Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Exopolyphosphatase

Gene

PPX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Degradation of inorganic polyphosphates.

Miscellaneous

Present with 3170 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.

Cofactori

Mn2+CuratedNote: Binds 2 manganese ions per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi39Manganese 1By similarity1
Metal bindingi41Manganese 2By similarity1
Metal bindingi127Manganese 1By similarity1
Metal bindingi127Manganese 2By similarity1
Metal bindingi148Manganese 2By similarity1
Metal bindingi202Manganese 2By similarity1

GO - Molecular functioni

  • exopolyphosphatase activity Source: SGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • polyphosphate catabolic process Source: SGD

Keywordsi

Molecular functionHydrolase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YHR201C-MONOMER
BRENDAi3.6.1.11 984

Names & Taxonomyi

Protein namesi
Recommended name:
Exopolyphosphatase (EC:3.6.1.11)
Short name:
ExopolyPase
Alternative name(s):
Metaphosphatase
Gene namesi
Name:PPX1
Ordered Locus Names:YHR201C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR201C
SGDiS000001244 PPX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586011 – 397ExopolyphosphataseAdd BLAST397

Proteomic databases

MaxQBiP38698
PaxDbiP38698
PRIDEiP38698

Interactioni

Protein-protein interaction databases

BioGridi36635, 196 interactors
DIPiDIP-5633N
IntActiP38698, 3 interactors
MINTiP38698
STRINGi4932.YHR201C

Structurei

Secondary structure

1397
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 17Combined sources10
Helixi20 – 23Combined sources4
Beta strandi28 – 33Combined sources6
Helixi40 – 58Combined sources19
Helixi60 – 62Combined sources3
Beta strandi63 – 65Combined sources3
Beta strandi72 – 74Combined sources3
Helixi79 – 84Combined sources6
Helixi86 – 94Combined sources9
Helixi99 – 101Combined sources3
Helixi105 – 114Combined sources10
Beta strandi120 – 127Combined sources8
Helixi133 – 135Combined sources3
Turni136 – 138Combined sources3
Beta strandi141 – 147Combined sources7
Beta strandi159 – 163Combined sources5
Helixi169 – 180Combined sources12
Turni181 – 183Combined sources3
Helixi185 – 202Combined sources18
Turni203 – 207Combined sources5
Helixi212 – 226Combined sources15
Helixi235 – 251Combined sources17
Helixi259 – 264Combined sources6
Beta strandi267 – 272Combined sources6
Beta strandi275 – 278Combined sources4
Beta strandi280 – 289Combined sources10
Helixi291 – 297Combined sources7
Helixi301 – 314Combined sources14
Beta strandi318 – 328Combined sources11
Beta strandi331 – 340Combined sources10
Helixi342 – 356Combined sources15
Beta strandi358 – 364Combined sources7
Helixi365 – 367Combined sources3
Beta strandi369 – 374Combined sources6
Helixi381 – 393Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QB6X-ray1.80A/B1-397[»]
2QB7X-ray1.60A/B1-397[»]
2QB8X-ray1.90A/B1-397[»]
ProteinModelPortaliP38698
SMRiP38698
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38698

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.Curated

Phylogenomic databases

GeneTreeiENSGT00450000040262
HOGENOMiHOG000248436
InParanoidiP38698
KOiK01514
OMAiIYMDLEA
OrthoDBiEOG092C2PKQ

Family and domain databases

Gene3Di3.10.310.20, 1 hit
InterProiView protein in InterPro
IPR001667 DDH_dom
IPR038763 DHH_sf
IPR004097 DHHA2
IPR038222 DHHA2_dom_sf
PfamiView protein in Pfam
PF01368 DHH, 1 hit
PF02833 DHHA2, 1 hit
SMARTiView protein in SMART
SM01131 DHHA2, 1 hit
SUPFAMiSSF64182 SSF64182, 1 hit

Sequencei

Sequence statusi: Complete.

P38698-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPLRKTVPE FLAHLKSLPI SKIASNDVLT ICVGNESADM DSIASAITYS
60 70 80 90 100
YCQYIYNEGT YSEEKKKGSF IVPIIDIPRE DLSLRRDVMY VLEKLKIKEE
110 120 130 140 150
ELFFIEDLKS LKQNVSQGTE LNSYLVDNND TPKNLKNYID NVVGIIDHHF
160 170 180 190 200
DLQKHLDAEP RIVKVSGSCS SLVFNYWYEK LQGDREVVMN IAPLLMGAIL
210 220 230 240 250
IDTSNMRRKV EESDKLAIER CQAVLSGAVN EVSAQGLEDS SEFYKEIKSR
260 270 280 290 300
KNDIKGFSVS DILKKDYKQF NFQGKGHKGL EIGLSSIVKR MSWLFNEHGG
310 320 330 340 350
EADFVNQCRR FQAERGLDVL VLLTSWRKAG DSHRELVILG DSNVVRELIE
360 370 380 390
RVSDKLQLQL FGGNLDGGVA MFKQLNVEAT RKQVVPYLEE AYSNLEE
Length:397
Mass (Da):45,051
Last modified:February 1, 1995 - v1
Checksum:i9494CB47790E07B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193P → L in AAA65933 (PubMed:7860598).Curated1
Sequence conflicti284L → F in AAA65933 (PubMed:7860598).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28711 Genomic DNA Translation: AAA65933.1
U00030 Genomic DNA Translation: AAB68368.1
BK006934 Genomic DNA Translation: DAA06894.1
PIRiS46691
RefSeqiNP_012071.1, NM_001179332.1

Genome annotation databases

EnsemblFungiiYHR201C; YHR201C; YHR201C
GeneIDi856608
KEGGisce:YHR201C

Similar proteinsi

Entry informationi

Entry nameiPPX1_YEAST
AccessioniPrimary (citable) accession number: P38698
Secondary accession number(s): D3DLF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health