Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30SubstrateUniRule annotation1
Binding sitei44SubstrateUniRule annotation1
Binding sitei56SubstrateUniRule annotation1
Metal bindingi66Magnesium 1UniRule annotation1
Metal bindingi71Magnesium 1UniRule annotation1
Metal bindingi71Magnesium 2UniRule annotation1
Metal bindingi103Magnesium 1UniRule annotation1
Binding sitei140SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.1.1. 2305.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaUniRule annotation
Ordered Locus Names:TTHA1965
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001375352 – 175Inorganic pyrophosphataseAdd BLAST174

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi300852.TTHA1965.

Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Turni11 – 15Combined sources5
Beta strandi16 – 23Combined sources8
Beta strandi29 – 34Combined sources6
Turni35 – 38Combined sources4
Beta strandi39 – 45Combined sources7
Beta strandi47 – 49Combined sources3
Beta strandi53 – 58Combined sources6
Beta strandi71 – 75Combined sources5
Beta strandi85 – 100Combined sources16
Beta strandi102 – 110Combined sources9
Helixi114 – 116Combined sources3
Helixi122 – 124Combined sources3
Helixi127 – 139Combined sources13
Helixi142 – 147Combined sources6
Beta strandi151 – 157Combined sources7
Helixi159 – 174Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PRDX-ray2.00A2-175[»]
ProteinModelPortaliP38576.
SMRiP38576.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38576.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236472.
KOiK01507.
OMAiDGVANYK.
PhylomeDBiP38576.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLKSLPVG DKAPEVVHMV IEVPRGSGNK YEYDPDLGAI KLDRVLPGAQ
60 70 80 90 100
FYPGDYGFIP STLAEDGDPL DGLVLSTYPL LPGVVVEVRV VGLLLMEDEK
110 120 130 140 150
GGDAKVIGVV AEDQRLDHIQ DIGDVPEGVK QEIQHFFETY KALEAKKGKW
160 170
VKVTGWRDRK AALEEVRACI ARYKG
Length:175
Mass (Da):19,216
Last modified:January 23, 2007 - v2
Checksum:i01306D30B31DB061
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010580 Genomic DNA. Translation: BAA24521.1.
AP008226 Genomic DNA. Translation: BAD71788.1.
RefSeqiWP_011173971.1. NC_006461.1.
YP_145231.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71788; BAD71788; BAD71788.
GeneIDi3169724.
KEGGittj:TTHA1965.
PATRICi23958909. VBITheThe93045_1936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010580 Genomic DNA. Translation: BAA24521.1.
AP008226 Genomic DNA. Translation: BAD71788.1.
RefSeqiWP_011173971.1. NC_006461.1.
YP_145231.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PRDX-ray2.00A2-175[»]
ProteinModelPortaliP38576.
SMRiP38576.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1965.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71788; BAD71788; BAD71788.
GeneIDi3169724.
KEGGittj:TTHA1965.
PATRICi23958909. VBITheThe93045_1936.

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236472.
KOiK01507.
OMAiDGVANYK.
PhylomeDBiP38576.

Enzyme and pathway databases

BRENDAi3.6.1.1. 2305.

Miscellaneous databases

EvolutionaryTraceiP38576.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPYR_THET8
AccessioniPrimary (citable) accession number: P38576
Secondary accession number(s): Q5SGW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.