SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P38656

- LA_RAT

UniProt

P38656 - LA_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Lupus La protein homolog
Gene
Ssb, Ss-b
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro

GO - Biological processi

  1. tRNA processing Source: RGD
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lupus La protein homolog
Alternative name(s):
La autoantigen homolog
La ribonucleoprotein
Gene namesi
Name:Ssb
Synonyms:Ss-b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620804. Ssb.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. ribonucleoprotein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Lupus La protein homolog
PRO_0000207602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei116 – 1161N6-acetyllysine By similarity
Modified residuei128 – 1281N6-acetyllysine By similarity
Modified residuei327 – 3271N6-acetyllysine By similarity
Modified residuei356 – 3561N6-acetyllysine By similarity

Post-translational modificationi

Phosphorylated By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP38656.
PRIDEiP38656.

PTM databases

PhosphoSiteiP38656.

Expressioni

Gene expression databases

GenevestigatoriP38656.

Interactioni

Subunit structurei

Interacts with DDX15. May interact with RUFY1 By similarity.

Protein-protein interaction databases

DIPiDIP-46500N.
MINTiMINT-4565707.

Structurei

3D structure databases

ProteinModelPortaliP38656.
SMRiP38656. Positions 5-192, 224-332.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 9993HTH La-type RNA-binding
Add
BLAST
Domaini111 – 18777RRM
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5193.
HOGENOMiHOG000006947.
HOVERGENiHBG001407.
InParanoidiP38656.
PhylomeDBiP38656.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR014886. RRM_3.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38656-1 [UniParc]FASTAAdd to Basket

« Hide

MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE    50
TMIKFNRLNR LTTDFNVIVQ ALSKSKANLM EVSADKTKIR RSPSRPLPEV 100
TDEYKNDVKN RSVYIKGFPT DATLDDIKEW LDDKGQILNI QMRRTLHKTF 150
KGSIFAVFDS IQSAKKFVDT PGQKYKDTNL LILFKEDYFA KKNEERKQSK 200
VEAKLKAKQE HEGRHKPGST ETRALEGKMG CLLKFSGDLD DQTCREDFHF 250
LFSNHGEIKW IDFVRGAKEG IILFKEKAKD ALEKARSANN GNLLLRNKKV 300
TWKVLEGHAE KDAMKKITDD QQESLNKWKS KGGHAARRFK GSHVFTAARR 350
FKGRGKGNRP AYAGAPKGRG QFQGRRTRFD DDDHRRGPVK RGIDGRDREE 400
PASKHKKREN GARDK 415
Length:415
Mass (Da):47,777
Last modified:February 1, 1995 - v1
Checksum:i033FD9CC1E475F98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67859 mRNA. Translation: CAA48043.1.
PIRiJC1494.
UniGeneiRn.24494.

Genome annotation databases

UCSCiRGD:620804. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67859 mRNA. Translation: CAA48043.1 .
PIRi JC1494.
UniGenei Rn.24494.

3D structure databases

ProteinModelPortali P38656.
SMRi P38656. Positions 5-192, 224-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-46500N.
MINTi MINT-4565707.

PTM databases

PhosphoSitei P38656.

Proteomic databases

PaxDbi P38656.
PRIDEi P38656.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:620804. rat.

Organism-specific databases

RGDi 620804. Ssb.

Phylogenomic databases

eggNOGi COG5193.
HOGENOMi HOG000006947.
HOVERGENi HBG001407.
InParanoidi P38656.
PhylomeDBi P38656.

Miscellaneous databases

PROi P38656.

Gene expression databases

Genevestigatori P38656.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProi IPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR014886. RRM_3.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view ]
PRINTSi PR00302. LUPUSLA.
SMARTi SM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of rat cDNA clones coding for the autoantigen SS-B/La: detection of species-specific variations."
    Semsei I., Troester H., Bartsch H., Schwemmle M., Igloi G.L., Bachmann M.
    Gene 126:265-268(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiLA_RAT
AccessioniPrimary (citable) accession number: P38656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi