Reviewed,
UniProtKB/Swiss-Prot P38570 (ITAE_HUMAN)
Last modified
November 25, 2008.
Version 85.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Integrin alpha-E Alternative name(s): Mucosal lymphocyte 1 antigen HML-1 antigen Integrin alpha-IEL CD_antigen=CD103 Cleaved into the following 2 chains: 1- Recommended name: Integrin alpha-E light chain 2- Recommended name: Integrin alpha-E heavy chain | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1179 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. |
| Subunit structure | Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7. |
| Subcellular location | |
| Tissue specificity | Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells. |
| Domain | The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. |
| Sequence similarities | Belongs to the integrin alpha chain family. Contains 5 FG-GAP repeats. Contains 1 VWFA domain. |
Ontologies
Keywords | |
|---|---|
| Biological process | Cell adhesion |
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat Signal Transmembrane |
| Ligand | Calcium Magnesium |
| Molecular function | Integrin Receptor |
| PTM | Cleavage on pair of basic residues Glycoprotein |
| Technical term | Direct protein sequencing |
Gene Ontology (GO) | |
| Biological process | cell adhesion Inferred from electronic annotation. Source: InterPro integrin-mediated signaling pathwayInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integrin complex Ref.1 Traceable author statement. Source: ProtInc |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from electronic annotation. Source: UniProtKB-KW receptor activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 18 | 18 | |||||||||
| Chain | 19 – 1179 | 1161 | Integrin alpha-E | PRO_0000016283 | |||||||
| Chain | 19 – 177 | 159 | Integrin alpha-E light chain | PRO_0000016284 | |||||||
| Chain | 179 – 1177 | 999 | Integrin alpha-E heavy chain | PRO_0000016285 | |||||||
Regions | |||||||||||
| Topological domain | 19 – 1124 | 1106 | Extracellular Potential | ||||||||
| Transmembrane | 1125 – 1147 | 23 | Potential | ||||||||
| Topological domain | 1148 – 1179 | 32 | Cytoplasmic Potential | ||||||||
| Domain | 200 – 391 | 192 | VWFA | ||||||||
| Repeat | 401 – 456 | 56 | FG-GAP 1 | ||||||||
| Repeat | 457 – 506 | 50 | FG-GAP 2 | ||||||||
| Repeat | 510 – 571 | 62 | FG-GAP 3 | ||||||||
| Repeat | 573 – 638 | 66 | FG-GAP 4 | ||||||||
| Repeat | 641 – 693 | 53 | FG-GAP 5 | ||||||||
| Calcium binding | 522 – 530 | 9 | Potential | ||||||||
| Calcium binding | 586 – 594 | 9 | Potential | ||||||||
| Calcium binding | 654 – 662 | 9 | Potential | ||||||||
| Region | 145 – 199 | 55 | X-domain (extra domain) | ||||||||
| Motif | 1150 – 1154 | 5 | GFFKR motif | ||||||||
| Compositional bias | 181 – 198 | 18 | Glu-rich (acidic) | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 49 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 271 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 321 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 444 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 726 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 782 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 857 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 934 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 954 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1065 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1096 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 70 ↔ 79 | By similarity | |||||||||
| Disulfide bond | 126 ↔ 159 | By similarity | |||||||||
| Disulfide bond | 706 ↔ 762 | By similarity | |||||||||
| Disulfide bond | 823 ↔ 829 | By similarity | |||||||||
| Disulfide bond | 893 ↔ 907 | By similarity | |||||||||
| Disulfide bond | 1008 ↔ 1033 | By similarity | |||||||||
| Disulfide bond | 1041 ↔ 1057 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 360 | 1 | D → E | VAR_008884 | |||||||
| Natural variant | 892 | 1 | Q → H: dbSNP rs3744679. | VAR_020037 | |||||||
| Natural variant | 950 | 1 | R → W: dbSNP rs1716. | VAR_034025 | |||||||
| Natural variant | 1041 | 1 | C → S | VAR_008885 | |||||||
Experimental info | |||||||||||
| Mutagenesis | 208 | 1 | D → A: Loss of E-cadherin binding | ||||||||
| Mutagenesis | 316 | 1 | F → A: Loss of E-cadherin binding | ||||||||
| Sequence conflict | 477 | 1 | V → I in AAF43107. Ref.4 | ||||||||
| Sequence conflict | 482 | 1 | Q → R in AAF43107. Ref.4 | ||||||||
| Sequence conflict | 1019 | 1 | A → V in AAF43107. Ref.4 | ||||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution." Shaw S.K., Cepek K.L., Murphy E.A., Russell G.J., Brenner M.B., Parker C.M. J. Biol. Chem. 269:6016-6025(1994) [PubMed: 8119947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-38 AND 179-188. Tissue: Leukemia and Lymphocyte. |
| [2] | Parker C.M. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 88-114. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion." Touchman J.W., Anikster Y., Dietrich N.L., Maduro V.V.B., McDowell G., Shotelersuk V., Bouffard G.G., Beckstrom-Sternberg S.M., Gahl W.A., Green E.D. Genome Res. 10:165-173(2000) [PubMed: 10673275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-1179, VARIANT TRP-950. Tissue: Fetal kidney. |
| [5] | "The role of alpha and beta chains in ligand recognition by beta 7 integrins." Higgins J.M.G., Cernadas M., Tan K., Irie A., Wang J.-H., Takada Y., Brenner M.B. J. Biol. Chem. 275:25652-25664(2000) [PubMed: 10837471] [Abstract] Cited for: MUTAGENESIS OF ASP-208 AND PHE-316. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| L25851 mRNA. Translation: AAB59359.2. BC113436 mRNA. Translation: AAI13437.1. BC117207 mRNA. Translation: AAI17208.1. AF168787 Genomic DNA. Translation: AAF43107.1. | |
| PIR | A53213. |
| RefSeq | NP_002199.3. |
| UniGene | Hs.513867 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BHQ based on UniProtKB P11215. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P38570. |
PTM databases | |
| PhosphoSite | P38570. |
Genome annotation databases | |
| Ensembl | ENSG00000083457. Homo sapiens. [Contig view] |
| GeneID | 3682. |
| KEGG | hsa:3682. |
Organism-specific databases | |
| H-InvDB | HIX0013432. |
| HGNC | HGNC:6147. ITGAE. |
| MIM | 604682. gene. |
| PharmGKB | PA29947. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P38570. |
| HOVERGEN | P38570. |
Gene expression databases | |
| ArrayExpress | P38570. |
| CleanEx | HS_ITGAE. |
| GermOnline | ENSG00000083457. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR013517. FG-GAP. IPR013519. Int_alpha_beta-p. IPR000413. Integrin_alpha. IPR013649. Integrin_alpha-2. IPR013513. Integrin_alpha_C. IPR002035. VWF_A. [Graphical view] |
| Pfam | PF01839. FG-GAP. 2 hits. PF00357. Integrin_alpha. 1 hit. PF08441. Integrin_alpha2. 1 hit. PF00092. VWA. 1 hit. [Graphical view] |
| PRINTS | PR01185. INTEGRINA. PR00453. VWFADOMAIN. |
| SMART | SM00191. Int_alpha. 4 hits. SM00327. VWA. 1 hit. [Graphical view] |
| PROSITE | PS00242. INTEGRIN_ALPHA. 1 hit. PS50234. VWFA. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | P38570. |
| NextBio | 14411. |
| SOURCE | Search... |
Entry information
| Entry name | ITAE_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P38570 Secondary accession number(s): Q17RS6, Q9NZU9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


