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P38693 (PPAC_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acid phosphatase PHO12

EC=3.1.3.2
Gene names
Name:PHO12
Ordered Locus Names:YHR215W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Induction

S.cerevisiae has 2 types of acid phosphatase: one is constitutive and the other is repressible by inorganic phosphate.

Post-translational modification

Glycosylated during secretion across the membrane.

Miscellaneous

Present with 3290 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentfungal-type vacuole

Inferred from direct assay PubMed 14562095. Source: SGD

   Molecular_functionacid phosphatase activity

Inferred from sequence or structural similarity PubMed 2688928. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 By similarity
Chain18 – 467450Acid phosphatase PHO12
PRO_0000023957

Sites

Active site751Nucleophile By similarity
Active site3381Proton donor By similarity

Amino acid modifications

Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1621N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation3151N-linked (GlcNAc...) Potential
Glycosylation3561N-linked (GlcNAc...) Potential
Glycosylation3901N-linked (GlcNAc...) Potential
Glycosylation4391N-linked (GlcNAc...) Potential
Glycosylation4451N-linked (GlcNAc...) Potential
Glycosylation4611N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P38693 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: BEC606CDF39B845B

FASTA46752,700
        10         20         30         40         50         60 
MLKSAVYSIL AASLVNAGTI PLGKLSDIDK IGTQTEIFPF LGGSGPYYSF PGDYGISRDL 

        70         80         90        100        110        120 
PESCEMKQVQ MVGRHGERYP TVSKAKSIMT TWYKLSNYTG QFSGALSFLN DDYEFFIRDT 

       130        140        150        160        170        180 
KNLEMETTLA NSVNVLNPYT GEMNAKRHAR DFLAQYGYMV ENQTSFAVFT SNSNRCHDTA 

       190        200        210        220        230        240 
QYFIDGLGDK FNISLQTISE AESAGANTLS AHHSCPAWDD DVNDDILKKY DTKYLSGIAK 

       250        260        270        280        290        300 
RLNKENKGLN LTSSDANTFF AWCAYEINAR GYSDICNIFT KDELVRFSYG QDLETYYQTG 

       310        320        330        340        350        360 
PGYDVVRSVG ANLFNASVKL LKESEVQDQK VWLSFTHDTD ILNYLTTIGI IDDQNNLTAE 

       370        380        390        400        410        420 
HVPFMENTFH RSWYVPQGAR VYTEKFQCSN DTYVRYVIND AVVPIETCST GPGFSCEIND 

       430        440        450        460 
FYGYAEKRVA GTDFLKVCNV SSVSNSTELT FFWDWNTKHY NDTLLKQ 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00029 Genomic DNA. Translation: AAB69729.1.
BK006934 Genomic DNA. Translation: DAA06914.1.
PIRS48996.
RefSeqNP_012087.1. NM_001179346.1.

3D structure databases

ProteinModelPortalP38693.
SMRP38693. Positions 37-457.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-1325N.
IntActP38693. 3 interactions.
MINTMINT-411702.
STRING4932.YHR215W.

Proteomic databases

PaxDbP38693.
PeptideAtlasP38693.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR215W; YHR215W; YHR215W.
GeneID856625.
KEGGsce:YHR215W.

Organism-specific databases

CYGDYHR215w.
SGDS000001258. PHO12.

Phylogenomic databases

eggNOGNOG260296.
GeneTreeENSGT00510000050349.
HOGENOMHOG000189191.
KOK01078.
OMACEISFAQ.
OrthoDBEOG45HW5S.

Gene expression databases

GenevestigatorP38693.
GermOnlineYHR215W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR000560. His_Pase_superF_clade-2.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
PIRSFPIRSF000894. Acid_phosphatase. 1 hit.
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982565.

Entry information

Entry namePPAC_YEAST
AccessionPrimary (citable) accession number: P38693
Secondary accession number(s): D3DLH0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

SIMILARITY comments

Index of protein domains and families