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P38570

- ITAE_HUMAN

UniProt

P38570 - ITAE_HUMAN

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Protein
Integrin alpha-E
Gene
ITGAE
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi522 – 5309 Reviewed prediction
Calcium bindingi586 – 5949 Reviewed prediction
Calcium bindingi654 – 6629 Reviewed prediction

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. extracellular matrix organization Source: Reactome
  3. integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_13552. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-E
Alternative name(s):
HML-1 antigen
Integrin alpha-IEL
Mucosal lymphocyte 1 antigen
CD_antigen: CD103
Cleaved into the following 2 chains:
Gene namesi
Name:ITGAE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6147. ITGAE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 11241106Extracellular Reviewed prediction
Add
BLAST
Transmembranei1125 – 114723Helical; Reviewed prediction
Add
BLAST
Topological domaini1148 – 117932Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. integrin complex Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi208 – 2081D → A: Loss of E-cadherin binding. 1 Publication
Mutagenesisi316 – 3161F → A: Loss of E-cadherin binding. 1 Publication

Organism-specific databases

PharmGKBiPA29947.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 Publication
Add
BLAST
Chaini19 – 11791161Integrin alpha-E
PRO_0000016283Add
BLAST
Chaini19 – 177159Integrin alpha-E light chain
PRO_0000016284Add
BLAST
Chaini179 – 1177999Integrin alpha-E heavy chain
PRO_0000016285Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi70 ↔ 79 By similarity
Disulfide bondi126 ↔ 159 By similarity
Glycosylationi271 – 2711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi321 – 3211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi444 – 4441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi706 ↔ 762 By similarity
Glycosylationi726 – 7261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi782 – 7821N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi823 ↔ 829 By similarity
Glycosylationi857 – 8571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi893 ↔ 907 By similarity
Glycosylationi934 – 9341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi954 – 9541N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1008 ↔ 1033 By similarity
Disulfide bondi1041 ↔ 1057 By similarity
Glycosylationi1065 – 10651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1096 – 10961N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP38570.
PRIDEiP38570.

PTM databases

PhosphoSiteiP38570.

Expressioni

Tissue specificityi

Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

Inductioni

Integrin alpha-E/beta-7 is induced by TGFB1.1 Publication

Gene expression databases

BgeeiP38570.
CleanExiHS_ITGAE.
GenevestigatoriP38570.

Organism-specific databases

HPAiCAB026461.
HPA036313.
HPA052147.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

Protein-protein interaction databases

BioGridi109888. 4 interactions.
IntActiP38570. 1 interaction.
MINTiMINT-1397425.
STRINGi9606.ENSP00000263087.

Structurei

3D structure databases

ProteinModelPortaliP38570.
SMRiP38570. Positions 201-375, 395-1162.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati22 – 7958FG-GAP 1
Add
BLAST
Repeati80 – 13859FG-GAP 2
Add
BLAST
Domaini200 – 389190VWFA
Add
BLAST
Repeati390 – 44253FG-GAP 3
Add
BLAST
Repeati447 – 50155FG-GAP 4
Add
BLAST
Repeati502 – 56059FG-GAP 5
Add
BLAST
Repeati563 – 62765FG-GAP 6
Add
BLAST
Repeati631 – 69161FG-GAP 7
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni145 – 19955X-domain (extra domain)
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1150 – 11545GFFKR motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 19818Glu-rich (acidic)
Add
BLAST

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG240019.
HOGENOMiHOG000049185.
HOVERGENiHBG006187.
InParanoidiP38570.
KOiK06524.
OMAiNHRTKIT.
OrthoDBiEOG74TWXT.
PhylomeDBiP38570.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 4 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51470. FG_GAP. 5 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38570-1 [UniParc]FASTAAdd to Basket

