Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase KIC1

Gene

KIC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein kinase involved in morphogenesis and cell integrity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521ATPPROSITE-ProRule annotation
Active sitei144 – 1441Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 379ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: SGD
  • protein serine/threonine kinase activity Source: SGD
  • receptor signaling protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • budding cell apical bud growth Source: SGD
  • cell morphogenesis Source: SGD
  • fungal-type cell wall organization Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31147-MONOMER.
ReactomeiR-SCE-2559580. Oxidative Stress Induced Senescence.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase KIC1 (EC:2.7.11.1)
Alternative name(s):
Kinase that interacts with CDC31
N-rich kinase 1
Gene namesi
Name:KIC1
Synonyms:NRK1
Ordered Locus Names:YHR102W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR102W.
SGDiS000001144. KIC1.

Subcellular locationi

GO - Cellular componenti

  • cellular bud Source: SGD
  • incipient cellular bud site Source: SGD
  • mating projection tip Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10801080Serine/threonine-protein kinase KIC1PRO_0000086127Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei735 – 7351PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38692.
PRIDEiP38692.

PTM databases

iPTMnetiP38692.

Interactioni

Subunit structurei

Interacts with CDC31.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HYM1P324644EBI-12253,EBI-8859
SLT2Q007722EBI-12253,EBI-17372
SOG2Q088175EBI-12253,EBI-30849

Protein-protein interaction databases

BioGridi36535. 32 interactions.
DIPiDIP-1999N.
IntActiP38692. 16 interactions.
MINTiMINT-384442.

Structurei

3D structure databases

ProteinModelPortaliP38692.
SMRiP38692. Positions 18-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 276254Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00810000125351.
HOGENOMiHOG000248092.
InParanoidiP38692.
KOiK08286.
OMAiNLWILME.
OrthoDBiEOG092C2N7K.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38692-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTKPQNSKQ GLAEGEMDVS SLFKRTEVIG RGKFGVVYKG YNVKTGRVYA
60 70 80 90 100
IKVLNLDSDS DEVEDVQREI QFLASLKQIS NITRYYGSYL KDTSLWIIME
110 120 130 140 150
HCAGGSLRSL LRPGKIDEKY IGVIMRELLV ALKCIHKDNV IHRDIKAANV
160 170 180 190 200
LITNEGNVKL CDFGVAAQVN QTSLRRQTMA GTPYWMAPEV IMEGVYYDTK
210 220 230 240 250
VDIWSLGITT YEIATGNPPY CDVEALRAMQ LIIKSKPPRL EDRSYSTSLK
260 270 280 290 300
EFIALCLDED PKERLSADDL LKSKFIRAHK ATPTSILKEL ISRYLLFRDK
310 320 330 340 350
NKNKYKIEGS IPENEPSKPS EAPKPSQNGG GDEAQKSIAS NDNEIKRVNE
360 370 380 390 400
GDVEMKWDFD SLSSSDYIIE NNINLDALAE DNNEWATAQH DLFNYAYPDE
410 420 430 440 450
DSYYFDPTSH NTRPFVYQGT TIGKGYPGTI AQNSTLNAPV TNNYTNSKYP
460 470 480 490 500
SKMVAGTTNT SGTHTAGPMT SSKRLESKAP KQLLELFEDN EIITAENDVN
510 520 530 540 550
TEAPKISKSI SSLNAGNSSR DDFIPSISNE VNGNINNNKM RPHLPPLSSG
560 570 580 590 600
NNYYSQSTPA LPLLQTKFNK TSKGPPTSGL TTAPTSIEIE IPEELPNSAL
610 620 630 640 650
PTPASADPVL IPSTKARSST VTAGTPSSSS SIQYKSPSNV PRRLTVSNNR
660 670 680 690 700
PEHCPSTITN QKLGSAVASN SGISSTPNNS NNYNNNTDSE NSRGSSGSNT
710 720 730 740 750
ANSTQMGITN PGNVTKLSTH KASSPSRPLF GVGTSPNRKP AGSPTQNIGH
760 770 780 790 800
NSTHTNLAPP PTMKPMANSK DNKDILLQPL NSIPSSSTLN TISGNSSNNL
810 820 830 840 850
TSSNYFSNEK EGSRVNGDFK RNNPNLKLQM PLPTPVVRNK LLDPNTATSQ
860 870 880 890 900
NNNGMPGSAG ISTNENINQF GFNTSSASNI PVSMTPISEK HIDFGGKIKR
910 920 930 940 950
SQSISNRKNS SASEHPLNIL GSSVSGNVSG IGNNNVGSNN NSGPNNSVPL
960 970 980 990 1000
SANTGNTTIK ANSTTIATSS SAAASTTAPI SQQTIPSGTQ FNHILSSAAT
1010 1020 1030 1040 1050
AANSVNSLGF GMCPPPQSLQ MEMFLDLESF LPGKQRRVDR KPQVLKELEN
1060 1070 1080
LLQMFEEGLP CIEHALKEQL ISTPIKDNEH
Length:1,080
Mass (Da):117,062
Last modified:February 1, 1995 - v1
Checksum:i9989EAF315EE0B94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29980 Genomic DNA. Translation: BAA06250.1.
U00059 Genomic DNA. Translation: AAB68860.1.
BK006934 Genomic DNA. Translation: DAA06796.1.
PIRiS48944.
RefSeqiNP_011970.1. NM_001179232.1.

Genome annotation databases

EnsemblFungiiYHR102W; YHR102W; YHR102W.
GeneIDi856502.
KEGGisce:YHR102W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29980 Genomic DNA. Translation: BAA06250.1.
U00059 Genomic DNA. Translation: AAB68860.1.
BK006934 Genomic DNA. Translation: DAA06796.1.
PIRiS48944.
RefSeqiNP_011970.1. NM_001179232.1.

3D structure databases

ProteinModelPortaliP38692.
SMRiP38692. Positions 18-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36535. 32 interactions.
DIPiDIP-1999N.
IntActiP38692. 16 interactions.
MINTiMINT-384442.

PTM databases

iPTMnetiP38692.

Proteomic databases

MaxQBiP38692.
PRIDEiP38692.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR102W; YHR102W; YHR102W.
GeneIDi856502.
KEGGisce:YHR102W.

Organism-specific databases

EuPathDBiFungiDB:YHR102W.
SGDiS000001144. KIC1.

Phylogenomic databases

GeneTreeiENSGT00810000125351.
HOGENOMiHOG000248092.
InParanoidiP38692.
KOiK08286.
OMAiNLWILME.
OrthoDBiEOG092C2N7K.

Enzyme and pathway databases

BioCyciYEAST:G3O-31147-MONOMER.
ReactomeiR-SCE-2559580. Oxidative Stress Induced Senescence.

Miscellaneous databases

PROiP38692.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIC1_YEAST
AccessioniPrimary (citable) accession number: P38692
Secondary accession number(s): D3DL52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: September 7, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1040 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.