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Protein

Uroplakin-3a

Gene

UPK3A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-3a
Short name:
UP3a
Alternative name(s):
Uroplakin III
Short name:
UPIII
Gene namesi
Name:UPK3A
Synonyms:UPK3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 207189LumenalSequence analysisAdd
BLAST
Transmembranei208 – 23528HelicalSequence analysisAdd
BLAST
Topological domaini236 – 28752CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 287269Uroplakin-3aPRO_0000022636Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP38574.
PRIDEiP38574.

Expressioni

Tissue specificityi

Bladder epithelium.

Interactioni

Subunit structurei

Heterodimer with uroplakin-1B (UPK1B).

Protein-protein interaction databases

MINTiMINT-1513931.
STRINGi9913.ENSBTAP00000013081.

Family & Domainsi

Sequence similaritiesi

Belongs to the uroplakin-3 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE9T. Eukaryota.
ENOG41123W4. LUCA.
GeneTreeiENSGT00510000048620.
HOGENOMiHOG000143412.
HOVERGENiHBG058769.
InParanoidiP38574.
KOiK19520.
OMAiETTHDSQ.
OrthoDBiEOG7J9VQC.
TreeFamiTF336628.

Family and domain databases

InterProiIPR024831. Uroplakin-3.
IPR024825. Uroplakin-3a.
[Graphical view]
PANTHERiPTHR15446. PTHR15446. 1 hit.
PTHR15446:SF17. PTHR15446:SF17. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPLWVVLAL GCLRLGSGVN LQPQLASVTF ATNNPTLTTV ALEKPLCMFD
60 70 80 90 100
SSAALHGTYE VYLYVLVDSA SFRNASVQDS TKTPLSSTFQ QTQGGRTGPY
110 120 130 140 150
KAAAFDLTPC SDSPSLDAVR DVSRASEILN AYLIRVGTNG TCLLDPNFQG
160 170 180 190 200
LCNPPLSAAT EYRFKYVLVN MSSGLVQDQT LWSDPIRTDR LTLYSAIDTW
210 220 230 240 250
PGRRSGGMIV ITSILGSLPF FLLIGFAGAI VLSLVDRGDA DGATSHDSQI
260 270 280
TQEAVPKSLG TSEPSYTSVN RGPSLDRAEV YASKLQD
Length:287
Mass (Da):30,757
Last modified:October 1, 1994 - v1
Checksum:i177185A017E233B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19542 mRNA. Translation: AAC37309.1.
PIRiI45986.
RefSeqiNP_777134.1. NM_174709.3.
UniGeneiBt.60952.

Genome annotation databases

EnsembliENSBTAT00000013081; ENSBTAP00000013081; ENSBTAG00000009913.
GeneIDi100336102.
KEGGibta:100336102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19542 mRNA. Translation: AAC37309.1.
PIRiI45986.
RefSeqiNP_777134.1. NM_174709.3.
UniGeneiBt.60952.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1513931.
STRINGi9913.ENSBTAP00000013081.

Proteomic databases

PaxDbiP38574.
PRIDEiP38574.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013081; ENSBTAP00000013081; ENSBTAG00000009913.
GeneIDi100336102.
KEGGibta:100336102.

Organism-specific databases

CTDi7380.

Phylogenomic databases

eggNOGiENOG410IE9T. Eukaryota.
ENOG41123W4. LUCA.
GeneTreeiENSGT00510000048620.
HOGENOMiHOG000143412.
HOVERGENiHBG058769.
InParanoidiP38574.
KOiK19520.
OMAiETTHDSQ.
OrthoDBiEOG7J9VQC.
TreeFamiTF336628.

Family and domain databases

InterProiIPR024831. Uroplakin-3.
IPR024825. Uroplakin-3a.
[Graphical view]
PANTHERiPTHR15446. PTHR15446. 1 hit.
PTHR15446:SF17. PTHR15446:SF17. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoprotein."
    Wu X.-R., Sun T.-T.
    J. Cell Sci. 106:31-43(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-45; 174-181 AND 209-235.
    Tissue: Urinary bladder urothelium.
  2. "Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum."
    Tu L., Sun T.-T., Kreibich G.
    Mol. Biol. Cell 13:4221-4230(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UPK1B, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiUPK3A_BOVIN
AccessioniPrimary (citable) accession number: P38574
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.