Reviewed, UniProtKB/Swiss-Prot P38702 (LEU5_YEAST)

Names and origin

Protein names

Recommended name:
    Mitochondrial carrier protein LEU5

Gene names

Name:	LEU5
Ordered Locus Names:	YHR002W

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Required for the accumulation of coenzyme A in the mitochondrial matrix. Ref.2
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the mitochondrial carrier family. Contains 3 Solcar repeats.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Repeat Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A transport Ref.2 Inferred from mutant phenotype. Source: SGD transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membrane Ref.2 Inferred from direct assay. Source: SGD
Molecular function	binding Inferred from electronic annotation. Source: InterPro coenzyme A transmembrane transporter activity Ref.2 Inferred from mutant phenotype. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Mitochondrial carrier protein LEU5		PRO_0000090683
Regions
	Transmembrane	31 – 47	17	1 Potential
	Transmembrane	103 – 119	17	2 Potential
	Transmembrane	136 – 153	18	3 Potential
	Transmembrane	208 – 228	21	4 Potential
	Transmembrane	269 – 285	17	5 Potential
	Transmembrane	325 – 347	23	6 Potential
	Repeat	31 – 122	92	Solcar 1
	Repeat	130 – 231	102	Solcar 2
	Repeat	262 – 354	93	Solcar 3

Sequences

	Sequence		Length	Mass (Da)
	P38702-1 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 16266B2CD4B996D5	FASTA	357	40,825
	10 20 30 40 50 60 MTRDSPDSND SYKHINKNTT QKTSFDRNSF DYIVRSGLAG GISGSCAKTL IAPLDRIKIL 70 80 90 100 110 120 FQTSNPHYTK YTGSLIGLVE AAKHIWINDG VRGFFQGHSA TLLRIFPYAA VKFVAYEQIR 130 140 150 160 170 180 NTLIPSKEFE SHWRRLVSGS LAGLCSVFIT YPLDLVRVRL AYETEHKRVK LGRIIKKIYK 190 200 210 220 230 240 EPASATLIKN DYIPNWFCHW CNFYRGYVPT VLGMIPYAGV SFFAHDLLHD VLKSPFFAPY 250 260 270 280 290 300 SVLELSEDDE LERVQKKQRR PLRTWAELIS GGLAGMASQT AAYPFEIIRR RLQVSALSPK 310 320 330 340 350 TMYDHKFQSI SEIAHIIFKE RGVRGFFVGL SIGYIKVTPM VACSFFVYER MKWNFGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed: 8091229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix." Prohl C., Pelzer W., Diekert K., Kmita H., Bedekovics T., Kispal G., Lill R. Mol. Cell. Biol. 21:1089-1097(2001) [PubMed: 11158296] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U10555 Genomic DNA. Translation: AAB68424.1.
PIR	S46795.
RefSeq	NP_011865.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:8164N.
Genome annotation databases
Ensembl	YHR002W; YHR002W; YHR002W; Saccharomyces cerevisiae. [Genome view]
GeneID	856391.
KEGG	sce:YHR002W.
NMPDR	fig|4932.3.peg.3009.
Organism-specific databases
CYGD	YHR002w.
SGD	S000001044. LEU5.
Phylogenomic databases
HOGENOM	P38702.
OMA	LYGIFPY
OrthoDB	EOG9VQC59
Gene expression databases
ArrayExpress	P38702.
Genevestigator	P38702.
GermOnline	YHR002W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR002167. Graves_DC. IPR002067. Mit_carrier. IPR001993. Mitochondria_substrate_carrier. IPR018108. Mitochondrial_sb/sol_carrier. [Graphical view]
PANTHER	PTHR11896. Mitoch_carrier. 1 hit.
Pfam	PF00153. Mito_carr. 3 hits. [Graphical view]
PRINTS	PR00928. GRAVESDC. PR00926. MITOCARRIER.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	981905.

Entry information

Entry name

LEU5_YEAST

Accession

Primary (citable) accession number: P38702

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	November 24, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)