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Protein

Probable UTP--glucose-1-phosphate uridylyltransferase

Gene

YHL012W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.By similarity

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

GO - Molecular functioni

  1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_328453. Formation of the active cofactor, UDP-glucuronate.
REACT_331189. Glycogen synthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
Ordered Locus Names:YHL012W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VIII

Organism-specific databases

CYGDiYHL012w.
SGDiS000001004. YHL012W.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Probable UTP--glucose-1-phosphate uridylyltransferasePRO_0000185766Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP38709.

Interactioni

Protein-protein interaction databases

BioGridi36411. 25 interactions.
IntActiP38709. 1 interaction.
STRINGi4932.YHL012W.

Structurei

3D structure databases

ProteinModelPortaliP38709.
SMRiP38709. Positions 23-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

eggNOGiCOG4284.
HOGENOMiHOG000113618.
InParanoidiP38709.
KOiK00963.
OrthoDBiEOG7HXD0T.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

P38709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVFSGVNKI EFEGTFEGIG KDVVMSQMIR ALQKHFPSIR DKNYEFSLFL
60 70 80 90 100
HIFQRYVLEN TSITHDLVCD KIRLPIIDEV VELDDIKNYG LLEGKLLSKL
110 120 130 140 150
AILKLTGKAN PIIGKESPLF EVKNGMSSLD VIVRQTQNLN VRYNSDVPLI
160 170 180 190 200
FMTSLETESQ VSNFLEEHYS SSKVRWKTVV QSSFPQIDKD RLLPIDLQIN
210 220 230 240 250
SHENDFWYPC GTGNLTDTLY FSGELDKLIA QGKEILFVSN VDNLGATGDL
260 270 280 290 300
NILNFIINEK IEYLVEVVER TANVSNTGVL ATYKGKLRSV YYNCLSNESA
310 320 330 340 350
STCRIVNTNN IWIDLKKLKV LIESNSLNLP IHSSESKITH KNEEIECLQF
360 370 380 390 400
KTQLVDCIAF FPNSRVLKVS RDRFLPLRTC KDLFLLKSTL YDLDSNGTFN
410 420 430 440 450
LYPLKFGLLP SIDLGDEFAT YETFKIGVPD IPNILELEHL TVMGNVFFGR
460 470 480 490
NITLKGTVII ICDENDVITV PDGSILENVT IWHKSQLEDM NGY
Length:493
Mass (Da):56,000
Last modified:January 31, 1995 - v1
Checksum:iEFC7FA4A8F681DE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11582 Genomic DNA. Translation: AAB65065.1.
BK006934 Genomic DNA. Translation: DAA06674.1.
PIRiS46826.
RefSeqiNP_011851.1. NM_001179092.1.

Genome annotation databases

EnsemblFungiiYHL012W; YHL012W; YHL012W.
GeneIDi856374.
KEGGisce:YHL012W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11582 Genomic DNA. Translation: AAB65065.1.
BK006934 Genomic DNA. Translation: DAA06674.1.
PIRiS46826.
RefSeqiNP_011851.1. NM_001179092.1.

3D structure databases

ProteinModelPortaliP38709.
SMRiP38709. Positions 23-481.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36411. 25 interactions.
IntActiP38709. 1 interaction.
STRINGi4932.YHL012W.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHL012W; YHL012W; YHL012W.
GeneIDi856374.
KEGGisce:YHL012W.

Organism-specific databases

CYGDiYHL012w.
SGDiS000001004. YHL012W.

Phylogenomic databases

eggNOGiCOG4284.
HOGENOMiHOG000113618.
InParanoidiP38709.
KOiK00963.
OrthoDBiEOG7HXD0T.

Enzyme and pathway databases

ReactomeiREACT_328453. Formation of the active cofactor, UDP-glucuronate.
REACT_331189. Glycogen synthesis.

Miscellaneous databases

NextBioi981858.

Gene expression databases

GenevestigatoriP38709.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiUGPA2_YEAST
AccessioniPrimary (citable) accession number: P38709
Secondary accession number(s): D3DKQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1995
Last sequence update: January 31, 1995
Last modified: March 31, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.