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P38693

- PPAC_YEAST

UniProt

P38693 - PPAC_YEAST

Protein

Acid phosphatase PHO12

Gene

PHO12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei75 – 751NucleophileBy similarity
    Active sitei338 – 3381Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: SGD

    GO - Biological processi

    1. dephosphorylation Source: GOC

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciYEAST:YHR215W-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acid phosphatase PHO12 (EC:3.1.3.2)
    Gene namesi
    Name:PHO12
    Ordered Locus Names:YHR215W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR215w.
    SGDiS000001258. PHO12.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717By similarityAdd
    BLAST
    Chaini18 – 467450Acid phosphatase PHO12PRO_0000023957Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi445 – 4451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated during secretion across the membrane.

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP38693.
    PeptideAtlasiP38693.

    Expressioni

    Inductioni

    S.cerevisiae has 2 types of acid phosphatase: one is constitutive and the other is repressible by inorganic phosphate.

    Gene expression databases

    GenevestigatoriP38693.

    Interactioni

    Protein-protein interaction databases

    BioGridi36650. 7 interactions.
    DIPiDIP-1325N.
    IntActiP38693. 3 interactions.
    MINTiMINT-411702.
    STRINGi4932.YHR215W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38693.
    SMRiP38693. Positions 37-457.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG260296.
    GeneTreeiENSGT00510000050349.
    HOGENOMiHOG000189191.
    KOiK01078.
    OrthoDBiEOG7TQV9N.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    IPR016274. Histidine_acid_Pase_euk.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000894. Acid_phosphatase. 1 hit.
    SUPFAMiSSF53254. SSF53254. 1 hit.
    PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P38693-1 [UniParc]FASTAAdd to Basket

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    MLKSAVYSIL AASLVNAGTI PLGKLSDIDK IGTQTEIFPF LGGSGPYYSF    50
    PGDYGISRDL PESCEMKQVQ MVGRHGERYP TVSKAKSIMT TWYKLSNYTG 100
    QFSGALSFLN DDYEFFIRDT KNLEMETTLA NSVNVLNPYT GEMNAKRHAR 150
    DFLAQYGYMV ENQTSFAVFT SNSNRCHDTA QYFIDGLGDK FNISLQTISE 200
    AESAGANTLS AHHSCPAWDD DVNDDILKKY DTKYLSGIAK RLNKENKGLN 250
    LTSSDANTFF AWCAYEINAR GYSDICNIFT KDELVRFSYG QDLETYYQTG 300
    PGYDVVRSVG ANLFNASVKL LKESEVQDQK VWLSFTHDTD ILNYLTTIGI 350
    IDDQNNLTAE HVPFMENTFH RSWYVPQGAR VYTEKFQCSN DTYVRYVIND 400
    AVVPIETCST GPGFSCEIND FYGYAEKRVA GTDFLKVCNV SSVSNSTELT 450
    FFWDWNTKHY NDTLLKQ 467
    Length:467
    Mass (Da):52,700
    Last modified:February 1, 1995 - v1
    Checksum:iBEC606CDF39B845B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00029 Genomic DNA. Translation: AAB69729.1.
    BK006934 Genomic DNA. Translation: DAA06914.1.
    PIRiS48996.
    RefSeqiNP_012087.1. NM_001179346.1.

    Genome annotation databases

    EnsemblFungiiYHR215W; YHR215W; YHR215W.
    GeneIDi856625.
    KEGGisce:YHR215W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00029 Genomic DNA. Translation: AAB69729.1 .
    BK006934 Genomic DNA. Translation: DAA06914.1 .
    PIRi S48996.
    RefSeqi NP_012087.1. NM_001179346.1.

    3D structure databases

    ProteinModelPortali P38693.
    SMRi P38693. Positions 37-457.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36650. 7 interactions.
    DIPi DIP-1325N.
    IntActi P38693. 3 interactions.
    MINTi MINT-411702.
    STRINGi 4932.YHR215W.

    Proteomic databases

    PaxDbi P38693.
    PeptideAtlasi P38693.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR215W ; YHR215W ; YHR215W .
    GeneIDi 856625.
    KEGGi sce:YHR215W.

    Organism-specific databases

    CYGDi YHR215w.
    SGDi S000001258. PHO12.

    Phylogenomic databases

    eggNOGi NOG260296.
    GeneTreei ENSGT00510000050349.
    HOGENOMi HOG000189191.
    KOi K01078.
    OrthoDBi EOG7TQV9N.

    Enzyme and pathway databases

    BioCyci YEAST:YHR215W-MONOMER.

    Miscellaneous databases

    NextBioi 982565.

    Gene expression databases

    Genevestigatori P38693.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    IPR016274. Histidine_acid_Pase_euk.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000894. Acid_phosphatase. 1 hit.
    SUPFAMi SSF53254. SSF53254. 1 hit.
    PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPPAC_YEAST
    AccessioniPrimary (citable) accession number: P38693
    Secondary accession number(s): D3DLH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3290 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3