Reviewed, UniProtKB/Swiss-Prot P38652 (PGM1_RAT)

Names and origin

Protein names

Recommended name:
    Phosphoglucomutase-1
      Short name=PGM 1
    EC=5.4.2.2
Alternative name(s):
    Glucose phosphomutase 1

Gene names

Name:

Pgm1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	562 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This enzyme participates in both the breakdown and synthesis of glucose.
Catalytic activity	Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	cellular calcium ion homeostasis Traceable author statement. Source: RGD glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW response to radiation Inferred from expression pattern. Source: RGD
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglucomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 562	561	Phosphoglucomutase-1		PRO_0000147780
Sites
	Active site	117	1	Phosphoserine intermediate By similarity
	Metal binding	117	1	Magnesium; via phosphate group By similarity
	Metal binding	288	1	Magnesium By similarity
	Metal binding	290	1	Magnesium By similarity
	Metal binding	292	1	Magnesium By similarity
Amino acid modifications
	Modified residue	16	1	N6-acetyllysine By similarity
	Modified residue	115	1	Phosphothreonine By similarity
	Modified residue	117	1	Phosphoserine By similarity
	Modified residue	353	1	Phosphotyrosine By similarity
	Modified residue	419	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P38652-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 584FAC13B7C3B256	FASTA	562	61,403
	10 20 30 40 50 60 MVKIVTVKTQ AYPDQKPGTS GLRKRVKVFQ GNANYAENFI QSIVSTVEPA LRQEATLVVG 70 80 90 100 110 120 GDGRFYMTEA IQLIVRIAAA NGIGRLVIGQ NGILSTPAVS CIIRKIKAIG GIILTASHNP 130 140 150 160 170 180 GGPNGDFGIK FNISNGGPAP EAITDKIFQI SKTIEEYAIC PDLKVDLGVL GKQQFDLENK 190 200 210 220 230 240 FKPFTVEIVD SVEAYATMLR NIFDFNALKE LLSGPNRLKI RIDAMHGVVG PYVKKILCEE 250 260 270 280 290 300 LGAPANSAVN CVPLEDFGGH HPDPNLTYAA DLVETMKSGE HDFGAAFDGD GDRNMILGKH 310 320 330 340 350 360 GFFVNPSDSV AVIAANIFSI PYFQQTGVRG FARSMPTSGA LDRVANATKI ASYETPTGWK 370 380 390 400 410 420 FFGNLMDASK LSLCGEESFG TGSDHIREKD GLWAVLAWLS ILATRKQRVE DILKDHWQKF 430 440 450 460 470 480 GRNFFTRYDY EEVEAEGANK MMKDLEALML DRSFVGKQFS ANDKVYTVEK ADNFEYSDPV 490 500 510 520 530 540 DGSISKNQGL RLIFADGSRI IFRLSGTGSA GATIRLYIDS YEKDAAKINQ DPQVMLAPLI 550 560 SIALKVSQLQ ERTGRTAPTV IT

References

[1]	"Isolation and expression of a rat liver cDNA encoding phosphoglucomutase." Rivera A.A., Elton T.S., Dey N.B., Bounelis P., Marchase R.B. Gene 133:261-266(1993) [PubMed: 8224913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L11694 mRNA. Translation: AAA16862.1.
IPI	IPI00231641.
PIR	PMRT. JC2011.
UniGene	Rn.9970
3D structure databases
HSSP	HSSP built from PDB template 3PMG based on UniProtKB P00949.
SMR	P38652. Positions 2-562.
ModBase	Search...
Protein-protein interaction databases
STRING	P38652.
Proteomic databases
PRIDE	P38652.
Genome annotation databases
Ensembl	ENSRNOT00000013785; ENSRNOP00000013785; ENSRNOG00000009889; Rattus norvegicus. [Genome view]
UCSC	NM_017033. rat.
Organism-specific databases
RGD	3316. Pgm1.
Phylogenomic databases
HOVERGEN	P38652.
Enzyme and pathway databases
BRENDA	5.4.2.2. 248.
Gene expression databases
ArrayExpress	P38652.
Genevestigator	P38652.
GermOnline	ENSRNOG00000009889. Rattus norvegicus.
Family and domain databases
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. A-D-PHexomutase_N. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 2 hits.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGM1_RAT

Accession

Primary (citable) accession number: P38652

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	January 23, 2007
Last modified:	October 13, 2009
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)