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Protein

Probable glucose transporter HXT5

Gene

HXT5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable glucose transporter.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • glucose import Source: GO_Central
  • glucose transport Source: SGD
  • hexose transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31141-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucose transporter HXT5
Gene namesi
Name:HXT5
Ordered Locus Names:YHR096C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR096C.
SGDiS000001138. HXT5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 81CytoplasmicSequence analysisAdd BLAST81
Transmembranei82 – 102Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini103 – 137ExtracellularSequence analysisAdd BLAST35
Transmembranei138 – 158Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini159 – 164CytoplasmicSequence analysis6
Transmembranei165 – 185Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini186 – 195ExtracellularSequence analysis10
Transmembranei196 – 216Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini217 – 222CytoplasmicSequence analysis6
Transmembranei223 – 243Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini244 – 257ExtracellularSequence analysisAdd BLAST14
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 361CytoplasmicSequence analysisAdd BLAST83
Transmembranei362 – 378Helical; Name=7Sequence analysisAdd BLAST17
Topological domaini379 – 384ExtracellularSequence analysis6
Transmembranei385 – 402Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini403 – 409CytoplasmicSequence analysis7
Transmembranei410 – 430Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini431 – 452ExtracellularSequence analysisAdd BLAST22
Transmembranei453 – 473Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini474 – 490CytoplasmicSequence analysisAdd BLAST17
Transmembranei491 – 511Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini512ExtracellularSequence analysis1
Transmembranei513 – 533Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini534 – 592CytoplasmicSequence analysisAdd BLAST59

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503951 – 592Probable glucose transporter HXT5Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Glycosylationi126N-linked (GlcNAc...)Sequence analysis1
Glycosylationi249N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP38695.
PRIDEiP38695.

PTM databases

iPTMnetiP38695.

Interactioni

Protein-protein interaction databases

BioGridi36529. 49 interactors.
DIPiDIP-5594N.
IntActiP38695. 20 interactors.
MINTiMINT-536314.

Structurei

3D structure databases

ProteinModelPortaliP38695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiP38695.
KOiK08139.
OMAiVTGKPQM.
OrthoDBiEOG092C1Q5W.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELENAHQG PLEGSATVST NSNSYNEKSG NSTAPGTAGY NDNLAQAKPV
60 70 80 90 100
SSYISHEGPP KDELEELQKE VDKQLEKKSK SDLLFVSVCC LMVAFGGFVF
110 120 130 140 150
GWDTGTISGF VRQTDFIRRF GSTRANGTTY LSDVRTGLMV SIFNIGCAIG
160 170 180 190 200
GIVLSKLGDM YGRKIGLMTV VVIYSIGIII QIASIDKWYQ YFIGRIISGL
210 220 230 240 250
GVGGITVLAP MLISEVSPKQ LRGTLVSCYQ LMITFGIFLG YCTNFGTKNY
260 270 280 290 300
SNSVQWRVPL GLCFAWSIFM IVGMTFVPES PRYLVEVGKI EEAKRSLARA
310 320 330 340 350
NKTTEDSPLV TLEMENYQSS IEAERLAGSA SWGELVTGKP QMFRRTLMGM
360 370 380 390 400
MIQSLQQLTG DNYFFYYGTT IFQAVGLEDS FETAIVLGVV NFVSTFFSLY
410 420 430 440 450
TVDRFGRRNC LLWGCVGMIC CYVVYASVGV TRLWPNGQDQ PSSKGAGNCM
460 470 480 490 500
IVFACFYIFC FATTWAPVAY VLISESYPLR VRGKAMSIAS ACNWIWGFLI
510 520 530 540 550
SFFTPFITSA INFYYGYVFM GCMVFAYFYV FFFVPETKGL TLEEVNEMYE
560 570 580 590
ENVLPWKSTK WIPPSRRTTD YDLDATRNDP RPFYKRMFTK EK
Length:592
Mass (Da):66,251
Last modified:February 1, 1995 - v1
Checksum:i6906721BAC1A5F87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77961 Genomic DNA. Translation: CAA54923.1.
U00060 Genomic DNA. Translation: AAB68934.1.
BK006934 Genomic DNA. Translation: DAA06790.1.
PIRiS43742.
RefSeqiNP_011964.1. NM_001179226.1.

Genome annotation databases

EnsemblFungiiYHR096C; YHR096C; YHR096C.
GeneIDi856496.
KEGGisce:YHR096C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77961 Genomic DNA. Translation: CAA54923.1.
U00060 Genomic DNA. Translation: AAB68934.1.
BK006934 Genomic DNA. Translation: DAA06790.1.
PIRiS43742.
RefSeqiNP_011964.1. NM_001179226.1.

3D structure databases

ProteinModelPortaliP38695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36529. 49 interactors.
DIPiDIP-5594N.
IntActiP38695. 20 interactors.
MINTiMINT-536314.

PTM databases

iPTMnetiP38695.

Proteomic databases

MaxQBiP38695.
PRIDEiP38695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR096C; YHR096C; YHR096C.
GeneIDi856496.
KEGGisce:YHR096C.

Organism-specific databases

EuPathDBiFungiDB:YHR096C.
SGDiS000001138. HXT5.

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiP38695.
KOiK08139.
OMAiVTGKPQM.
OrthoDBiEOG092C1Q5W.

Enzyme and pathway databases

BioCyciYEAST:G3O-31141-MONOMER.

Miscellaneous databases

PROiP38695.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXT5_YEAST
AccessioniPrimary (citable) accession number: P38695
Secondary accession number(s): D3DL46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Glucose transport is thought to be mediated by two kinetically distinct systems, a glucose-repressible high-affinity system and a constitutive low-affinity system.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.