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P38615 (RIM11_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase RIM11/MSD1

EC=2.7.11.1
Alternative name(s):
Regulator of IME2 protein 11
Gene names
Name:RIM11
Synonyms:GSK3, MDS1
Ordered Locus Names:YMR139W
ORF Names:YM9375.08
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serine/threonine protein kinase that is thought to function in regulating kinetochore activity and entry into meiosis. Could phosphorylates IME1.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with TDA1. Ref.13

Miscellaneous

Present with 6990 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

Contains 1 protein kinase domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NAP1P252938EBI-10642,EBI-11850

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370Serine/threonine-protein kinase RIM11/MSD1
PRO_0000086319

Regions

Domain39 – 322284Protein kinase
Nucleotide binding45 – 539ATP By similarity

Sites

Active site1641Proton acceptor By similarity
Binding site681ATP By similarity

Amino acid modifications

Modified residue1991Phosphotyrosine Ref.7 Ref.10 Ref.12

Experimental info

Sequence conflict571V → I in AAA16206. Ref.3
Sequence conflict3311K → R in AAS56320. Ref.6
Sequence conflict3431E → G in AAA16206. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P38615 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 59D92C9D42408E97

FASTA37043,005
        10         20         30         40         50         60 
MNIQSNNSPN LSNNIVSKQV YYAHPPPTID PNDPVQISFP TTEVVGHGSF GVVFATVIQE 

        70         80         90        100        110        120 
TNEKVAIKKV LQDKRFKNRE LEIMKMLSHI NIIDLKYFFY ERDSQDEIYL NLILEYMPQS 

       130        140        150        160        170        180 
LYQRLRHFVH QRTPMSRLEI KYYMFQLFKS LNYLHHFANV CHRDIKPQNL LVDPETWSLK 

       190        200        210        220        230        240 
LCDFGSAKQL KPTEPNVSYI CSRYYRAPEL IFGATNYTNQ IDIWSSGCVM AELLLGQPMF 

       250        260        270        280        290        300 
PGESGIDQLV EIIKILGTPS KQEICSMNPN YMEHKFPQIK PIPLSRVFKK EDDQTVEFLA 

       310        320        330        340        350        360 
DVLKYDPLER FNALQCLCSP YFDELKLDDG KINQITTDLK LLEFDENVEL GHLSPDELSS 

       370 
VKKKLYPKSK 

« Hide

References

« Hide 'large scale' references
[1]"MDS1, a dosage suppressor of an mck1 mutant, encodes a putative yeast homolog of glycogen synthase kinase 3."
Puziss J.W., Hardy T.A., Johnson R.B., Roach P.J., Hieter P.
Mol. Cell. Biol. 14:831-839(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ATCC 204508 / S288c.
[2]"Analysis of RIM11, a yeast protein kinase that phosphorylates the meiotic activator IME1."
Bowdish K.S., Yuan H.E., Mitchell A.P.
Mol. Cell. Biol. 14:7909-7919(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"A Saccharomyces cerevisiae protein-serine kinase related to mammalian glycogen synthase kinase-3 and the Drosophila melanogaster gene shaggy product."
Bianchi M.W., Plyte S.E., Kreis M., Woodgett J.R.
Gene 134:51-56(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[4]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[6]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[7]"Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosis and sporulation."
Zhan X.L., Hong Y., Zhu T., Mitchell A.P., Deschenes R.J., Guan K.L.
Mol. Biol. Cell 11:663-676(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT TYR-199.
[8]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[9]"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: YAL6B.
[10]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-199, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[11]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-199, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes."
Fasolo J., Sboner A., Sun M.G., Yu H., Chen R., Sharon D., Kim P.M., Gerstein M., Snyder M.
Genes Dev. 25:767-778(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TDA1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U03280 Unassigned DNA. Translation: AAC48917.1.
L29284 Genomic DNA. Translation: AAB04166.1.
L12761 Unassigned DNA. Translation: AAA16206.1.
Z47071 Genomic DNA. Translation: CAA87353.1.
AY557994 Genomic DNA. Translation: AAS56320.1.
BK006946 Genomic DNA. Translation: DAA10036.1.
PIRA56347.
RefSeqNP_013859.1. NM_001182641.1.

3D structure databases

ProteinModelPortalP38615.
SMRP38615. Positions 33-360.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35316. 104 interactions.
DIPDIP-1566N.
IntActP38615. 19 interactions.
MINTMINT-397554.
STRING4932.YMR139W.

Proteomic databases

PaxDbP38615.
PeptideAtlasP38615.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR139W; YMR139W; YMR139W.
GeneID855170.
KEGGsce:YMR139W.

Organism-specific databases

CYGDYMR139w.
SGDS000004747. RIM11.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00520000055635.
KOK12766.
OMAILEYMPQ.
OrthoDBEOG7CZKGN.

Enzyme and pathway databases

BioCycYEAST:G3O-32832-MONOMER.
BRENDA2.7.11.26. 984.

Gene expression databases

GenevestigatorP38615.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio978608.
PROP38615.

Entry information

Entry nameRIM11_YEAST
AccessionPrimary (citable) accession number: P38615
Secondary accession number(s): D6VZW2, Q6Q5K4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 19, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families