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Protein

Probable UTP--glucose-1-phosphate uridylyltransferase

Gene

YHL012W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.By similarity

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei181UTPBy similarity1
Binding sitei211UTP; via amide nitrogenBy similarity1
Binding sitei242UTPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
Ordered Locus Names:YHL012W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHL012W
SGDiS000001004 YHL012W

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857661 – 493Probable UTP--glucose-1-phosphate uridylyltransferaseAdd BLAST493

Proteomic databases

PaxDbiP38709
PRIDEiP38709
TopDownProteomicsiP38709

Interactioni

Protein-protein interaction databases

BioGridi36411, 52 interactors
IntActiP38709, 1 interactor
STRINGi4932.YHL012W

Structurei

3D structure databases

ProteinModelPortaliP38709
SMRiP38709
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni105 – 108UTP bindingBy similarity4
Regioni107 – 108Substrate bindingBy similarity2
Regioni240 – 242Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

HOGENOMiHOG000113618
InParanoidiP38709
KOiK00963
OrthoDBiEOG092C1PFF

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR029044 Nucleotide-diphossugar_trans
IPR002618 UDPGP_fam
IPR016267 UDPGP_trans
PfamiView protein in Pfam
PF01704 UDPGP, 1 hit
PIRSFiPIRSF000806 UDPGP, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

P38709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVFSGVNKI EFEGTFEGIG KDVVMSQMIR ALQKHFPSIR DKNYEFSLFL
60 70 80 90 100
HIFQRYVLEN TSITHDLVCD KIRLPIIDEV VELDDIKNYG LLEGKLLSKL
110 120 130 140 150
AILKLTGKAN PIIGKESPLF EVKNGMSSLD VIVRQTQNLN VRYNSDVPLI
160 170 180 190 200
FMTSLETESQ VSNFLEEHYS SSKVRWKTVV QSSFPQIDKD RLLPIDLQIN
210 220 230 240 250
SHENDFWYPC GTGNLTDTLY FSGELDKLIA QGKEILFVSN VDNLGATGDL
260 270 280 290 300
NILNFIINEK IEYLVEVVER TANVSNTGVL ATYKGKLRSV YYNCLSNESA
310 320 330 340 350
STCRIVNTNN IWIDLKKLKV LIESNSLNLP IHSSESKITH KNEEIECLQF
360 370 380 390 400
KTQLVDCIAF FPNSRVLKVS RDRFLPLRTC KDLFLLKSTL YDLDSNGTFN
410 420 430 440 450
LYPLKFGLLP SIDLGDEFAT YETFKIGVPD IPNILELEHL TVMGNVFFGR
460 470 480 490
NITLKGTVII ICDENDVITV PDGSILENVT IWHKSQLEDM NGY
Length:493
Mass (Da):56,000
Last modified:February 1, 1995 - v1
Checksum:iEFC7FA4A8F681DE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11582 Genomic DNA Translation: AAB65065.1
BK006934 Genomic DNA Translation: DAA06674.1
PIRiS46826
RefSeqiNP_011851.1, NM_001179092.1

Genome annotation databases

EnsemblFungiiYHL012W; YHL012W; YHL012W
GeneIDi856374
KEGGisce:YHL012W

Similar proteinsi

Entry informationi

Entry nameiUGPA2_YEAST
AccessioniPrimary (citable) accession number: P38709
Secondary accession number(s): D3DKQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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