MSC7

Functionⁱ

Miscellaneous

Present with 2500 molecules/cell in log phase SD medium.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	248	Transition state stabilizerBy similarity	1
Active siteⁱ	354	Proton acceptorPROSITE-ProRule annotation	1
Active siteⁱ	389	NucleophilePROSITE-ProRule annotation	1

GO - Molecular functionⁱ

aldehyde dehydrogenase (NAD) activity Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

reciprocal meiotic recombination
Source: SGD
Inferred from mutant phenotypeⁱ
- 10511544

Complete GO annotation...

Keywordsⁱ

Molecular function	Oxidoreductase

Molecular function

Oxidoreductase

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31098-MONOMER.

BioCycⁱ

YEAST:G3O-31098-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Putative aldehyde dehydrogenase-like protein YHR039C (EC:1.2.1.-) Alternative name(s): Meiotic sister-chromatid recombination protein 7
Gene namesⁱ	Name:MSC7 Ordered Locus Names:YHR039C
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome VIII

Organism-specific databases

EuPathDBⁱ	FungiDB:YHR039C.
Saccharomyces Genome Database More...SGDⁱ	S000001081. MSC7.

Subcellular locationⁱ

Endoplasmic reticulum
1 Publication
Manual assertion based on experiment inⁱ
- Ref.3
  "Global analysis of protein localization in budding yeast."
  Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
  Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

GO - Cellular componentⁱ

endoplasmic reticulum Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Endoplasmic reticulum

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000056596	1 – 644	Putative aldehyde dehydrogenase-like protein YHR039CAdd BLAST		644

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	15	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	565	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	627	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

N-glycosylated.1 Publication

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P38694.
PRIDEⁱ	P38694.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	36470. 100 interactors.
Database of interacting proteins More...DIPⁱ	DIP-1878N.
IntActⁱ	P38694. 13 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-404998.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P38694.
SMRⁱ	P38694.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

HOGENOMⁱ	HOG000271512.
InParanoidⁱ	P38694.
OMAⁱ	ALVSWNY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C1LLH.

Family and domain databases

Gene3Dⁱ	3.40.605.10. 1 hit.
InterProⁱ	View protein in InterPro IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS_CYS. IPR029510. Ald_DH_CS_GLU. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00171. Aldedh. 1 hit.
SUPFAMⁱ	SSF53720. SSF53720. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P38694-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKVYLNSDM INHLNSTVQA YFNLWLEKQN AIMRSQPQII QDNQKLIGIT 
        60         70         80         90        100
TLVASIFTLY VLVKIISTPA KCSSSYKPVK FSLPAPEAAQ NNWKGKRSVS 
       110        120        130        140        150
TNIWNPEEPN FIQCHCPATG QYLGSFPSKT EADIDEMVSK AGKAQSTWGN 
       160        170        180        190        200
SDFSRRLRVL ASLHDYILNN QDLIARVACR DSGKTMLDAS MGEILVTLEK 
       210        220        230        240        250
IQWTIKHGQR ALQPSRRPGP TNFFMKWYKG AEIRYEPLGV ISSIVSWNYP 
       260        270        280        290        300
FHNLLGPIIA ALFTGNAIVV KCSEQVVWSS EFFVELIRKC LEACDEDPDL 
       310        320        330        340        350
VQLCYCLPPT ENDDSANYFT SHPGFKHITF IGSQPVAHYI LKCAAKSLTP 
       360        370        380        390        400
VVVELGGKDA FIVLDSAKNL DALSSIIMRG TFQSSGQNCI GIERVIVSKE 
       410        420        430        440        450
NYDDLVKILN DRMTANPLRQ GSDIDHLENV DMGAMISDNR FDELEALVKD 
       460        470        480        490        500
AVAKGARLLQ GGSRFKHPKY PQGHYFQPTL LVDVTPEMKI AQNEVFGPIL 
       510        520        530        540        550
VMMKAKNTDH CVQLANSAPF GLGGSVFGAD IKECNYVANS LQTGNVAIND 
       560        570        580        590        600
FATFYVCQLP FGGINGSGYG KFGGEEGLLG LCNAKSVCFD TLPFVSTQIP 
       610        620        630        640 
KPLDYPIRNN AKAWNFVKSF IVGAYTNSTW QRIKSLFSLA KEAS

Length:644

Mass (Da):71,321

Last modified:February 1, 1995 - v1

Checksum:ⁱ54DADDAEB2A16D4D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00062 Genomic DNA. Translation: AAB68915.1. BK006934 Genomic DNA. Translation: DAA06730.1.
PIRⁱ	S46746.
NCBI Reference Sequences More...RefSeqⁱ	NP_011904.1. NM_001179169.1.

Genome annotation databases

EnsemblFungiⁱ	YHR039C; YHR039C; YHR039C.
GeneIDⁱ	856434.
KEGGⁱ	sce:YHR039C.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00062 Genomic DNA. Translation: AAB68915.1. BK006934 Genomic DNA. Translation: DAA06730.1.
PIRⁱ	S46746.
NCBI Reference Sequences More...RefSeqⁱ	NP_011904.1. NM_001179169.1.

3D structure databases

ProteinModelPortalⁱ	P38694.
SMRⁱ	P38694.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	36470. 100 interactors.
Database of interacting proteins More...DIPⁱ	DIP-1878N.
IntActⁱ	P38694. 13 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-404998.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P38694.
PRIDEⁱ	P38694.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YHR039C; YHR039C; YHR039C.
GeneIDⁱ	856434.
KEGGⁱ	sce:YHR039C.

Organism-specific databases

EuPathDBⁱ	FungiDB:YHR039C.
Saccharomyces Genome Database More...SGDⁱ	S000001081. MSC7.

Phylogenomic databases

HOGENOMⁱ	HOG000271512.
InParanoidⁱ	P38694.
OMAⁱ	ALVSWNY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C1LLH.

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-31098-MONOMER.

BioCycⁱ

YEAST:G3O-31098-MONOMER.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P38694.

PROⁱ

PR:P38694.

Family and domain databases

Gene3Dⁱ	3.40.605.10. 1 hit.
InterProⁱ	View protein in InterPro IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS_CYS. IPR029510. Ald_DH_CS_GLU. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00171. Aldedh. 1 hit.
SUPFAMⁱ	SSF53720. SSF53720. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MSC7_YEAST
Accessionⁱ	P38694Primary (citable) accession number: P38694 Secondary accession number(s): D3DKY6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	February 1, 1995
	Last modified:	June 7, 2017
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome VIII
Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P38694 (MSC7_YEAST)

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Putative aldehyde dehydrogenase-like protein YHR039C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