Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P38702

- LEU5_YEAST

UniProt

P38702 - LEU5_YEAST

Protein

Mitochondrial carrier protein LEU5

Gene

LEU5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for the accumulation of coenzyme A in the mitochondrial matrix.1 Publication

    GO - Molecular functioni

    1. coenzyme A transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. coenzyme A transmembrane transport Source: GOC
    2. coenzyme A transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31067-MONOMER.

    Protein family/group databases

    TCDBi2.A.29.12.4. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial carrier protein LEU5
    Gene namesi
    Name:LEU5
    Ordered Locus Names:YHR002W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR002w.
    SGDiS000001044. LEU5.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357Mitochondrial carrier protein LEU5PRO_0000090683Add
    BLAST

    Proteomic databases

    MaxQBiP38702.

    Expressioni

    Gene expression databases

    GenevestigatoriP38702.

    Interactioni

    Protein-protein interaction databases

    BioGridi36427. 42 interactions.
    DIPiDIP-8164N.
    STRINGi4932.YHR002W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38702.
    SMRiP38702. Positions 38-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 4717Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei103 – 11917Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei136 – 15318Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei208 – 22821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 28517Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei325 – 34723Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati31 – 12292Solcar 1Add
    BLAST
    Repeati130 – 231102Solcar 2Add
    BLAST
    Repeati262 – 35493Solcar 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274055.
    GeneTreeiENSGT00750000117595.
    HOGENOMiHOG000165726.
    KOiK15084.
    OMAiKHIWIND.
    OrthoDBiEOG712V5N.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002167. Graves_DC.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00928. GRAVESDC.
    PR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38702-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRDSPDSND SYKHINKNTT QKTSFDRNSF DYIVRSGLAG GISGSCAKTL    50
    IAPLDRIKIL FQTSNPHYTK YTGSLIGLVE AAKHIWINDG VRGFFQGHSA 100
    TLLRIFPYAA VKFVAYEQIR NTLIPSKEFE SHWRRLVSGS LAGLCSVFIT 150
    YPLDLVRVRL AYETEHKRVK LGRIIKKIYK EPASATLIKN DYIPNWFCHW 200
    CNFYRGYVPT VLGMIPYAGV SFFAHDLLHD VLKSPFFAPY SVLELSEDDE 250
    LERVQKKQRR PLRTWAELIS GGLAGMASQT AAYPFEIIRR RLQVSALSPK 300
    TMYDHKFQSI SEIAHIIFKE RGVRGFFVGL SIGYIKVTPM VACSFFVYER 350
    MKWNFGI 357
    Length:357
    Mass (Da):40,825
    Last modified:February 1, 1995 - v1
    Checksum:i16266B2CD4B996D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10555 Genomic DNA. Translation: AAB68424.1.
    BK006934 Genomic DNA. Translation: DAA06689.1.
    PIRiS46795.
    RefSeqiNP_011865.1. NM_001179132.1.

    Genome annotation databases

    EnsemblFungiiYHR002W; YHR002W; YHR002W.
    GeneIDi856391.
    KEGGisce:YHR002W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10555 Genomic DNA. Translation: AAB68424.1 .
    BK006934 Genomic DNA. Translation: DAA06689.1 .
    PIRi S46795.
    RefSeqi NP_011865.1. NM_001179132.1.

    3D structure databases

    ProteinModelPortali P38702.
    SMRi P38702. Positions 38-356.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36427. 42 interactions.
    DIPi DIP-8164N.
    STRINGi 4932.YHR002W.

    Protein family/group databases

    TCDBi 2.A.29.12.4. the mitochondrial carrier (mc) family.

    Proteomic databases

    MaxQBi P38702.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR002W ; YHR002W ; YHR002W .
    GeneIDi 856391.
    KEGGi sce:YHR002W.

    Organism-specific databases

    CYGDi YHR002w.
    SGDi S000001044. LEU5.

    Phylogenomic databases

    eggNOGi NOG274055.
    GeneTreei ENSGT00750000117595.
    HOGENOMi HOG000165726.
    KOi K15084.
    OMAi KHIWIND.
    OrthoDBi EOG712V5N.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31067-MONOMER.

    Miscellaneous databases

    NextBioi 981905.
    PROi P38702.

    Gene expression databases

    Genevestigatori P38702.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002167. Graves_DC.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00928. GRAVESDC.
    PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix."
      Prohl C., Pelzer W., Diekert K., Kmita H., Bedekovics T., Kispal G., Lill R.
      Mol. Cell. Biol. 21:1089-1097(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiLEU5_YEAST
    AccessioniPrimary (citable) accession number: P38702
    Secondary accession number(s): D3DKR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3