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Protein

Signal recognition particle subunit SRP72

Gene

SRP72

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP72 binds the 7S RNA only in presence of SRP68.2 Publications

Miscellaneous

Present with 11800 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein

Enzyme and pathway databases

BioCyciYEAST:G3O-34101-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle subunit SRP72
Alternative name(s):
Signal recognition particle 72 kDa protein homolog
Gene namesi
Name:SRP72
Ordered Locus Names:YPL210C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL210C.
SGDiS000006131. SRP72.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus, Signal recognition particle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001352381 – 640Signal recognition particle subunit SRP72Add BLAST640

Proteomic databases

MaxQBiP38688.
PRIDEiP38688.

PTM databases

iPTMnetiP38688.

Interactioni

Subunit structurei

Fungal signal recognition particle (SRP) complex consists of a 7S RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14. At least SRP14, SRP21, SRP68 and SRP72 are proposed to get assembled together with scR1 RNA as a pre-SRP complex in the nucleolus which is exported to the cytoplasm.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35975. 86 interactors.
DIPiDIP-6763N.
IntActiP38688. 22 interactors.
MINTiMINT-620431.
STRINGi4932.YPL210C.

Structurei

3D structure databases

ProteinModelPortaliP38688.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati188 – 221TPRAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi539 – 640Lys-richAdd BLAST102

Sequence similaritiesi

Belongs to the SRP72 family.Curated

Keywords - Domaini

TPR repeat

Phylogenomic databases

HOGENOMiHOG000000979.
InParanoidiP38688.
KOiK03108.
OMAiRSYYKPT.
OrthoDBiEOG092C2OB4.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiView protein in InterPro
IPR013699. Signal_recog_part_SRP72_RNA-bd.
IPR026270. SRP72.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
PANTHERiPTHR14094. PTHR14094. 1 hit.
PfamiView protein in Pfam
PF08492. SRP72. 1 hit.
PIRSFiPIRSF038922. SRP72. 1 hit.
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiView protein in PROSITE
PS50293. TPR_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

P38688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDNLTNLL SQLNIQLSQD EHSQVEQTCV KLLDSGCENP ADVFRRCLVA
60 70 80 90 100
VIQQDKYQKA LHYLKKFKHI DDKYGRKFAL EKLYIFYKLN MPDEFNTLYT
110 120 130 140 150
AIITDDLDTV LKKDIESLRG ILHVRAQYCY KNGLYQEAFK IYQHLASHNE
160 170 180 190 200
KDQDSQIELS CNERVPLSVA TELMNRSPLV TPMDESSYDL LFNESFIMAS
210 220 230 240 250
VGKYDKAIEL LEKALQGATN EGYQNDINTI KLQLSFVLQM VGKTAQSKEI
260 270 280 290 300
LKGLLQELKA DSPFSLICQN NLNAFVDFSK YNTNFNLLLR ELNVEKLNTF
310 320 330 340 350
NLQTFTHEQW SNIQRNVLFL RLFNNVKIHS QESLLSRTFD KYSKLVDNVT
360 370 380 390 400
LESYKTQAKK LYHHTTKTIL SGTDGSTIGI LLLTIQLLII EKEWENAIRI
410 420 430 440 450
GELFLNESWK SSFEKFNDSQ AIVCYILFEL YKIKGRNNSK SVLLKKLGSV
460 470 480 490 500
RVQLSGKIQE NIPFWKHVGF ELLSMGNAKE SKALLREISN FSKGDADVLV
510 520 530 540 550
DRVVSSDSLD IAQGIDLVRD IDIDKLIQLG VKPLESSAKR SKNTAVSKVQ
560 570 580 590 600
KRKVLELKKK RKIKRLEKFL QGRDTSKLPD PERWLPLRDR STYRPKKKQQ
610 620 630 640
GAKQTQGGAM NKKSEQALDI SKKGKPTVNK KPKNKKKGRK
Length:640
Mass (Da):73,541
Last modified:November 8, 2005 - v2
Checksum:iDB2F536212F0871B
GO

Sequence cautioni

The sequence AAA53400 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA97925 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35178 Genomic DNA. Translation: AAA53400.1. Different initiation.
Z73566 Genomic DNA. Translation: CAA97925.1. Different initiation.
BK006949 Genomic DNA. Translation: DAA11226.1.
PIRiS47929.
RefSeqiNP_015114.2. NM_001184024.1.

Genome annotation databases

EnsemblFungiiYPL210C; YPL210C; YPL210C.
GeneIDi855891.
KEGGisce:YPL210C.

Similar proteinsi

Entry informationi

Entry nameiSRP72_YEAST
AccessioniPrimary (citable) accession number: P38688
Secondary accession number(s): D6W3G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 8, 2005
Last modified: September 27, 2017
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names