P38570 (ITAE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Integrin alpha-E

Alternative name(s):
HML-1 antigen
Integrin alpha-IEL
Mucosal lymphocyte 1 antigen
CD_antigen=CD103

Cleaved into the following 2 chains:

1. Integrin alpha-E light chain
2. Integrin alpha-E heavy chain

Gene names

Name:

ITGAE

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1179 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.
Subunit structure	Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.
Induction	Integrin alpha-E/beta-7 is induced by TGFB1. Ref.6
Domain	The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Sequence similarities	Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. Contains 1 VWFA domain.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Magnesium Metal-binding
Molecular function	Integrin Receptor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW integrin-mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	external side of plasma membrane Inferred from electronic annotation. Source: Compara integrin complex Traceable author statement Ref.1. Source: ProtInc
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Ref.1
	Chain	19 – 1179	1161	Integrin alpha-E		PRO_0000016283
	Chain	19 – 177	159	Integrin alpha-E light chain		PRO_0000016284
	Chain	179 – 1177	999	Integrin alpha-E heavy chain		PRO_0000016285
Regions
	Topological domain	19 – 1124	1106	Extracellular Potential
	Transmembrane	1125 – 1147	23	Helical; Potential
	Topological domain	1148 – 1179	32	Cytoplasmic Potential
	Repeat	22 – 79	58	FG-GAP 1
	Repeat	80 – 138	59	FG-GAP 2
	Domain	200 – 389	190	VWFA
	Repeat	390 – 442	53	FG-GAP 3
	Repeat	447 – 501	55	FG-GAP 4
	Repeat	502 – 560	59	FG-GAP 5
	Repeat	563 – 627	65	FG-GAP 6
	Repeat	631 – 691	61	FG-GAP 7
	Calcium binding	522 – 530	9	Potential
	Calcium binding	586 – 594	9	Potential
	Calcium binding	654 – 662	9	Potential
	Region	145 – 199	55	X-domain (extra domain)
	Motif	1150 – 1154	5	GFFKR motif
	Compositional bias	181 – 198	18	Glu-rich (acidic)
Amino acid modifications
	Glycosylation	49	1	N-linked (GlcNAc...) Potential
	Glycosylation	271	1	N-linked (GlcNAc...) Potential
	Glycosylation	321	1	N-linked (GlcNAc...) Potential
	Glycosylation	444	1	N-linked (GlcNAc...) Potential
	Glycosylation	726	1	N-linked (GlcNAc...) Potential
	Glycosylation	782	1	N-linked (GlcNAc...) Potential
	Glycosylation	857	1	N-linked (GlcNAc...) Potential
	Glycosylation	934	1	N-linked (GlcNAc...) Potential
	Glycosylation	954	1	N-linked (GlcNAc...) Potential
	Glycosylation	1065	1	N-linked (GlcNAc...) Potential
	Glycosylation	1096	1	N-linked (GlcNAc...) Potential
	Disulfide bond	70 ↔ 79		By similarity
	Disulfide bond	126 ↔ 159		By similarity
	Disulfide bond	706 ↔ 762		By similarity
	Disulfide bond	823 ↔ 829		By similarity
	Disulfide bond	893 ↔ 907		By similarity
	Disulfide bond	1008 ↔ 1033		By similarity
	Disulfide bond	1041 ↔ 1057		By similarity
Natural variations
	Natural variant	360	1	D → E.		VAR_008884
	Natural variant	477	1	I → V. Ref.1 Ref.4 Corresponds to variant rs220479 [ dbSNP | Ensembl ].		VAR_054889
