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P38700 (APM2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adaptin medium chain homolog APM2
Alternative name(s):
Adaptin-mu1-II
Gene names
Name:APM2
Ordered Locus Names:YHL019C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length605 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with APL2, probably forming an alternative AP-1-like complex. Ref.5

Subcellular location

Membranecoated pit.

Miscellaneous

Present with 2890 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the adaptor complexes medium subunit family.

Contains 1 MHD (mu homology) domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

APL2P360007EBI-2705,EBI-2206

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 605605Adaptin medium chain homolog APM2
PRO_0000193793

Regions

Domain269 – 604336MHD

Sequences

Sequence LengthMass (Da)Tools
P38700 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 7E216B11325EEE3C

FASTA60569,990
        10         20         30         40         50         60 
MSSSLFILDE NLEPLVSKNI RALPNLSSVL SSFKQCYHDG SPPILSQNDW FFIHLKRDFL 

        70         80         90        100        110        120 
HFVSVIHTTD KPNIDLMTIL AFLEQFYHLL QKYFEIEVLT KNVILDNILL VLELIDECID 

       130        140        150        160        170        180 
FGIVQVTDPS IIKDYIRVKV NVPRVTVDNE EWSPGEESSS SSGSDSDSEY SNTNKRKDKK 

       190        200        210        220        230        240 
KKRKKKKGTK GKSVGKSKLK SIMVNNKENR GINVVETVKE TLRNKNDTGK EAANDELPND 

       250        260        270        280        290        300 
GNDLYINGDI AKTIIMPISW RTKGIHYAKN EFFLDVIERV QYLMDFEKGV IRKNLIHGEI 

       310        320        330        340        350        360 
VCRCYLSGMP KLKISINKIL NRDPQFMSNS SFHQCVSLDS INTIEKDEEK NSDDDAGLQA 

       370        380        390        400        410        420 
ATDAREIEFI PPDGEFVLCQ YELKRHVKDA PMVRLKDFEI KPKLKKFKIQ IVTKIQTNFK 

       430        440        450        460        470        480 
PTNSTSKLNV RIPLTKVFQE YKIDLSKQIR FKANIGKVVF NLSDDFLLWE IQTMKGHREH 

       490        500        510        520        530        540 
STNKSSQYNS DEDDPNTCAS MVAEFPLFNQ EEYDRLQEEM KTSMNPPPLR TGPRLEELYR 

       550        560        570        580        590        600 
QVHDQQTSHV TPRDKLVNID FEIPYCTCSG LKVEYLKVEE PQLQYQSFPW VRYKTVSDEE 


YAYIV 

« Hide

References

« Hide 'large scale' references
[1]"A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related protein."
Stepp J.D., Pellicena-Palle A., Hamilton S., Kirchhausen T., Lemmon S.K.
Mol. Biol. Cell 6:41-58(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S288c / REE526.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Adaptor complex-independent clathrin function in yeast."
Yeung B.G., Phan H.L., Payne G.S.
Mol. Biol. Cell 10:3643-3659(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH APL2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U09841 Genomic DNA. Translation: AAA83415.1.
U11582 Genomic DNA. Translation: AAB65072.1.
BK006934 Genomic DNA. Translation: DAA06666.1.
PIRS46833.
RefSeqNP_011844.1. NM_001179099.1.

3D structure databases

ProteinModelPortalP38700.
SMRP38700. Positions 2-135, 258-593.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36404. 15 interactions.
DIPDIP-1200N.
IntActP38700. 9 interactions.
MINTMINT-404347.
STRING4932.YHL019C.

Proteomic databases

PaxDbP38700.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHL019C; YHL019C; YHL019C.
GeneID856367.
KEGGsce:YHL019C.

Organism-specific databases

CYGDYHL019c.
SGDS000001011. APM2.

Phylogenomic databases

eggNOGNOG292341.
HOGENOMHOG000033997.
OMAKNEFFLD.
OrthoDBEOG7HXD0Q.

Enzyme and pathway databases

BioCycYEAST:G3O-31039-MONOMER.

Gene expression databases

GenevestigatorP38700.

Family and domain databases

InterProIPR027200. Apm2.
IPR008968. Clathrin_mu_C.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PANTHERPTHR11998:SF5. PTHR11998:SF5. 1 hit.
PfamPF00928. Adap_comp_sub. 1 hit.
[Graphical view]
SUPFAMSSF49447. SSF49447. 2 hits.
SSF64356. SSF64356. 1 hit.
PROSITEPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio981837.

Entry information

Entry nameAPM2_YEAST
AccessionPrimary (citable) accession number: P38700
Secondary accession number(s): D3DKR4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families