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P38667

- PGK_NEUCR

UniProt

P38667 - PGK_NEUCR

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Protein

Phosphoglycerate kinase

Gene

pgk-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401SubstrateBy similarity
Binding sitei123 – 1231SubstrateBy similarity
Binding sitei171 – 1711SubstrateBy similarity
Binding sitei220 – 2201ATPBy similarity
Binding sitei313 – 3131ATP; via carbonyl oxygenBy similarity
Binding sitei344 – 3441ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi373 – 3764ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk-1
Synonyms:pgk, pgka
ORF Names:NCU07914
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 4, Linkage Group IV

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Phosphoglycerate kinasePRO_0000145883Add
BLAST

Proteomic databases

PRIDEiP38667.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi5141.NCU07914.1.

Structurei

3D structure databases

ProteinModelPortaliP38667.
SMRiP38667. Positions 2-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate bindingBy similarity
Regioni64 – 674Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
InParanoidiP38667.
KOiK00927.
OMAiFNVPLRE.
OrthoDBiEOG71K6D7.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38667-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLSNKLSIE DVDLKGKRVL IRVDFNVPLD AEKKVTNPQR IAGAIPTIKY
60 70 80 90 100
ALDHGAKAVV LMSHLGRPDG KPNPKYSLKP VVPELEKLLG KKVTFAPDCV
110 120 130 140 150
GPEVEEIVNK ADNGEVILLE NLRFHIEEEG KGTDAEGNKV KADKAKVEEF
160 170 180 190 200
RKNLTKLGDV YINDAFGTAH RAHSSMVGID LPVKAAGFLM KKELQYFAKV
210 220 230 240 250
LESPQRPFLS ILGGAKVSDK IQLIDNLLDK VNTLIVCGGM AFTFKKTLQN
260 270 280 290 300
MPIGNSLFDE AGAKIVPDLV KKAEKNNVKL VLPVDFTIAD KFDKDANTGY
310 320 330 340 350
ATDKDGIPDG WMGLDCGEES VKLFTQAINE SQTILWNGPA GVFEFDKFAK
360 370 380 390 400
GTKATLDACV KAAEEGRTVI IGGGDTATVA AKYGVEDKLS HVSTGGGASL
410
ELLEGKALPG VVALSERQ
Length:418
Mass (Da):45,057
Last modified:September 27, 2004 - v2
Checksum:i3BDD4B14655D90F2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701G → R in CAA39865. (PubMed:1385737)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56512 mRNA. Translation: CAA39865.1.
CM002239 Genomic DNA. Translation: EAA33194.1.
PIRiA56616.
T43864.
RefSeqiXP_962430.1. XM_957337.2.

Genome annotation databases

EnsemblFungiiEFNCRT00000008212; EFNCRP00000008201; EFNCRG00000008198.
GeneIDi3878602.
KEGGincr:NCU07914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56512 mRNA. Translation: CAA39865.1 .
CM002239 Genomic DNA. Translation: EAA33194.1 .
PIRi A56616.
T43864.
RefSeqi XP_962430.1. XM_957337.2.

3D structure databases

ProteinModelPortali P38667.
SMRi P38667. Positions 2-415.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU07914.1.

Proteomic databases

PRIDEi P38667.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000008212 ; EFNCRP00000008201 ; EFNCRG00000008198 .
GeneIDi 3878602.
KEGGi ncr:NCU07914.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227107.
InParanoidi P38667.
KOi K00927.
OMAi FNVPLRE.
OrthoDBi EOG71K6D7.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and in vitro expression of the N. crassa phosphoglycerate kinase."
    Azevedo J.E., Tropschug M., Werner S.
    DNA Seq. 2:265-267(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 74A.
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiPGK_NEUCR
AccessioniPrimary (citable) accession number: P38667
Secondary accession number(s): Q7RVG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: September 27, 2004
Last modified: October 29, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3