	Natural variant	482	1	R → Q. Ref.1 Ref.4 Corresponds to variant rs2272606 [ dbSNP | Ensembl ].		VAR_054890
	Natural variant	892	1	Q → H. Corresponds to variant rs3744679 [ dbSNP | Ensembl ].		VAR_020037
	Natural variant	950	1	R → W. Ref.5 Corresponds to variant rs1716 [ dbSNP | Ensembl ].		VAR_034025
	Natural variant	1019	1	V → A. Ref.1 Ref.4 Corresponds to variant rs2976230 [ dbSNP | Ensembl ].		VAR_054891
	Natural variant	1041	1	C → S.		VAR_008885
Experimental info
	Mutagenesis	208	1	D → A: Loss of E-cadherin binding. Ref.7
	Mutagenesis	316	1	F → A: Loss of E-cadherin binding. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	P38570 [UniParc]. Last modified April 14, 2009. Version 3. Checksum: 6645F8FFF9A0F045	FASTA	1,179	130,159
	10 20 30 40 50 60 MWLFHTLLCI ASLALLAAFN VDVARPWLTP KGGAPFVLSS LLHQDPSTNQ TWLLVTSPRT 70 80 90 100 110 120 KRTPGPLHRC SLVQDEILCH PVEHVPIPKG RHRGVTVVRS HHGVLICIQV LVRRPHSLSS 130 140 150 160 170 180 ELTGTCSLLG PDLRPQAQAN FFDLENLLDP DARVDTGDCY SNKEGGGEDD VNTARQRRAL 190 200 210 220 230 240 EKEEEEDKEE EEDEEEEEAG TEIAIILDGS GSIDPPDFQR AKDFISNMMR NFYEKCFECN 250 260 270 280 290 300 FALVQYGGVI QTEFDLRDSQ DVMASLARVQ NITQVGSVTK TASAMQHVLD SIFTSSHGSR 310 320 330 340 350 360 RKASKVMVVL TDGGIFEDPL NLTTVINSPK MQGVERFAIG VGEEFKSART ARELNLIASD 370 380 390 400 410 420 PDETHAFKVT NYMALDGLLS KLRYNIISME GTVGDALHYQ LAQIGFSAQI LDERQVLLGA 430 440 450 460 470 480 VGAFDWSGGA LLYDTRSRRG RFLNQTAAAA ADAEAAQYSY LGYAVAVLHK TCSLSYIAGA 490 500 510 520 530 540 PRYKHHGAVF ELQKEGREAS FLPVLEGEQM GSYFGSELCP VDIDMDGSTD FLLVAAPFYH 550 560 570 580 590 600 VHGEEGRVYV YRLSEQDGSF SLARILSGHP GFTNARFGFA MAAMGDLSQD KLTDVAIGAP 610 620 630 640 650 660 LEGFGADDGA SFGSVYIYNG HWDGLSASPS QRIRASTVAP GLQYFGMSMA GGFDISGDGL 670 680 690 700 710 720 ADITVGTLGQ AVVFRSRPVV RLKVSMAFTP SALPIGFNGV VNVRLCFEIS SVTTASESGL 730 740 750 760 770 780 REALLNFTLD VDVGKQRRRL QCSDVRSCLG CLREWSSGSQ LCEDLLLMPT EGELCEEDCF 790 800 810 820 830 840 SNASVKVSYQ LQTPEGQTDH PQPILDRYTE PFAIFQLPYE KACKNKLFCV AELQLATTVS 850 860 870 880 890 900 QQELVVGLTK ELTLNINLTN SGEDSYMTSM ALNYPRNLQL KRMQKPPSPN IQCDDPQPVA 910 920 930 940 950 960 SVLIMNCRIG HPVLKRSSAH VSVVWQLEEN AFPNRTADIT VTVTNSNERR SLANETHTLQ 970 980 990 1000 1010 1020 FRHGFVAVLS KPSIMYVNTG QGLSHHKEFL FHVHGENLFG AEYQLQICVP TKLRGLQVVA 1030 1040 1050 1060 1070 1080 VKKLTRTQAS TVCTWSQERA CAYSSVQHVE EWHSVSCVIA SDKENVTVAA EISWDHSEEL 1090 1100 1110 1120 1130 1140 LKDVTELQIL GEISFNKSLY EGLNAENHRT KITVVFLKDE KYHSLPIIIK GSVGGLLVLI 1150 1160 1170 VILVILFKCG FFKRKYQQLN LESIRKAQLK SENLLEEEN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution." Shaw S.K., Cepek K.L., Murphy E.A., Russell G.J., Brenner M.B., Parker C.M. J. Biol. Chem. 269:6016-6025(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-38 AND 179-188, VARIANTS VAL-477; GLN-482 AND ALA-1019. Tissue: Leukemia and Lymphocyte.
[2]	Parker C.M. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 88-114.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-477; GLN-482 AND ALA-1019.
