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P38693

- PPAC_YEAST

UniProt

P38693 - PPAC_YEAST

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Protein
Acid phosphatase PHO12
Gene
PHO12, YHR215W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Nucleophile By similarity
Active sitei338 – 3381Proton donor By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: SGD

GO - Biological processi

  1. dephosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciYEAST:YHR215W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase PHO12 (EC:3.1.3.2)
Gene namesi
Name:PHO12
Ordered Locus Names:YHR215W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR215w.
SGDiS000001258. PHO12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 By similarity
Add
BLAST
Chaini18 – 467450Acid phosphatase PHO12
PRO_0000023957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi162 – 1621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi250 – 2501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi315 – 3151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi356 – 3561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi390 – 3901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi439 – 4391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi445 – 4451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi461 – 4611N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Glycosylated during secretion across the membrane.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP38693.
PeptideAtlasiP38693.

Expressioni

Inductioni

S.cerevisiae has 2 types of acid phosphatase: one is constitutive and the other is repressible by inorganic phosphate.

Gene expression databases

GenevestigatoriP38693.

Interactioni

Protein-protein interaction databases

BioGridi36650. 7 interactions.
DIPiDIP-1325N.
IntActiP38693. 3 interactions.
MINTiMINT-411702.
STRINGi4932.YHR215W.

Structurei

3D structure databases

ProteinModelPortaliP38693.
SMRiP38693. Positions 37-457.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG260296.
GeneTreeiENSGT00510000050349.
HOGENOMiHOG000189191.
KOiK01078.
OrthoDBiEOG7TQV9N.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38693-1 [UniParc]FASTAAdd to Basket

« Hide

MLKSAVYSIL AASLVNAGTI PLGKLSDIDK IGTQTEIFPF LGGSGPYYSF    50
PGDYGISRDL PESCEMKQVQ MVGRHGERYP TVSKAKSIMT TWYKLSNYTG 100
QFSGALSFLN DDYEFFIRDT KNLEMETTLA NSVNVLNPYT GEMNAKRHAR 150
DFLAQYGYMV ENQTSFAVFT SNSNRCHDTA QYFIDGLGDK FNISLQTISE 200
AESAGANTLS AHHSCPAWDD DVNDDILKKY DTKYLSGIAK RLNKENKGLN 250
LTSSDANTFF AWCAYEINAR GYSDICNIFT KDELVRFSYG QDLETYYQTG 300
PGYDVVRSVG ANLFNASVKL LKESEVQDQK VWLSFTHDTD ILNYLTTIGI 350
IDDQNNLTAE HVPFMENTFH RSWYVPQGAR VYTEKFQCSN DTYVRYVIND 400
AVVPIETCST GPGFSCEIND FYGYAEKRVA GTDFLKVCNV SSVSNSTELT 450
FFWDWNTKHY NDTLLKQ 467
Length:467
Mass (Da):52,700
Last modified:February 1, 1995 - v1
Checksum:iBEC606CDF39B845B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00029 Genomic DNA. Translation: AAB69729.1.
BK006934 Genomic DNA. Translation: DAA06914.1.
PIRiS48996.
RefSeqiNP_012087.1. NM_001179346.1.

Genome annotation databases

EnsemblFungiiYHR215W; YHR215W; YHR215W.
GeneIDi856625.
KEGGisce:YHR215W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00029 Genomic DNA. Translation: AAB69729.1 .
BK006934 Genomic DNA. Translation: DAA06914.1 .
PIRi S48996.
RefSeqi NP_012087.1. NM_001179346.1.

3D structure databases

ProteinModelPortali P38693.
SMRi P38693. Positions 37-457.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36650. 7 interactions.
DIPi DIP-1325N.
IntActi P38693. 3 interactions.
MINTi MINT-411702.
STRINGi 4932.YHR215W.

Proteomic databases

PaxDbi P38693.
PeptideAtlasi P38693.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR215W ; YHR215W ; YHR215W .
GeneIDi 856625.
KEGGi sce:YHR215W.

Organism-specific databases

CYGDi YHR215w.
SGDi S000001258. PHO12.

Phylogenomic databases

eggNOGi NOG260296.
GeneTreei ENSGT00510000050349.
HOGENOMi HOG000189191.
KOi K01078.
OrthoDBi EOG7TQV9N.

Enzyme and pathway databases

BioCyci YEAST:YHR215W-MONOMER.

Miscellaneous databases

NextBioi 982565.

Gene expression databases

Genevestigatori P38693.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPPAC_YEAST
AccessioniPrimary (citable) accession number: P38693
Secondary accession number(s): D3DLH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3290 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi