saccharomyces cerevisiae. [Contig view]
GeneID	856512.
GenomeReviews	Gene locus YHR112C in contig U00093_GR.
KEGG	sce:YHR112C.
NMPDR	fig|4932.3.peg.3141.
Organism-specific databases
CYGD	YHR112c.
SGD	S000001154. YHR112C.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	P38716.
Gene expression databases
ArrayExpress	P38716.
GermOnline	YHR112C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR000277. Cys/Met-Metab_PyrdxlP-dep_enz. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
PANTHER	PTHR11808. Cys_Met_Meta_PP. 1 hit.
Pfam	PF01053. Cys_Met_Meta_PP. 1 hit. [Graphical view]
PIRSF	PIRSF001434. CGS. 1 hit.
PROSITE	PS00868. CYS_MET_METAB_PP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	P38716.
NextBio	982254.

Entry information

Entry name

YHR2_YEAST

Accession

Primary (citable) accession number: P38716

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 25, 2008
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)