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Protein

Serine/threonine-protein kinase RIM11/MSD1

Gene

RIM11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase that is thought to function in regulating kinetochore activity and entry into meiosis. Could phosphorylates IME1.

Miscellaneous

Present with 6990 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68ATPPROSITE-ProRule annotation1
Active sitei164Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 53ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • ascospore formation Source: SGD
  • cellular response to heat Source: SGD
  • cellular response to salt stress Source: SGD
  • protein phosphorylation Source: SGD
  • proteolysis Source: SGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32832-MONOMER
BRENDAi2.7.11.26 984
ReactomeiR-SCE-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase RIM11/MSD1 (EC:2.7.11.1)
Alternative name(s):
Regulator of IME2 protein 11
Gene namesi
Name:RIM11
Synonyms:GSK3, MDS1
Ordered Locus Names:YMR139W
ORF Names:YM9375.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR139W
SGDiS000004747 RIM11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863191 – 370Serine/threonine-protein kinase RIM11/MSD1Add BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei199PhosphotyrosineCombined sources1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38615
PaxDbiP38615
PRIDEiP38615

PTM databases

iPTMnetiP38615

Interactioni

Subunit structurei

Interacts with TDA1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NAP1P252938EBI-10642,EBI-11850

Protein-protein interaction databases

BioGridi35316, 192 interactors
DIPiDIP-1566N
IntActiP38615, 41 interactors
MINTiP38615
STRINGi4932.YMR139W

Structurei

3D structure databases

ProteinModelPortaliP38615
SMRiP38615
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 322Protein kinasePROSITE-ProRule annotationAdd BLAST284

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00520000055635
InParanoidiP38615
KOiK12766
OMAiYSNGDKK
OrthoDBiEOG092C1O26

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P38615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIQSNNSPN LSNNIVSKQV YYAHPPPTID PNDPVQISFP TTEVVGHGSF
60 70 80 90 100
GVVFATVIQE TNEKVAIKKV LQDKRFKNRE LEIMKMLSHI NIIDLKYFFY
110 120 130 140 150
ERDSQDEIYL NLILEYMPQS LYQRLRHFVH QRTPMSRLEI KYYMFQLFKS
160 170 180 190 200
LNYLHHFANV CHRDIKPQNL LVDPETWSLK LCDFGSAKQL KPTEPNVSYI
210 220 230 240 250
CSRYYRAPEL IFGATNYTNQ IDIWSSGCVM AELLLGQPMF PGESGIDQLV
260 270 280 290 300
EIIKILGTPS KQEICSMNPN YMEHKFPQIK PIPLSRVFKK EDDQTVEFLA
310 320 330 340 350
DVLKYDPLER FNALQCLCSP YFDELKLDDG KINQITTDLK LLEFDENVEL
360 370
GHLSPDELSS VKKKLYPKSK
Length:370
Mass (Da):43,005
Last modified:October 1, 1994 - v1
Checksum:i59D92C9D42408E97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57V → I in AAA16206 (PubMed:8244030).Curated1
Sequence conflicti331K → R in AAS56320 (PubMed:17322287).Curated1
Sequence conflicti343E → G in AAA16206 (PubMed:8244030).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03280 Unassigned DNA Translation: AAC48917.1
L29284 Genomic DNA Translation: AAB04166.1
L12761 Unassigned DNA Translation: AAA16206.1
Z47071 Genomic DNA Translation: CAA87353.1
AY557994 Genomic DNA Translation: AAS56320.1
BK006946 Genomic DNA Translation: DAA10036.1
PIRiA56347
RefSeqiNP_013859.1, NM_001182641.1

Genome annotation databases

EnsemblFungiiYMR139W; YMR139W; YMR139W
GeneIDi855170
KEGGisce:YMR139W

Similar proteinsi

Entry informationi

Entry nameiRIM11_YEAST
AccessioniPrimary (citable) accession number: P38615
Secondary accession number(s): D6VZW2, Q6Q5K4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
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