P38702 (LEU5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial carrier protein LEU5

Gene names

Name:	LEU5
Ordered Locus Names:	YHR002W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the accumulation of coenzyme A in the mitochondrial matrix. Ref.3
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein Ref.3.
Sequence similarities	Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification] Contains 3 Solcar repeats.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD mitochondrial inner membrane Inferred from direct assay Ref.3. Source: SGD
Molecular_function	coenzyme A transmembrane transporter activity Inferred from mutant phenotype Ref.3. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Mitochondrial carrier protein LEU5		PRO_0000090683
Regions
	Transmembrane	31 – 47	17	Helical; Name=1; Potential
	Transmembrane	103 – 119	17	Helical; Name=2; Potential
	Transmembrane	136 – 153	18	Helical; Name=3; Potential
	Transmembrane	208 – 228	21	Helical; Name=4; Potential
	Transmembrane	269 – 285	17	Helical; Name=5; Potential
	Transmembrane	325 – 347	23	Helical; Name=6; Potential
	Repeat	31 – 122	92	Solcar 1
	Repeat	130 – 231	102	Solcar 2
	Repeat	262 – 354	93	Solcar 3

Sequences

	Sequence		Length	Mass (Da)
	P38702 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 16266B2CD4B996D5	FASTA	357	40,825
	10 20 30 40 50 60 MTRDSPDSND SYKHINKNTT QKTSFDRNSF DYIVRSGLAG GISGSCAKTL IAPLDRIKIL 70 80 90 100 110 120 FQTSNPHYTK YTGSLIGLVE AAKHIWINDG VRGFFQGHSA TLLRIFPYAA VKFVAYEQIR 130 140 150 160 170 180 NTLIPSKEFE SHWRRLVSGS LAGLCSVFIT YPLDLVRVRL AYETEHKRVK LGRIIKKIYK 190 200 210 220 230 240 EPASATLIKN DYIPNWFCHW CNFYRGYVPT VLGMIPYAGV SFFAHDLLHD VLKSPFFAPY 250 260 270 280 290 300 SVLELSEDDE LERVQKKQRR PLRTWAELIS GGLAGMASQT AAYPFEIIRR RLQVSALSPK 310 320 330 340 350 TMYDHKFQSI SEIAHIIFKE RGVRGFFVGL SIGYIKVTPM VACSFFVYER MKWNFGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix." Prohl C., Pelzer W., Diekert K., Kmita H., Bedekovics T., Kispal G., Lill R. Mol. Cell. Biol. 21:1089-1097(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10555 Genomic DNA. Translation: AAB68424.1. BK006934 Genomic DNA. Translation: DAA06689.1.
PIR	S46795.
RefSeq	NP_011865.1. NM_001179132.1.
3D structure databases
ProteinModelPortal	P38702.
SMR	P38702. Positions 38-329.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-8164N.
STRING	4932.YHR002W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR002W; YHR002W; YHR002W.
GeneID	856391.
KEGG	sce:YHR002W.
Organism-specific databases
CYGD	YHR002w.
SGD	S000001044. LEU5.
Phylogenomic databases
eggNOG	NOG274055.
GeneTree	ENSGT00390000010947.
HOGENOM	HOG000165726.
KO	K15084.
OMA	ESHWRRL.
OrthoDB	EOG4V9Z07.
Gene expression databases
Genevestigator	P38702.
GermOnline	YHR002W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	1.50.40.10. 1 hit.
InterPro	IPR002167. Graves_DC. IPR002067. Mit_carrier. IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Pfam	PF00153. Mito_carr. 3 hits. [Graphical view]
PRINTS	PR00928. GRAVESDC. PR00926. MITOCARRIER.
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	981905.

Entry information

Entry name

LEU5_YEAST

Accession

Primary (citable) accession number: P38702
Secondary accession number(s): D3DKR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program