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Protein

Tubulin--tyrosine ligase

Gene

Ttl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.By similarity

Catalytic activityi

ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.By similarity

Cofactori

Protein has several cofactor binding sites:

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • tubulin-tyrosine ligase activity Source: MGI

GO - Biological processi

  • cellular protein modification process Source: InterPro
  • microtubule cytoskeleton organization Source: MGI
  • regulation of axon extension Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin--tyrosine ligase (EC:6.3.2.25By similarity)
Short name:
TTL
Gene namesi
Name:Ttl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916987. Ttl.

Subcellular locationi

GO - Cellular componenti

  • microtubule Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Tubulin--tyrosine ligasePRO_0000212435Add
BLAST

Proteomic databases

EPDiP38585.
MaxQBiP38585.
PaxDbiP38585.
PRIDEiP38585.

PTM databases

PhosphoSiteiP38585.

Expressioni

Gene expression databases

BgeeiP38585.
CleanExiMM_TTL.
ExpressionAtlasiP38585. baseline and differential.
GenevisibleiP38585. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046883.

Structurei

3D structure databases

ProteinModelPortaliP38585.
SMRiP38585. Positions 1-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 370368TTLPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Curated
Contains 1 TTL domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2157. Eukaryota.
ENOG410XQDM. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000231734.
HOVERGENiHBG016579.
InParanoidiP38585.
KOiK06047.
OMAiQNYGRYE.
OrthoDBiEOG72ZCDZ.
PhylomeDBiP38585.
TreeFamiTF350555.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
[Graphical view]
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTFVVRDEN SSVYAEVSRL LLATGYWKRL RRDNPRFNLM LGERNRLPFG
60 70 80 90 100
RLGHEPGLAQ LVNYYRGADK LCRKASLVKL VKTSPELSES CSWFPESYVI
110 120 130 140 150
YPTNLKTPVA PAQNGIQLPV SNSRTDEREF FLASYNRKKE DGEGNVWIAK
160 170 180 190 200
SSAGAKGEGI LISSEASELL DFIDSQGQVH VIQKYLERPL LLEPGHRKFD
210 220 230 240 250
IRSWVLVDHQ YNIYLYREGV LRTASEPYHV DNFQDKTCHL TNHCIQKEYS
260 270 280 290 300
KNYGKYEEGN EMFFEEFNQY LTSALNITLE SSILLQIKHI IRSCLMSVEP
310 320 330 340 350
AISTKHLPYQ SFQLLGFDFM VDEELKVWLI EVNGAPACAQ KLYAELCQGI
360 370
VDIAISSVFP PPDTEQVPQQ PAAFVKL
Length:377
Mass (Da):43,136
Last modified:May 10, 2004 - v2
Checksum:i4D4E75243BB2CEDD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti222 – 2221R → Q (PubMed:8093886).Curated
Sequence conflicti230 – 2301V → M (PubMed:8093886).Curated
Sequence conflicti239 – 2391H → Q (PubMed:8093886).Curated
Sequence conflicti251 – 2511K → N in AAH24414 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018513 mRNA. Translation: AAH18513.1.
BC024414 mRNA. Translation: AAH24414.1.
CCDSiCCDS16719.1.
RefSeqiNP_081468.1. NM_027192.2.
UniGeneiMm.33909.
Mm.479291.

Genome annotation databases

EnsembliENSMUST00000035812; ENSMUSP00000046883; ENSMUSG00000027394.
GeneIDi69737.
KEGGimmu:69737.
UCSCiuc008mhe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018513 mRNA. Translation: AAH18513.1.
BC024414 mRNA. Translation: AAH24414.1.
CCDSiCCDS16719.1.
RefSeqiNP_081468.1. NM_027192.2.
UniGeneiMm.33909.
Mm.479291.

3D structure databases

ProteinModelPortaliP38585.
SMRiP38585. Positions 1-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046883.

PTM databases

PhosphoSiteiP38585.

Proteomic databases

EPDiP38585.
MaxQBiP38585.
PaxDbiP38585.
PRIDEiP38585.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035812; ENSMUSP00000046883; ENSMUSG00000027394.
GeneIDi69737.
KEGGimmu:69737.
UCSCiuc008mhe.2. mouse.

Organism-specific databases

CTDi150465.
MGIiMGI:1916987. Ttl.

Phylogenomic databases

eggNOGiKOG2157. Eukaryota.
ENOG410XQDM. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000231734.
HOVERGENiHBG016579.
InParanoidiP38585.
KOiK06047.
OMAiQNYGRYE.
OrthoDBiEOG72ZCDZ.
PhylomeDBiP38585.
TreeFamiTF350555.

Miscellaneous databases

NextBioi330220.
PROiP38585.
SOURCEiSearch...

Gene expression databases

BgeeiP38585.
CleanExiMM_TTL.
ExpressionAtlasiP38585. baseline and differential.
GenevisibleiP38585. MM.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
[Graphical view]
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 177-239.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue and Lung.

Entry informationi

Entry nameiTTL_MOUSE
AccessioniPrimary (citable) accession number: P38585
Secondary accession number(s): Q8R1L7, Q8VEG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: May 10, 2004
Last modified: May 11, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.