[5]	"The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion." Touchman J.W., Anikster Y., Dietrich N.L., Maduro V.V.B., McDowell G., Shotelersuk V., Bouffard G.G., Beckstrom-Sternberg S.M., Gahl W.A., Green E.D. Genome Res. 10:165-173(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-1179, VARIANT TRP-950. Tissue: Fetal kidney.
[6]	"A family of beta 7 integrins on human mucosal lymphocytes." Parker C.M., Cepek K.L., Russell G.J., Shaw S.K., Posnett D.N., Schwarting R., Brenner M.B. Proc. Natl. Acad. Sci. U.S.A. 89:1924-1928(1992) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH INTEGRIN BETA-7, INDUCTION.
[7]	"The role of alpha and beta chains in ligand recognition by beta 7 integrins." Higgins J.M.G., Cernadas M., Tan K., Irie A., Wang J.-H., Takada Y., Brenner M.B. J. Biol. Chem. 275:25652-25664(2000) [PubMed] [Europe PMC] [Abstract] Cited for: MUTAGENESIS OF ASP-208 AND PHE-316.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L25851 mRNA. Translation: AAB59359.2. AC116914 Genomic DNA. No translation available. BC113436 mRNA. Translation: AAI13437.1. BC117207 mRNA. Translation: AAI17208.1. AF168787 Genomic DNA. Translation: AAF43107.1.
IPI	IPI00007205.
PIR	A53213.
RefSeq	NP_002199.3. NM_002208.4.
UniGene	Hs.513867.
3D structure databases
ProteinModelPortal	P38570.
ModBase	Search...
Protein-protein interaction databases
IntAct	P38570. 1 interaction.
MINT	MINT-1397425.
STRING	9606.ENSP00000263087.
PTM databases
PhosphoSite	P38570.
Polymorphism databases
DMDM	226694184.
Proteomic databases
PaxDb	P38570.
PRIDE	P38570.
Protocols and materials databases
DNASU	3682.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263087; ENSP00000263087; ENSG00000083457.
GeneID	3682.
KEGG	hsa:3682.
UCSC	uc002fwo.4. human.
Organism-specific databases
CTD	3682.
GeneCards	GC17M003617.
H-InvDB	HIX0202464.
HGNC	HGNC:6147. ITGAE.
HPA	CAB026461. HPA036313.
MIM	604682. gene.
neXtProt	NX_P38570.
PharmGKB	PA29947.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG240019.
HOGENOM	HOG000049185.
HOVERGEN	HBG006187.
InParanoid	P38570.
KO	K06524.
OMA	HGENLFG.
OrthoDB	EOG4K6G3D.
PhylomeDB	P38570.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P38570.
CleanEx	HS_ITGAE.
Genevestigator	P38570.
GermOnline	ENSG00000083457. Homo sapiens.
Family and domain databases
InterPro	IPR013519. Int_alpha_beta-p. IPR000413. Integrin_alpha. IPR013649. Integrin_alpha-2. IPR018184. Integrin_alpha_C_CS. IPR002035. VWF_A. [Graphical view]
Pfam	PF00357. Integrin_alpha. 1 hit. PF08441. Integrin_alpha2. 1 hit. PF00092. VWA. 1 hit. [Graphical view]
PRINTS	PR01185. INTEGRINA.
SMART	SM00191. Int_alpha. 4 hits. SM00327. VWA. 1 hit. [Graphical view]
PROSITE	PS51470. FG_GAP. 5 hits. PS00242. INTEGRIN_ALPHA. 1 hit. PS50234. VWFA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ITGAE. human.
GenomeRNAi	3682.
NextBio	14411.
SOURCE	Search...

Entry information

Entry name

ITAE_HUMAN

Accession

Primary (citable) accession number: P38570
Secondary accession number(s): Q17RS6, Q9NZU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	April 14, 2009
Last modified:	May 1, 2013
This is version 133 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.