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P38636

- ATX1_YEAST

UniProt

P38636 - ATX1_YEAST

Protein

Metal homeostasis factor ATX1

Gene

ATX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Shuttles copper to the transport ATPase CCC2. Protects against oxygen toxicity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi15 – 151Copper
    Metal bindingi18 – 181Copper

    GO - Molecular functioni

    1. copper chaperone activity Source: SGD

    GO - Biological processi

    1. cellular iron ion homeostasis Source: SGD
    2. cellular response to oxidative stress Source: SGD
    3. copper ion transport Source: SGD

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Copper transport, Ion transport, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33255-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metal homeostasis factor ATX1
    Gene namesi
    Name:ATX1
    Ordered Locus Names:YNL259C
    ORF Names:N0840
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL259c.
    SGDiS000005203. ATX1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7373Metal homeostasis factor ATX1PRO_0000212535Add
    BLAST

    Proteomic databases

    MaxQBiP38636.
    PaxDbiP38636.

    Expressioni

    Gene expression databases

    GenevestigatoriP38636.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PRO3P322631EBI-2046026,EBI-13885
    PSA1P419401EBI-2046026,EBI-11191
    RNR2P099381EBI-2046026,EBI-15240

    Protein-protein interaction databases

    BioGridi35580. 45 interactions.
    DIPiDIP-813N.
    IntActiP38636. 2 interactions.
    MINTiMINT-367601.
    STRINGi4932.YNL259C.

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 117
    Helixi16 – 2712
    Turni28 – 314
    Beta strandi32 – 398
    Turni40 – 434
    Beta strandi44 – 518
    Helixi53 – 619
    Turni62 – 643
    Beta strandi67 – 737

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1CC7X-ray1.20A1-73[»]
    1CC8X-ray1.02A1-73[»]
    1FD8NMR-A1-73[»]
    1FESNMR-A1-73[»]
    1UV1model-A1-73[»]
    1UV2model-A1-73[»]
    2GGPNMR-A1-73[»]
    3K7RX-ray2.28A/B/C/D/E/F/G/H/I/J/K/L1-73[»]
    ProteinModelPortaliP38636.
    SMRiP38636. Positions 2-73.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP38636.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 6965HMAPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ATX1 family.Curated
    Contains 1 HMA domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2608.
    HOGENOMiHOG000038877.
    KOiK07213.
    OMAiSEHQYKF.
    OrthoDBiEOG7G4QR6.

    Family and domain databases

    InterProiIPR017969. Heavy-metal-associated_CS.
    IPR006121. HeavyMe-assoc_HMA.
    [Graphical view]
    PfamiPF00403. HMA. 1 hit.
    [Graphical view]
    SUPFAMiSSF55008. SSF55008. 1 hit.
    PROSITEiPS01047. HMA_1. 1 hit.
    PS50846. HMA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38636-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEIKHYQFN VVMTCSGCSG AVNKVLTKLE PDVSKIDISL EKQLVDVYTT   50
    LPYDFILEKI KKTGKEVRSG KQL 73
    Length:73
    Mass (Da):8,221
    Last modified:October 1, 1994 - v1
    Checksum:i9BDF0B542F80EA83
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81Q → H in AAS56693. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35270 Genomic DNA. Translation: AAC37428.1.
    X96722 Genomic DNA. Translation: CAA65485.1.
    Z71535 Genomic DNA. Translation: CAA96166.1.
    AY558367 Genomic DNA. Translation: AAS56693.1.
    BK006947 Genomic DNA. Translation: DAA10300.1.
    PIRiS47930.
    RefSeqiNP_014140.1. NM_001183097.1.

    Genome annotation databases

    EnsemblFungiiYNL259C; YNL259C; YNL259C.
    GeneIDi855462.
    KEGGisce:YNL259C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35270 Genomic DNA. Translation: AAC37428.1 .
    X96722 Genomic DNA. Translation: CAA65485.1 .
    Z71535 Genomic DNA. Translation: CAA96166.1 .
    AY558367 Genomic DNA. Translation: AAS56693.1 .
    BK006947 Genomic DNA. Translation: DAA10300.1 .
    PIRi S47930.
    RefSeqi NP_014140.1. NM_001183097.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1CC7 X-ray 1.20 A 1-73 [» ]
    1CC8 X-ray 1.02 A 1-73 [» ]
    1FD8 NMR - A 1-73 [» ]
    1FES NMR - A 1-73 [» ]
    1UV1 model - A 1-73 [» ]
    1UV2 model - A 1-73 [» ]
    2GGP NMR - A 1-73 [» ]
    3K7R X-ray 2.28 A/B/C/D/E/F/G/H/I/J/K/L 1-73 [» ]
    ProteinModelPortali P38636.
    SMRi P38636. Positions 2-73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35580. 45 interactions.
    DIPi DIP-813N.
    IntActi P38636. 2 interactions.
    MINTi MINT-367601.
    STRINGi 4932.YNL259C.

    Proteomic databases

    MaxQBi P38636.
    PaxDbi P38636.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL259C ; YNL259C ; YNL259C .
    GeneIDi 855462.
    KEGGi sce:YNL259C.

    Organism-specific databases

    CYGDi YNL259c.
    SGDi S000005203. ATX1.

    Phylogenomic databases

    eggNOGi COG2608.
    HOGENOMi HOG000038877.
    KOi K07213.
    OMAi SEHQYKF.
    OrthoDBi EOG7G4QR6.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33255-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P38636.
    NextBioi 979391.

    Gene expression databases

    Genevestigatori P38636.

    Family and domain databases

    InterProi IPR017969. Heavy-metal-associated_CS.
    IPR006121. HeavyMe-assoc_HMA.
    [Graphical view ]
    Pfami PF00403. HMA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55008. SSF55008. 1 hit.
    PROSITEi PS01047. HMA_1. 1 hit.
    PS50846. HMA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The ATX1 gene of Saccharomyces cerevisiae encodes a small metal homeostasis factor that protects cells against reactive oxygen toxicity."
      Lin S.-J., Culotta V.L.
      Proc. Natl. Acad. Sci. U.S.A. 92:3784-3788(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence analysis of the 33 kb long region between ORC5 and SUI1 from the left arm of chromosome XIV from Saccharomyces cerevisiae."
      Sen-Gupta M., Gueldener U., Beinhauer J.D., Fiedler T.A., Hegemann J.H.
      Yeast 13:849-860(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. "Crystal structure of the Atx1 metallochaperone protein at 1.02 A resolution."
      Rosenzweig A.C., Huffman D.L., Hou M.Y., Wernimont A.K., Pufahl R.A., O'Halloran T.V.
      Structure 7:605-617(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.02 ANGSTROMS).

    Entry informationi

    Entry nameiATX1_YEAST
    AccessioniPrimary (citable) accession number: P38636
    Secondary accession number(s): D6W0T4, E9P8W0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3