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P38698

- PPX1_YEAST

UniProt

P38698 - PPX1_YEAST

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Protein

Exopolyphosphatase

Gene

PPX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Degradation of inorganic polyphosphates.

Catalytic activityi

(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.

Cofactori

Binds 2 manganese ions per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi39 – 391Manganese 1By similarity
Metal bindingi41 – 411Manganese 2By similarity
Metal bindingi127 – 1271Manganese 1By similarity
Metal bindingi127 – 1271Manganese 2By similarity
Metal bindingi148 – 1481Manganese 2By similarity
Metal bindingi202 – 2021Manganese 2By similarity

GO - Molecular functioni

  1. exopolyphosphatase activity Source: SGD
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. polyphosphate catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YHR201C-MONOMER.
BRENDAi3.6.1.11. 984.

Names & Taxonomyi

Protein namesi
Recommended name:
Exopolyphosphatase (EC:3.6.1.11)
Short name:
ExopolyPase
Alternative name(s):
Metaphosphatase
Gene namesi
Name:PPX1
Ordered Locus Names:YHR201C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR201c.
SGDiS000001244. PPX1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. cytosol Source: SGD
  3. mitochondrial matrix Source: SGD
  4. plasma membrane Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397ExopolyphosphatasePRO_0000158601Add
BLAST

Proteomic databases

MaxQBiP38698.
PaxDbiP38698.
PeptideAtlasiP38698.
PRIDEiP38698.

Expressioni

Gene expression databases

GenevestigatoriP38698.

Interactioni

Protein-protein interaction databases

BioGridi36635. 14 interactions.
DIPiDIP-5633N.
IntActiP38698. 2 interactions.
MINTiMINT-540566.
STRINGi4932.YHR201C.

Structurei

Secondary structure

1
397
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 1710
Helixi20 – 234
Beta strandi28 – 336
Helixi40 – 5819
Helixi60 – 623
Beta strandi63 – 653
Beta strandi72 – 743
Helixi79 – 846
Helixi86 – 949
Helixi99 – 1013
Helixi105 – 11410
Beta strandi120 – 1278
Helixi133 – 1353
Turni136 – 1383
Beta strandi141 – 1477
Beta strandi159 – 1635
Helixi169 – 18012
Turni181 – 1833
Helixi185 – 20218
Turni203 – 2075
Helixi212 – 22615
Helixi235 – 25117
Helixi259 – 2646
Beta strandi267 – 2726
Beta strandi275 – 2784
Beta strandi280 – 28910
Helixi291 – 2977
Helixi301 – 31414
Beta strandi318 – 32811
Beta strandi331 – 34010
Helixi342 – 35615
Beta strandi358 – 3647
Helixi365 – 3673
Beta strandi369 – 3746
Helixi381 – 39313

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QB6X-ray1.80A/B1-397[»]
2QB7X-ray1.60A/B1-397[»]
2QB8X-ray1.90A/B1-397[»]
ProteinModelPortaliP38698.
SMRiP38698. Positions 5-397.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38698.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.Curated

Phylogenomic databases

eggNOGiCOG1227.
GeneTreeiENSGT00450000040262.
HOGENOMiHOG000248436.
InParanoidiP38698.
KOiK01514.
OMAiDTVNFEP.
OrthoDBiEOG7FNCH9.

Family and domain databases

InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38698-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPLRKTVPE FLAHLKSLPI SKIASNDVLT ICVGNESADM DSIASAITYS
60 70 80 90 100
YCQYIYNEGT YSEEKKKGSF IVPIIDIPRE DLSLRRDVMY VLEKLKIKEE
110 120 130 140 150
ELFFIEDLKS LKQNVSQGTE LNSYLVDNND TPKNLKNYID NVVGIIDHHF
160 170 180 190 200
DLQKHLDAEP RIVKVSGSCS SLVFNYWYEK LQGDREVVMN IAPLLMGAIL
210 220 230 240 250
IDTSNMRRKV EESDKLAIER CQAVLSGAVN EVSAQGLEDS SEFYKEIKSR
260 270 280 290 300
KNDIKGFSVS DILKKDYKQF NFQGKGHKGL EIGLSSIVKR MSWLFNEHGG
310 320 330 340 350
EADFVNQCRR FQAERGLDVL VLLTSWRKAG DSHRELVILG DSNVVRELIE
360 370 380 390
RVSDKLQLQL FGGNLDGGVA MFKQLNVEAT RKQVVPYLEE AYSNLEE
Length:397
Mass (Da):45,051
Last modified:February 1, 1995 - v1
Checksum:i9494CB47790E07B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti193 – 1931P → L in AAA65933. (PubMed:7860598)Curated
Sequence conflicti284 – 2841L → F in AAA65933. (PubMed:7860598)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28711 Genomic DNA. Translation: AAA65933.1.
U00030 Genomic DNA. Translation: AAB68368.1.
BK006934 Genomic DNA. Translation: DAA06894.1.
PIRiS46691.
RefSeqiNP_012071.1. NM_001179332.1.

Genome annotation databases

EnsemblFungiiYHR201C; YHR201C; YHR201C.
GeneIDi856608.
KEGGisce:YHR201C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28711 Genomic DNA. Translation: AAA65933.1 .
U00030 Genomic DNA. Translation: AAB68368.1 .
BK006934 Genomic DNA. Translation: DAA06894.1 .
PIRi S46691.
RefSeqi NP_012071.1. NM_001179332.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2QB6 X-ray 1.80 A/B 1-397 [» ]
2QB7 X-ray 1.60 A/B 1-397 [» ]
2QB8 X-ray 1.90 A/B 1-397 [» ]
ProteinModelPortali P38698.
SMRi P38698. Positions 5-397.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36635. 14 interactions.
DIPi DIP-5633N.
IntActi P38698. 2 interactions.
MINTi MINT-540566.
STRINGi 4932.YHR201C.

Proteomic databases

MaxQBi P38698.
PaxDbi P38698.
PeptideAtlasi P38698.
PRIDEi P38698.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR201C ; YHR201C ; YHR201C .
GeneIDi 856608.
KEGGi sce:YHR201C.

Organism-specific databases

CYGDi YHR201c.
SGDi S000001244. PPX1.

Phylogenomic databases

eggNOGi COG1227.
GeneTreei ENSGT00450000040262.
HOGENOMi HOG000248436.
InParanoidi P38698.
KOi K01514.
OMAi DTVNFEP.
OrthoDBi EOG7FNCH9.

Enzyme and pathway databases

BioCyci YEAST:YHR201C-MONOMER.
BRENDAi 3.6.1.11. 984.

Miscellaneous databases

EvolutionaryTracei P38698.
NextBioi 982520.
PROi P38698.

Gene expression databases

Genevestigatori P38698.

Family and domain databases

InterProi IPR001667. DDH_dom.
IPR004097. DHHA2.
[Graphical view ]
Pfami PF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The gene for a major exopolyphosphatase of Saccharomyces cerevisiae."
    Wurst H., Shiba T., Kornberg A.
    J. Bacteriol. 177:898-906(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / SNY243.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPPX1_YEAST
AccessioniPrimary (citable) accession number: P38698
Secondary accession number(s): D3DLF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3170 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3