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P38700

- APM2_YEAST

UniProt

P38700 - APM2_YEAST

Protein

Adaptin medium chain homolog APM2

Gene

APM2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. clathrin binding Source: SGD
    2. protein binding Source: IntAct

    GO - Biological processi

    1. Golgi to vacuole transport Source: SGD
    2. intracellular protein transport Source: InterPro
    3. vesicle-mediated transport Source: SGD

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31039-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adaptin medium chain homolog APM2
    Alternative name(s):
    Adaptin-mu1-II
    Gene namesi
    Name:APM2
    Ordered Locus Names:YHL019C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHL019c.
    SGDiS000001011. APM2.

    Subcellular locationi

    GO - Cellular componenti

    1. AP-1 adaptor complex Source: SGD
    2. coated pit Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Coated pit, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 605605Adaptin medium chain homolog APM2PRO_0000193793Add
    BLAST

    Proteomic databases

    MaxQBiP38700.
    PaxDbiP38700.

    Expressioni

    Gene expression databases

    GenevestigatoriP38700.

    Interactioni

    Subunit structurei

    Interacts with APL2, probably forming an alternative AP-1-like complex.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    APL2P360007EBI-2705,EBI-2206

    Protein-protein interaction databases

    BioGridi36404. 16 interactions.
    DIPiDIP-1200N.
    IntActiP38700. 9 interactions.
    MINTiMINT-404347.
    STRINGi4932.YHL019C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38700.
    SMRiP38700. Positions 2-135, 258-593.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini269 – 604336MHDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG292341.
    HOGENOMiHOG000033997.
    OMAiAINWRPK.
    OrthoDBiEOG7HXD0Q.

    Family and domain databases

    InterProiIPR027200. Apm2.
    IPR008968. Clathrin_mu_C.
    IPR018240. Clathrin_mu_CS.
    IPR011012. Longin-like_dom.
    IPR028565. MHD.
    [Graphical view]
    PANTHERiPTHR11998:SF24. PTHR11998:SF24. 1 hit.
    PfamiPF00928. Adap_comp_sub. 1 hit.
    [Graphical view]
    SUPFAMiSSF49447. SSF49447. 2 hits.
    SSF64356. SSF64356. 1 hit.
    PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
    PS00991. CLAT_ADAPTOR_M_2. 1 hit.
    PS51072. MHD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38700-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSLFILDE NLEPLVSKNI RALPNLSSVL SSFKQCYHDG SPPILSQNDW    50
    FFIHLKRDFL HFVSVIHTTD KPNIDLMTIL AFLEQFYHLL QKYFEIEVLT 100
    KNVILDNILL VLELIDECID FGIVQVTDPS IIKDYIRVKV NVPRVTVDNE 150
    EWSPGEESSS SSGSDSDSEY SNTNKRKDKK KKRKKKKGTK GKSVGKSKLK 200
    SIMVNNKENR GINVVETVKE TLRNKNDTGK EAANDELPND GNDLYINGDI 250
    AKTIIMPISW RTKGIHYAKN EFFLDVIERV QYLMDFEKGV IRKNLIHGEI 300
    VCRCYLSGMP KLKISINKIL NRDPQFMSNS SFHQCVSLDS INTIEKDEEK 350
    NSDDDAGLQA ATDAREIEFI PPDGEFVLCQ YELKRHVKDA PMVRLKDFEI 400
    KPKLKKFKIQ IVTKIQTNFK PTNSTSKLNV RIPLTKVFQE YKIDLSKQIR 450
    FKANIGKVVF NLSDDFLLWE IQTMKGHREH STNKSSQYNS DEDDPNTCAS 500
    MVAEFPLFNQ EEYDRLQEEM KTSMNPPPLR TGPRLEELYR QVHDQQTSHV 550
    TPRDKLVNID FEIPYCTCSG LKVEYLKVEE PQLQYQSFPW VRYKTVSDEE 600
    YAYIV 605
    Length:605
    Mass (Da):69,990
    Last modified:February 1, 1995 - v1
    Checksum:i7E216B11325EEE3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09841 Genomic DNA. Translation: AAA83415.1.
    U11582 Genomic DNA. Translation: AAB65072.1.
    BK006934 Genomic DNA. Translation: DAA06666.1.
    PIRiS46833.
    RefSeqiNP_011844.1. NM_001179099.1.

    Genome annotation databases

    EnsemblFungiiYHL019C; YHL019C; YHL019C.
    GeneIDi856367.
    KEGGisce:YHL019C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09841 Genomic DNA. Translation: AAA83415.1 .
    U11582 Genomic DNA. Translation: AAB65072.1 .
    BK006934 Genomic DNA. Translation: DAA06666.1 .
    PIRi S46833.
    RefSeqi NP_011844.1. NM_001179099.1.

    3D structure databases

    ProteinModelPortali P38700.
    SMRi P38700. Positions 2-135, 258-593.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36404. 16 interactions.
    DIPi DIP-1200N.
    IntActi P38700. 9 interactions.
    MINTi MINT-404347.
    STRINGi 4932.YHL019C.

    Proteomic databases

    MaxQBi P38700.
    PaxDbi P38700.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHL019C ; YHL019C ; YHL019C .
    GeneIDi 856367.
    KEGGi sce:YHL019C.

    Organism-specific databases

    CYGDi YHL019c.
    SGDi S000001011. APM2.

    Phylogenomic databases

    eggNOGi NOG292341.
    HOGENOMi HOG000033997.
    OMAi AINWRPK.
    OrthoDBi EOG7HXD0Q.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31039-MONOMER.

    Miscellaneous databases

    NextBioi 981837.

    Gene expression databases

    Genevestigatori P38700.

    Family and domain databases

    InterProi IPR027200. Apm2.
    IPR008968. Clathrin_mu_C.
    IPR018240. Clathrin_mu_CS.
    IPR011012. Longin-like_dom.
    IPR028565. MHD.
    [Graphical view ]
    PANTHERi PTHR11998:SF24. PTHR11998:SF24. 1 hit.
    Pfami PF00928. Adap_comp_sub. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49447. SSF49447. 2 hits.
    SSF64356. SSF64356. 1 hit.
    PROSITEi PS00990. CLAT_ADAPTOR_M_1. 1 hit.
    PS00991. CLAT_ADAPTOR_M_2. 1 hit.
    PS51072. MHD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related protein."
      Stepp J.D., Pellicena-Palle A., Hamilton S., Kirchhausen T., Lemmon S.K.
      Mol. Biol. Cell 6:41-58(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: S288c / REE526.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Adaptor complex-independent clathrin function in yeast."
      Yeung B.G., Phan H.L., Payne G.S.
      Mol. Biol. Cell 10:3643-3659(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH APL2.

    Entry informationi

    Entry nameiAPM2_YEAST
    AccessioniPrimary (citable) accession number: P38700
    Secondary accession number(s): D3DKR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2890 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3