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P38702

- LEU5_YEAST

UniProt

P38702 - LEU5_YEAST

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Protein

Mitochondrial carrier protein LEU5

Gene

LEU5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for the accumulation of coenzyme A in the mitochondrial matrix.1 Publication

GO - Molecular functioni

  1. coenzyme A transmembrane transporter activity Source: SGD

GO - Biological processi

  1. coenzyme A transmembrane transport Source: GOC
  2. coenzyme A transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31067-MONOMER.
ReactomeiREACT_255671. Coenzyme A biosynthesis.

Protein family/group databases

TCDBi2.A.29.12.4. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carrier protein LEU5
Gene namesi
Name:LEU5
Ordered Locus Names:YHR002W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR002w.
SGDiS000001044. LEU5.

Subcellular locationi

Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 4717Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei103 – 11917Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei136 – 15318Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei208 – 22821Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei269 – 28517Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei325 – 34723Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Mitochondrial carrier protein LEU5PRO_0000090683Add
BLAST

Proteomic databases

MaxQBiP38702.

Expressioni

Gene expression databases

GenevestigatoriP38702.

Interactioni

Protein-protein interaction databases

BioGridi36427. 42 interactions.
DIPiDIP-8164N.
STRINGi4932.YHR002W.

Structurei

3D structure databases

ProteinModelPortaliP38702.
SMRiP38702. Positions 38-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 12292Solcar 1Add
BLAST
Repeati130 – 231102Solcar 2Add
BLAST
Repeati262 – 35493Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274055.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165726.
InParanoidiP38702.
KOiK15084.
OMAiKHIWIND.
OrthoDBiEOG712V5N.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38702-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRDSPDSND SYKHINKNTT QKTSFDRNSF DYIVRSGLAG GISGSCAKTL
60 70 80 90 100
IAPLDRIKIL FQTSNPHYTK YTGSLIGLVE AAKHIWINDG VRGFFQGHSA
110 120 130 140 150
TLLRIFPYAA VKFVAYEQIR NTLIPSKEFE SHWRRLVSGS LAGLCSVFIT
160 170 180 190 200
YPLDLVRVRL AYETEHKRVK LGRIIKKIYK EPASATLIKN DYIPNWFCHW
210 220 230 240 250
CNFYRGYVPT VLGMIPYAGV SFFAHDLLHD VLKSPFFAPY SVLELSEDDE
260 270 280 290 300
LERVQKKQRR PLRTWAELIS GGLAGMASQT AAYPFEIIRR RLQVSALSPK
310 320 330 340 350
TMYDHKFQSI SEIAHIIFKE RGVRGFFVGL SIGYIKVTPM VACSFFVYER

MKWNFGI
Length:357
Mass (Da):40,825
Last modified:February 1, 1995 - v1
Checksum:i16266B2CD4B996D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10555 Genomic DNA. Translation: AAB68424.1.
BK006934 Genomic DNA. Translation: DAA06689.1.
PIRiS46795.
RefSeqiNP_011865.1. NM_001179132.1.

Genome annotation databases

EnsemblFungiiYHR002W; YHR002W; YHR002W.
GeneIDi856391.
KEGGisce:YHR002W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10555 Genomic DNA. Translation: AAB68424.1 .
BK006934 Genomic DNA. Translation: DAA06689.1 .
PIRi S46795.
RefSeqi NP_011865.1. NM_001179132.1.

3D structure databases

ProteinModelPortali P38702.
SMRi P38702. Positions 38-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36427. 42 interactions.
DIPi DIP-8164N.
STRINGi 4932.YHR002W.

Protein family/group databases

TCDBi 2.A.29.12.4. the mitochondrial carrier (mc) family.

Proteomic databases

MaxQBi P38702.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR002W ; YHR002W ; YHR002W .
GeneIDi 856391.
KEGGi sce:YHR002W.

Organism-specific databases

CYGDi YHR002w.
SGDi S000001044. LEU5.

Phylogenomic databases

eggNOGi NOG274055.
GeneTreei ENSGT00760000119245.
HOGENOMi HOG000165726.
InParanoidi P38702.
KOi K15084.
OMAi KHIWIND.
OrthoDBi EOG712V5N.

Enzyme and pathway databases

BioCyci YEAST:G3O-31067-MONOMER.
Reactomei REACT_255671. Coenzyme A biosynthesis.

Miscellaneous databases

NextBioi 981905.
PROi P38702.

Gene expression databases

Genevestigatori P38702.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix."
    Prohl C., Pelzer W., Diekert K., Kmita H., Bedekovics T., Kispal G., Lill R.
    Mol. Cell. Biol. 21:1089-1097(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiLEU5_YEAST
AccessioniPrimary (citable) accession number: P38702
Secondary accession number(s): D3DKR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3