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Protein

Probable glucose transporter HXT5

Gene

HXT5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable glucose transporter.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD

GO - Biological processi

  • fructose transport Source: GOC
  • glucose transmembrane transport Source: GOC
  • glucose transport Source: SGD
  • hexose transport Source: SGD
  • mannose transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31141-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucose transporter HXT5
Gene namesi
Name:HXT5
Ordered Locus Names:YHR096C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR096C.
SGDiS000001138. HXT5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8181CytoplasmicSequence analysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini103 – 13735ExtracellularSequence analysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini159 – 1646CytoplasmicSequence analysis
Transmembranei165 – 18521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini186 – 19510ExtracellularSequence analysis
Transmembranei196 – 21621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini217 – 2226CytoplasmicSequence analysis
Transmembranei223 – 24321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini244 – 25714ExtracellularSequence analysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini279 – 36183CytoplasmicSequence analysisAdd
BLAST
Transmembranei362 – 37817Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini379 – 3846ExtracellularSequence analysis
Transmembranei385 – 40218Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini403 – 4097CytoplasmicSequence analysis
Transmembranei410 – 43021Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini431 – 45222ExtracellularSequence analysisAdd
BLAST
Transmembranei453 – 47321Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini474 – 49017CytoplasmicSequence analysisAdd
BLAST
Transmembranei491 – 51121Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini512 – 5121ExtracellularSequence analysis
Transmembranei513 – 53321Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini534 – 59259CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 592592Probable glucose transporter HXT5PRO_0000050395Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki61 – 61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence analysis
Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP38695.

PTM databases

iPTMnetiP38695.

Interactioni

Protein-protein interaction databases

BioGridi36529. 49 interactions.
DIPiDIP-5594N.
IntActiP38695. 20 interactions.
MINTiMINT-536314.

Structurei

3D structure databases

ProteinModelPortaliP38695.
SMRiP38695. Positions 91-550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
InParanoidiP38695.
KOiK08139.
OMAiVTGKPQM.
OrthoDBiEOG73JM4H.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELENAHQG PLEGSATVST NSNSYNEKSG NSTAPGTAGY NDNLAQAKPV
60 70 80 90 100
SSYISHEGPP KDELEELQKE VDKQLEKKSK SDLLFVSVCC LMVAFGGFVF
110 120 130 140 150
GWDTGTISGF VRQTDFIRRF GSTRANGTTY LSDVRTGLMV SIFNIGCAIG
160 170 180 190 200
GIVLSKLGDM YGRKIGLMTV VVIYSIGIII QIASIDKWYQ YFIGRIISGL
210 220 230 240 250
GVGGITVLAP MLISEVSPKQ LRGTLVSCYQ LMITFGIFLG YCTNFGTKNY
260 270 280 290 300
SNSVQWRVPL GLCFAWSIFM IVGMTFVPES PRYLVEVGKI EEAKRSLARA
310 320 330 340 350
NKTTEDSPLV TLEMENYQSS IEAERLAGSA SWGELVTGKP QMFRRTLMGM
360 370 380 390 400
MIQSLQQLTG DNYFFYYGTT IFQAVGLEDS FETAIVLGVV NFVSTFFSLY
410 420 430 440 450
TVDRFGRRNC LLWGCVGMIC CYVVYASVGV TRLWPNGQDQ PSSKGAGNCM
460 470 480 490 500
IVFACFYIFC FATTWAPVAY VLISESYPLR VRGKAMSIAS ACNWIWGFLI
510 520 530 540 550
SFFTPFITSA INFYYGYVFM GCMVFAYFYV FFFVPETKGL TLEEVNEMYE
560 570 580 590
ENVLPWKSTK WIPPSRRTTD YDLDATRNDP RPFYKRMFTK EK
Length:592
Mass (Da):66,251
Last modified:February 1, 1995 - v1
Checksum:i6906721BAC1A5F87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77961 Genomic DNA. Translation: CAA54923.1.
U00060 Genomic DNA. Translation: AAB68934.1.
BK006934 Genomic DNA. Translation: DAA06790.1.
PIRiS43742.
RefSeqiNP_011964.1. NM_001179226.1.

Genome annotation databases

EnsemblFungiiYHR096C; YHR096C; YHR096C.
GeneIDi856496.
KEGGisce:YHR096C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77961 Genomic DNA. Translation: CAA54923.1.
U00060 Genomic DNA. Translation: AAB68934.1.
BK006934 Genomic DNA. Translation: DAA06790.1.
PIRiS43742.
RefSeqiNP_011964.1. NM_001179226.1.

3D structure databases

ProteinModelPortaliP38695.
SMRiP38695. Positions 91-550.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36529. 49 interactions.
DIPiDIP-5594N.
IntActiP38695. 20 interactions.
MINTiMINT-536314.

PTM databases

iPTMnetiP38695.

Proteomic databases

MaxQBiP38695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR096C; YHR096C; YHR096C.
GeneIDi856496.
KEGGisce:YHR096C.

Organism-specific databases

EuPathDBiFungiDB:YHR096C.
SGDiS000001138. HXT5.

Phylogenomic databases

GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
InParanoidiP38695.
KOiK08139.
OMAiVTGKPQM.
OrthoDBiEOG73JM4H.

Enzyme and pathway databases

BioCyciYEAST:G3O-31141-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.

Miscellaneous databases

NextBioi982206.
PROiP38695.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Reifenberger E., Koetter P., Ciriacy M.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MC996.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-61.
    Strain: SUB592.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHXT5_YEAST
AccessioniPrimary (citable) accession number: P38695
Secondary accession number(s): D3DL46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 11, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Glucose transport is thought to be mediated by two kinetically distinct systems, a glucose-repressible high-affinity system and a constitutive low-affinity system.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.