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P38714

- SYRM_YEAST

UniProt

P38714 - SYRM_YEAST

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Protein

Arginine--tRNA ligase, mitochondrial

Gene
MSR1, YHR091C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: SGD
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: SGD
  2. mitochondrial arginyl-tRNA aminoacylation Source: SGD
  3. mitochondrial translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31138-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase, mitochondrial (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:MSR1
Ordered Locus Names:YHR091C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

SGDiS000001133. MSR1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 643Arginine--tRNA ligase, mitochondrialPRO_0000035799
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

MaxQBiP38714.
PaxDbiP38714.

Expressioni

Gene expression databases

GenevestigatoriP38714.

Interactioni

Protein-protein interaction databases

BioGridi36526. 8 interactions.
DIPiDIP-1452N.
IntActiP38714. 2 interactions.
MINTiMINT-394875.
STRINGi4932.YHR091C.

Structurei

3D structure databases

ProteinModelPortaliP38714.
SMRiP38714. Positions 70-643.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi188 – 19811"HIGH" regionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0018.
GeneTreeiENSGT00530000063407.
HOGENOMiHOG000247211.
KOiK01887.
OMAiKLEINIG.
OrthoDBiEOG7NKKV8.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38714-1 [UniParc]FASTAAdd to Basket

« Hide

MFGIVYLKNR SLLCKNPFSS YPRYGFMPSF DTQFSNQFRK LEINIGRKRY    50
SSKTLNTKYT DQPEGPIYPL DVLRLDISKA LHDISGIDHS LILNALESTN 100
SMDRGDLLLP LPKIKVADPV AVANRWAIEL STHGCIGKVC AKGPFLQFFL 150
DQRYLIQSTV PNILLQKGKY GQKKSRHQKK VVVEFSSPNI AKPFHAGHLR 200
STIIGGFLSN LYEAMGWSVT RMNYLGDWGR QFGLLAVGFK RYGDEKTLQK 250
QPIQHLFDVY VKINMDLAKE EINGNSKCGI SGEARSFFKN LENGDENAIK 300
IWNRFRSLSI HHYIQTYSRL NINFDIFSGE SQVSKESMNE ALDIFRKNNL 350
VKEIDGALVI DLTQWSKRLG RVVVQKSDGT TLYLTRDVGA AIERKKNLHF 400
DKMVYVISSQ QDLYMSQFFM ILKKMNFEWA KDLQHINFGM VQGMSTRKGN 450
VVFLDTILDE ARDKALQIME NNKMKISQVD NPQRVADLIG VSAIIIQDMK 500
SKRINNYEFN WNRMLSFEGD TGPYLQYTHS RLRSLERTSS DFTTDMLIHA 550
DFSNLNEPQL VELVRLLAQY PDVLRRAFET QEPATIVTYL FKVCHQVSSC 600
YKKIWVSGKP ADIAIPRLAV YSASRQVLHN AMSLLGLVPV DRM 643
Length:643
Mass (Da):73,694
Last modified:October 5, 2010 - v3
Checksum:i7C92C0EAD5A19E0E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti499 – 4991M → T in AAA61486. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L39019 Genomic DNA. Translation: AAA61486.1.
U00060 Genomic DNA. Translation: AAB68931.1.
BK006934 Genomic DNA. Translation: DAA06787.1.
PIRiS46723.
RefSeqiNP_011959.1. NM_001179221.1.

Genome annotation databases

EnsemblFungiiYHR091C; YHR091C; YHR091C.
GeneIDi856491.
KEGGisce:YHR091C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L39019 Genomic DNA. Translation: AAA61486.1 .
U00060 Genomic DNA. Translation: AAB68931.1 .
BK006934 Genomic DNA. Translation: DAA06787.1 .
PIRi S46723.
RefSeqi NP_011959.1. NM_001179221.1.

3D structure databases

ProteinModelPortali P38714.
SMRi P38714. Positions 70-643.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36526. 8 interactions.
DIPi DIP-1452N.
IntActi P38714. 2 interactions.
MINTi MINT-394875.
STRINGi 4932.YHR091C.

Proteomic databases

MaxQBi P38714.
PaxDbi P38714.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR091C ; YHR091C ; YHR091C .
GeneIDi 856491.
KEGGi sce:YHR091C.

Organism-specific databases

SGDi S000001133. MSR1.

Phylogenomic databases

eggNOGi COG0018.
GeneTreei ENSGT00530000063407.
HOGENOMi HOG000247211.
KOi K01887.
OMAi KLEINIG.
OrthoDBi EOG7NKKV8.

Enzyme and pathway databases

BioCyci YEAST:G3O-31138-MONOMER.

Miscellaneous databases

NextBioi 982197.

Gene expression databases

Genevestigatori P38714.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast MSR1 gene."
    Tzagoloff A.A., Shtanko A.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 24657 / D273-10B.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiSYRM_YEAST
AccessioniPrimary (citable) accession number: P38714
Secondary accession number(s): D3DL43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 5, 2010
Last modified: May 14, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

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