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P38667 (PGK_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk-1
Synonyms:pgk, pgka
ORF Names:NCU07914
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Subunit structure

Monomer.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145883

Regions

Nucleotide binding373 – 3764ATP By similarity
Region24 – 263Substrate binding By similarity
Region64 – 674Substrate binding By similarity

Sites

Binding site401Substrate By similarity
Binding site1231Substrate By similarity
Binding site1711Substrate By similarity
Binding site2201ATP By similarity
Binding site3131ATP; via carbonyl oxygen By similarity
Binding site3441ATP By similarity

Experimental info

Sequence conflict701G → R in CAA39865. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P38667 [UniParc].

Last modified September 27, 2004. Version 2.
Checksum: 3BDD4B14655D90F2

FASTA41845,057
        10         20         30         40         50         60 
MSLSNKLSIE DVDLKGKRVL IRVDFNVPLD AEKKVTNPQR IAGAIPTIKY ALDHGAKAVV 

        70         80         90        100        110        120 
LMSHLGRPDG KPNPKYSLKP VVPELEKLLG KKVTFAPDCV GPEVEEIVNK ADNGEVILLE 

       130        140        150        160        170        180 
NLRFHIEEEG KGTDAEGNKV KADKAKVEEF RKNLTKLGDV YINDAFGTAH RAHSSMVGID 

       190        200        210        220        230        240 
LPVKAAGFLM KKELQYFAKV LESPQRPFLS ILGGAKVSDK IQLIDNLLDK VNTLIVCGGM 

       250        260        270        280        290        300 
AFTFKKTLQN MPIGNSLFDE AGAKIVPDLV KKAEKNNVKL VLPVDFTIAD KFDKDANTGY 

       310        320        330        340        350        360 
ATDKDGIPDG WMGLDCGEES VKLFTQAINE SQTILWNGPA GVFEFDKFAK GTKATLDACV 

       370        380        390        400        410 
KAAEEGRTVI IGGGDTATVA AKYGVEDKLS HVSTGGGASL ELLEGKALPG VVALSERQ 

« Hide

References

« Hide 'large scale' references
[1]"Primary structure and in vitro expression of the N. crassa phosphoglycerate kinase."
Azevedo J.E., Tropschug M., Werner S.
DNA Seq. 2:265-267(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 74A.
[2]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56512 mRNA. Translation: CAA39865.1.
CM002239 Genomic DNA. Translation: EAA33194.1.
PIRA56616.
T43864.
RefSeqXP_962430.1. XM_957337.2.

3D structure databases

ProteinModelPortalP38667.
SMRP38667. Positions 2-415.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU07914.1.

Proteomic databases

PRIDEP38667.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000008212; EFNCRP00000008201; EFNCRG00000008198.
GeneID3878602.
KEGGncr:NCU07914.

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMATEYHANT.
OrthoDBEOG71K6D7.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_NEUCR
AccessionPrimary (citable) accession number: P38667
Secondary accession number(s): Q7RVG7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: September 27, 2004
Last modified: February 19, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families