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P38656

- LA_RAT

UniProt

P38656 - LA_RAT

Protein

Lupus La protein homolog

Gene

Ssb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. tRNA processing Source: RGD

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lupus La protein homolog
    Alternative name(s):
    La autoantigen homolog
    La ribonucleoprotein
    Gene namesi
    Name:Ssb
    Synonyms:Ss-b
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620804. Ssb.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. ribonucleoprotein complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415Lupus La protein homologPRO_0000207602Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei116 – 1161N6-acetyllysineBy similarity
    Modified residuei128 – 1281N6-acetyllysineBy similarity
    Modified residuei327 – 3271N6-acetyllysineBy similarity
    Modified residuei356 – 3561N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylated.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP38656.
    PRIDEiP38656.

    PTM databases

    PhosphoSiteiP38656.

    Expressioni

    Gene expression databases

    GenevestigatoriP38656.

    Interactioni

    Subunit structurei

    Interacts with DDX15. May interact with RUFY1 By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-46500N.
    MINTiMINT-4565707.

    Structurei

    3D structure databases

    ProteinModelPortaliP38656.
    SMRiP38656. Positions 5-192, 224-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 9993HTH La-type RNA-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini111 – 18777RRMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5193.
    HOGENOMiHOG000006947.
    HOVERGENiHBG001407.
    InParanoidiP38656.
    PhylomeDBiP38656.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.30.70.330. 2 hits.
    InterProiIPR002344. Lupus_La.
    IPR006630. Lupus_La_RNA-bd.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR014886. RRM_3.
    IPR000504. RRM_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF05383. La. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF08777. RRM_3. 1 hit.
    [Graphical view]
    PRINTSiPR00302. LUPUSLA.
    SMARTiSM00715. LA. 1 hit.
    SM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50961. HTH_LA. 1 hit.
    PS50102. RRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38656-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE    50
    TMIKFNRLNR LTTDFNVIVQ ALSKSKANLM EVSADKTKIR RSPSRPLPEV 100
    TDEYKNDVKN RSVYIKGFPT DATLDDIKEW LDDKGQILNI QMRRTLHKTF 150
    KGSIFAVFDS IQSAKKFVDT PGQKYKDTNL LILFKEDYFA KKNEERKQSK 200
    VEAKLKAKQE HEGRHKPGST ETRALEGKMG CLLKFSGDLD DQTCREDFHF 250
    LFSNHGEIKW IDFVRGAKEG IILFKEKAKD ALEKARSANN GNLLLRNKKV 300
    TWKVLEGHAE KDAMKKITDD QQESLNKWKS KGGHAARRFK GSHVFTAARR 350
    FKGRGKGNRP AYAGAPKGRG QFQGRRTRFD DDDHRRGPVK RGIDGRDREE 400
    PASKHKKREN GARDK 415
    Length:415
    Mass (Da):47,777
    Last modified:February 1, 1995 - v1
    Checksum:i033FD9CC1E475F98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67859 mRNA. Translation: CAA48043.1.
    PIRiJC1494.
    UniGeneiRn.24494.

    Genome annotation databases

    UCSCiRGD:620804. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67859 mRNA. Translation: CAA48043.1 .
    PIRi JC1494.
    UniGenei Rn.24494.

    3D structure databases

    ProteinModelPortali P38656.
    SMRi P38656. Positions 5-192, 224-332.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-46500N.
    MINTi MINT-4565707.

    PTM databases

    PhosphoSitei P38656.

    Proteomic databases

    PaxDbi P38656.
    PRIDEi P38656.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:620804. rat.

    Organism-specific databases

    RGDi 620804. Ssb.

    Phylogenomic databases

    eggNOGi COG5193.
    HOGENOMi HOG000006947.
    HOVERGENi HBG001407.
    InParanoidi P38656.
    PhylomeDBi P38656.

    Miscellaneous databases

    PROi P38656.

    Gene expression databases

    Genevestigatori P38656.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.30.70.330. 2 hits.
    InterProi IPR002344. Lupus_La.
    IPR006630. Lupus_La_RNA-bd.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR014886. RRM_3.
    IPR000504. RRM_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF05383. La. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF08777. RRM_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00302. LUPUSLA.
    SMARTi SM00715. LA. 1 hit.
    SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50961. HTH_LA. 1 hit.
    PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of rat cDNA clones coding for the autoantigen SS-B/La: detection of species-specific variations."
      Semsei I., Troester H., Bartsch H., Schwemmle M., Igloi G.L., Bachmann M.
      Gene 126:265-268(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiLA_RAT
    AccessioniPrimary (citable) accession number: P38656
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3