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P38714 (SYRM_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase, mitochondrial

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:MSR1
Ordered Locus Names:YHR091C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length643 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

Subcellular location

Mitochondrion matrix.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 643Arginine--tRNA ligase, mitochondrialPRO_0000035799

Regions

Motif188 – 19811"HIGH" region

Experimental info

Sequence conflict4991M → T in AAA61486. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P38714 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 7C92C0EAD5A19E0E

FASTA64373,694
        10         20         30         40         50         60 
MFGIVYLKNR SLLCKNPFSS YPRYGFMPSF DTQFSNQFRK LEINIGRKRY SSKTLNTKYT 

        70         80         90        100        110        120 
DQPEGPIYPL DVLRLDISKA LHDISGIDHS LILNALESTN SMDRGDLLLP LPKIKVADPV 

       130        140        150        160        170        180 
AVANRWAIEL STHGCIGKVC AKGPFLQFFL DQRYLIQSTV PNILLQKGKY GQKKSRHQKK 

       190        200        210        220        230        240 
VVVEFSSPNI AKPFHAGHLR STIIGGFLSN LYEAMGWSVT RMNYLGDWGR QFGLLAVGFK 

       250        260        270        280        290        300 
RYGDEKTLQK QPIQHLFDVY VKINMDLAKE EINGNSKCGI SGEARSFFKN LENGDENAIK 

       310        320        330        340        350        360 
IWNRFRSLSI HHYIQTYSRL NINFDIFSGE SQVSKESMNE ALDIFRKNNL VKEIDGALVI 

       370        380        390        400        410        420 
DLTQWSKRLG RVVVQKSDGT TLYLTRDVGA AIERKKNLHF DKMVYVISSQ QDLYMSQFFM 

       430        440        450        460        470        480 
ILKKMNFEWA KDLQHINFGM VQGMSTRKGN VVFLDTILDE ARDKALQIME NNKMKISQVD 

       490        500        510        520        530        540 
NPQRVADLIG VSAIIIQDMK SKRINNYEFN WNRMLSFEGD TGPYLQYTHS RLRSLERTSS 

       550        560        570        580        590        600 
DFTTDMLIHA DFSNLNEPQL VELVRLLAQY PDVLRRAFET QEPATIVTYL FKVCHQVSSC 

       610        620        630        640 
YKKIWVSGKP ADIAIPRLAV YSASRQVLHN AMSLLGLVPV DRM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L39019 Genomic DNA. Translation: AAA61486.1.
U00060 Genomic DNA. Translation: AAB68931.1.
BK006934 Genomic DNA. Translation: DAA06787.1.
PIRS46723.
RefSeqNP_011959.1. NM_001179221.1.

3D structure databases

ProteinModelPortalP38714.
SMRP38714. Positions 70-643.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36526. 8 interactions.
DIPDIP-1452N.
IntActP38714. 2 interactions.
MINTMINT-394875.
STRING4932.YHR091C.

Proteomic databases

MaxQBP38714.
PaxDbP38714.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR091C; YHR091C; YHR091C.
GeneID856491.
KEGGsce:YHR091C.

Organism-specific databases

SGDS000001133. MSR1.

Phylogenomic databases

eggNOGCOG0018.
GeneTreeENSGT00530000063407.
HOGENOMHOG000247211.
KOK01887.
OMAKLEINIG.
OrthoDBEOG7NKKV8.

Enzyme and pathway databases

BioCycYEAST:G3O-31138-MONOMER.

Gene expression databases

GenevestigatorP38714.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982197.

Entry information

Entry nameSYRM_YEAST
AccessionPrimary (citable) accession number: P38714
Secondary accession number(s): D3DL43
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 5, 2010
Last modified: May 14, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries