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P38570

- ITAE_HUMAN

UniProt

P38570 - ITAE_HUMAN

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Protein

Integrin alpha-E

Gene

ITGAE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi522 – 5309Sequence Analysis
Calcium bindingi586 – 5949Sequence Analysis
Calcium bindingi654 – 6629Sequence Analysis

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. extracellular matrix organization Source: Reactome
  3. integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_13552. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-E
Alternative name(s):
HML-1 antigen
Integrin alpha-IEL
Mucosal lymphocyte 1 antigen
CD_antigen: CD103
Cleaved into the following 2 chains:
Gene namesi
Name:ITGAE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6147. ITGAE.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. integrin complex Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi208 – 2081D → A: Loss of E-cadherin binding. 1 Publication
Mutagenesisi316 – 3161F → A: Loss of E-cadherin binding. 1 Publication

Organism-specific databases

PharmGKBiPA29947.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 11791161Integrin alpha-EPRO_0000016283Add
BLAST
Chaini19 – 177159Integrin alpha-E light chainPRO_0000016284Add
BLAST
Chaini179 – 1177999Integrin alpha-E heavy chainPRO_0000016285Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi70 ↔ 79By similarity
Disulfide bondi126 ↔ 159By similarity
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi706 ↔ 762By similarity
Glycosylationi726 – 7261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi782 – 7821N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi823 ↔ 829By similarity
Glycosylationi857 – 8571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi893 ↔ 907By similarity
Glycosylationi934 – 9341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi954 – 9541N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1008 ↔ 1033By similarity
Disulfide bondi1041 ↔ 1057By similarity
Glycosylationi1065 – 10651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1096 – 10961N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP38570.
PRIDEiP38570.

PTM databases

PhosphoSiteiP38570.

Expressioni

Tissue specificityi

Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

Inductioni

Integrin alpha-E/beta-7 is induced by TGFB1.1 Publication

Gene expression databases

BgeeiP38570.
CleanExiHS_ITGAE.
GenevestigatoriP38570.

Organism-specific databases

HPAiCAB026461.
HPA036313.
HPA052147.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

Protein-protein interaction databases

BioGridi109888. 4 interactions.
IntActiP38570. 1 interaction.
MINTiMINT-1397425.
STRINGi9606.ENSP00000263087.

Structurei

3D structure databases

ProteinModelPortaliP38570.
SMRiP38570. Positions 201-375, 395-1122.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 11241106ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1148 – 117932CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1125 – 114723HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati22 – 7958FG-GAP 1Add
BLAST
Repeati80 – 13859FG-GAP 2Add
BLAST
Domaini200 – 389190VWFAPROSITE-ProRule annotationAdd
BLAST
Repeati390 – 44253FG-GAP 3Add
BLAST
Repeati447 – 50155FG-GAP 4Add
BLAST
Repeati502 – 56059FG-GAP 5Add
BLAST
Repeati563 – 62765FG-GAP 6Add
BLAST
Repeati631 – 69161FG-GAP 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni145 – 19955X-domain (extra domain)Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1150 – 11545GFFKR motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 19818Glu-rich (acidic)Add
BLAST

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG240019.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000049185.
HOVERGENiHBG006187.
InParanoidiP38570.
KOiK06524.
OMAiNHRTKIT.
OrthoDBiEOG74TWXT.
PhylomeDBiP38570.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 4 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51470. FG_GAP. 5 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38570-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWLFHTLLCI ASLALLAAFN VDVARPWLTP KGGAPFVLSS LLHQDPSTNQ
60 70 80 90 100
TWLLVTSPRT KRTPGPLHRC SLVQDEILCH PVEHVPIPKG RHRGVTVVRS
110 120 130 140 150
HHGVLICIQV LVRRPHSLSS ELTGTCSLLG PDLRPQAQAN FFDLENLLDP
160 170 180 190 200
DARVDTGDCY SNKEGGGEDD VNTARQRRAL EKEEEEDKEE EEDEEEEEAG
210 220 230 240 250
TEIAIILDGS GSIDPPDFQR AKDFISNMMR NFYEKCFECN FALVQYGGVI
260 270 280 290 300
QTEFDLRDSQ DVMASLARVQ NITQVGSVTK TASAMQHVLD SIFTSSHGSR
310 320 330 340 350
RKASKVMVVL TDGGIFEDPL NLTTVINSPK MQGVERFAIG VGEEFKSART
360 370 380 390 400
ARELNLIASD PDETHAFKVT NYMALDGLLS KLRYNIISME GTVGDALHYQ
410 420 430 440 450
LAQIGFSAQI LDERQVLLGA VGAFDWSGGA LLYDTRSRRG RFLNQTAAAA
460 470 480 490 500
ADAEAAQYSY LGYAVAVLHK TCSLSYIAGA PRYKHHGAVF ELQKEGREAS
510 520 530 540 550
FLPVLEGEQM GSYFGSELCP VDIDMDGSTD FLLVAAPFYH VHGEEGRVYV
560 570 580 590 600
YRLSEQDGSF SLARILSGHP GFTNARFGFA MAAMGDLSQD KLTDVAIGAP
610 620 630 640 650
LEGFGADDGA SFGSVYIYNG HWDGLSASPS QRIRASTVAP GLQYFGMSMA
660 670 680 690 700
GGFDISGDGL ADITVGTLGQ AVVFRSRPVV RLKVSMAFTP SALPIGFNGV
710 720 730 740 750
VNVRLCFEIS SVTTASESGL REALLNFTLD VDVGKQRRRL QCSDVRSCLG
760 770 780 790 800
CLREWSSGSQ LCEDLLLMPT EGELCEEDCF SNASVKVSYQ LQTPEGQTDH
810 820 830 840 850
PQPILDRYTE PFAIFQLPYE KACKNKLFCV AELQLATTVS QQELVVGLTK
860 870 880 890 900
ELTLNINLTN SGEDSYMTSM ALNYPRNLQL KRMQKPPSPN IQCDDPQPVA
910 920 930 940 950
SVLIMNCRIG HPVLKRSSAH VSVVWQLEEN AFPNRTADIT VTVTNSNERR
960 970 980 990 1000
SLANETHTLQ FRHGFVAVLS KPSIMYVNTG QGLSHHKEFL FHVHGENLFG
1010 1020 1030 1040 1050
AEYQLQICVP TKLRGLQVVA VKKLTRTQAS TVCTWSQERA CAYSSVQHVE
1060 1070 1080 1090 1100
EWHSVSCVIA SDKENVTVAA EISWDHSEEL LKDVTELQIL GEISFNKSLY
1110 1120 1130 1140 1150
EGLNAENHRT KITVVFLKDE KYHSLPIIIK GSVGGLLVLI VILVILFKCG
1160 1170
FFKRKYQQLN LESIRKAQLK SENLLEEEN
Length:1,179
Mass (Da):130,159
Last modified:April 14, 2009 - v3
Checksum:i6645F8FFF9A0F045
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti360 – 3601D → E.
VAR_008884
Natural varianti477 – 4771I → V.2 Publications
Corresponds to variant rs220479 [ dbSNP | Ensembl ].
VAR_054889
Natural varianti482 – 4821R → Q.2 Publications
Corresponds to variant rs2272606 [ dbSNP | Ensembl ].
VAR_054890
Natural varianti892 – 8921Q → H.
Corresponds to variant rs3744679 [ dbSNP | Ensembl ].
VAR_020037
Natural varianti950 – 9501R → W.1 Publication
Corresponds to variant rs1716 [ dbSNP | Ensembl ].
VAR_034025
Natural varianti1019 – 10191V → A.2 Publications
Corresponds to variant rs2976230 [ dbSNP | Ensembl ].
VAR_054891
Natural varianti1041 – 10411C → S.
VAR_008885

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25851 mRNA. Translation: AAB59359.2.
AC116914 Genomic DNA. No translation available.
BC113436 mRNA. Translation: AAI13437.1.
BC117207 mRNA. Translation: AAI17208.1.
AF168787 Genomic DNA. Translation: AAF43107.1.
CCDSiCCDS32531.1.
PIRiA53213.
RefSeqiNP_002199.3. NM_002208.4.
UniGeneiHs.513867.

