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Protein

Probable glucose transporter HXT5

Gene

HXT5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable glucose transporter.

Miscellaneous

Glucose transport is thought to be mediated by two kinetically distinct systems, a glucose-repressible high-affinity system and a constitutive low-affinity system.

GO - Molecular functioni

  • carbohydrate:proton symporter activity Source: GO_Central
  • fructose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD

GO - Biological processi

  • glucose import Source: GO_Central
  • glucose transmembrane transport Source: SGD
  • hexose transmembrane transport Source: SGD

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31141-MONOMER
ReactomeiR-SCE-189200 Cellular hexose transport
R-SCE-8856825 Cargo recognition for clathrin-mediated endocytosis
SABIO-RKP38695

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucose transporter HXT5
Gene namesi
Name:HXT5
Ordered Locus Names:YHR096C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR096C
SGDiS000001138 HXT5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 81CytoplasmicSequence analysisAdd BLAST81
Transmembranei82 – 102Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini103 – 137ExtracellularSequence analysisAdd BLAST35
Transmembranei138 – 158Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini159 – 164CytoplasmicSequence analysis6
Transmembranei165 – 185Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini186 – 195ExtracellularSequence analysis10
Transmembranei196 – 216Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini217 – 222CytoplasmicSequence analysis6
Transmembranei223 – 243Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini244 – 257ExtracellularSequence analysisAdd BLAST14
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 361CytoplasmicSequence analysisAdd BLAST83
Transmembranei362 – 378Helical; Name=7Sequence analysisAdd BLAST17
Topological domaini379 – 384ExtracellularSequence analysis6
Transmembranei385 – 402Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini403 – 409CytoplasmicSequence analysis7
Transmembranei410 – 430Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini431 – 452ExtracellularSequence analysisAdd BLAST22
Transmembranei453 – 473Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini474 – 490CytoplasmicSequence analysisAdd BLAST17
Transmembranei491 – 511Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini512ExtracellularSequence analysis1
Transmembranei513 – 533Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini534 – 592CytoplasmicSequence analysisAdd BLAST59

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503951 – 592Probable glucose transporter HXT5Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP38695
PaxDbiP38695
PRIDEiP38695

PTM databases

iPTMnetiP38695

Interactioni

Protein-protein interaction databases

BioGridi36529, 81 interactors
DIPiDIP-5594N
IntActiP38695, 21 interactors
MINTiP38695
STRINGi4932.YHR096C

Structurei

3D structure databases

ProteinModelPortaliP38695
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00910000144141
HOGENOMiHOG000202870
InParanoidiP38695
KOiK08139
OMAiMGASIGW
OrthoDBiEOG092C1Q5W

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P38695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELENAHQG PLEGSATVST NSNSYNEKSG NSTAPGTAGY NDNLAQAKPV
60 70 80 90 100
SSYISHEGPP KDELEELQKE VDKQLEKKSK SDLLFVSVCC LMVAFGGFVF
110 120 130 140 150
GWDTGTISGF VRQTDFIRRF GSTRANGTTY LSDVRTGLMV SIFNIGCAIG
160 170 180 190 200
GIVLSKLGDM YGRKIGLMTV VVIYSIGIII QIASIDKWYQ YFIGRIISGL
210 220 230 240 250
GVGGITVLAP MLISEVSPKQ LRGTLVSCYQ LMITFGIFLG YCTNFGTKNY
260 270 280 290 300
SNSVQWRVPL GLCFAWSIFM IVGMTFVPES PRYLVEVGKI EEAKRSLARA
310 320 330 340 350
NKTTEDSPLV TLEMENYQSS IEAERLAGSA SWGELVTGKP QMFRRTLMGM
360 370 380 390 400
MIQSLQQLTG DNYFFYYGTT IFQAVGLEDS FETAIVLGVV NFVSTFFSLY
410 420 430 440 450
TVDRFGRRNC LLWGCVGMIC CYVVYASVGV TRLWPNGQDQ PSSKGAGNCM
460 470 480 490 500
IVFACFYIFC FATTWAPVAY VLISESYPLR VRGKAMSIAS ACNWIWGFLI
510 520 530 540 550
SFFTPFITSA INFYYGYVFM GCMVFAYFYV FFFVPETKGL TLEEVNEMYE
560 570 580 590
ENVLPWKSTK WIPPSRRTTD YDLDATRNDP RPFYKRMFTK EK
Length:592
Mass (Da):66,251
Last modified:February 1, 1995 - v1
Checksum:i6906721BAC1A5F87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77961 Genomic DNA Translation: CAA54923.1
U00060 Genomic DNA Translation: AAB68934.1
BK006934 Genomic DNA Translation: DAA06790.1
PIRiS43742
RefSeqiNP_011964.1, NM_001179226.1

Genome annotation databases

EnsemblFungiiYHR096C; YHR096C; YHR096C
GeneIDi856496
KEGGisce:YHR096C

Similar proteinsi

Entry informationi

Entry nameiHXT5_YEAST
AccessioniPrimary (citable) accession number: P38695
Secondary accession number(s): D3DL46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health