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P38694 (MSC7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative aldehyde dehydrogenase-like protein YHR039C

EC=1.2.1.-
Alternative name(s):
Meiotic sister-chromatid recombination protein 7
Gene names
Name:MSC7
Ordered Locus Names:YHR039C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length644 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Endoplasmic reticulum Ref.3.

Post-translational modification

N-glycosylated.

Miscellaneous

Present with 2500 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 644644Putative aldehyde dehydrogenase-like protein YHR039C
PRO_0000056596

Sites

Active site3541Proton acceptor By similarity
Active site3891Nucleophile By similarity
Site2481Transition state stabilizer By similarity

Amino acid modifications

Glycosylation151N-linked (GlcNAc...) Potential
Glycosylation5651N-linked (GlcNAc...) Potential
Glycosylation6271N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P38694 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 54DADDAEB2A16D4D

FASTA64471,321
        10         20         30         40         50         60 
MSKVYLNSDM INHLNSTVQA YFNLWLEKQN AIMRSQPQII QDNQKLIGIT TLVASIFTLY 

        70         80         90        100        110        120 
VLVKIISTPA KCSSSYKPVK FSLPAPEAAQ NNWKGKRSVS TNIWNPEEPN FIQCHCPATG 

       130        140        150        160        170        180 
QYLGSFPSKT EADIDEMVSK AGKAQSTWGN SDFSRRLRVL ASLHDYILNN QDLIARVACR 

       190        200        210        220        230        240 
DSGKTMLDAS MGEILVTLEK IQWTIKHGQR ALQPSRRPGP TNFFMKWYKG AEIRYEPLGV 

       250        260        270        280        290        300 
ISSIVSWNYP FHNLLGPIIA ALFTGNAIVV KCSEQVVWSS EFFVELIRKC LEACDEDPDL 

       310        320        330        340        350        360 
VQLCYCLPPT ENDDSANYFT SHPGFKHITF IGSQPVAHYI LKCAAKSLTP VVVELGGKDA 

       370        380        390        400        410        420 
FIVLDSAKNL DALSSIIMRG TFQSSGQNCI GIERVIVSKE NYDDLVKILN DRMTANPLRQ 

       430        440        450        460        470        480 
GSDIDHLENV DMGAMISDNR FDELEALVKD AVAKGARLLQ GGSRFKHPKY PQGHYFQPTL 

       490        500        510        520        530        540 
LVDVTPEMKI AQNEVFGPIL VMMKAKNTDH CVQLANSAPF GLGGSVFGAD IKECNYVANS 

       550        560        570        580        590        600 
LQTGNVAIND FATFYVCQLP FGGINGSGYG KFGGEEGLLG LCNAKSVCFD TLPFVSTQIP 

       610        620        630        640 
KPLDYPIRNN AKAWNFVKSF IVGAYTNSTW QRIKSLFSLA KEAS 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes."
Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H.
Mol. Syst. Biol. 5:308-308(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00062 Genomic DNA. Translation: AAB68915.1.
BK006934 Genomic DNA. Translation: DAA06730.1.
PIRS46746.
RefSeqNP_011904.1. NM_001179169.1.

3D structure databases

ProteinModelPortalP38694.
SMRP38694. Positions 4-592.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36470. 47 interactions.
DIPDIP-1878N.
IntActP38694. 13 interactions.
MINTMINT-404998.
STRING4932.YHR039C.

Proteomic databases

MaxQBP38694.
PaxDbP38694.
PeptideAtlasP38694.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR039C; YHR039C; YHR039C.
GeneID856434.
KEGGsce:YHR039C.

Organism-specific databases

CYGDYHR039c.
SGDS000001081. MSC7.

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271512.
OMAKHITFIG.
OrthoDBEOG79PJXX.

Enzyme and pathway databases

BioCycYEAST:G3O-31098-MONOMER.

Gene expression databases

GenevestigatorP38694.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982030.

Entry information

Entry nameMSC7_YEAST
AccessionPrimary (citable) accession number: P38694
Secondary accession number(s): D3DKY6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families