P38694 (MSC7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative aldehyde dehydrogenase-like protein YHR039C
EC=1.2.1.-

Alternative name(s):
Meiotic sister-chromatid recombination protein 7

Gene names

Name:	MSC7
Ordered Locus Names:	YHR039C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	644 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Endoplasmic reticulum Ref.3.
Post-translational modification	N-glycosylated.
Miscellaneous	Present with 2500 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Molecular function	Oxidoreductase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	reciprocal meiotic recombination Inferred from mutant phenotype PubMed 10511544. Source: SGD
Cellular_component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 644	644	Putative aldehyde dehydrogenase-like protein YHR039C		PRO_0000056596
Sites
	Active site	354	1	Proton acceptor By similarity
	Active site	389	1	Nucleophile By similarity
	Site	248	1	Transition state stabilizer By similarity
Amino acid modifications
	Glycosylation	15	1	N-linked (GlcNAc...) Potential
	Glycosylation	565	1	N-linked (GlcNAc...) Potential
	Glycosylation	627	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P38694 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 54DADDAEB2A16D4D	FASTA	644	71,321
	10 20 30 40 50 60 MSKVYLNSDM INHLNSTVQA YFNLWLEKQN AIMRSQPQII QDNQKLIGIT TLVASIFTLY 70 80 90 100 110 120 VLVKIISTPA KCSSSYKPVK FSLPAPEAAQ NNWKGKRSVS TNIWNPEEPN FIQCHCPATG 130 140 150 160 170 180 QYLGSFPSKT EADIDEMVSK AGKAQSTWGN SDFSRRLRVL ASLHDYILNN QDLIARVACR 190 200 210 220 230 240 DSGKTMLDAS MGEILVTLEK IQWTIKHGQR ALQPSRRPGP TNFFMKWYKG AEIRYEPLGV 250 260 270 280 290 300 ISSIVSWNYP FHNLLGPIIA ALFTGNAIVV KCSEQVVWSS EFFVELIRKC LEACDEDPDL 310 320 330 340 350 360 VQLCYCLPPT ENDDSANYFT SHPGFKHITF IGSQPVAHYI LKCAAKSLTP VVVELGGKDA 370 380 390 400 410 420 FIVLDSAKNL DALSSIIMRG TFQSSGQNCI GIERVIVSKE NYDDLVKILN DRMTANPLRQ 430 440 450 460 470 480 GSDIDHLENV DMGAMISDNR FDELEALVKD AVAKGARLLQ GGSRFKHPKY PQGHYFQPTL 490 500 510 520 530 540 LVDVTPEMKI AQNEVFGPIL VMMKAKNTDH CVQLANSAPF GLGGSVFGAD IKECNYVANS 550 560 570 580 590 600 LQTGNVAIND FATFYVCQLP FGGINGSGYG KFGGEEGLLG LCNAKSVCFD TLPFVSTQIP 610 620 630 640 KPLDYPIRNN AKAWNFVKSF IVGAYTNSTW QRIKSLFSLA KEAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M. Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes." Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H. Mol. Syst. Biol. 5:308-308(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00062 Genomic DNA. Translation: AAB68915.1. BK006934 Genomic DNA. Translation: DAA06730.1.
PIR	S46746.
RefSeq	NP_011904.1. NM_001179169.1.
3D structure databases
ProteinModelPortal	P38694.
SMR	P38694. Positions 112-608.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	36470. 47 interactions.
DIP	DIP-1878N.
IntAct	P38694. 13 interactions.
MINT	MINT-404998.
STRING	4932.YHR039C.
Proteomic databases
PaxDb	P38694.
PeptideAtlas	P38694.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YHR039C; YHR039C; YHR039C.
GeneID	856434.
KEGG	sce:YHR039C.
Organism-specific databases
CYGD	YHR039c.
SGD	S000001081. MSC7.
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HOG000271512.
OMA	AIVSWNY.
OrthoDB	EOG79PJXX.
Enzyme and pathway databases
BioCyc	YEAST:G3O-31098-MONOMER.
Gene expression databases
Genevestigator	P38694.
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. SSF53720. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	982030.

Entry information

Entry name

MSC7_YEAST

Accession

Primary (citable) accession number: P38694
Secondary accession number(s): D3DKY6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	March 19, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program