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Protein

Uncharacterized protein YHR033W

Gene

YHR033W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511SubstrateBy similarity
Binding sitei138 – 1381SubstrateBy similarity
Binding sitei150 – 1501Substrate; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi170 – 1712ATPBy similarity
Nucleotide bindingi214 – 2207ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate 5-kinase activity Source: InterPro
  3. RNA binding Source: InterPro

GO - Biological processi

  1. proline biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31093-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein YHR033W
Gene namesi
Ordered Locus Names:YHR033W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR033w.
SGDiS000001075. YHR033W.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Uncharacterized protein YHR033WPRO_0000109779Add
BLAST

Proteomic databases

MaxQBiP38690.
PaxDbiP38690.
PeptideAtlasiP38690.

Expressioni

Gene expression databases

GenevestigatoriP38690.

Interactioni

Protein-protein interaction databases

BioGridi36464. 31 interactions.
DIPiDIP-5036N.
IntActiP38690. 2 interactions.
MINTiMINT-515715.
STRINGi4932.YHR033W.

Structurei

3D structure databases

ProteinModelPortaliP38690.
SMRiP38690. Positions 6-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini315 – 40692PUAAdd
BLAST

Sequence similaritiesi

Belongs to the glutamate 5-kinase family.Curated
Contains 1 PUA domain.Curated

Phylogenomic databases

eggNOGiCOG0263.
GeneTreeiENSGT00550000075661.
HOGENOMiHOG000246369.
InParanoidiP38690.
KOiK00931.
OMAiVSEYVAH.
OrthoDBiEOG7SFJ62.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPiMF_00456. ProB.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view]
PIRSFiPIRSF000729. GK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR01027. proB. 1 hit.
PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
PS50890. PUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKAYTIVIK LGSSSLVDES TKEPKLSIMT LIVETVTNLK RMGHKVIIVS
60 70 80 90 100
SGGIAVGLDA LNIPHKPKQL SEVQAIAAVG QGRLIARWNM LFSQYGEQTA
110 120 130 140 150
QILLTRNDIL RWNQYNNARN TINELLAMGV IPIVNENDTL SISEIEFGDN
160 170 180 190 200
DTLSAITAAL VGADFLFLLT DVDCLYTDNP RTNPDARPIV LVPELSEGLP
210 220 230 240 250
GVNTSSGSGS EVGTGGMRTK LIAADLASNA GIETIVMKSD RPEYVPKIVD
260 270 280 290 300
YIQHHFRPPR HIGNGTQQQF LDLQDTELEQ LRRYDVPMHT KFLANDNKHK
310 320 330 340 350
LKNREFWILH GLITKGAIII DENSYDKLLS KDMASLTPNA VIEVRDNFHE
360 370 380 390 400
LECVDLKIGQ RLPNGELDIS KPIQSVGCVR SNYTSLELAK IKGLPSEKIH
410 420
DVLGYSVSEY VAHRENIAFP PQF
Length:423
Mass (Da):46,864
Last modified:February 1, 1995 - v1
Checksum:iC7CBF7B1773F1981
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1171N → D in AAU09740 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68910.1.
AY723823 Genomic DNA. Translation: AAU09740.1.
BK006934 Genomic DNA. Translation: DAA06724.1.
PIRiS46741.
RefSeqiNP_011898.1. NM_001179163.1.

Genome annotation databases

EnsemblFungiiYHR033W; YHR033W; YHR033W.
GeneIDi856428.
KEGGisce:YHR033W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00062 Genomic DNA. Translation: AAB68910.1.
AY723823 Genomic DNA. Translation: AAU09740.1.
BK006934 Genomic DNA. Translation: DAA06724.1.
PIRiS46741.
RefSeqiNP_011898.1. NM_001179163.1.

3D structure databases

ProteinModelPortaliP38690.
SMRiP38690. Positions 6-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36464. 31 interactions.
DIPiDIP-5036N.
IntActiP38690. 2 interactions.
MINTiMINT-515715.
STRINGi4932.YHR033W.

Proteomic databases

MaxQBiP38690.
PaxDbiP38690.
PeptideAtlasiP38690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR033W; YHR033W; YHR033W.
GeneIDi856428.
KEGGisce:YHR033W.

Organism-specific databases

CYGDiYHR033w.
SGDiS000001075. YHR033W.

Phylogenomic databases

eggNOGiCOG0263.
GeneTreeiENSGT00550000075661.
HOGENOMiHOG000246369.
InParanoidiP38690.
KOiK00931.
OMAiVSEYVAH.
OrthoDBiEOG7SFJ62.

Enzyme and pathway databases

BioCyciYEAST:G3O-31093-MONOMER.

Miscellaneous databases

NextBioi982012.

Gene expression databases

GenevestigatoriP38690.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPiMF_00456. ProB.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view]
PIRSFiPIRSF000729. GK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR01027. proB. 1 hit.
PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
PS50890. PUA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiYHJ3_YEAST
AccessioniPrimary (citable) accession number: P38690
Secondary accession number(s): D3DKY0, Q66R86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: January 7, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.