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Protein

Lupus La protein homolog

Gene

Ssb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. RNA processing Source: InterPro
  2. tRNA processing Source: RGD
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lupus La protein homolog
Alternative name(s):
La autoantigen homolog
La ribonucleoprotein
Gene namesi
Name:Ssb
Synonyms:Ss-b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620804. Ssb.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. ribonucleoprotein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Lupus La protein homologPRO_0000207602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei116 – 1161N6-acetyllysineBy similarity
Modified residuei128 – 1281N6-acetyllysineBy similarity
Modified residuei327 – 3271N6-acetyllysineBy similarity
Modified residuei356 – 3561N6-acetyllysineBy similarity
Modified residuei377 – 3771PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP38656.
PRIDEiP38656.

PTM databases

PhosphoSiteiP38656.

Expressioni

Gene expression databases

GenevestigatoriP38656.

Interactioni

Subunit structurei

Interacts with DDX15. May interact with RUFY1 (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-46500N.
MINTiMINT-4565707.

Structurei

3D structure databases

ProteinModelPortaliP38656.
SMRiP38656. Positions 5-192, 224-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 9993HTH La-type RNA-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini111 – 18777RRMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5193.
HOGENOMiHOG000006947.
HOVERGENiHBG001407.
InParanoidiP38656.
PhylomeDBiP38656.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR014886. RRM_3.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE
60 70 80 90 100
TMIKFNRLNR LTTDFNVIVQ ALSKSKANLM EVSADKTKIR RSPSRPLPEV
110 120 130 140 150
TDEYKNDVKN RSVYIKGFPT DATLDDIKEW LDDKGQILNI QMRRTLHKTF
160 170 180 190 200
KGSIFAVFDS IQSAKKFVDT PGQKYKDTNL LILFKEDYFA KKNEERKQSK
210 220 230 240 250
VEAKLKAKQE HEGRHKPGST ETRALEGKMG CLLKFSGDLD DQTCREDFHF
260 270 280 290 300
LFSNHGEIKW IDFVRGAKEG IILFKEKAKD ALEKARSANN GNLLLRNKKV
310 320 330 340 350
TWKVLEGHAE KDAMKKITDD QQESLNKWKS KGGHAARRFK GSHVFTAARR
360 370 380 390 400
FKGRGKGNRP AYAGAPKGRG QFQGRRTRFD DDDHRRGPVK RGIDGRDREE
410
PASKHKKREN GARDK
Length:415
Mass (Da):47,777
Last modified:January 31, 1995 - v1
Checksum:i033FD9CC1E475F98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67859 mRNA. Translation: CAA48043.1.
PIRiJC1494.
UniGeneiRn.24494.

Genome annotation databases

UCSCiRGD:620804. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67859 mRNA. Translation: CAA48043.1.
PIRiJC1494.
UniGeneiRn.24494.

3D structure databases

ProteinModelPortaliP38656.
SMRiP38656. Positions 5-192, 224-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46500N.
MINTiMINT-4565707.

PTM databases

PhosphoSiteiP38656.

Proteomic databases

PaxDbiP38656.
PRIDEiP38656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620804. rat.

Organism-specific databases

RGDi620804. Ssb.

Phylogenomic databases

eggNOGiCOG5193.
HOGENOMiHOG000006947.
HOVERGENiHBG001407.
InParanoidiP38656.
PhylomeDBiP38656.

Miscellaneous databases

PROiP38656.

Gene expression databases

GenevestigatoriP38656.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR014886. RRM_3.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of rat cDNA clones coding for the autoantigen SS-B/La: detection of species-specific variations."
    Semsei I., Troester H., Bartsch H., Schwemmle M., Igloi G.L., Bachmann M.
    Gene 126:265-268(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiLA_RAT
AccessioniPrimary (citable) accession number: P38656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1995
Last sequence update: January 31, 1995
Last modified: March 31, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.