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P38606

- VATA_HUMAN

UniProt

P38606 - VATA_HUMAN

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Protein
V-type proton ATPase catalytic subunit A
Gene
ATP6V1A, ATP6A1, ATP6V1A1, VPP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi250 – 2578ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. proton-transporting ATPase activity, rotational mechanism Source: InterPro

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. cellular iron ion homeostasis Source: Reactome
  3. insulin receptor signaling pathway Source: Reactome
  4. interaction with host Source: Reactome
  5. phagosome maturation Source: Reactome
  6. transferrin transport Source: Reactome
  7. transmembrane transport Source: Reactome
  8. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS03781-MONOMER.
ReactomeiREACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Protein family/group databases

TCDBi3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase catalytic subunit A (EC:3.6.3.14)
Short name:
V-ATPase subunit A
Alternative name(s):
V-ATPase 69 kDa subunit
Vacuolar ATPase isoform VA68
Vacuolar proton pump subunit alpha
Gene namesi
Name:ATP6V1A
Synonyms:ATP6A1, ATP6V1A1, VPP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:851. ATP6V1A.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cytosol Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. integral component of plasma membrane Source: ProtInc
  5. lysosomal membrane Source: UniProtKB
  6. microvillus Source: Ensembl
  7. mitochondrion Source: Ensembl
  8. plasma membrane Source: UniProtKB
  9. proton-transporting V-type ATPase, V1 domain Source: InterPro
  10. proton-transporting two-sector ATPase complex Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25152.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617V-type proton ATPase catalytic subunit AUniRule annotation
PRO_0000144560Add
BLAST

Proteomic databases

MaxQBiP38606.
PaxDbiP38606.
PeptideAtlasiP38606.
PRIDEiP38606.

PTM databases

PhosphoSiteiP38606.

Expressioni

Tissue specificityi

Present in all tissues analyzed.

Gene expression databases

ArrayExpressiP38606.
BgeeiP38606.
CleanExiHS_ATP6V1A.
GenevestigatoriP38606.

Organism-specific databases

HPAiCAB006910.
HPA035083.
HPA035084.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein).

Protein-protein interaction databases

BioGridi107007. 47 interactions.
IntActiP38606. 63 interactions.
MINTiMINT-224589.
STRINGi9606.ENSP00000273398.

Structurei

3D structure databases

ProteinModelPortaliP38606.
SMRiP38606. Positions 40-587.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1155.
HOGENOMiHOG000161057.
HOVERGENiHBG053351.
InParanoidiP38606.
KOiK02145.
OMAiENKITWN.
OrthoDBiEOG7Q8CMM.
PhylomeDBiP38606.
TreeFamiTF300811.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00309. ATP_synth_A_arch.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR005725. ATPase_V1-cplx_asu.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01042. V-ATPase_V1_A. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38606-1 [UniParc]FASTAAdd to Basket

« Hide

MDFSKLPKIL DEDKESTFGY VHGVSGPVVT ACDMAGAAMY ELVRVGHSEL    50
VGEIIRLEGD MATIQVYEET SGVSVGDPVL RTGKPLSVEL GPGIMGAIFD 100
GIQRPLSDIS SQTQSIYIPR GVNVSALSRD IKWDFTPCKN LRVGSHITGG 150
DIYGIVSENS LIKHKIMLPP RNRGTVTYIA PPGNYDTSDV VLELEFEGVK 200
EKFTMVQVWP VRQVRPVTEK LPANHPLLTG QRVLDALFPC VQGGTTAIPG 250
AFGCGKTVIS QSLSKYSNSD VIIYVGCGER GNEMSEVLRD FPELTMEVDG 300
KVESIMKRTA LVANTSNMPV AAREASIYTG ITLSEYFRDM GYHVSMMADS 350
TSRWAEALRE ISGRLAEMPA DSGYPAYLGA RLASFYERAG RVKCLGNPER 400
EGSVSIVGAV SPPGGDFSDP VTSATLGIVQ VFWGLDKKLA QRKHFPSVNW 450
LISYSKYMRA LDEYYDKHFT EFVPLRTKAK EILQEEEDLA EIVQLVGKAS 500
LAETDKITLE VAKLIKDDFL QQNGYTPYDR FCPFYKTVGM LSNMIAFYDM 550
ARRAVETTAQ SDNKITWSII REHMGDILYK LSSMKFKDPL KDGEAKIKSD 600
YAQLLEDMQN AFRSLED 617
Length:617
Mass (Da):68,304
Last modified:August 2, 2002 - v2
Checksum:iDB409A8731D772CB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711S → C in AAA83249. 1 Publication
Sequence conflicti89 – 902EL → DV in AAA83249. 1 Publication
Sequence conflicti211 – 2111V → A in AAA83249. 1 Publication
Sequence conflicti211 – 2111V → A in AAF14870. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L09235 mRNA. Translation: AAA83249.1.
AF113129 mRNA. Translation: AAF14870.1.
BT006672 mRNA. Translation: AAP35318.1.
AK314779 mRNA. Translation: BAG37315.1.
CH471052 Genomic DNA. Translation: EAW79625.1.
CH471052 Genomic DNA. Translation: EAW79626.1.
BC013138 mRNA. Translation: AAH13138.1.
CCDSiCCDS2976.1.
PIRiB46091.
RefSeqiNP_001681.2. NM_001690.3.
UniGeneiHs.477155.

