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Protein

Adaptin medium chain homolog APM2

Gene

APM2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 2890 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • clathrin binding Source: SGD

GO - Biological processi

  • Golgi to vacuole transport Source: SGD
  • intracellular protein transport Source: InterPro
  • vesicle-mediated transport Source: SGD

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31039-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Adaptin medium chain homolog APM2
Alternative name(s):
Adaptin-mu1-II
Gene namesi
Name:APM2
Ordered Locus Names:YHL019C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHL019C
SGDiS000001011 APM2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937931 – 605Adaptin medium chain homolog APM2Add BLAST605

Proteomic databases

MaxQBiP38700
PaxDbiP38700
PRIDEiP38700
TopDownProteomicsiP38700

Interactioni

Subunit structurei

Interacts with APL2, probably forming an alternative AP-1-like complex.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • clathrin binding Source: SGD

Protein-protein interaction databases

BioGridi36404, 40 interactors
DIPiDIP-1200N
IntActiP38700, 11 interactors
MINTiP38700
STRINGi4932.YHL019C

Structurei

3D structure databases

ProteinModelPortaliP38700
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini269 – 604MHDPROSITE-ProRule annotationAdd BLAST336

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000033997
InParanoidiP38700
OMAiSTHNQAV
OrthoDBiEOG092C2NDI

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR027200 Apm2
IPR018240 Clathrin_mu_CS
IPR011012 Longin-like_dom_sf
IPR028565 MHD
PANTHERiPTHR10529:SF271 PTHR10529:SF271, 1 hit
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
SUPFAMiSSF49447 SSF49447, 2 hits
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990 CLAT_ADAPTOR_M_1, 1 hit
PS00991 CLAT_ADAPTOR_M_2, 1 hit
PS51072 MHD, 1 hit

Sequencei

Sequence statusi: Complete.

P38700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSLFILDE NLEPLVSKNI RALPNLSSVL SSFKQCYHDG SPPILSQNDW
60 70 80 90 100
FFIHLKRDFL HFVSVIHTTD KPNIDLMTIL AFLEQFYHLL QKYFEIEVLT
110 120 130 140 150
KNVILDNILL VLELIDECID FGIVQVTDPS IIKDYIRVKV NVPRVTVDNE
160 170 180 190 200
EWSPGEESSS SSGSDSDSEY SNTNKRKDKK KKRKKKKGTK GKSVGKSKLK
210 220 230 240 250
SIMVNNKENR GINVVETVKE TLRNKNDTGK EAANDELPND GNDLYINGDI
260 270 280 290 300
AKTIIMPISW RTKGIHYAKN EFFLDVIERV QYLMDFEKGV IRKNLIHGEI
310 320 330 340 350
VCRCYLSGMP KLKISINKIL NRDPQFMSNS SFHQCVSLDS INTIEKDEEK
360 370 380 390 400
NSDDDAGLQA ATDAREIEFI PPDGEFVLCQ YELKRHVKDA PMVRLKDFEI
410 420 430 440 450
KPKLKKFKIQ IVTKIQTNFK PTNSTSKLNV RIPLTKVFQE YKIDLSKQIR
460 470 480 490 500
FKANIGKVVF NLSDDFLLWE IQTMKGHREH STNKSSQYNS DEDDPNTCAS
510 520 530 540 550
MVAEFPLFNQ EEYDRLQEEM KTSMNPPPLR TGPRLEELYR QVHDQQTSHV
560 570 580 590 600
TPRDKLVNID FEIPYCTCSG LKVEYLKVEE PQLQYQSFPW VRYKTVSDEE

YAYIV
Length:605
Mass (Da):69,990
Last modified:February 1, 1995 - v1
Checksum:i7E216B11325EEE3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09841 Genomic DNA Translation: AAA83415.1
U11582 Genomic DNA Translation: AAB65072.1
BK006934 Genomic DNA Translation: DAA06666.1
PIRiS46833
RefSeqiNP_011844.1, NM_001179099.1

Genome annotation databases

EnsemblFungiiYHL019C; YHL019C; YHL019C
GeneIDi856367
KEGGisce:YHL019C

Similar proteinsi

Entry informationi

Entry nameiAPM2_YEAST
AccessioniPrimary (citable) accession number: P38700
Secondary accession number(s): D3DKR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health