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P38680

- MTR_NEUCR

UniProt

P38680 - MTR_NEUCR

Protein

N amino acid transport system protein

Gene

mtr

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Required for the transport of neutral aliphatic and aromatic amino acids via the N system.

    GO - Biological processi

    1. amino acid transport Source: UniProtKB-KW

    Keywords - Biological processi

    Amino-acid transport, Transport

    Protein family/group databases

    TCDBi2.A.18.4.1. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N amino acid transport system protein
    Alternative name(s):
    Methyltryptophan resistance protein
    Gene namesi
    Name:mtr
    ORF Names:NCU06619
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 4, Linkage Group IV

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 470470N amino acid transport system proteinPRO_0000093819Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU06619.1.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5656ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini99 – 13133ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini153 – 16816CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini212 – 23625CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 27518ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini297 – 31620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini338 – 35720ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini379 – 3868CytoplasmicSequence Analysis
    Topological domaini408 – 42720ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini449 – 47022CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei57 – 7721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei169 – 18921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei191 – 21121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei276 – 29621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei317 – 33721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei358 – 37821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei387 – 40721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei428 – 44821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG126188.
    HOGENOMiHOG000158005.
    OMAiWPKEGTT.
    OrthoDBiEOG7RRFHQ.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38680-1 [UniParc]FASTAAdd to Basket

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    MDSQYETKKN DPNAIMPYPE SNDEHVGEVR GLGGGIMDKE PEAQEGHAKF    50
    HRLGWKRLTV VLIVEAIALG SLSLPGAFAT LGMVPGVILS VGMGLICIYT 100
    AHVIGQTKLK HPEIAHYADV GRVMFGRWGY EIISFMFVLQ LIFIVGSHVL 150
    TGTIMWGTIT DNGNGTCSLV FGIVSAIILF LLAIPPSFAE VAILGYIDFV 200
    SICAAILITM IATGIRSSHQ EGGLAAVPWS CWPKEDLSLA EGFIAVSNIV 250
    FAYSFAMCQF SFMDEMHTPS DYKKSIVALG LIEIFIYTVT GGVVYAFVGP 300
    EVQSPALLSA GPLLAKVAFG IALPVIFISG SINTVVVSRY LIERIWPNNV 350
    IRYVNTPAGW MVWLGFDFGI TLIAWVIAEA IPFFSDLLAI CSALFISGFS 400
    FYFPALMYFK ITRNDAKSQG KKYFLDALNM LCFVIGMGIL GIGTYAAIQD 450
    IMDRYDHGKV SKPYSCAPLA 470
    Length:470
    Mass (Da):51,162
    Last modified:November 1, 1997 - v2
    Checksum:iE8132D1A62373300
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34605 Genomic DNA. Translation: AAA33600.1.
    CM002239 Genomic DNA. Translation: EAA33125.1.
    S81767 Genomic DNA. Translation: AAB21410.1.
    PIRiS47892.
    RefSeqiXP_962361.1. XM_957268.1.
    UniGeneiNcr.19075.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000006380; EFNCRP00000006372; EFNCRG00000006369.
    GeneIDi3878509.
    KEGGincr:NCU06619.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34605 Genomic DNA. Translation: AAA33600.1 .
    CM002239 Genomic DNA. Translation: EAA33125.1 .
    S81767 Genomic DNA. Translation: AAB21410.1 .
    PIRi S47892.
    RefSeqi XP_962361.1. XM_957268.1.
    UniGenei Ncr.19075.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU06619.1.

    Protein family/group databases

    TCDBi 2.A.18.4.1. the amino acid/auxin permease (aaap) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000006380 ; EFNCRP00000006372 ; EFNCRG00000006369 .
    GeneIDi 3878509.
    KEGGi ncr:NCU06619.

    Phylogenomic databases

    eggNOGi NOG126188.
    HOGENOMi HOG000158005.
    OMAi WPKEGTT.
    OrthoDBi EOG7RRFHQ.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Spontaneous mutation at the mtr locus in neurospora: the molecular spectrum in wild-type and a mutator strain."
      Dillon D., Stadler D.
      Genetics 138:61-74(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Oak Ridge.
    2. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    3. "Sequence and structure of mtr, an amino acid transport gene of Neurospora crassa."
      Koo K., Stuart W.D.
      Genome 34:644-651(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-470.

    Entry informationi

    Entry nameiMTR_NEUCR
    AccessioniPrimary (citable) accession number: P38680
    Secondary accession number(s): Q7RVG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3