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Protein

Signal recognition particle subunit SRP68

Gene

SRP68

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently.

Miscellaneous

Present with 6280 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34129-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle subunit SRP68
Alternative name(s):
Signal recognition particle 68 kDa protein homolog
Gene namesi
Name:SRP68
Ordered Locus Names:YPL243W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL243W
SGDiS000006164 SRP68

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signal recognition particle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001352321 – 599Signal recognition particle subunit SRP68Add BLAST599

Proteomic databases

MaxQBiP38687
PaxDbiP38687
PRIDEiP38687

PTM databases

iPTMnetiP38687

Interactioni

Subunit structurei

Fungal signal recognition particle (SRP) complex consists of a 7S RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.1 Publication

Protein-protein interaction databases

BioGridi35920, 67 interactors
DIPiDIP-6742N
IntActiP38687, 20 interactors
MINTiP38687
STRINGi4932.YPL243W

Structurei

3D structure databases

ProteinModelPortaliP38687
SMRiP38687
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SRP68 family.Curated

Phylogenomic databases

HOGENOMiHOG000141896
InParanoidiP38687
KOiK03107
OMAiAFSIAKC
OrthoDBiEOG092C3ATO

Family and domain databases

CDDicd15481 SRP68-RBD, 1 hit
Gene3Di1.10.3450.40, 1 hit
InterProiView protein in InterPro
IPR026258 SRP68
IPR034652 SRP68-RBD
IPR038253 SRP68_N_sf
PANTHERiPTHR12860 PTHR12860, 1 hit
PfamiView protein in Pfam
PF16969 SRP68, 1 hit
PIRSFiPIRSF038995 SRP68, 1 hit

Sequencei

Sequence statusi: Complete.

P38687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAYSPIIAT YGNRAEQFLE TDSDFAKYHA KLNKKLQHLR SRCHLVTKDT
60 70 80 90 100
KKYSSKNKYG EINSEDYDNK TKLIGVLILL HAERDLALAE TLKLRARQRG
110 120 130 140 150
KLKKSEEKVL STRLKKACKT ADKLVNVTQN EQQWITRAQY LAFAKLVHSE
160 170 180 190 200
YLINGKRFKR KDNAKISNNL ALVFAALEHL KNLSLLAEEV VDNIVNKYQY
210 220 230 240 250
SLKQYAGNLI TTPEINNFIV ERVQSDENKD DELVKLLLDN GFNMKKITTS
260 270 280 290 300
TEDQKVTTNI NWRSFNAKII DAEVAQFLEQ GLSIHPTQIT QYTQRLSKLE
310 320 330 340 350
KALDRHEFFI ANHDDQDDID EMVENSSENN QIILAYIKYN ILLTSISRER
360 370 380 390 400
DLFTHLWNQW LKLNTSLPSK LTKYKEMERI VKNLTKYLSD IMELPGVYSD
410 420 430 440 450
DELLSQLDLC KLYFQLFLNT GCLSVLYQSK GRYMEALALY VDAYRRLENK
460 470 480 490 500
LSEIESLDEI LLPANLLSLN SVRSLQKRIE NGGNSVITLA EYEKRNHGGS
510 520 530 540 550
LGKYDLTVIE KLDSKKILPT DIQLKNLFPL KPKMLPIPSK PTLFDLAFNY
560 570 580 590
ITYDKQEPSA SQVKDSVTET ESISQTPISN EQTEGEPKKK RGFLGLFGR
Length:599
Mass (Da):69,006
Last modified:February 1, 1995 - v1
Checksum:i241749187CE95499
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35177 Genomic DNA Translation: AAA53401.1
Z67751 Genomic DNA Translation: CAA91601.1
Z73599 Genomic DNA Translation: CAA97964.1
BK006949 Genomic DNA Translation: DAA11194.1
PIRiS47928
RefSeqiNP_015081.1, NM_001184057.1

Genome annotation databases

EnsemblFungiiYPL243W; YPL243W; YPL243W
GeneIDi855833
KEGGisce:YPL243W

Similar proteinsi

Entry informationi

Entry nameiSRP68_YEAST
AccessioniPrimary (citable) accession number: P38687
Secondary accession number(s): D6W3C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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