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Protein

Histo-blood group ABO system transferase

Gene

Abo

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-N-acetyl-alpha-beta-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-(alpha-L-fucosyl-(1->2))-beta-D-galactose.By similarity
UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->2))-D-galactosyl-R.By similarity

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105UDP-N-acetyl-galactosamineBy similarity1
Metal bindingi190ManganeseBy similarity1
Metal bindingi192ManganeseBy similarity1
Binding sitei212Glycoprotein fucosyl-galactosyl groupBy similarity1
Binding sitei224Glycoprotein fucosyl-galactosyl groupBy similarity1
Active sitei282NucleophileBy similarity1
Binding sitei282Glycoprotein fucosyl-galactosyl groupBy similarity1
Binding sitei305Glycoprotein fucosyl-galactosyl groupBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BRENDAi2.4.1.37. 3477.
2.4.1.40. 3477.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT6. Glycosyltransferase Family 6.

Names & Taxonomyi

Protein namesi
Recommended name:
Histo-blood group ABO system transferase
Alternative name(s):
Cis-AB transferase
Fucosylglycoprotein 3-alpha-galactosyltransferase
Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase
Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase (EC:2.4.1.40By similarity)
Glycoprotein-fucosylgalactoside alpha-galactosyltransferase (EC:2.4.1.37By similarity)
Histo-blood group A transferase
Short name:
A transferase
Histo-blood group B transferase
Short name:
B transferase
NAGAT
Gene namesi
Name:Abo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2135738. Abo.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini35 – 332LumenalSequence analysisAdd BLAST298

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001572931 – 332Histo-blood group ABO system transferaseAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP38649.
PRIDEiP38649.

PTM databases

iPTMnetiP38649.
PhosphoSitePlusiP38649.

Expressioni

Tissue specificityi

Submaxillary glands (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000015787.
ExpressionAtlasiP38649. baseline and differential.
GenevisibleiP38649. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099964.

Structurei

3D structure databases

ProteinModelPortaliP38649.
SMRiP38649.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni100 – 102UDP-N-acetyl-galactosamine bindingBy similarity3
Regioni190 – 192UDP-N-acetyl-galactosamine bindingBy similarity3

Domaini

The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.

Sequence similaritiesi

Belongs to the glycosyltransferase 6 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFQJ. Eukaryota.
ENOG4111IPQ. LUCA.
GeneTreeiENSGT00400000022032.
HOGENOMiHOG000234339.
HOVERGENiHBG003563.
InParanoidiP38649.
KOiK00709.
PhylomeDBiP38649.
TreeFamiTF330991.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005076. Glyco_trans_6.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR10462. PTHR10462. 1 hit.
PfamiPF03414. Glyco_transf_6. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

P38649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLRGRPKCN FLHLGILPFA VFVLVFFGYL FLSFRSQNLG HPGAVTRNAY
60 70 80 90 100
LQPRVLKPTR KDVLVLTPWL APIIWEGTFN IDILNEQFRI RNTTIGLTVF
110 120 130 140 150
AIKKYVVFLK LFLETAEQHF MVGHKVIYYV FTDRPADVPQ VILGAGRQLV
160 170 180 190 200
VLTVRNYTRW QDVSMHRMEM ISHFSERRFL REVDYLVCAD ADMKFSDHVG
210 220 230 240 250
VEILSTFFGT LHPGFYSSSR EAFTYERRPQ SQAYIPWDRG DFYYGGAFFG
260 270 280 290 300
GSVLEVYHLT KACHEAMMED KANGIEPVWH DESYLNKYLL YHKPTKVLSP
310 320 330
EYLWDQQLLG WPSIMKKLRY VAVPKDHQAI RN
Length:332
Mass (Da):38,777
Last modified:December 16, 2008 - v2
Checksum:iC48DB1090EA0D3E4
GO

Sequence cautioni

The sequence CAM23695 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77G → R in BAC29005 (PubMed:16141072).Curated1
Sequence conflicti109L → I in BAC29005 (PubMed:16141072).Curated1
Sequence conflicti160W → C in BAC28473 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041038 Genomic DNA. Translation: BAB20559.1.
AB041039 mRNA. Translation: BAB20560.1.
AK033786 mRNA. Translation: BAC28473.1.
AK035261 mRNA. Translation: BAC29005.1.
AL773563 Genomic DNA. Translation: CAM23695.1. Sequence problems.
AL773563 Genomic DNA. Translation: CAM23696.1.
CH466542 Genomic DNA. Translation: EDL08332.1.
BC116759 mRNA. Translation: AAI16760.1.
BC116761 mRNA. Translation: AAI16762.1.
CCDSiCCDS15811.1.
RefSeqiNP_001277373.1. NM_001290444.1.
NP_109643.3. NM_030718.5.
UniGeneiMm.160386.

Genome annotation databases

EnsembliENSMUST00000102900; ENSMUSP00000099964; ENSMUSG00000015787.
GeneIDi80908.
KEGGimmu:80908.
UCSCiuc008iwb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041038 Genomic DNA. Translation: BAB20559.1.
AB041039 mRNA. Translation: BAB20560.1.
AK033786 mRNA. Translation: BAC28473.1.
AK035261 mRNA. Translation: BAC29005.1.
AL773563 Genomic DNA. Translation: CAM23695.1. Sequence problems.
AL773563 Genomic DNA. Translation: CAM23696.1.
CH466542 Genomic DNA. Translation: EDL08332.1.
BC116759 mRNA. Translation: AAI16760.1.
BC116761 mRNA. Translation: AAI16762.1.
CCDSiCCDS15811.1.
RefSeqiNP_001277373.1. NM_001290444.1.
NP_109643.3. NM_030718.5.
UniGeneiMm.160386.

3D structure databases

ProteinModelPortaliP38649.
SMRiP38649.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099964.

Protein family/group databases

CAZyiGT6. Glycosyltransferase Family 6.

PTM databases

iPTMnetiP38649.
PhosphoSitePlusiP38649.

Proteomic databases

PaxDbiP38649.
PRIDEiP38649.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102900; ENSMUSP00000099964; ENSMUSG00000015787.
GeneIDi80908.
KEGGimmu:80908.
UCSCiuc008iwb.2. mouse.

Organism-specific databases

CTDi28.
MGIiMGI:2135738. Abo.

Phylogenomic databases

eggNOGiENOG410IFQJ. Eukaryota.
ENOG4111IPQ. LUCA.
GeneTreeiENSGT00400000022032.
HOGENOMiHOG000234339.
HOVERGENiHBG003563.
InParanoidiP38649.
KOiK00709.
PhylomeDBiP38649.
TreeFamiTF330991.

Enzyme and pathway databases

UniPathwayiUPA00378.
BRENDAi2.4.1.37. 3477.
2.4.1.40. 3477.

Miscellaneous databases

PROiP38649.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015787.
ExpressionAtlasiP38649. baseline and differential.
GenevisibleiP38649. MM.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005076. Glyco_trans_6.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR10462. PTHR10462. 1 hit.
PfamiPF03414. Glyco_transf_6. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBGAT_MOUSE
AccessioniPrimary (citable) accession number: P38649
Secondary accession number(s): A2AL98
, Q8BZH3, Q8BZQ6, Q9EQW2, Q9EQW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 16, 2008
Last modified: November 30, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.