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P38694

- MSC7_YEAST

UniProt

P38694 - MSC7_YEAST

Protein

Putative aldehyde dehydrogenase-like protein YHR039C

Gene

MSC7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei248 – 2481Transition state stabilizerBy similarity
    Active sitei354 – 3541Proton acceptorPROSITE-ProRule annotation
    Active sitei389 – 3891NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro

    GO - Biological processi

    1. reciprocal meiotic recombination Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31098-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative aldehyde dehydrogenase-like protein YHR039C (EC:1.2.1.-)
    Alternative name(s):
    Meiotic sister-chromatid recombination protein 7
    Gene namesi
    Name:MSC7
    Ordered Locus Names:YHR039C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR039c.
    SGDiS000001081. MSC7.

    Subcellular locationi

    Endoplasmic reticulum 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 644644Putative aldehyde dehydrogenase-like protein YHR039CPRO_0000056596Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi565 – 5651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi627 – 6271N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP38694.
    PaxDbiP38694.
    PeptideAtlasiP38694.

    Expressioni

    Gene expression databases

    GenevestigatoriP38694.

    Interactioni

    Protein-protein interaction databases

    BioGridi36470. 47 interactions.
    DIPiDIP-1878N.
    IntActiP38694. 13 interactions.
    MINTiMINT-404998.
    STRINGi4932.YHR039C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38694.
    SMRiP38694. Positions 4-592.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271512.
    OMAiKHITFIG.
    OrthoDBiEOG79PJXX.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38694-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKVYLNSDM INHLNSTVQA YFNLWLEKQN AIMRSQPQII QDNQKLIGIT    50
    TLVASIFTLY VLVKIISTPA KCSSSYKPVK FSLPAPEAAQ NNWKGKRSVS 100
    TNIWNPEEPN FIQCHCPATG QYLGSFPSKT EADIDEMVSK AGKAQSTWGN 150
    SDFSRRLRVL ASLHDYILNN QDLIARVACR DSGKTMLDAS MGEILVTLEK 200
    IQWTIKHGQR ALQPSRRPGP TNFFMKWYKG AEIRYEPLGV ISSIVSWNYP 250
    FHNLLGPIIA ALFTGNAIVV KCSEQVVWSS EFFVELIRKC LEACDEDPDL 300
    VQLCYCLPPT ENDDSANYFT SHPGFKHITF IGSQPVAHYI LKCAAKSLTP 350
    VVVELGGKDA FIVLDSAKNL DALSSIIMRG TFQSSGQNCI GIERVIVSKE 400
    NYDDLVKILN DRMTANPLRQ GSDIDHLENV DMGAMISDNR FDELEALVKD 450
    AVAKGARLLQ GGSRFKHPKY PQGHYFQPTL LVDVTPEMKI AQNEVFGPIL 500
    VMMKAKNTDH CVQLANSAPF GLGGSVFGAD IKECNYVANS LQTGNVAIND 550
    FATFYVCQLP FGGINGSGYG KFGGEEGLLG LCNAKSVCFD TLPFVSTQIP 600
    KPLDYPIRNN AKAWNFVKSF IVGAYTNSTW QRIKSLFSLA KEAS 644
    Length:644
    Mass (Da):71,321
    Last modified:February 1, 1995 - v1
    Checksum:i54DADDAEB2A16D4D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00062 Genomic DNA. Translation: AAB68915.1.
    BK006934 Genomic DNA. Translation: DAA06730.1.
    PIRiS46746.
    RefSeqiNP_011904.1. NM_001179169.1.

    Genome annotation databases

    EnsemblFungiiYHR039C; YHR039C; YHR039C.
    GeneIDi856434.
    KEGGisce:YHR039C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00062 Genomic DNA. Translation: AAB68915.1 .
    BK006934 Genomic DNA. Translation: DAA06730.1 .
    PIRi S46746.
    RefSeqi NP_011904.1. NM_001179169.1.

    3D structure databases

    ProteinModelPortali P38694.
    SMRi P38694. Positions 4-592.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36470. 47 interactions.
    DIPi DIP-1878N.
    IntActi P38694. 13 interactions.
    MINTi MINT-404998.
    STRINGi 4932.YHR039C.

    Proteomic databases

    MaxQBi P38694.
    PaxDbi P38694.
    PeptideAtlasi P38694.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR039C ; YHR039C ; YHR039C .
    GeneIDi 856434.
    KEGGi sce:YHR039C.

    Organism-specific databases

    CYGDi YHR039c.
    SGDi S000001081. MSC7.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271512.
    OMAi KHITFIG.
    OrthoDBi EOG79PJXX.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31098-MONOMER.

    Miscellaneous databases

    NextBioi 982030.

    Gene expression databases

    Genevestigatori P38694.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes."
      Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H.
      Mol. Syst. Biol. 5:308-308(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMSC7_YEAST
    AccessioniPrimary (citable) accession number: P38694
    Secondary accession number(s): D3DKY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2500 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3