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Protein

Arginine--tRNA ligase, mitochondrial

Gene

MSR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

GO - Biological processi

  • arginyl-tRNA aminoacylation Source: SGD
  • mitochondrial arginyl-tRNA aminoacylation Source: SGD
  • mitochondrial translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31138-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase, mitochondrial (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:MSR1
Ordered Locus Names:YHR091C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR091C.
SGDiS000001133. MSR1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 643Arginine--tRNA ligase, mitochondrialPRO_0000035799
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

MaxQBiP38714.
PaxDbiP38714.

Interactioni

Protein-protein interaction databases

BioGridi36526. 7 interactions.
DIPiDIP-1452N.
IntActiP38714. 2 interactions.
MINTiMINT-394875.

Structurei

3D structure databases

ProteinModelPortaliP38714.
SMRiP38714. Positions 70-643.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi188 – 19811"HIGH" regionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0018.
GeneTreeiENSGT00530000063407.
HOGENOMiHOG000247211.
InParanoidiP38714.
KOiK01887.
OMAiKLEINIG.
OrthoDBiEOG7NKKV8.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGIVYLKNR SLLCKNPFSS YPRYGFMPSF DTQFSNQFRK LEINIGRKRY
60 70 80 90 100
SSKTLNTKYT DQPEGPIYPL DVLRLDISKA LHDISGIDHS LILNALESTN
110 120 130 140 150
SMDRGDLLLP LPKIKVADPV AVANRWAIEL STHGCIGKVC AKGPFLQFFL
160 170 180 190 200
DQRYLIQSTV PNILLQKGKY GQKKSRHQKK VVVEFSSPNI AKPFHAGHLR
210 220 230 240 250
STIIGGFLSN LYEAMGWSVT RMNYLGDWGR QFGLLAVGFK RYGDEKTLQK
260 270 280 290 300
QPIQHLFDVY VKINMDLAKE EINGNSKCGI SGEARSFFKN LENGDENAIK
310 320 330 340 350
IWNRFRSLSI HHYIQTYSRL NINFDIFSGE SQVSKESMNE ALDIFRKNNL
360 370 380 390 400
VKEIDGALVI DLTQWSKRLG RVVVQKSDGT TLYLTRDVGA AIERKKNLHF
410 420 430 440 450
DKMVYVISSQ QDLYMSQFFM ILKKMNFEWA KDLQHINFGM VQGMSTRKGN
460 470 480 490 500
VVFLDTILDE ARDKALQIME NNKMKISQVD NPQRVADLIG VSAIIIQDMK
510 520 530 540 550
SKRINNYEFN WNRMLSFEGD TGPYLQYTHS RLRSLERTSS DFTTDMLIHA
560 570 580 590 600
DFSNLNEPQL VELVRLLAQY PDVLRRAFET QEPATIVTYL FKVCHQVSSC
610 620 630 640
YKKIWVSGKP ADIAIPRLAV YSASRQVLHN AMSLLGLVPV DRM
Length:643
Mass (Da):73,694
Last modified:October 5, 2010 - v3
Checksum:i7C92C0EAD5A19E0E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti499 – 4991M → T in AAA61486 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39019 Genomic DNA. Translation: AAA61486.1.
U00060 Genomic DNA. Translation: AAB68931.1.
BK006934 Genomic DNA. Translation: DAA06787.1.
PIRiS46723.
RefSeqiNP_011959.1. NM_001179221.1.

Genome annotation databases

EnsemblFungiiYHR091C; YHR091C; YHR091C.
GeneIDi856491.
KEGGisce:YHR091C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39019 Genomic DNA. Translation: AAA61486.1.
U00060 Genomic DNA. Translation: AAB68931.1.
BK006934 Genomic DNA. Translation: DAA06787.1.
PIRiS46723.
RefSeqiNP_011959.1. NM_001179221.1.

3D structure databases

ProteinModelPortaliP38714.
SMRiP38714. Positions 70-643.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36526. 7 interactions.
DIPiDIP-1452N.
IntActiP38714. 2 interactions.
MINTiMINT-394875.

Proteomic databases

MaxQBiP38714.
PaxDbiP38714.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR091C; YHR091C; YHR091C.
GeneIDi856491.
KEGGisce:YHR091C.

Organism-specific databases

EuPathDBiFungiDB:YHR091C.
SGDiS000001133. MSR1.

Phylogenomic databases

eggNOGiCOG0018.
GeneTreeiENSGT00530000063407.
HOGENOMiHOG000247211.
InParanoidiP38714.
KOiK01887.
OMAiKLEINIG.
OrthoDBiEOG7NKKV8.

Enzyme and pathway databases

BioCyciYEAST:G3O-31138-MONOMER.

Miscellaneous databases

NextBioi982197.
PROiP38714.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast MSR1 gene."
    Tzagoloff A.A., Shtanko A.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 24657 / D273-10B.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiSYRM_YEAST
AccessioniPrimary (citable) accession number: P38714
Secondary accession number(s): D3DL43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 5, 2010
Last modified: July 22, 2015
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.