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P38687

- SRP68_YEAST

UniProt

P38687 - SRP68_YEAST

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Protein

Signal recognition particle subunit SRP68

Gene

SRP68

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. signal sequence binding Source: SGD

GO - Biological processi

  1. protein targeting to ER Source: SGD
  2. SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34129-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle subunit SRP68
Alternative name(s):
Signal recognition particle 68 kDa protein homolog
Gene namesi
Name:SRP68
Ordered Locus Names:YPL243W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPL243w.
SGDiS000006164. SRP68.

Subcellular locationi

Cytoplasm By similarity. Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. signal recognition particle, endoplasmic reticulum targeting Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signal recognition particle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Signal recognition particle subunit SRP68PRO_0000135232Add
BLAST

Proteomic databases

MaxQBiP38687.
PaxDbiP38687.
PeptideAtlasiP38687.

Expressioni

Gene expression databases

GenevestigatoriP38687.

Interactioni

Subunit structurei

Fungal signal recognition particle (SRP) complex consists of a 7S RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.1 Publication

Protein-protein interaction databases

BioGridi35920. 24 interactions.
DIPiDIP-6742N.
IntActiP38687. 18 interactions.
MINTiMINT-626446.
STRINGi4932.YPL243W.

Structurei

3D structure databases

ProteinModelPortaliP38687.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SRP68 family.Curated

Phylogenomic databases

eggNOGiNOG321930.
HOGENOMiHOG000141896.
InParanoidiP38687.
KOiK03107.
OMAiLPGVYND.
OrthoDBiEOG79PJZ9.

Sequencei

Sequence statusi: Complete.

P38687-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAYSPIIAT YGNRAEQFLE TDSDFAKYHA KLNKKLQHLR SRCHLVTKDT
60 70 80 90 100
KKYSSKNKYG EINSEDYDNK TKLIGVLILL HAERDLALAE TLKLRARQRG
110 120 130 140 150
KLKKSEEKVL STRLKKACKT ADKLVNVTQN EQQWITRAQY LAFAKLVHSE
160 170 180 190 200
YLINGKRFKR KDNAKISNNL ALVFAALEHL KNLSLLAEEV VDNIVNKYQY
210 220 230 240 250
SLKQYAGNLI TTPEINNFIV ERVQSDENKD DELVKLLLDN GFNMKKITTS
260 270 280 290 300
TEDQKVTTNI NWRSFNAKII DAEVAQFLEQ GLSIHPTQIT QYTQRLSKLE
310 320 330 340 350
KALDRHEFFI ANHDDQDDID EMVENSSENN QIILAYIKYN ILLTSISRER
360 370 380 390 400
DLFTHLWNQW LKLNTSLPSK LTKYKEMERI VKNLTKYLSD IMELPGVYSD
410 420 430 440 450
DELLSQLDLC KLYFQLFLNT GCLSVLYQSK GRYMEALALY VDAYRRLENK
460 470 480 490 500
LSEIESLDEI LLPANLLSLN SVRSLQKRIE NGGNSVITLA EYEKRNHGGS
510 520 530 540 550
LGKYDLTVIE KLDSKKILPT DIQLKNLFPL KPKMLPIPSK PTLFDLAFNY
560 570 580 590
ITYDKQEPSA SQVKDSVTET ESISQTPISN EQTEGEPKKK RGFLGLFGR
Length:599
Mass (Da):69,006
Last modified:February 1, 1995 - v1
Checksum:i241749187CE95499
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L35177 Genomic DNA. Translation: AAA53401.1.
Z67751 Genomic DNA. Translation: CAA91601.1.
Z73599 Genomic DNA. Translation: CAA97964.1.
BK006949 Genomic DNA. Translation: DAA11194.1.
PIRiS47928.
RefSeqiNP_015081.1. NM_001184057.1.

Genome annotation databases

EnsemblFungiiYPL243W; YPL243W; YPL243W.
GeneIDi855833.
KEGGisce:YPL243W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L35177 Genomic DNA. Translation: AAA53401.1 .
Z67751 Genomic DNA. Translation: CAA91601.1 .
Z73599 Genomic DNA. Translation: CAA97964.1 .
BK006949 Genomic DNA. Translation: DAA11194.1 .
PIRi S47928.
RefSeqi NP_015081.1. NM_001184057.1.

3D structure databases

ProteinModelPortali P38687.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35920. 24 interactions.
DIPi DIP-6742N.
IntActi P38687. 18 interactions.
MINTi MINT-626446.
STRINGi 4932.YPL243W.

Proteomic databases

MaxQBi P38687.
PaxDbi P38687.
PeptideAtlasi P38687.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPL243W ; YPL243W ; YPL243W .
GeneIDi 855833.
KEGGi sce:YPL243W.

Organism-specific databases

CYGDi YPL243w.
SGDi S000006164. SRP68.

Phylogenomic databases

eggNOGi NOG321930.
HOGENOMi HOG000141896.
InParanoidi P38687.
KOi K03107.
OMAi LPGVYND.
OrthoDBi EOG79PJZ9.

Enzyme and pathway databases

BioCyci YEAST:G3O-34129-MONOMER.

Miscellaneous databases

NextBioi 980398.
PROi P38687.

Gene expression databases

Genevestigatori P38687.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression."
    Brown J.D., Hann B.C., Medzihradszky K.F., Niwa M., Burlingame A.L., Walter P.
    EMBO J. 13:4390-4400(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, IDENTIFICATION IN THE SRP COMPLEX.
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export."
    Grosshans H., Deinert K., Hurt E.C., Simos G.
    J. Cell Biol. 153:745-762(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSEMBLY OF THE SRP COMPLEX, SUBCELLULAR LOCATION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSRP68_YEAST
AccessioniPrimary (citable) accession number: P38687
Secondary accession number(s): D6W3C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6280 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3