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Protein

Inositol monophosphatase 1

Gene

INM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides.By similarity2 Publications

Miscellaneous

Present with 2440 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactori

Enzyme regulationi

Inhibited by Li+ and Na+.1 Publication

Kineticsi

  1. KM=0.08 mM for inositol 1-phosphate1 Publication
  1. Vmax=20 µmol/min/mg enzyme for inositol 1-phosphate1 Publication

Pathwayi: myo-inositol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Inositol-3-phosphate synthase (INO1)
  2. Inositol monophosphatase 2 (INM2), Inositol monophosphatase 1 (INM1)
This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi73Magnesium 1By similarity1
Binding sitei73SubstrateBy similarity1
Metal bindingi92Magnesium 1By similarity1
Metal bindingi92Magnesium 2By similarity1
Metal bindingi94Magnesium 1; via carbonyl oxygenBy similarity1
Metal bindingi95Magnesium 2By similarity1
Metal bindingi231Magnesium 2By similarity1
Binding sitei231SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandLithium, Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YHR046C-MONOMER
ReactomeiR-SCE-1855183 Synthesis of IP2, IP, and Ins in the cytosol
UniPathwayiUPA00823; UER00788

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol monophosphatase 1 (EC:3.1.3.25)
Short name:
IMP 1
Short name:
IMPase 1
Alternative name(s):
Inositol-1(or 4)-monophosphatase 1
Gene namesi
Name:INM1
Synonyms:IMP1
Ordered Locus Names:YHR046C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR046C
SGDiS000001088 INM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001425851 – 295Inositol monophosphatase 1Add BLAST295

Proteomic databases

MaxQBiP38710
PaxDbiP38710
PRIDEiP38710

Interactioni

Protein-protein interaction databases

BioGridi36478, 132 interactors
DIPiDIP-6506N
IntActiP38710, 1 interactor
MINTiP38710
STRINGi4932.YHR046C

Structurei

3D structure databases

ProteinModelPortaliP38710
SMRiP38710
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 97Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000014699
HOGENOMiHOG000282238
InParanoidiP38710
KOiK01092
OMAiRCATVGL
OrthoDBiEOG092C47JH

Family and domain databases

CDDicd01639 IMPase, 1 hit
InterProiView protein in InterPro
IPR033942 IMPase
IPR020583 Inositol_monoP_metal-BS
IPR000760 Inositol_monophosphatase-like
IPR020550 Inositol_monophosphatase_CS
PfamiView protein in Pfam
PF00459 Inositol_P, 1 hit
PRINTSiPR00377 IMPHPHTASES
PROSITEiView protein in PROSITE
PS00629 IMP_1, 1 hit
PS00630 IMP_2, 1 hit

Sequencei

Sequence statusi: Complete.

P38710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIDLASIEK FLCELATEKV GPIIKSKSGT QKDYDLKTGS RSVDIVTAID
60 70 80 90 100
KQVEKLIWES VKTQYPTFKF IGEESYVKGE TVITDDPTFI IDPIDGTTNF
110 120 130 140 150
VHDFPFSCTS LGLTVNKEPV VGVIYNPHIN LLVSASKGNG MRVNNKDYDY
160 170 180 190 200
KSKLESMGSL ILNKSVVALQ PGSAREGKNF QTKMATYEKL LSCDYGFVHG
210 220 230 240 250
FRNLGSSAMT MAYIAMGYLD SYWDGGCYSW DVCAGWCILK EVGGRVVGAN
260 270 280 290
PGEWSIDVDN RTYLAVRGTI NNESDEQTKY ITDFWNCVDG HLKYD
Length:295
Mass (Da):32,823
Last modified:February 1, 1995 - v1
Checksum:i1DF052114912C6CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA Translation: AAB68918.1
BK006934 Genomic DNA Translation: DAA06738.1
PIRiS46749
RefSeqiNP_011912.1, NM_001179176.1

Genome annotation databases

EnsemblFungiiYHR046C; YHR046C; YHR046C
GeneIDi856442
KEGGisce:YHR046C

Similar proteinsi

Entry informationi

Entry nameiINM1_YEAST
AccessioniPrimary (citable) accession number: P38710
Secondary accession number(s): D3DKZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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