« Hide

MWLFHTLLCI ASLALLAAFN VDVARPWLTP KGGAPFVLSS LLHQDPSTNQ     50
TWLLVTSPRT KRTPGPLHRC SLVQDEILCH PVEHVPIPKG RHRGVTVVRS 100
HHGVLICIQV LVRRPHSLSS ELTGTCSLLG PDLRPQAQAN FFDLENLLDP 150
DARVDTGDCY SNKEGGGEDD VNTARQRRAL EKEEEEDKEE EEDEEEEEAG 200
TEIAIILDGS GSIDPPDFQR AKDFISNMMR NFYEKCFECN FALVQYGGVI 250
QTEFDLRDSQ DVMASLARVQ NITQVGSVTK TASAMQHVLD SIFTSSHGSR 300
RKASKVMVVL TDGGIFEDPL NLTTVINSPK MQGVERFAIG VGEEFKSART 350
ARELNLIASD PDETHAFKVT NYMALDGLLS KLRYNIISME GTVGDALHYQ 400
LAQIGFSAQI LDERQVLLGA VGAFDWSGGA LLYDTRSRRG RFLNQTAAAA 450
ADAEAAQYSY LGYAVAVLHK TCSLSYIAGA PRYKHHGAVF ELQKEGREAS 500
FLPVLEGEQM GSYFGSELCP VDIDMDGSTD FLLVAAPFYH VHGEEGRVYV 550
YRLSEQDGSF SLARILSGHP GFTNARFGFA MAAMGDLSQD KLTDVAIGAP 600
LEGFGADDGA SFGSVYIYNG HWDGLSASPS QRIRASTVAP GLQYFGMSMA 650
GGFDISGDGL ADITVGTLGQ AVVFRSRPVV RLKVSMAFTP SALPIGFNGV 700
VNVRLCFEIS SVTTASESGL REALLNFTLD VDVGKQRRRL QCSDVRSCLG 750
CLREWSSGSQ LCEDLLLMPT EGELCEEDCF SNASVKVSYQ LQTPEGQTDH 800
PQPILDRYTE PFAIFQLPYE KACKNKLFCV AELQLATTVS QQELVVGLTK 850
ELTLNINLTN SGEDSYMTSM ALNYPRNLQL KRMQKPPSPN IQCDDPQPVA 900
SVLIMNCRIG HPVLKRSSAH VSVVWQLEEN AFPNRTADIT VTVTNSNERR 950
SLANETHTLQ FRHGFVAVLS KPSIMYVNTG QGLSHHKEFL FHVHGENLFG 1000
AEYQLQICVP TKLRGLQVVA VKKLTRTQAS TVCTWSQERA CAYSSVQHVE 1050
EWHSVSCVIA SDKENVTVAA EISWDHSEEL LKDVTELQIL GEISFNKSLY 1100
EGLNAENHRT KITVVFLKDE KYHSLPIIIK GSVGGLLVLI VILVILFKCG 1150
FFKRKYQQLN LESIRKAQLK SENLLEEEN 1179
Length:1,179
Mass (Da):130,159
Last modified:April 14, 2009 - v3
Checksum:i6645F8FFF9A0F045
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti360 – 3601D → E.
VAR_008884
Natural varianti477 – 4771I → V.2 Publications
Corresponds to variant rs220479 [ dbSNP | Ensembl ].
VAR_054889
Natural varianti482 – 4821R → Q.2 Publications
Corresponds to variant rs2272606 [ dbSNP | Ensembl ].
VAR_054890
Natural varianti892 – 8921Q → H.
Corresponds to variant rs3744679 [ dbSNP | Ensembl ].
VAR_020037
Natural varianti950 – 9501R → W.1 Publication
Corresponds to variant rs1716 [ dbSNP | Ensembl ].
VAR_034025
Natural varianti1019 – 10191V → A.2 Publications
Corresponds to variant rs2976230 [ dbSNP | Ensembl ].
VAR_054891
Natural varianti1041 – 10411C → S.
VAR_008885

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25851 mRNA. Translation: AAB59359.2.
AC116914 Genomic DNA. No translation available.
BC113436 mRNA. Translation: AAI13437.1.
BC117207 mRNA. Translation: AAI17208.1.
AF168787 Genomic DNA. Translation: AAF43107.1.
CCDSiCCDS32531.1.
PIRiA53213.
RefSeqiNP_002199.3. NM_002208.4.
UniGeneiHs.513867.