Genome annotation databases

EnsembliENST00000263087; ENSP00000263087; ENSG00000083457.
GeneIDi3682.
KEGGihsa:3682.
UCSCiuc002fwo.4. human.

Polymorphism databases

DMDMi226694184.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25851 mRNA. Translation: AAB59359.2 .
AC116914 Genomic DNA. No translation available.
BC113436 mRNA. Translation: AAI13437.1 .
BC117207 mRNA. Translation: AAI17208.1 .
AF168787 Genomic DNA. Translation: AAF43107.1 .
CCDSi CCDS32531.1.
PIRi A53213.
RefSeqi NP_002199.3. NM_002208.4.
UniGenei Hs.513867.

3D structure databases

ProteinModelPortali P38570.
SMRi P38570. Positions 201-375, 395-1122.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109888. 4 interactions.
IntActi P38570. 1 interaction.
MINTi MINT-1397425.
STRINGi 9606.ENSP00000263087.

PTM databases

PhosphoSitei P38570.

Polymorphism databases

DMDMi 226694184.

Proteomic databases

PaxDbi P38570.
PRIDEi P38570.

Protocols and materials databases

DNASUi 3682.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263087 ; ENSP00000263087 ; ENSG00000083457 .
GeneIDi 3682.
KEGGi hsa:3682.
UCSCi uc002fwo.4. human.

Organism-specific databases

CTDi 3682.
GeneCardsi GC17M003617.
H-InvDB HIX0202464.
HGNCi HGNC:6147. ITGAE.
HPAi CAB026461.
HPA036313.
HPA052147.
MIMi 604682. gene.
neXtProti NX_P38570.
PharmGKBi PA29947.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240019.
GeneTreei ENSGT00760000118782.
HOGENOMi HOG000049185.
HOVERGENi HBG006187.
InParanoidi P38570.
KOi K06524.
OMAi NHRTKIT.
OrthoDBi EOG74TWXT.
PhylomeDBi P38570.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_13552. Integrin cell surface interactions.

Miscellaneous databases

ChiTaRSi ITGAE. human.
GeneWikii ITGAE.
GenomeRNAii 3682.
NextBioi 14411.
PROi P38570.
SOURCEi Search...

Gene expression databases

Bgeei P38570.
CleanExi HS_ITGAE.
Genevestigatori P38570.

Family and domain databases

InterProi IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 4 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS51470. FG_GAP. 5 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution."
    Shaw S.K., Cepek K.L., Murphy E.A., Russell G.J., Brenner M.B., Parker C.M.
    J. Biol. Chem. 269:6016-6025(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-38 AND 179-188, VARIANTS VAL-477; GLN-482 AND ALA-1019.
    Tissue: Leukemia and Lymphocyte.
  2. Parker C.M.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 88-114.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-477; GLN-482 AND ALA-1019.
  5. "The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion."
    Touchman J.W., Anikster Y., Dietrich N.L., Maduro V.V.B., McDowell G., Shotelersuk V., Bouffard G.G., Beckstrom-Sternberg S.M., Gahl W.A., Green E.D.
    Genome Res. 10:165-173(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-1179, VARIANT TRP-950.
    Tissue: Fetal kidney.
  6. Cited for: INTERACTION WITH INTEGRIN BETA-7, INDUCTION.
  7. "The role of alpha and beta chains in ligand recognition by beta 7 integrins."
    Higgins J.M.G., Cernadas M., Tan K., Irie A., Wang J.-H., Takada Y., Brenner M.B.
    J. Biol. Chem. 275:25652-25664(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ASP-208 AND PHE-316.

Entry informationi

Entry nameiITAE_HUMAN
AccessioniPrimary (citable) accession number: P38570
Secondary accession number(s): Q17RS6, Q9NZU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: April 14, 2009
Last modified: October 29, 2014
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3