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P38615

- RIM11_YEAST

UniProt

P38615 - RIM11_YEAST

Protein

Serine/threonine-protein kinase RIM11/MSD1

Gene

RIM11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Serine/threonine protein kinase that is thought to function in regulating kinetochore activity and entry into meiosis. Could phosphorylates IME1.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei68 – 681ATPPROSITE-ProRule annotation
    Active sitei164 – 1641Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi45 – 539ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein serine/threonine kinase activity Source: SGD

    GO - Biological processi

    1. ascospore formation Source: SGD
    2. cellular response to heat Source: SGD
    3. cellular response to salt stress Source: SGD
    4. protein phosphorylation Source: SGD
    5. proteolysis Source: SGD

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32832-MONOMER.
    BRENDAi2.7.11.26. 984.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase RIM11/MSD1 (EC:2.7.11.1)
    Alternative name(s):
    Regulator of IME2 protein 11
    Gene namesi
    Name:RIM11
    Synonyms:GSK3, MDS1
    Ordered Locus Names:YMR139W
    ORF Names:YM9375.08
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR139w.
    SGDiS000004747. RIM11.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Serine/threonine-protein kinase RIM11/MSD1PRO_0000086319Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei199 – 1991Phosphotyrosine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP38615.
    PaxDbiP38615.
    PeptideAtlasiP38615.

    Expressioni

    Gene expression databases

    GenevestigatoriP38615.

    Interactioni

    Subunit structurei

    Interacts with TDA1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NAP1P252938EBI-10642,EBI-11850

    Protein-protein interaction databases

    BioGridi35316. 104 interactions.
    DIPiDIP-1566N.
    IntActiP38615. 19 interactions.
    MINTiMINT-397554.
    STRINGi4932.YMR139W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38615.
    SMRiP38615. Positions 2-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 322284Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00520000055635.
    KOiK12766.
    OMAiTHEVKIC.
    OrthoDBiEOG7CZKGN.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38615-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIQSNNSPN LSNNIVSKQV YYAHPPPTID PNDPVQISFP TTEVVGHGSF    50
    GVVFATVIQE TNEKVAIKKV LQDKRFKNRE LEIMKMLSHI NIIDLKYFFY 100
    ERDSQDEIYL NLILEYMPQS LYQRLRHFVH QRTPMSRLEI KYYMFQLFKS 150
    LNYLHHFANV CHRDIKPQNL LVDPETWSLK LCDFGSAKQL KPTEPNVSYI 200
    CSRYYRAPEL IFGATNYTNQ IDIWSSGCVM AELLLGQPMF PGESGIDQLV 250
    EIIKILGTPS KQEICSMNPN YMEHKFPQIK PIPLSRVFKK EDDQTVEFLA 300
    DVLKYDPLER FNALQCLCSP YFDELKLDDG KINQITTDLK LLEFDENVEL 350
    GHLSPDELSS VKKKLYPKSK 370
    Length:370
    Mass (Da):43,005
    Last modified:October 1, 1994 - v1
    Checksum:i59D92C9D42408E97
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571V → I in AAA16206. (PubMed:8244030)Curated
    Sequence conflicti331 – 3311K → R in AAS56320. (PubMed:17322287)Curated
    Sequence conflicti343 – 3431E → G in AAA16206. (PubMed:8244030)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03280 Unassigned DNA. Translation: AAC48917.1.
    L29284 Genomic DNA. Translation: AAB04166.1.
    L12761 Unassigned DNA. Translation: AAA16206.1.
    Z47071 Genomic DNA. Translation: CAA87353.1.
    AY557994 Genomic DNA. Translation: AAS56320.1.
    BK006946 Genomic DNA. Translation: DAA10036.1.
    PIRiA56347.
    RefSeqiNP_013859.1. NM_001182641.1.

    Genome annotation databases

    EnsemblFungiiYMR139W; YMR139W; YMR139W.
    GeneIDi855170.
    KEGGisce:YMR139W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03280 Unassigned DNA. Translation: AAC48917.1 .
    L29284 Genomic DNA. Translation: AAB04166.1 .
    L12761 Unassigned DNA. Translation: AAA16206.1 .
    Z47071 Genomic DNA. Translation: CAA87353.1 .
    AY557994 Genomic DNA. Translation: AAS56320.1 .
    BK006946 Genomic DNA. Translation: DAA10036.1 .
    PIRi A56347.
    RefSeqi NP_013859.1. NM_001182641.1.

    3D structure databases

    ProteinModelPortali P38615.
    SMRi P38615. Positions 2-332.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35316. 104 interactions.
    DIPi DIP-1566N.
    IntActi P38615. 19 interactions.
    MINTi MINT-397554.
    STRINGi 4932.YMR139W.

    Proteomic databases

    MaxQBi P38615.
    PaxDbi P38615.
    PeptideAtlasi P38615.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR139W ; YMR139W ; YMR139W .
    GeneIDi 855170.
    KEGGi sce:YMR139W.

    Organism-specific databases

    CYGDi YMR139w.
    SGDi S000004747. RIM11.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00520000055635.
    KOi K12766.
    OMAi THEVKIC.
    OrthoDBi EOG7CZKGN.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32832-MONOMER.
    BRENDAi 2.7.11.26. 984.

    Miscellaneous databases

    NextBioi 978608.
    PROi P38615.

    Gene expression databases

    Genevestigatori P38615.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MDS1, a dosage suppressor of an mck1 mutant, encodes a putative yeast homolog of glycogen synthase kinase 3."
      Puziss J.W., Hardy T.A., Johnson R.B., Roach P.J., Hieter P.
      Mol. Cell. Biol. 14:831-839(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC 204508 / S288c.
    2. "Analysis of RIM11, a yeast protein kinase that phosphorylates the meiotic activator IME1."
      Bowdish K.S., Yuan H.E., Mitchell A.P.
      Mol. Cell. Biol. 14:7909-7919(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "A Saccharomyces cerevisiae protein-serine kinase related to mammalian glycogen synthase kinase-3 and the Drosophila melanogaster gene shaggy product."
      Bianchi M.W., Plyte S.E., Kreis M., Woodgett J.R.
      Gene 134:51-56(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    7. "Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosis and sporulation."
      Zhan X.L., Hong Y., Zhu T., Mitchell A.P., Deschenes R.J., Guan K.L.
      Mol. Biol. Cell 11:663-676(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-199.
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
      Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
      Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: YAL6B.
    10. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-199, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    11. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-199, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes."
      Fasolo J., Sboner A., Sun M.G., Yu H., Chen R., Sharon D., Kim P.M., Gerstein M., Snyder M.
      Genes Dev. 25:767-778(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TDA1.

    Entry informationi

    Entry nameiRIM11_YEAST
    AccessioniPrimary (citable) accession number: P38615
    Secondary accession number(s): D6VZW2, Q6Q5K4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 144 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 6990 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3