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P38656 (LA_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lupus La protein homolog
Alternative name(s):
La autoantigen homolog
La ribonucleoprotein
Gene names
Name:Ssb
Synonyms:Ss-b
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.

Subunit structure

Interacts with DDX15. May interact with RUFY1 By similarity.

Subcellular location

Nucleus Probable.

Post-translational modification

Phosphorylated By similarity.

Sequence similarities

Contains 1 HTH La-type RNA-binding domain.

Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandRNA-binding
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtRNA processing

Inferred from mutant phenotype PubMed 12049746. Source: RGD

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

ribonucleoprotein complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Lupus La protein homolog
PRO_0000207602

Regions

Domain7 – 9993HTH La-type RNA-binding
Domain111 – 18777RRM

Amino acid modifications

Modified residue1161N6-acetyllysine By similarity
Modified residue1281N6-acetyllysine By similarity
Modified residue3271N6-acetyllysine By similarity
Modified residue3561N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P38656 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 033FD9CC1E475F98

FASTA41547,777
        10         20         30         40         50         60 
MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE TMIKFNRLNR 

        70         80         90        100        110        120 
LTTDFNVIVQ ALSKSKANLM EVSADKTKIR RSPSRPLPEV TDEYKNDVKN RSVYIKGFPT 

       130        140        150        160        170        180 
DATLDDIKEW LDDKGQILNI QMRRTLHKTF KGSIFAVFDS IQSAKKFVDT PGQKYKDTNL 

       190        200        210        220        230        240 
LILFKEDYFA KKNEERKQSK VEAKLKAKQE HEGRHKPGST ETRALEGKMG CLLKFSGDLD 

       250        260        270        280        290        300 
DQTCREDFHF LFSNHGEIKW IDFVRGAKEG IILFKEKAKD ALEKARSANN GNLLLRNKKV 

       310        320        330        340        350        360 
TWKVLEGHAE KDAMKKITDD QQESLNKWKS KGGHAARRFK GSHVFTAARR FKGRGKGNRP 

       370        380        390        400        410 
AYAGAPKGRG QFQGRRTRFD DDDHRRGPVK RGIDGRDREE PASKHKKREN GARDK 

« Hide

References

[1]"Isolation of rat cDNA clones coding for the autoantigen SS-B/La: detection of species-specific variations."
Semsei I., Troester H., Bartsch H., Schwemmle M., Igloi G.L., Bachmann M.
Gene 126:265-268(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X67859 mRNA. Translation: CAA48043.1.
PIRJC1494.
UniGeneRn.24494.

3D structure databases

ProteinModelPortalP38656.
SMRP38656. Positions 5-192, 224-332.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-46500N.
MINTMINT-4565707.

PTM databases

PhosphoSiteP38656.

Proteomic databases

PaxDbP38656.
PRIDEP38656.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:620804. rat.

Organism-specific databases

RGD620804. Ssb.

Phylogenomic databases

eggNOGCOG5193.
HOGENOMHOG000006947.
HOVERGENHBG001407.
InParanoidP38656.
PhylomeDBP38656.

Gene expression databases

GenevestigatorP38656.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR014886. RRM_3.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSPR00302. LUPUSLA.
SMARTSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
PROSITEPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP38656.

Entry information

Entry nameLA_RAT
AccessionPrimary (citable) accession number: P38656
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families