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Reviewed, UniProtKB/Swiss-Prot P38693 (PPAC_YEAST)

Last modified October 13, 2009. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Acid phosphatase PHO12
    EC=3.1.3.2
Gene names
Name: PHO12
Ordered Locus Names: YHR215W
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Induction

S.cerevisiae has 2 types of acid phosphatase: one is constitutive and the other is repressible by inorganic phosphate.

Post-translational modification

Glycosylated during secretion across the membrane.

Miscellaneous

Present with 3290 molecules/cell in log phase SD medium. Ref.2

Sequence similarities

Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentfungal-type vacuole

Inferred from direct assay. Source: SGD

   Molecular functionacid phosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 By similarity
Chain18 – 467450Acid phosphatase PHO12
PRO_0000023957

Sites

Active site751Nucleophile By similarity
Active site3381Proton donor By similarity

Amino acid modifications

Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1621N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation3151N-linked (GlcNAc...) Potential
Glycosylation3561N-linked (GlcNAc...) Potential
Glycosylation3901N-linked (GlcNAc...) Potential
Glycosylation4391N-linked (GlcNAc...) Potential
Glycosylation4451N-linked (GlcNAc...) Potential
Glycosylation4611N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P38693-1 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: BEC606CDF39B845B

FASTA46752,700
        10         20         30         40         50         60 
MLKSAVYSIL AASLVNAGTI PLGKLSDIDK IGTQTEIFPF LGGSGPYYSF PGDYGISRDL 

        70         80         90        100        110        120 
PESCEMKQVQ MVGRHGERYP TVSKAKSIMT TWYKLSNYTG QFSGALSFLN DDYEFFIRDT 

       130        140        150        160        170        180 
KNLEMETTLA NSVNVLNPYT GEMNAKRHAR DFLAQYGYMV ENQTSFAVFT SNSNRCHDTA 

       190        200        210        220        230        240 
QYFIDGLGDK FNISLQTISE AESAGANTLS AHHSCPAWDD DVNDDILKKY DTKYLSGIAK 

       250        260        270        280        290        300 
RLNKENKGLN LTSSDANTFF AWCAYEINAR GYSDICNIFT KDELVRFSYG QDLETYYQTG 

       310        320        330        340        350        360 
PGYDVVRSVG ANLFNASVKL LKESEVQDQK VWLSFTHDTD ILNYLTTIGI IDDQNNLTAE 

       370        380        390        400        410        420 
HVPFMENTFH RSWYVPQGAR VYTEKFQCSN DTYVRYVIND AVVPIETCST GPGFSCEIND 

       430        440        450        460 
FYGYAEKRVA GTDFLKVCNV SSVSNSTELT FFWDWNTKHY NDTLLKQ 

« Hide

Cross-references

Sequence databases

U00029 Genomic DNA. Translation: AAB69729.1.
PIRS48996.
RefSeqNP_012087.1.

3D structure databases

HSSPHSSP built from PDB template 1QFX based on UniProtKB P34755.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:1325N.
IntActP38693. 5 interactions.
STRINGP38693.

Proteomic databases

PeptideAtlasP38693.

Genome annotation databases

EnsemblYHR215W; YHR215W; YHR215W; Saccharomyces cerevisiae. [Genome view]
GeneID856625.
GenomeReviewsGene locus YHR215W in contig U00093_GR.
KEGGsce:YHR215W.

Organism-specific databases

CYGDYHR215w.
SGDS000001258. PHO12.

Phylogenomic databases

HOGENOMP38693.

Enzyme and pathway databases

BRENDA3.1.3.2. 250.

Gene expression databases

GenevestigatorP38693.
GermOnlineYHR215W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR000560. Histidine_acid_Pase.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamPF00328. Acid_phosphat_A. 1 hit.
[Graphical view]
PIRSFPIRSF000894. Acid_phosphatase. 1 hit.
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio982565.

Entry information

Entry namePPAC_YEAST
AccessionPrimary (citable) accession number: P38693
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 13, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents