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Protein

Lupus La protein homolog

Gene

Ssb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.

GO - Molecular functioni

GO - Biological processi

  • tRNA processing Source: RGD

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lupus La protein homolog
Alternative name(s):
La autoantigen homolog
La ribonucleoprotein
Gene namesi
Name:Ssb
Synonyms:Ss-b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620804 Ssb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076021 – 415Lupus La protein homologAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92PhosphoserineCombined sources1
Modified residuei94PhosphoserineBy similarity1
Modified residuei116N6-acetyllysineBy similarity1
Modified residuei120PhosphothreonineBy similarity1
Modified residuei128N6-acetyllysineBy similarity1
Modified residuei327N6-acetyllysineBy similarity1
Modified residuei356N6-acetyllysineBy similarity1
Modified residuei377PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP38656
PRIDEiP38656

PTM databases

iPTMnetiP38656
PhosphoSitePlusiP38656

Interactioni

Subunit structurei

Interacts with DDX15. May interact with RUFY1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Sumo1Q5I0H33EBI-15649175,EBI-7253100

Protein-protein interaction databases

DIPiDIP-46500N
IntActiP38656, 4 interactors
STRINGi10116.ENSRNOP00000011175

Structurei

3D structure databases

ProteinModelPortaliP38656
SMRiP38656
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 99HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST93
Domaini111 – 187RRMPROSITE-ProRule annotationAdd BLAST77

Phylogenomic databases

eggNOGiENOG410IQXQ Eukaryota
COG5193 LUCA
HOGENOMiHOG000006947
HOVERGENiHBG001407
InParanoidiP38656
PhylomeDBiP38656

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR006630 La_HTH
IPR014886 La_RRM
IPR002344 Lupus_La
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383 La, 1 hit
PF00076 RRM_1, 1 hit
PF08777 RRM_3, 1 hit
PRINTSiPR00302 LUPUSLA
SMARTiView protein in SMART
SM00715 LA, 1 hit
SM00360 RRM, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

P38656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE
60 70 80 90 100
TMIKFNRLNR LTTDFNVIVQ ALSKSKANLM EVSADKTKIR RSPSRPLPEV
110 120 130 140 150
TDEYKNDVKN RSVYIKGFPT DATLDDIKEW LDDKGQILNI QMRRTLHKTF
160 170 180 190 200
KGSIFAVFDS IQSAKKFVDT PGQKYKDTNL LILFKEDYFA KKNEERKQSK
210 220 230 240 250
VEAKLKAKQE HEGRHKPGST ETRALEGKMG CLLKFSGDLD DQTCREDFHF
260 270 280 290 300
LFSNHGEIKW IDFVRGAKEG IILFKEKAKD ALEKARSANN GNLLLRNKKV
310 320 330 340 350
TWKVLEGHAE KDAMKKITDD QQESLNKWKS KGGHAARRFK GSHVFTAARR
360 370 380 390 400
FKGRGKGNRP AYAGAPKGRG QFQGRRTRFD DDDHRRGPVK RGIDGRDREE
410
PASKHKKREN GARDK
Length:415
Mass (Da):47,777
Last modified:February 1, 1995 - v1
Checksum:i033FD9CC1E475F98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67859 mRNA Translation: CAA48043.1
PIRiJC1494
UniGeneiRn.24494

Genome annotation databases

UCSCiRGD:620804 rat

Similar proteinsi

Entry informationi

Entry nameiLA_RAT
AccessioniPrimary (citable) accession number: P38656
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health