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P38694

- MSC7_YEAST

UniProt

P38694 - MSC7_YEAST

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Protein

Putative aldehyde dehydrogenase-like protein YHR039C

Gene

MSC7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei248 – 2481Transition state stabilizerBy similarity
Active sitei354 – 3541Proton acceptorPROSITE-ProRule annotation
Active sitei389 – 3891NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

  1. oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro

GO - Biological processi

  1. reciprocal meiotic recombination Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciYEAST:G3O-31098-MONOMER.
ReactomeiREACT_255230. Branched-chain amino acid catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aldehyde dehydrogenase-like protein YHR039C (EC:1.2.1.-)
Alternative name(s):
Meiotic sister-chromatid recombination protein 7
Gene namesi
Name:MSC7
Ordered Locus Names:YHR039C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR039c.
SGDiS000001081. MSC7.

Subcellular locationi

Endoplasmic reticulum 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 644644Putative aldehyde dehydrogenase-like protein YHR039CPRO_0000056596Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi565 – 5651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi627 – 6271N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP38694.
PaxDbiP38694.
PeptideAtlasiP38694.

Expressioni

Gene expression databases

GenevestigatoriP38694.

Interactioni

Protein-protein interaction databases

BioGridi36470. 47 interactions.
DIPiDIP-1878N.
IntActiP38694. 13 interactions.
MINTiMINT-404998.
STRINGi4932.YHR039C.

Structurei

3D structure databases

ProteinModelPortaliP38694.
SMRiP38694. Positions 112-621.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271512.
InParanoidiP38694.
OMAiKHITFIG.
OrthoDBiEOG79PJXX.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38694-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKVYLNSDM INHLNSTVQA YFNLWLEKQN AIMRSQPQII QDNQKLIGIT
60 70 80 90 100
TLVASIFTLY VLVKIISTPA KCSSSYKPVK FSLPAPEAAQ NNWKGKRSVS
110 120 130 140 150
TNIWNPEEPN FIQCHCPATG QYLGSFPSKT EADIDEMVSK AGKAQSTWGN
160 170 180 190 200
SDFSRRLRVL ASLHDYILNN QDLIARVACR DSGKTMLDAS MGEILVTLEK
210 220 230 240 250
IQWTIKHGQR ALQPSRRPGP TNFFMKWYKG AEIRYEPLGV ISSIVSWNYP
260 270 280 290 300
FHNLLGPIIA ALFTGNAIVV KCSEQVVWSS EFFVELIRKC LEACDEDPDL
310 320 330 340 350
VQLCYCLPPT ENDDSANYFT SHPGFKHITF IGSQPVAHYI LKCAAKSLTP
360 370 380 390 400
VVVELGGKDA FIVLDSAKNL DALSSIIMRG TFQSSGQNCI GIERVIVSKE
410 420 430 440 450
NYDDLVKILN DRMTANPLRQ GSDIDHLENV DMGAMISDNR FDELEALVKD
460 470 480 490 500
AVAKGARLLQ GGSRFKHPKY PQGHYFQPTL LVDVTPEMKI AQNEVFGPIL
510 520 530 540 550
VMMKAKNTDH CVQLANSAPF GLGGSVFGAD IKECNYVANS LQTGNVAIND
560 570 580 590 600
FATFYVCQLP FGGINGSGYG KFGGEEGLLG LCNAKSVCFD TLPFVSTQIP
610 620 630 640
KPLDYPIRNN AKAWNFVKSF IVGAYTNSTW QRIKSLFSLA KEAS
Length:644
Mass (Da):71,321
Last modified:February 1, 1995 - v1
Checksum:i54DADDAEB2A16D4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68915.1.
BK006934 Genomic DNA. Translation: DAA06730.1.
PIRiS46746.
RefSeqiNP_011904.1. NM_001179169.1.

Genome annotation databases

EnsemblFungiiYHR039C; YHR039C; YHR039C.
GeneIDi856434.
KEGGisce:YHR039C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68915.1 .
BK006934 Genomic DNA. Translation: DAA06730.1 .
PIRi S46746.
RefSeqi NP_011904.1. NM_001179169.1.

3D structure databases

ProteinModelPortali P38694.
SMRi P38694. Positions 112-621.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36470. 47 interactions.
DIPi DIP-1878N.
IntActi P38694. 13 interactions.
MINTi MINT-404998.
STRINGi 4932.YHR039C.

Proteomic databases

MaxQBi P38694.
PaxDbi P38694.
PeptideAtlasi P38694.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR039C ; YHR039C ; YHR039C .
GeneIDi 856434.
KEGGi sce:YHR039C.

Organism-specific databases

CYGDi YHR039c.
SGDi S000001081. MSC7.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271512.
InParanoidi P38694.
OMAi KHITFIG.
OrthoDBi EOG79PJXX.

Enzyme and pathway databases

BioCyci YEAST:G3O-31098-MONOMER.
Reactomei REACT_255230. Branched-chain amino acid catabolism.

Miscellaneous databases

NextBioi 982030.

Gene expression databases

Genevestigatori P38694.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes."
    Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H.
    Mol. Syst. Biol. 5:308-308(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMSC7_YEAST
AccessioniPrimary (citable) accession number: P38694
Secondary accession number(s): D3DKY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2500 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3