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P38702 (LEU5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial carrier protein LEU5
Gene names
Name:LEU5
Ordered Locus Names:YHR002W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the accumulation of coenzyme A in the mitochondrial matrix. Ref.3

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein Ref.3.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Mitochondrial carrier protein LEU5
PRO_0000090683

Regions

Transmembrane31 – 4717Helical; Name=1; Potential
Transmembrane103 – 11917Helical; Name=2; Potential
Transmembrane136 – 15318Helical; Name=3; Potential
Transmembrane208 – 22821Helical; Name=4; Potential
Transmembrane269 – 28517Helical; Name=5; Potential
Transmembrane325 – 34723Helical; Name=6; Potential
Repeat31 – 12292Solcar 1
Repeat130 – 231102Solcar 2
Repeat262 – 35493Solcar 3

Sequences

Sequence LengthMass (Da)Tools
P38702 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 16266B2CD4B996D5

FASTA35740,825
        10         20         30         40         50         60 
MTRDSPDSND SYKHINKNTT QKTSFDRNSF DYIVRSGLAG GISGSCAKTL IAPLDRIKIL 

        70         80         90        100        110        120 
FQTSNPHYTK YTGSLIGLVE AAKHIWINDG VRGFFQGHSA TLLRIFPYAA VKFVAYEQIR 

       130        140        150        160        170        180 
NTLIPSKEFE SHWRRLVSGS LAGLCSVFIT YPLDLVRVRL AYETEHKRVK LGRIIKKIYK 

       190        200        210        220        230        240 
EPASATLIKN DYIPNWFCHW CNFYRGYVPT VLGMIPYAGV SFFAHDLLHD VLKSPFFAPY 

       250        260        270        280        290        300 
SVLELSEDDE LERVQKKQRR PLRTWAELIS GGLAGMASQT AAYPFEIIRR RLQVSALSPK 

       310        320        330        340        350 
TMYDHKFQSI SEIAHIIFKE RGVRGFFVGL SIGYIKVTPM VACSFFVYER MKWNFGI 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix."
Prohl C., Pelzer W., Diekert K., Kmita H., Bedekovics T., Kispal G., Lill R.
Mol. Cell. Biol. 21:1089-1097(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U10555 Genomic DNA. Translation: AAB68424.1.
BK006934 Genomic DNA. Translation: DAA06689.1.
PIRS46795.
RefSeqNP_011865.1. NM_001179132.1.

3D structure databases

ProteinModelPortalP38702.
SMRP38702. Positions 38-355.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36427. 42 interactions.
DIPDIP-8164N.
STRING4932.YHR002W.

Protein family/group databases

TCDB2.A.29.12.4. the mitochondrial carrier (mc) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR002W; YHR002W; YHR002W.
GeneID856391.
KEGGsce:YHR002W.

Organism-specific databases

CYGDYHR002w.
SGDS000001044. LEU5.

Phylogenomic databases

eggNOGNOG274055.
GeneTreeENSGT00750000117595.
HOGENOMHOG000165726.
KOK15084.
OMAKHIWIND.
OrthoDBEOG712V5N.

Enzyme and pathway databases

BioCycYEAST:G3O-31067-MONOMER.

Gene expression databases

GenevestigatorP38702.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio981905.
PROP38702.

Entry information

Entry nameLEU5_YEAST
AccessionPrimary (citable) accession number: P38702
Secondary accession number(s): D3DKR9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families