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Protein

Metal homeostasis factor ATX1

Gene

ATX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Shuttles copper to the transport ATPase CCC2. Protects against oxygen toxicity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi15Copper1
Metal bindingi18Copper1

GO - Molecular functioni

  • copper chaperone activity Source: SGD

GO - Biological processi

  • cellular copper ion homeostasis Source: GO_Central
  • cellular iron ion homeostasis Source: SGD
  • cellular response to oxidative stress Source: SGD
  • copper ion transport Source: SGD
  • intracellular copper ion transport Source: GO_Central

Keywordsi

Molecular functionChaperone
Biological processCopper transport, Ion transport, Transport
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33255-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Metal homeostasis factor ATX1
Gene namesi
Name:ATX1
Ordered Locus Names:YNL259C
ORF Names:N0840
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL259C
SGDiS000005203 ATX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002125351 – 73Metal homeostasis factor ATX1Add BLAST73

Proteomic databases

MaxQBiP38636
PaxDbiP38636
PRIDEiP38636

Interactioni

Protein-protein interaction databases

BioGridi35580, 77 interactors
DIPiDIP-813N
IntActiP38636, 3 interactors
MINTiP38636
STRINGi4932.YNL259C

Structurei

Secondary structure

173
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 11Combined sources7
Helixi16 – 27Combined sources12
Turni28 – 31Combined sources4
Beta strandi32 – 39Combined sources8
Turni40 – 43Combined sources4
Beta strandi44 – 51Combined sources8
Helixi53 – 61Combined sources9
Turni62 – 64Combined sources3
Beta strandi67 – 73Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CC7X-ray1.20A1-73[»]
1CC8X-ray1.02A1-73[»]
1FD8NMR-A1-73[»]
1FESNMR-A1-73[»]
1UV1model-A1-73[»]
1UV2model-A1-73[»]
2GGPNMR-A1-73[»]
3K7RX-ray2.28A/B/C/D/E/F/G/H/I/J/K/L1-73[»]
5VDEX-ray1.65A/B/C/D1-73[»]
5VDFX-ray1.93A/B/C/D/E/F/G/H1-73[»]
ProteinModelPortaliP38636
SMRiP38636
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38636

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 69HMAPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Belongs to the ATX1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00840000132170
HOGENOMiHOG000038877
InParanoidiP38636
KOiK07213
OMAiHEFFVDM
OrthoDBiEOG092C5MKI

Family and domain databases

CDDicd00371 HMA, 1 hit
InterProiView protein in InterPro
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
PfamiView protein in Pfam
PF00403 HMA, 1 hit
SUPFAMiSSF55008 SSF55008, 1 hit
PROSITEiView protein in PROSITE
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P38636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEIKHYQFN VVMTCSGCSG AVNKVLTKLE PDVSKIDISL EKQLVDVYTT
60 70
LPYDFILEKI KKTGKEVRSG KQL
Length:73
Mass (Da):8,221
Last modified:October 1, 1994 - v1
Checksum:i9BDF0B542F80EA83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8Q → H in AAS56693 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35270 Genomic DNA Translation: AAC37428.1
X96722 Genomic DNA Translation: CAA65485.1
Z71535 Genomic DNA Translation: CAA96166.1
AY558367 Genomic DNA Translation: AAS56693.1
BK006947 Genomic DNA Translation: DAA10300.1
PIRiS47930
RefSeqiNP_014140.1, NM_001183097.1

Genome annotation databases

EnsemblFungiiYNL259C; YNL259C; YNL259C
GeneIDi855462
KEGGisce:YNL259C

Similar proteinsi

Entry informationi

Entry nameiATX1_YEAST
AccessioniPrimary (citable) accession number: P38636
Secondary accession number(s): D6W0T4, E9P8W0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 25, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health