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P38636 (ATX1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metal homeostasis factor ATX1
Gene names
Name:ATX1
Ordered Locus Names:YNL259C
ORF Names:N0840
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length73 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Shuttles copper to the transport ATPase CCC2. Protects against oxygen toxicity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the ATX1 family.

Contains 1 HMA domain.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7373Metal homeostasis factor ATX1
PRO_0000212535

Regions

Domain5 – 6965HMA

Sites

Metal binding151Copper
Metal binding181Copper

Experimental info

Sequence conflict81Q → H in AAS56693. Ref.5

Secondary structure

............. 73
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P38636 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 9BDF0B542F80EA83

FASTA738,221
        10         20         30         40         50         60 
MAEIKHYQFN VVMTCSGCSG AVNKVLTKLE PDVSKIDISL EKQLVDVYTT LPYDFILEKI 

        70 
KKTGKEVRSG KQL 

« Hide

References

« Hide 'large scale' references
[1]"The ATX1 gene of Saccharomyces cerevisiae encodes a small metal homeostasis factor that protects cells against reactive oxygen toxicity."
Lin S.-J., Culotta V.L.
Proc. Natl. Acad. Sci. U.S.A. 92:3784-3788(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of the 33 kb long region between ORC5 and SUI1 from the left arm of chromosome XIV from Saccharomyces cerevisiae."
Sen-Gupta M., Gueldener U., Beinhauer J.D., Fiedler T.A., Hegemann J.H.
Yeast 13:849-860(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"Crystal structure of the Atx1 metallochaperone protein at 1.02 A resolution."
Rosenzweig A.C., Huffman D.L., Hou M.Y., Wernimont A.K., Pufahl R.A., O'Halloran T.V.
Structure 7:605-617(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.02 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L35270 Genomic DNA. Translation: AAC37428.1.
X96722 Genomic DNA. Translation: CAA65485.1.
Z71535 Genomic DNA. Translation: CAA96166.1.
AY558367 Genomic DNA. Translation: AAS56693.1.
BK006947 Genomic DNA. Translation: DAA10300.1.
PIRS47930.
RefSeqNP_014140.1. NM_001183097.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1CC7X-ray1.20A1-73[»]
1CC8X-ray1.02A1-73[»]
1FD8NMR-A1-73[»]
1FESNMR-A1-73[»]
1UV1model-A1-73[»]
1UV2model-A1-73[»]
2GGPNMR-A1-73[»]
3K7RX-ray2.28A/B/C/D/E/F/G/H/I/J/K/L1-73[»]
ProteinModelPortalP38636.
SMRP38636. Positions 2-73.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35580. 45 interactions.
DIPDIP-813N.
IntActP38636. 2 interactions.
MINTMINT-367601.
STRING4932.YNL259C.

Proteomic databases

PaxDbP38636.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL259C; YNL259C; YNL259C.
GeneID855462.
KEGGsce:YNL259C.

Organism-specific databases

CYGDYNL259c.
SGDS000005203. ATX1.

Phylogenomic databases

eggNOGCOG2608.
HOGENOMHOG000038877.
KOK07213.
OMASEHQYKF.
OrthoDBEOG7G4QR6.

Enzyme and pathway databases

BioCycYEAST:G3O-33255-MONOMER.

Gene expression databases

GenevestigatorP38636.

Family and domain databases

InterProIPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
[Graphical view]
PfamPF00403. HMA. 1 hit.
[Graphical view]
SUPFAMSSF55008. SSF55008. 1 hit.
PROSITEPS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP38636.
NextBio979391.

Entry information

Entry nameATX1_YEAST
AccessionPrimary (citable) accession number: P38636
Secondary accession number(s): D6W0T4, E9P8W0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: February 19, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references