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Protein

Phosphoglycerate kinase

Gene

pgk-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40SubstrateBy similarity1
Binding sitei123SubstrateBy similarity1
Binding sitei171SubstrateBy similarity1
Binding sitei220ATPBy similarity1
Binding sitei313ATP; via carbonyl oxygenBy similarity1
Binding sitei344ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi373 – 376ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk-1
Synonyms:pgk, pgka
ORF Names:NCU07914
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 4, Linkage Group IV

Organism-specific databases

EuPathDBiFungiDB:NCU07914.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458831 – 418Phosphoglycerate kinaseAdd BLAST418

Proteomic databases

PRIDEiP38667.

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP38667.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingBy similarity3
Regioni64 – 67Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

HOGENOMiHOG000227107.
InParanoidiP38667.
KOiK00927.
OMAiKKVEMAP.
OrthoDBiEOG092C2GKC.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSNKLSIE DVDLKGKRVL IRVDFNVPLD AEKKVTNPQR IAGAIPTIKY
60 70 80 90 100
ALDHGAKAVV LMSHLGRPDG KPNPKYSLKP VVPELEKLLG KKVTFAPDCV
110 120 130 140 150
GPEVEEIVNK ADNGEVILLE NLRFHIEEEG KGTDAEGNKV KADKAKVEEF
160 170 180 190 200
RKNLTKLGDV YINDAFGTAH RAHSSMVGID LPVKAAGFLM KKELQYFAKV
210 220 230 240 250
LESPQRPFLS ILGGAKVSDK IQLIDNLLDK VNTLIVCGGM AFTFKKTLQN
260 270 280 290 300
MPIGNSLFDE AGAKIVPDLV KKAEKNNVKL VLPVDFTIAD KFDKDANTGY
310 320 330 340 350
ATDKDGIPDG WMGLDCGEES VKLFTQAINE SQTILWNGPA GVFEFDKFAK
360 370 380 390 400
GTKATLDACV KAAEEGRTVI IGGGDTATVA AKYGVEDKLS HVSTGGGASL
410
ELLEGKALPG VVALSERQ
Length:418
Mass (Da):45,057
Last modified:September 27, 2004 - v2
Checksum:i3BDD4B14655D90F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70G → R in CAA39865 (PubMed:1385737).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56512 mRNA. Translation: CAA39865.1.
CM002239 Genomic DNA. Translation: EAA33194.1.
PIRiA56616.
T43864.
RefSeqiXP_962430.1. XM_957337.3.

Genome annotation databases

EnsemblFungiiEAA33194; EAA33194; NCU07914.
GeneIDi3878602.
KEGGincr:NCU07914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56512 mRNA. Translation: CAA39865.1.
CM002239 Genomic DNA. Translation: EAA33194.1.
PIRiA56616.
T43864.
RefSeqiXP_962430.1. XM_957337.3.

3D structure databases

ProteinModelPortaliP38667.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP38667.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA33194; EAA33194; NCU07914.
GeneIDi3878602.
KEGGincr:NCU07914.

Organism-specific databases

EuPathDBiFungiDB:NCU07914.

Phylogenomic databases

HOGENOMiHOG000227107.
InParanoidiP38667.
KOiK00927.
OMAiKKVEMAP.
OrthoDBiEOG092C2GKC.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGK_NEUCR
AccessioniPrimary (citable) accession number: P38667
Secondary accession number(s): Q7RVG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: September 27, 2004
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.