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Protein

Putative proline--tRNA ligase YHR020W

Gene

YHR020W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

GO - Molecular functioni

  • aminoacyl-tRNA editing activity Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • proline-tRNA ligase activity Source: SGD

GO - Biological processi

  • prolyl-tRNA aminoacylation Source: SGD

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31081-MONOMER
SABIO-RKiP38708

Names & Taxonomyi

Protein namesi
Recommended name:
Putative proline--tRNA ligase YHR020W (EC:6.1.1.15)
Alternative name(s):
Prolyl-tRNA synthetase
Short name:
ProRS
Gene namesi
Ordered Locus Names:YHR020W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR020W
SGDiS000001062 YHR020W

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001393551 – 688Putative proline--tRNA ligase YHR020WAdd BLAST688

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei149PhosphoserineCombined sources1
Modified residuei170PhosphothreonineCombined sources1
Modified residuei655PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38708
PaxDbiP38708
PRIDEiP38708

PTM databases

iPTMnetiP38708

Interactioni

Protein-protein interaction databases

BioGridi36449, 211 interactors
DIPiDIP-6590N
IntActiP38708, 77 interactors
MINTiP38708
STRINGi4932.YHR020W

Structurei

3D structure databases

ProteinModelPortaliP38708
SMRiP38708
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074815
HOGENOMiHOG000167538
InParanoidiP38708
KOiK01881
OMAiEVYWVTH
OrthoDBiEOG092C1VT8

Family and domain databases

CDDicd00778 ProRS_core_arch_euk, 1 hit
Gene3Di3.30.110.30, 1 hit
3.40.50.800, 1 hit
3.90.960.10, 1 hit
HAMAPiMF_01571 Pro_tRNA_synth_type3, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR002316 Pro-tRNA-ligase_IIa
IPR004499 Pro-tRNA-ligase_IIa_arc-type
IPR016061 Pro-tRNA_ligase_II_C
IPR017449 Pro-tRNA_synth_II
IPR033721 ProRS_core_arch_euk
IPR036754 YbaK/aa-tRNA-synt-asso_dom_sf
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF09180 ProRS-C_1, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PRINTSiPR01046 TRNASYNTHPRO
SMARTiView protein in SMART
SM00946 ProRS-C_1, 1 hit
SUPFAMiSSF55826 SSF55826, 1 hit
SSF64586 SSF64586, 1 hit
TIGRFAMsiTIGR00408 proS_fam_I, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

P38708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVSEAFAKL CVNEKPPAES AVAVKSLVFK PKTPKSATPV PIVVVALQST
60 70 80 90 100
TTPSALIANA TSSKDPRLAR DDLVKQAFQS ESARAFILGD LANATSNFHL
110 120 130 140 150
LIDHELGTVD GDTILQLNDS TYMKKSDMMK FLNNFEDSQK VVDFSQEVSK
160 170 180 190 200
ETATEGKKQQ KKQQPSKAGT AAAAAAAALE DAKLIGITVD KALDFPGWYQ
210 220 230 240 250
QILTKGEMLD YYDVSGCYIL RPPSYAIWEN IQKWFDDKIK AIGVQNAYFP
260 270 280 290 300
MFVSSRVLEK EKDHVEGFAP EVAWVTRAGS SELEEPIAIR PTSETVMYPY
310 320 330 340 350
YAKWVQSYRD LPLKLNQWNS VVRWEFKHPQ PFLRTREFLW QEGHTAHLTA
360 370 380 390 400
KDAEEEVLQI LDFYAGVYEE LLAVPVVKGR KTEKEKFAGG DFTTTCEGYI
410 420 430 440 450
PQTGRGIQGA TSHHLGQNFS KMFNLSVENP LGSDHPKIFA YQNSWGLSTR
460 470 480 490 500
VIGVMVMIHS DNKGLVIPPR VSQFQSVVIP VGITKKTSEE QRKHIHETAR
510 520 530 540 550
SVESRLKKVG IRAFGDYNDN YTPGWKFSQY ELKGIPIRIE LGPKDIEKNQ
560 570 580 590 600
VVVVRRNDSK KYVVSFDELE ARIPEILEEM QGDLFKKAKE LFDTHRVIVN
610 620 630 640 650
EWSGFVPALN KKNVILAPWC GVMECEEDIK ESSAKKDDGE EFEEDDKAPS
660 670 680
MGAKSLCIPF DQPVLNEGQK CIKCERIAVN YCMFGRSY
Length:688
Mass (Da):77,386
Last modified:February 1, 1995 - v1
Checksum:i79EB480B24CA8CFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10399 Genomic DNA Translation: AAB68873.1
BK006934 Genomic DNA Translation: DAA06709.1
PIRiS46774
RefSeqiNP_011884.1, NM_001179150.1

Genome annotation databases

EnsemblFungiiYHR020W; YHR020W; YHR020W
GeneIDi856413
KEGGisce:YHR020W

Similar proteinsi

Entry informationi

Entry nameiYHI0_YEAST
AccessioniPrimary (citable) accession number: P38708
Secondary accession number(s): D3DKW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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