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P38700

- APM2_YEAST

UniProt

P38700 - APM2_YEAST

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Protein

Adaptin medium chain homolog APM2

Gene

APM2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. clathrin binding Source: SGD

GO - Biological processi

  1. Golgi to vacuole transport Source: SGD
  2. intracellular protein transport Source: InterPro
  3. vesicle-mediated transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31039-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adaptin medium chain homolog APM2
Alternative name(s):
Adaptin-mu1-II
Gene namesi
Name:APM2
Ordered Locus Names:YHL019C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHL019c.
SGDiS000001011. APM2.

Subcellular locationi

GO - Cellular componenti

  1. AP-1 adaptor complex Source: SGD
  2. coated pit Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 605605Adaptin medium chain homolog APM2PRO_0000193793Add
BLAST

Proteomic databases

MaxQBiP38700.
PaxDbiP38700.

Expressioni

Gene expression databases

GenevestigatoriP38700.

Interactioni

Subunit structurei

Interacts with APL2, probably forming an alternative AP-1-like complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
APL2P360007EBI-2705,EBI-2206

Protein-protein interaction databases

BioGridi36404. 16 interactions.
DIPiDIP-1200N.
IntActiP38700. 9 interactions.
MINTiMINT-404347.
STRINGi4932.YHL019C.

Structurei

3D structure databases

ProteinModelPortaliP38700.
SMRiP38700. Positions 2-604.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini269 – 604336MHDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG292341.
HOGENOMiHOG000033997.
InParanoidiP38700.
OMAiAINWRPK.
OrthoDBiEOG7HXD0Q.

Family and domain databases

InterProiIPR027200. Apm2.
IPR008968. Clathrin_mu_C.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PANTHERiPTHR11998:SF24. PTHR11998:SF24. 1 hit.
PfamiPF00928. Adap_comp_sub. 1 hit.
[Graphical view]
SUPFAMiSSF49447. SSF49447. 2 hits.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38700-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSSLFILDE NLEPLVSKNI RALPNLSSVL SSFKQCYHDG SPPILSQNDW
60 70 80 90 100
FFIHLKRDFL HFVSVIHTTD KPNIDLMTIL AFLEQFYHLL QKYFEIEVLT
110 120 130 140 150
KNVILDNILL VLELIDECID FGIVQVTDPS IIKDYIRVKV NVPRVTVDNE
160 170 180 190 200
EWSPGEESSS SSGSDSDSEY SNTNKRKDKK KKRKKKKGTK GKSVGKSKLK
210 220 230 240 250
SIMVNNKENR GINVVETVKE TLRNKNDTGK EAANDELPND GNDLYINGDI
260 270 280 290 300
AKTIIMPISW RTKGIHYAKN EFFLDVIERV QYLMDFEKGV IRKNLIHGEI
310 320 330 340 350
VCRCYLSGMP KLKISINKIL NRDPQFMSNS SFHQCVSLDS INTIEKDEEK
360 370 380 390 400
NSDDDAGLQA ATDAREIEFI PPDGEFVLCQ YELKRHVKDA PMVRLKDFEI
410 420 430 440 450
KPKLKKFKIQ IVTKIQTNFK PTNSTSKLNV RIPLTKVFQE YKIDLSKQIR
460 470 480 490 500
FKANIGKVVF NLSDDFLLWE IQTMKGHREH STNKSSQYNS DEDDPNTCAS
510 520 530 540 550
MVAEFPLFNQ EEYDRLQEEM KTSMNPPPLR TGPRLEELYR QVHDQQTSHV
560 570 580 590 600
TPRDKLVNID FEIPYCTCSG LKVEYLKVEE PQLQYQSFPW VRYKTVSDEE

YAYIV
Length:605
Mass (Da):69,990
Last modified:February 1, 1995 - v1
Checksum:i7E216B11325EEE3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09841 Genomic DNA. Translation: AAA83415.1.
U11582 Genomic DNA. Translation: AAB65072.1.
BK006934 Genomic DNA. Translation: DAA06666.1.
PIRiS46833.
RefSeqiNP_011844.1. NM_001179099.1.

Genome annotation databases

EnsemblFungiiYHL019C; YHL019C; YHL019C.
GeneIDi856367.
KEGGisce:YHL019C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09841 Genomic DNA. Translation: AAA83415.1 .
U11582 Genomic DNA. Translation: AAB65072.1 .
BK006934 Genomic DNA. Translation: DAA06666.1 .
PIRi S46833.
RefSeqi NP_011844.1. NM_001179099.1.

3D structure databases

ProteinModelPortali P38700.
SMRi P38700. Positions 2-604.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36404. 16 interactions.
DIPi DIP-1200N.
IntActi P38700. 9 interactions.
MINTi MINT-404347.
STRINGi 4932.YHL019C.

Proteomic databases

MaxQBi P38700.
PaxDbi P38700.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHL019C ; YHL019C ; YHL019C .
GeneIDi 856367.
KEGGi sce:YHL019C.

Organism-specific databases

CYGDi YHL019c.
SGDi S000001011. APM2.

Phylogenomic databases

eggNOGi NOG292341.
HOGENOMi HOG000033997.
InParanoidi P38700.
OMAi AINWRPK.
OrthoDBi EOG7HXD0Q.

Enzyme and pathway databases

BioCyci YEAST:G3O-31039-MONOMER.

Miscellaneous databases

NextBioi 981837.

Gene expression databases

Genevestigatori P38700.

Family and domain databases

InterProi IPR027200. Apm2.
IPR008968. Clathrin_mu_C.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view ]
PANTHERi PTHR11998:SF24. PTHR11998:SF24. 1 hit.
Pfami PF00928. Adap_comp_sub. 1 hit.
[Graphical view ]
SUPFAMi SSF49447. SSF49447. 2 hits.
SSF64356. SSF64356. 1 hit.
PROSITEi PS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related protein."
    Stepp J.D., Pellicena-Palle A., Hamilton S., Kirchhausen T., Lemmon S.K.
    Mol. Biol. Cell 6:41-58(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / REE526.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Adaptor complex-independent clathrin function in yeast."
    Yeung B.G., Phan H.L., Payne G.S.
    Mol. Biol. Cell 10:3643-3659(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH APL2.

Entry informationi

Entry nameiAPM2_YEAST
AccessioniPrimary (citable) accession number: P38700
Secondary accession number(s): D3DKR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2890 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3