Genome annotation databases

EnsembliENST00000263087; ENSP00000263087; ENSG00000083457.
GeneIDi3682.
KEGGihsa:3682.
UCSCiuc002fwo.4. human.

Polymorphism databases

DMDMi226694184.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25851 mRNA. Translation: AAB59359.2 .
AC116914 Genomic DNA. No translation available.
BC113436 mRNA. Translation: AAI13437.1 .
BC117207 mRNA. Translation: AAI17208.1 .
AF168787 Genomic DNA. Translation: AAF43107.1 .
CCDSi CCDS32531.1.
PIRi A53213.
RefSeqi NP_002199.3. NM_002208.4.
UniGenei Hs.513867.

3D structure databases

ProteinModelPortali P38570.
SMRi P38570. Positions 201-375, 395-1162.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109888. 4 interactions.
IntActi P38570. 1 interaction.
MINTi MINT-1397425.
STRINGi 9606.ENSP00000263087.

PTM databases

PhosphoSitei P38570.

Polymorphism databases

DMDMi 226694184.

Proteomic databases

PaxDbi P38570.
PRIDEi P38570.

Protocols and materials databases

DNASUi 3682.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263087 ; ENSP00000263087 ; ENSG00000083457 .
GeneIDi 3682.
KEGGi hsa:3682.
UCSCi uc002fwo.4. human.

Organism-specific databases

CTDi 3682.
GeneCardsi GC17M003617.
H-InvDB HIX0202464.
HGNCi HGNC:6147. ITGAE.
HPAi CAB026461.
HPA036313.
HPA052147.
MIMi 604682. gene.
neXtProti NX_P38570.
PharmGKBi PA29947.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240019.
HOGENOMi HOG000049185.
HOVERGENi HBG006187.
InParanoidi P38570.
KOi K06524.
OMAi NHRTKIT.
OrthoDBi EOG74TWXT.
PhylomeDBi P38570.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_13552. Integrin cell surface interactions.

Miscellaneous databases

ChiTaRSi ITGAE. human.
GeneWikii ITGAE.
GenomeRNAii 3682.
NextBioi 14411.
PROi P38570.
SOURCEi Search...

Gene expression databases

Bgeei P38570.
CleanExi HS_ITGAE.
Genevestigatori P38570.

Family and domain databases

InterProi IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 4 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS51470. FG_GAP. 5 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution."
    Shaw S.K., Cepek K.L., Murphy E.A., Russell G.J., Brenner M.B., Parker C.M.
    J. Biol. Chem. 269:6016-6025(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-38 AND 179-188, VARIANTS VAL-477; GLN-482 AND ALA-1019.
    Tissue: Leukemia and Lymphocyte.
  2. Parker C.M.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 88-114.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-477; GLN-482 AND ALA-1019.
  5. "The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion."
    Touchman J.W., Anikster Y., Dietrich N.L., Maduro V.V.B., McDowell G., Shotelersuk V., Bouffard G.G., Beckstrom-Sternberg S.M., Gahl W.A., Green E.D.
    Genome Res. 10:165-173(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-1179, VARIANT TRP-950.
    Tissue: Fetal kidney.
  6. Cited for: INTERACTION WITH INTEGRIN BETA-7, INDUCTION.
  7. "The role of alpha and beta chains in ligand recognition by beta 7 integrins."
    Higgins J.M.G., Cernadas M., Tan K., Irie A., Wang J.-H., Takada Y., Brenner M.B.
    J. Biol. Chem. 275:25652-25664(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ASP-208 AND PHE-316.

Entry informationi

Entry nameiITAE_HUMAN
AccessioniPrimary (citable) accession number: P38570
Secondary accession number(s): Q17RS6, Q9NZU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: April 14, 2009
Last modified: September 3, 2014
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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