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Protein

Serine/threonine-protein kinase RIM11/MSD1

Gene

RIM11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase that is thought to function in regulating kinetochore activity and entry into meiosis. Could phosphorylates IME1.

Miscellaneous

Present with 6990 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68ATPPROSITE-ProRule annotation1
Active sitei164Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 53ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • ascospore formation Source: SGD
  • cellular response to heat Source: SGD
  • cellular response to salt stress Source: SGD
  • protein phosphorylation Source: SGD
  • proteolysis Source: SGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32832-MONOMER.
BRENDAi2.7.11.26. 984.
ReactomeiR-SCE-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase RIM11/MSD1 (EC:2.7.11.1)
Alternative name(s):
Regulator of IME2 protein 11
Gene namesi
Name:RIM11
Synonyms:GSK3, MDS1
Ordered Locus Names:YMR139W
ORF Names:YM9375.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR139W.
SGDiS000004747. RIM11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863191 – 370Serine/threonine-protein kinase RIM11/MSD1Add BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei199PhosphotyrosineCombined sources1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38615.
PRIDEiP38615.

PTM databases

iPTMnetiP38615.

Interactioni

Subunit structurei

Interacts with TDA1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35316. 173 interactors.
DIPiDIP-1566N.
IntActiP38615. 41 interactors.
MINTiMINT-397554.
STRINGi4932.YMR139W.

Structurei

3D structure databases

ProteinModelPortaliP38615.
SMRiP38615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 322Protein kinasePROSITE-ProRule annotationAdd BLAST284

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00520000055635.
InParanoidiP38615.
KOiK12766.
OMAiYSNGDKK.
OrthoDBiEOG092C1O26.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

P38615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIQSNNSPN LSNNIVSKQV YYAHPPPTID PNDPVQISFP TTEVVGHGSF
60 70 80 90 100
GVVFATVIQE TNEKVAIKKV LQDKRFKNRE LEIMKMLSHI NIIDLKYFFY
110 120 130 140 150
ERDSQDEIYL NLILEYMPQS LYQRLRHFVH QRTPMSRLEI KYYMFQLFKS
160 170 180 190 200
LNYLHHFANV CHRDIKPQNL LVDPETWSLK LCDFGSAKQL KPTEPNVSYI
210 220 230 240 250
CSRYYRAPEL IFGATNYTNQ IDIWSSGCVM AELLLGQPMF PGESGIDQLV
260 270 280 290 300
EIIKILGTPS KQEICSMNPN YMEHKFPQIK PIPLSRVFKK EDDQTVEFLA
310 320 330 340 350
DVLKYDPLER FNALQCLCSP YFDELKLDDG KINQITTDLK LLEFDENVEL
360 370
GHLSPDELSS VKKKLYPKSK
Length:370
Mass (Da):43,005
Last modified:October 1, 1994 - v1
Checksum:i59D92C9D42408E97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57V → I in AAA16206 (PubMed:8244030).Curated1
Sequence conflicti331K → R in AAS56320 (PubMed:17322287).Curated1
Sequence conflicti343E → G in AAA16206 (PubMed:8244030).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03280 Unassigned DNA. Translation: AAC48917.1.
L29284 Genomic DNA. Translation: AAB04166.1.
L12761 Unassigned DNA. Translation: AAA16206.1.
Z47071 Genomic DNA. Translation: CAA87353.1.
AY557994 Genomic DNA. Translation: AAS56320.1.
BK006946 Genomic DNA. Translation: DAA10036.1.
PIRiA56347.
RefSeqiNP_013859.1. NM_001182641.1.

Genome annotation databases

EnsemblFungiiYMR139W; YMR139W; YMR139W.
GeneIDi855170.
KEGGisce:YMR139W.

Similar proteinsi

Entry informationi

Entry nameiRIM11_YEAST
AccessioniPrimary (citable) accession number: P38615
Secondary accession number(s): D6VZW2, Q6Q5K4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 27, 2017
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names