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P38698 (PPX1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exopolyphosphatase

Short name=ExopolyPase
EC=3.6.1.11
Alternative name(s):
Metaphosphatase
Gene names
Name:PPX1
Ordered Locus Names:YHR201C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Degradation of inorganic polyphosphates.

Catalytic activity

(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.

Cofactor

Binds 2 manganese ions per subunit Potential.

Miscellaneous

Present with 3170 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the PPase class C family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397Exopolyphosphatase
PRO_0000158601

Sites

Metal binding391Manganese 1 By similarity
Metal binding411Manganese 2 By similarity
Metal binding1271Manganese 1 By similarity
Metal binding1271Manganese 2 By similarity
Metal binding1481Manganese 2 By similarity
Metal binding2021Manganese 2 By similarity

Experimental info

Sequence conflict1931P → L in AAA65933. Ref.1
Sequence conflict2841L → F in AAA65933. Ref.1

Secondary structure

.................................................................. 397
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P38698 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 9494CB47790E07B8

FASTA39745,051
        10         20         30         40         50         60 
MSPLRKTVPE FLAHLKSLPI SKIASNDVLT ICVGNESADM DSIASAITYS YCQYIYNEGT 

        70         80         90        100        110        120 
YSEEKKKGSF IVPIIDIPRE DLSLRRDVMY VLEKLKIKEE ELFFIEDLKS LKQNVSQGTE 

       130        140        150        160        170        180 
LNSYLVDNND TPKNLKNYID NVVGIIDHHF DLQKHLDAEP RIVKVSGSCS SLVFNYWYEK 

       190        200        210        220        230        240 
LQGDREVVMN IAPLLMGAIL IDTSNMRRKV EESDKLAIER CQAVLSGAVN EVSAQGLEDS 

       250        260        270        280        290        300 
SEFYKEIKSR KNDIKGFSVS DILKKDYKQF NFQGKGHKGL EIGLSSIVKR MSWLFNEHGG 

       310        320        330        340        350        360 
EADFVNQCRR FQAERGLDVL VLLTSWRKAG DSHRELVILG DSNVVRELIE RVSDKLQLQL 

       370        380        390 
FGGNLDGGVA MFKQLNVEAT RKQVVPYLEE AYSNLEE 

« Hide

References

« Hide 'large scale' references
[1]"The gene for a major exopolyphosphatase of Saccharomyces cerevisiae."
Wurst H., Shiba T., Kornberg A.
J. Bacteriol. 177:898-906(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S288c / SNY243.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L28711 Genomic DNA. Translation: AAA65933.1.
U00030 Genomic DNA. Translation: AAB68368.1.
BK006934 Genomic DNA. Translation: DAA06894.1.
PIRS46691.
RefSeqNP_012071.1. NM_001179332.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2QB6X-ray1.80A/B1-397[»]
2QB7X-ray1.60A/B1-397[»]
2QB8X-ray1.90A/B1-397[»]
ProteinModelPortalP38698.
SMRP38698. Positions 5-397.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36635. 13 interactions.
DIPDIP-5633N.
IntActP38698. 2 interactions.
MINTMINT-540566.
STRING4932.YHR201C.

Proteomic databases

MaxQBP38698.
PaxDbP38698.
PeptideAtlasP38698.
PRIDEP38698.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR201C; YHR201C; YHR201C.
GeneID856608.
KEGGsce:YHR201C.

Organism-specific databases

CYGDYHR201c.
SGDS000001244. PPX1.

Phylogenomic databases

eggNOGCOG1227.
GeneTreeENSGT00450000040262.
HOGENOMHOG000248436.
KOK01514.
OMADTVNFEP.
OrthoDBEOG7FNCH9.

Enzyme and pathway databases

BioCycYEAST:YHR201C-MONOMER.
BRENDA3.6.1.11. 984.

Gene expression databases

GenevestigatorP38698.

Family and domain databases

InterProIPR004097. DHHA2.
IPR001667. Pesterase_RecJ.
[Graphical view]
PfamPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP38698.
NextBio982520.
PROP38698.

Entry information

Entry namePPX1_YEAST
AccessionPrimary (citable) accession number: P38698
Secondary accession number(s): D3DLF0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references