ID CMLE_NEUCR Reviewed; 366 AA. AC P38677; Q7RV80; DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 3. DT 24-JAN-2024, entry version 129. DE RecName: Full=Carboxy-cis,cis-muconate cyclase; DE EC=5.5.1.5; DE AltName: Full=3-carboxy-cis,cis-muconate lactonizing enzyme; DE Short=CMLE; GN ORFNames=NCU04071; OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / OS FGSC 987). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora. OX NCBI_TaxID=367110; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-41, AND CHARACTERIZATION. RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987; RX PubMed=8132467; DOI=10.1128/jb.176.6.1718-1728.1994; RA Mazur P., Henzel W.J., Mattoo S., Kozarich J.W.; RT "3-carboxy-cis,cis-muconate lactonizing enzyme from Neurospora crassa: an RT alternate cycloisomerase motif."; RL J. Bacteriol. 176:1718-1728(1994). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987; RX PubMed=12712197; DOI=10.1038/nature01554; RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.; RT "The genome sequence of the filamentous fungus Neurospora crassa."; RL Nature 422:859-868(2003). RN [3] RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS). RX PubMed=11937053; DOI=10.1016/s0969-2126(02)00744-x; RA Kajander T., Merckel M.C., Thompson A., Deacon A.M., Mazur P., RA Kozarich J.W., Goldman A.; RT "The structure of Neurospora crassa 3-carboxy-cis,cis-muconate lactonizing RT enzyme, a beta propeller cycloisomerase."; RL Structure 10:483-492(2002). CC -!- FUNCTION: Catalyzes a syn cycloisomerization. Also possesses mle CC activity. CC -!- CATALYTIC ACTIVITY: CC Reaction=3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy- CC cis,cis-muconate; Xref=Rhea:RHEA:14977, ChEBI:CHEBI:57496, CC ChEBI:CHEBI:57976; EC=5.5.1.5; CC -!- PATHWAY: Aromatic compound metabolism; beta-ketoadipate pathway; 3- CC carboxy-cis,cis-muconate from 3-carboxy-2,5-dihydro-5-oxofuran-2- CC acetate: step 1/1. CC -!- SUBUNIT: Homotetramer. CC -!- SIMILARITY: Belongs to the cycloisomerase 2 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L27538; AAA21020.1; -; mRNA. DR EMBL; CM002241; EAA28450.1; -; Genomic_DNA. DR PIR; A55525; A55525. DR RefSeq; XP_957686.1; XM_952593.2. DR PDB; 1JOF; X-ray; 2.50 A; A/B/C/D/E/F/G/H=2-366. DR PDBsum; 1JOF; -. DR AlphaFoldDB; P38677; -. DR SMR; P38677; -. DR STRING; 367110.P38677; -. DR PaxDb; 5141-EFNCRP00000003530; -. DR EnsemblFungi; EAA28450; EAA28450; NCU04071. DR GeneID; 3873776; -. DR KEGG; ncr:NCU04071; -. DR VEuPathDB; FungiDB:NCU04071; -. DR HOGENOM; CLU_045869_0_0_1; -. DR InParanoid; P38677; -. DR OMA; VQNYEYQ; -. DR OrthoDB; 2075815at2759; -. DR UniPathway; UPA00157; UER00308. DR EvolutionaryTrace; P38677; -. DR Proteomes; UP000001805; Chromosome 5, Linkage Group VI. DR GO; GO:0017057; F:6-phosphogluconolactonase activity; IBA:GO_Central. DR GO; GO:0047768; F:carboxy-cis,cis-muconate cyclase activity; IEA:UniProtKB-EC. DR GO; GO:0042952; P:beta-ketoadipate pathway; IEA:UniProtKB-UniPathway. DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1. DR InterPro; IPR019405; Lactonase_7-beta_prop. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR PANTHER; PTHR30344; 6-PHOSPHOGLUCONOLACTONASE-RELATED; 1. DR PANTHER; PTHR30344:SF4; CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED; 1. DR Pfam; PF10282; Lactonase; 1. DR SUPFAM; SSF75011; 3-carboxy-cis,cis-mucoante lactonizing enzyme; 1. PE 1: Evidence at protein level; KW 3D-structure; Direct protein sequencing; Isomerase; Reference proteome. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0000269|PubMed:8132467" FT CHAIN 2..366 FT /note="Carboxy-cis,cis-muconate cyclase" FT /id="PRO_0000171127" FT ACT_SITE 149 FT ACT_SITE 197 FT ACT_SITE 213 FT ACT_SITE 275 FT STRAND 3..14 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 16..23 FT /evidence="ECO:0007829|PDB:1JOF" FT TURN 24..27 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 28..36 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 44..48 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 52..60 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 62..70 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 73..81 FT /evidence="ECO:0007829|PDB:1JOF" FT HELIX 86..89 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 96..102 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 110..118 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 121..127 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 133..141 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 148..153 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 157..164 FT /evidence="ECO:0007829|PDB:1JOF" FT TURN 165..168 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 169..175 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 181..188 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 196..201 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 205..212 FT /evidence="ECO:0007829|PDB:1JOF" FT TURN 213..216 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 217..223 FT /evidence="ECO:0007829|PDB:1JOF" FT TURN 225..227 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 230..240 FT /evidence="ECO:0007829|PDB:1JOF" FT TURN 249..251 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 252..263 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 267..278 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 284..290 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 296..304 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 315..317 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 324..328 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 330..332 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 334..341 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 344..352 FT /evidence="ECO:0007829|PDB:1JOF" FT STRAND 358..365 FT /evidence="ECO:0007829|PDB:1JOF" SQ SEQUENCE 366 AA; 41329 MW; E71BA50509E72873 CRC64; MPLHHLMIGT WTPPGAIFTV QFDDEKLTCK LIKRTEIPQD EPISWMTFDH ERKNIYGAAM KKWSSFAVKS PTEIVHEASH PIGGHPRAND ADTNTRAIFL LAAKQPPYAV YANPFYKFAG YGNVFSVSET GKLEKNVQNY EYQENTGIHG MVFDPTETYL YSADLTANKL WTHRKLASGE VELVGSVDAP DPGDHPRWVA MHPTGNYLYA LMEAGNRICE YVIDPATHMP VYTHHSFPLI PPGIPDRDPE TGKGLYRADV CALTFSGKYM FASSRANKFE LQGYIAGFKL RDCGSIEKQL FLSPTPTSGG HSNAVSPCPW SDEWMAITDD QEGWLEIYRW KDEFLHRVAR VRIPEPGFGM NAIWYD //