P38716 (YHR2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized trans-sulfuration enzyme YHR112C

Gene names

Ordered Locus Names:

YHR112C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Cofactor	Pyridoxal phosphate By similarity.
Miscellaneous	Present with 1360 molecules/cell in log phase SD medium. Ref.3
Sequence similarities	Belongs to the trans-sulfuration enzymes family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from direct assay. Source: SGD nucleus Inferred from direct assay. Source: SGD
Molecular function	lyase activity Inferred from electronic annotation. Source: UniProtKB-KW pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PRP40	P33203	1	EBI-24682,EBI-701
RSP5	P39940	1	EBI-24682,EBI-16219
SSM4	P40318	1	EBI-24682,EBI-18208

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	Uncharacterized trans-sulfuration enzyme YHR112C		PRO_0000114766
Amino acid modifications
	Modified residue	198	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P38716 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 3300336DCC20EE5E	FASTA	378	42,445
	10 20 30 40 50 60 MVDLSTALIH GDDKDNRVTD VAPPINVSTT FRYDDDDLIP WTERENLDFM EKKPVYSRLA 70 80 90 100 110 120 HPNSTRLESI FSEILDGYAV IYSSGLAAFY AAMVHYNPKK IFIGQSYHGV RAIANILTRN 130 140 150 160 170 180 YGIEQHPLED IEKCASEGDI VHLESPVNPY GTSSDIESLA RRAHAKGALL IVDSTFASPP 190 200 210 220 230 240 LQYAWNFGAD IVLYSATKYF GGHSDLLSGV LVVKEEATSR QLKDDRIYLG TNVANLESFM 250 260 270 280 290 300 LLRSLRTYEM RITKQSENAT KLVRFLSDHQ SEFDKVLKTI YHSSLQTEEF VKKQLVGGYG 310 320 330 340 350 360 PVFAITLYTK EQCKQLPLKL KYFHHATSLG GIESLVEWRA MTDPYIDQTL IRVSVGCESA 370 NDLIKDLASA LKELQDAA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00059 Genomic DNA. Translation: AAB68864.1. BK006934 Genomic DNA. Translation: DAA06806.1.
PIR	S48954.
RefSeq	NP_011980.1. NM_001179242.1.
3D structure databases
ProteinModelPortal	P38716.
SMR	P38716. Positions 2-373.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2850N.
IntAct	P38716. 12 interactions.
MINT	MINT-505246.
STRING	P38716.
Proteomic databases
PeptideAtlas	P38716.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR112C; YHR112C; YHR112C.
GeneID	856512.
KEGG	sce:YHR112C.
NMPDR	fig|4932.3.peg.3141.
Organism-specific databases
CYGD	YHR112c.
SGD	S000001154. YHR112C.
Phylogenomic databases
eggNOG	fuNOG04453.
GeneTree	EFGT00050000003425.
HOGENOM	HBG754729.
OMA	HGSHEVI.
OrthoDB	EOG4X3M96.
Gene expression databases
ArrayExpress	P38716.
Genevestigator	P38716.
GermOnline	YHR112C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR000277. Cys/Met-Metab_PyrdxlP-dep_enz. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
PANTHER	PTHR11808. Cys_Met_Meta_PP. 1 hit.
Pfam	PF01053. Cys_Met_Meta_PP. 1 hit. [Graphical view]
PIRSF	PIRSF001434. CGS. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00868. CYS_MET_METAB_PP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	982254.

Entry information

Entry name

YHR2_YEAST

Accession

Primary (citable) accession number: P38716
Secondary accession number(s): D3DL62

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	December 14, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program