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P38594 (CYB_LEPWE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome b
Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Gene names
Name:MT-CYB
Synonyms:COB, CYTB, MTCYB
Encoded onMitochondrion
OrganismLeptonychotes weddelli (Weddell seal)
Taxonomic identifier9713 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Phocidae › Leptonychotes

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.

Cofactor

Binds 2 heme groups non-covalently By similarity.

Subunit structure

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1) By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm By similarity.

Sequence similarities

Belongs to the cytochrome b family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Cytochrome b
PRO_0000061116

Regions

Transmembrane33 – 5321Helical; Potential
Transmembrane76 – 9621Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane140 – 15819Helical; Potential
Transmembrane178 – 19821Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane320 – 34021Helical; Potential
Transmembrane348 – 36821Helical; Potential

Sites

Metal binding831Iron 1 (heme b562 axial ligand)
Metal binding971Iron 2 (heme b566 axial ligand)
Metal binding1821Iron 1 (heme b562 axial ligand)
Metal binding1961Iron 2 (heme b566 axial ligand)

Sequences

Sequence LengthMass (Da)Tools
P38594 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 1B17CC1C2D2714B7

FASTA37942,545
        10         20         30         40         50         60 
MTNIRKTHPL AKIINNSFID LPTPSNISAW WNFGSLLGIC LILQILTGLF LAMHYTSDTT 

        70         80         90        100        110        120 
TAFSSVTHIC RDVNYGWIIR YMHANGASMF FICLYMHVGR GLYYGSYTFT ETWNIGIILL 

       130        140        150        160        170        180 
FTVMATAFMG YVLPWGQMSF WGATVITNLL SAIPYIGTDL VQWIWGGFSV DKATLTRFFA 

       190        200        210        220        230        240 
FHFILPFVVS ALAAVHLLFL HETGSNNPSG IPSDSDKIPF HPYYTIKDIL GALLLILTLM 

       250        260        270        280        290        300 
LLVLFSPDLL GDPDNYTPAN PLSTPPHIKP EWYFLFAYAI LRSIPNKLGG VLALALSILI 

       310        320        330        340        350        360 
LAIIPLLHTS KQRGMMFRPI SQCLFWLLVA DLLTLTWIGG QPVEHPYITI GQLASILYFT 

       370 
ILLVLMPITS IIENNILKW

« Hide

References

[1]"The nucleotide sequence of the mitochondrial DNA molecule of the grey seal, Halichoerus grypus, and a comparison with mitochondrial sequences of other true seals."
Arnason U., Gullberg A., Johnsson E., Ledje C.
J. Mol. Evol. 37:323-330(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Pinniped phylogeny and a new hypothesis for their origin and dispersal."
Arnason U., Gullberg A., Janke A., Kullberg M., Lehman N., Petrov E.A., Vainola R.
Mol. Phylogenet. Evol. 41:345-354(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]Lento G.M., Hickson R.E., Chambers G.K., Penny D.
Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X72005 Genomic DNA. Translation: CAA50890.1.
AM181025 Genomic DNA. Translation: CAJ57000.1.
U12843 Genomic DNA. Translation: AAA67253.1.
PIRS41833.
RefSeqYP_778811.1. NC_008424.1.

3D structure databases

ProteinModelPortalP38594.
SMRP38594. Positions 1-379.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4355831.

Organism-specific databases

CTD4519.

Phylogenomic databases

HOVERGENHBG017694.
ProtClustDBMTH00100.

Family and domain databases

InterProIPR016175. Cyt_b/b6.
IPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PANTHERPTHR19271. PTHR19271. 1 hit.
PfamPF00032. Cytochrom_B_C. 1 hit.
PF13631. Cytochrom_B_N_2. 1 hit.
[Graphical view]
SUPFAMSSF81648. Cytochrome_b/b6_C. 1 hit.
SSF81342. Transmembr_di-haem_cytochrome. 1 hit.
PROSITEPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYB_LEPWE
AccessionPrimary (citable) accession number: P38594
Secondary accession number(s): Q08H98
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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