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P38680 (MTR_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N amino acid transport system protein
Alternative name(s):
Methyltryptophan resistance protein
Gene names
Name:mtr
ORF Names:NCU06619
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the transport of neutral aliphatic and aromatic amino acids via the N system.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the amino acid/polyamine transporter 2 family.

Ontologies

Keywords
   Biological processAmino-acid transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processamino acid transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470N amino acid transport system protein
PRO_0000093819

Regions

Topological domain1 – 5656Extracellular Potential
Transmembrane57 – 7721Helical; Potential
Transmembrane78 – 9821Helical; Potential
Topological domain99 – 13133Extracellular Potential
Transmembrane132 – 15221Helical; Potential
Topological domain153 – 16816Cytoplasmic Potential
Transmembrane169 – 18921Helical; Potential
Transmembrane191 – 21121Helical; Potential
Topological domain212 – 23625Cytoplasmic Potential
Transmembrane237 – 25721Helical; Potential
Topological domain258 – 27518Extracellular Potential
Transmembrane276 – 29621Helical; Potential
Topological domain297 – 31620Cytoplasmic Potential
Transmembrane317 – 33721Helical; Potential
Topological domain338 – 35720Extracellular Potential
Transmembrane358 – 37821Helical; Potential
Topological domain379 – 3868Cytoplasmic Potential
Transmembrane387 – 40721Helical; Potential
Topological domain408 – 42720Extracellular Potential
Transmembrane428 – 44821Helical; Potential
Topological domain449 – 47022Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P38680 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: E8132D1A62373300

FASTA47051,162
        10         20         30         40         50         60 
MDSQYETKKN DPNAIMPYPE SNDEHVGEVR GLGGGIMDKE PEAQEGHAKF HRLGWKRLTV 

        70         80         90        100        110        120 
VLIVEAIALG SLSLPGAFAT LGMVPGVILS VGMGLICIYT AHVIGQTKLK HPEIAHYADV 

       130        140        150        160        170        180 
GRVMFGRWGY EIISFMFVLQ LIFIVGSHVL TGTIMWGTIT DNGNGTCSLV FGIVSAIILF 

       190        200        210        220        230        240 
LLAIPPSFAE VAILGYIDFV SICAAILITM IATGIRSSHQ EGGLAAVPWS CWPKEDLSLA 

       250        260        270        280        290        300 
EGFIAVSNIV FAYSFAMCQF SFMDEMHTPS DYKKSIVALG LIEIFIYTVT GGVVYAFVGP 

       310        320        330        340        350        360 
EVQSPALLSA GPLLAKVAFG IALPVIFISG SINTVVVSRY LIERIWPNNV IRYVNTPAGW 

       370        380        390        400        410        420 
MVWLGFDFGI TLIAWVIAEA IPFFSDLLAI CSALFISGFS FYFPALMYFK ITRNDAKSQG 

       430        440        450        460        470 
KKYFLDALNM LCFVIGMGIL GIGTYAAIQD IMDRYDHGKV SKPYSCAPLA 

« Hide

References

« Hide 'large scale' references
[1]"Spontaneous mutation at the mtr locus in neurospora: the molecular spectrum in wild-type and a mutator strain."
Dillon D., Stadler D.
Genetics 138:61-74(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Oak Ridge.
[2]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]"Sequence and structure of mtr, an amino acid transport gene of Neurospora crassa."
Koo K., Stuart W.D.
Genome 34:644-651(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-470.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L34605 Genomic DNA. Translation: AAA33600.1.
CM002239 Genomic DNA. Translation: EAA33125.1.
S81767 Genomic DNA. Translation: AAB21410.1.
PIRS47892.
RefSeqXP_962361.1. XM_957268.1.
UniGeneNcr.19075.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU06619.1.

Protein family/group databases

TCDB2.A.18.4.1. the amino acid/auxin permease (aaap) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000006380; EFNCRP00000006372; EFNCRG00000006369.
GeneID3878509.
KEGGncr:NCU06619.

Phylogenomic databases

eggNOGNOG126188.
HOGENOMHOG000158005.
OMAWPKEGTT.
OrthoDBEOG7RRFHQ.

Family and domain databases

InterProIPR013057. AA_transpt_TM.
[Graphical view]
PfamPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTR_NEUCR
AccessionPrimary (citable) accession number: P38680
Secondary accession number(s): Q7RVG6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families