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P38714

- SYRM_YEAST

UniProt

P38714 - SYRM_YEAST

Protein

Arginine--tRNA ligase, mitochondrial

Gene

MSR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

    GO - Molecular functioni

    1. arginine-tRNA ligase activity Source: SGD
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: SGD
    2. mitochondrial arginyl-tRNA aminoacylation Source: SGD
    3. mitochondrial translation Source: SGD

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31138-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine--tRNA ligase, mitochondrial (EC:6.1.1.19)
    Alternative name(s):
    Arginyl-tRNA synthetase
    Short name:
    ArgRS
    Gene namesi
    Name:MSR1
    Ordered Locus Names:YHR091C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    SGDiS000001133. MSR1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrion Source: SGD

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 643Arginine--tRNA ligase, mitochondrialPRO_0000035799
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiP38714.
    PaxDbiP38714.

    Expressioni

    Gene expression databases

    GenevestigatoriP38714.

    Interactioni

    Protein-protein interaction databases

    BioGridi36526. 8 interactions.
    DIPiDIP-1452N.
    IntActiP38714. 2 interactions.
    MINTiMINT-394875.
    STRINGi4932.YHR091C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38714.
    SMRiP38714. Positions 70-643.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi188 – 19811"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0018.
    GeneTreeiENSGT00530000063407.
    HOGENOMiHOG000247211.
    KOiK01887.
    OMAiKLEINIG.
    OrthoDBiEOG7NKKV8.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11956. PTHR11956. 1 hit.
    PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR01038. TRNASYNTHARG.
    SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsiTIGR00456. argS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P38714-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFGIVYLKNR SLLCKNPFSS YPRYGFMPSF DTQFSNQFRK LEINIGRKRY    50
    SSKTLNTKYT DQPEGPIYPL DVLRLDISKA LHDISGIDHS LILNALESTN 100
    SMDRGDLLLP LPKIKVADPV AVANRWAIEL STHGCIGKVC AKGPFLQFFL 150
    DQRYLIQSTV PNILLQKGKY GQKKSRHQKK VVVEFSSPNI AKPFHAGHLR 200
    STIIGGFLSN LYEAMGWSVT RMNYLGDWGR QFGLLAVGFK RYGDEKTLQK 250
    QPIQHLFDVY VKINMDLAKE EINGNSKCGI SGEARSFFKN LENGDENAIK 300
    IWNRFRSLSI HHYIQTYSRL NINFDIFSGE SQVSKESMNE ALDIFRKNNL 350
    VKEIDGALVI DLTQWSKRLG RVVVQKSDGT TLYLTRDVGA AIERKKNLHF 400
    DKMVYVISSQ QDLYMSQFFM ILKKMNFEWA KDLQHINFGM VQGMSTRKGN 450
    VVFLDTILDE ARDKALQIME NNKMKISQVD NPQRVADLIG VSAIIIQDMK 500
    SKRINNYEFN WNRMLSFEGD TGPYLQYTHS RLRSLERTSS DFTTDMLIHA 550
    DFSNLNEPQL VELVRLLAQY PDVLRRAFET QEPATIVTYL FKVCHQVSSC 600
    YKKIWVSGKP ADIAIPRLAV YSASRQVLHN AMSLLGLVPV DRM 643
    Length:643
    Mass (Da):73,694
    Last modified:October 5, 2010 - v3
    Checksum:i7C92C0EAD5A19E0E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti499 – 4991M → T in AAA61486. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L39019 Genomic DNA. Translation: AAA61486.1.
    U00060 Genomic DNA. Translation: AAB68931.1.
    BK006934 Genomic DNA. Translation: DAA06787.1.
    PIRiS46723.
    RefSeqiNP_011959.1. NM_001179221.1.

    Genome annotation databases

    EnsemblFungiiYHR091C; YHR091C; YHR091C.
    GeneIDi856491.
    KEGGisce:YHR091C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L39019 Genomic DNA. Translation: AAA61486.1 .
    U00060 Genomic DNA. Translation: AAB68931.1 .
    BK006934 Genomic DNA. Translation: DAA06787.1 .
    PIRi S46723.
    RefSeqi NP_011959.1. NM_001179221.1.

    3D structure databases

    ProteinModelPortali P38714.
    SMRi P38714. Positions 70-643.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36526. 8 interactions.
    DIPi DIP-1452N.
    IntActi P38714. 2 interactions.
    MINTi MINT-394875.
    STRINGi 4932.YHR091C.

    Proteomic databases

    MaxQBi P38714.
    PaxDbi P38714.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR091C ; YHR091C ; YHR091C .
    GeneIDi 856491.
    KEGGi sce:YHR091C.

    Organism-specific databases

    SGDi S000001133. MSR1.

    Phylogenomic databases

    eggNOGi COG0018.
    GeneTreei ENSGT00530000063407.
    HOGENOMi HOG000247211.
    KOi K01887.
    OMAi KLEINIG.
    OrthoDBi EOG7NKKV8.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31138-MONOMER.

    Miscellaneous databases

    NextBioi 982197.

    Gene expression databases

    Genevestigatori P38714.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11956. PTHR11956. 1 hit.
    Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR01038. TRNASYNTHARG.
    SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsi TIGR00456. argS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Yeast MSR1 gene."
      Tzagoloff A.A., Shtanko A.
      Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 24657 / D273-10B.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiSYRM_YEAST
    AccessioniPrimary (citable) accession number: P38714
    Secondary accession number(s): D3DL43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 129 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3