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Protein

Metal homeostasis factor ATX1

Gene

ATX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Shuttles copper to the transport ATPase CCC2. Protects against oxygen toxicity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi15Copper1
Metal bindingi18Copper1

GO - Molecular functioni

  • copper chaperone activity Source: SGD

GO - Biological processi

  • cellular copper ion homeostasis Source: GO_Central
  • cellular iron ion homeostasis Source: SGD
  • cellular response to oxidative stress Source: SGD
  • copper ion transport Source: SGD
  • intracellular copper ion transport Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33255-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Metal homeostasis factor ATX1
Gene namesi
Name:ATX1
Ordered Locus Names:YNL259C
ORF Names:N0840
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL259C.
SGDiS000005203. ATX1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002125351 – 73Metal homeostasis factor ATX1Add BLAST73

Proteomic databases

MaxQBiP38636.
PRIDEiP38636.

Interactioni

Protein-protein interaction databases

BioGridi35580. 45 interactors.
DIPiDIP-813N.
IntActiP38636. 2 interactors.
MINTiMINT-367601.

Structurei

Secondary structure

173
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 11Combined sources7
Helixi16 – 27Combined sources12
Turni28 – 31Combined sources4
Beta strandi32 – 39Combined sources8
Turni40 – 43Combined sources4
Beta strandi44 – 51Combined sources8
Helixi53 – 61Combined sources9
Turni62 – 64Combined sources3
Beta strandi67 – 73Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CC7X-ray1.20A1-73[»]
1CC8X-ray1.02A1-73[»]
1FD8NMR-A1-73[»]
1FESNMR-A1-73[»]
1UV1model-A1-73[»]
1UV2model-A1-73[»]
2GGPNMR-A1-73[»]
3K7RX-ray2.28A/B/C/D/E/F/G/H/I/J/K/L1-73[»]
ProteinModelPortaliP38636.
SMRiP38636.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38636.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 69HMAPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Belongs to the ATX1 family.Curated
Contains 1 HMA domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00840000132170.
HOGENOMiHOG000038877.
InParanoidiP38636.
KOiK07213.
OMAiMADTHTY.
OrthoDBiEOG092C5MKI.

Family and domain databases

CDDicd00371. HMA. 1 hit.
InterProiIPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
[Graphical view]
PfamiPF00403. HMA. 1 hit.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 1 hit.
PROSITEiPS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEIKHYQFN VVMTCSGCSG AVNKVLTKLE PDVSKIDISL EKQLVDVYTT
60 70
LPYDFILEKI KKTGKEVRSG KQL
Length:73
Mass (Da):8,221
Last modified:October 1, 1994 - v1
Checksum:i9BDF0B542F80EA83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8Q → H in AAS56693 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35270 Genomic DNA. Translation: AAC37428.1.
X96722 Genomic DNA. Translation: CAA65485.1.
Z71535 Genomic DNA. Translation: CAA96166.1.
AY558367 Genomic DNA. Translation: AAS56693.1.
BK006947 Genomic DNA. Translation: DAA10300.1.
PIRiS47930.
RefSeqiNP_014140.1. NM_001183097.1.

Genome annotation databases

EnsemblFungiiYNL259C; YNL259C; YNL259C.
GeneIDi855462.
KEGGisce:YNL259C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35270 Genomic DNA. Translation: AAC37428.1.
X96722 Genomic DNA. Translation: CAA65485.1.
Z71535 Genomic DNA. Translation: CAA96166.1.
AY558367 Genomic DNA. Translation: AAS56693.1.
BK006947 Genomic DNA. Translation: DAA10300.1.
PIRiS47930.
RefSeqiNP_014140.1. NM_001183097.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CC7X-ray1.20A1-73[»]
1CC8X-ray1.02A1-73[»]
1FD8NMR-A1-73[»]
1FESNMR-A1-73[»]
1UV1model-A1-73[»]
1UV2model-A1-73[»]
2GGPNMR-A1-73[»]
3K7RX-ray2.28A/B/C/D/E/F/G/H/I/J/K/L1-73[»]
ProteinModelPortaliP38636.
SMRiP38636.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35580. 45 interactors.
DIPiDIP-813N.
IntActiP38636. 2 interactors.
MINTiMINT-367601.

Proteomic databases

MaxQBiP38636.
PRIDEiP38636.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL259C; YNL259C; YNL259C.
GeneIDi855462.
KEGGisce:YNL259C.

Organism-specific databases

EuPathDBiFungiDB:YNL259C.
SGDiS000005203. ATX1.

Phylogenomic databases

GeneTreeiENSGT00840000132170.
HOGENOMiHOG000038877.
InParanoidiP38636.
KOiK07213.
OMAiMADTHTY.
OrthoDBiEOG092C5MKI.

Enzyme and pathway databases

BioCyciYEAST:G3O-33255-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP38636.
PROiP38636.

Family and domain databases

CDDicd00371. HMA. 1 hit.
InterProiIPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
[Graphical view]
PfamiPF00403. HMA. 1 hit.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 1 hit.
PROSITEiPS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATX1_YEAST
AccessioniPrimary (citable) accession number: P38636
Secondary accession number(s): D6W0T4, E9P8W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.