Genome annotation databases

EnsembliENST00000273398; ENSP00000273398; ENSG00000114573.
GeneIDi523.
KEGGihsa:523.
UCSCiuc003eao.3. human.

Polymorphism databases

DMDMi22096378.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L09235 mRNA. Translation: AAA83249.1 .
AF113129 mRNA. Translation: AAF14870.1 .
BT006672 mRNA. Translation: AAP35318.1 .
AK314779 mRNA. Translation: BAG37315.1 .
CH471052 Genomic DNA. Translation: EAW79625.1 .
CH471052 Genomic DNA. Translation: EAW79626.1 .
BC013138 mRNA. Translation: AAH13138.1 .
CCDSi CCDS2976.1.
PIRi B46091.
RefSeqi NP_001681.2. NM_001690.3.
UniGenei Hs.477155.

3D structure databases

ProteinModelPortali P38606.
SMRi P38606. Positions 40-587.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107007. 47 interactions.
IntActi P38606. 63 interactions.
MINTi MINT-224589.
STRINGi 9606.ENSP00000273398.

Protein family/group databases

TCDBi 3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSitei P38606.

Polymorphism databases

DMDMi 22096378.

Proteomic databases

MaxQBi P38606.
PaxDbi P38606.
PeptideAtlasi P38606.
PRIDEi P38606.

Protocols and materials databases

DNASUi 523.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000273398 ; ENSP00000273398 ; ENSG00000114573 .
GeneIDi 523.
KEGGi hsa:523.
UCSCi uc003eao.3. human.

Organism-specific databases

CTDi 523.
GeneCardsi GC03P113465.
HGNCi HGNC:851. ATP6V1A.
HPAi CAB006910.
HPA035083.
HPA035084.
MIMi 607027. gene.
neXtProti NX_P38606.
PharmGKBi PA25152.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1155.
HOGENOMi HOG000161057.
HOVERGENi HBG053351.
InParanoidi P38606.
KOi K02145.
OMAi ENKITWN.
OrthoDBi EOG7Q8CMM.
PhylomeDBi P38606.
TreeFami TF300811.

Enzyme and pathway databases

BioCyci MetaCyc:HS03781-MONOMER.
Reactomei REACT_1109. Insulin receptor recycling.
REACT_121256. Phagosomal maturation (early endosomal stage).
REACT_25283. Transferrin endocytosis and recycling.

Miscellaneous databases

ChiTaRSi ATP6V1A. human.
GeneWikii ATP6V1A.
GenomeRNAii 523.
NextBioi 2175.
PROi P38606.
SOURCEi Search...

Gene expression databases

ArrayExpressi P38606.
Bgeei P38606.
CleanExi HS_ATP6V1A.
Genevestigatori P38606.

Family and domain databases

Gene3Di 1.10.1140.10. 1 hit.
3.40.50.300. 2 hits.
HAMAPi MF_00309. ATP_synth_A_arch.
InterProi IPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR005725. ATPase_V1-cplx_asu.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view ]
Pfami PF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01042. V-ATPase_V1_A. 1 hit.
PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two subunit A isoforms of the vacuolar H(+)-ATPase in human osteoclastoma."
    van Hille B., Richener H., Evans D.B., Green J.R., Bilbe G.
    J. Biol. Chem. 268:7075-7080(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal adrenal gland and Leukocyte.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hypothalamus.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVATA_HUMAN
AccessioniPrimary (citable) accession number: P38606
Secondary accession number(s): B2RBR8
, D3DN75, Q53YD9, Q96DY6, Q9UHY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: August 2, 2002
Last modified: September 3, 2014
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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