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P38570

- ITAE_HUMAN

UniProt

P38570 - ITAE_HUMAN

Protein

Integrin alpha-E

Gene

ITGAE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 3 (14 Apr 2009)
      Previous versions | rss
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    Functioni

    Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi522 – 5309Sequence Analysis
    Calcium bindingi586 – 5949Sequence Analysis
    Calcium bindingi654 – 6629Sequence Analysis

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. extracellular matrix organization Source: Reactome
    3. integrin-mediated signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Magnesium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_13552. Integrin cell surface interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin alpha-E
    Alternative name(s):
    HML-1 antigen
    Integrin alpha-IEL
    Mucosal lymphocyte 1 antigen
    CD_antigen: CD103
    Cleaved into the following 2 chains:
    Gene namesi
    Name:ITGAE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:6147. ITGAE.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. integrin complex Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi208 – 2081D → A: Loss of E-cadherin binding. 1 Publication
    Mutagenesisi316 – 3161F → A: Loss of E-cadherin binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA29947.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18181 PublicationAdd
    BLAST
    Chaini19 – 11791161Integrin alpha-EPRO_0000016283Add
    BLAST
    Chaini19 – 177159Integrin alpha-E light chainPRO_0000016284Add
    BLAST
    Chaini179 – 1177999Integrin alpha-E heavy chainPRO_0000016285Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi70 ↔ 79By similarity
    Disulfide bondi126 ↔ 159By similarity
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi706 ↔ 762By similarity
    Glycosylationi726 – 7261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi782 – 7821N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi823 ↔ 829By similarity
    Glycosylationi857 – 8571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi893 ↔ 907By similarity
    Glycosylationi934 – 9341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi954 – 9541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1008 ↔ 1033By similarity
    Disulfide bondi1041 ↔ 1057By similarity
    Glycosylationi1065 – 10651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1096 – 10961N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP38570.
    PRIDEiP38570.

    PTM databases

    PhosphoSiteiP38570.

    Expressioni

    Tissue specificityi

    Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

    Inductioni

    Integrin alpha-E/beta-7 is induced by TGFB1.1 Publication

    Gene expression databases

    BgeeiP38570.
    CleanExiHS_ITGAE.
    GenevestigatoriP38570.

    Organism-specific databases

    HPAiCAB026461.
    HPA036313.
    HPA052147.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

    Protein-protein interaction databases

    BioGridi109888. 4 interactions.
    IntActiP38570. 1 interaction.
    MINTiMINT-1397425.
    STRINGi9606.ENSP00000263087.

    Structurei

    3D structure databases

    ProteinModelPortaliP38570.
    SMRiP38570. Positions 201-375, 395-1162.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 11241106ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1148 – 117932CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1125 – 114723HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati22 – 7958FG-GAP 1Add
    BLAST
    Repeati80 – 13859FG-GAP 2Add
    BLAST
    Domaini200 – 389190VWFAPROSITE-ProRule annotationAdd
    BLAST
    Repeati390 – 44253FG-GAP 3Add
    BLAST
    Repeati447 – 50155FG-GAP 4Add
    BLAST
    Repeati502 – 56059FG-GAP 5Add
    BLAST
    Repeati563 – 62765FG-GAP 6Add
    BLAST
    Repeati631 – 69161FG-GAP 7Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni145 – 19955X-domain (extra domain)Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1150 – 11545GFFKR motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi181 – 19818Glu-rich (acidic)Add
    BLAST

    Domaini

    The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.Curated
    Contains 7 FG-GAP repeats.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG240019.
    HOGENOMiHOG000049185.
    HOVERGENiHBG006187.
    InParanoidiP38570.
    KOiK06524.
    OMAiNHRTKIT.
    OrthoDBiEOG74TWXT.
    PhylomeDBiP38570.
    TreeFamiTF105391.

    Family and domain databases

    InterProiIPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 4 hits.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    PROSITEiPS51470. FG_GAP. 5 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    PS50234. VWFA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P38570-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWLFHTLLCI ASLALLAAFN VDVARPWLTP KGGAPFVLSS LLHQDPSTNQ     50
    TWLLVTSPRT KRTPGPLHRC SLVQDEILCH PVEHVPIPKG RHRGVTVVRS 100
    HHGVLICIQV LVRRPHSLSS ELTGTCSLLG PDLRPQAQAN FFDLENLLDP 150
    DARVDTGDCY SNKEGGGEDD VNTARQRRAL EKEEEEDKEE EEDEEEEEAG 200
    TEIAIILDGS GSIDPPDFQR AKDFISNMMR NFYEKCFECN FALVQYGGVI 250
    QTEFDLRDSQ DVMASLARVQ NITQVGSVTK TASAMQHVLD SIFTSSHGSR 300
    RKASKVMVVL TDGGIFEDPL NLTTVINSPK MQGVERFAIG VGEEFKSART 350
    ARELNLIASD PDETHAFKVT NYMALDGLLS KLRYNIISME GTVGDALHYQ 400
    LAQIGFSAQI LDERQVLLGA VGAFDWSGGA LLYDTRSRRG RFLNQTAAAA 450
    ADAEAAQYSY LGYAVAVLHK TCSLSYIAGA PRYKHHGAVF ELQKEGREAS 500
    FLPVLEGEQM GSYFGSELCP VDIDMDGSTD FLLVAAPFYH VHGEEGRVYV 550
    YRLSEQDGSF SLARILSGHP GFTNARFGFA MAAMGDLSQD KLTDVAIGAP 600
    LEGFGADDGA SFGSVYIYNG HWDGLSASPS QRIRASTVAP GLQYFGMSMA 650
    GGFDISGDGL ADITVGTLGQ AVVFRSRPVV RLKVSMAFTP SALPIGFNGV 700
    VNVRLCFEIS SVTTASESGL REALLNFTLD VDVGKQRRRL QCSDVRSCLG 750
    CLREWSSGSQ LCEDLLLMPT EGELCEEDCF SNASVKVSYQ LQTPEGQTDH 800
    PQPILDRYTE PFAIFQLPYE KACKNKLFCV AELQLATTVS QQELVVGLTK 850
    ELTLNINLTN SGEDSYMTSM ALNYPRNLQL KRMQKPPSPN IQCDDPQPVA 900
    SVLIMNCRIG HPVLKRSSAH VSVVWQLEEN AFPNRTADIT VTVTNSNERR 950
    SLANETHTLQ FRHGFVAVLS KPSIMYVNTG QGLSHHKEFL FHVHGENLFG 1000
    AEYQLQICVP TKLRGLQVVA VKKLTRTQAS TVCTWSQERA CAYSSVQHVE 1050
    EWHSVSCVIA SDKENVTVAA EISWDHSEEL LKDVTELQIL GEISFNKSLY 1100
    EGLNAENHRT KITVVFLKDE KYHSLPIIIK GSVGGLLVLI VILVILFKCG 1150
    FFKRKYQQLN LESIRKAQLK SENLLEEEN 1179
    Length:1,179
    Mass (Da):130,159
    Last modified:April 14, 2009 - v3
    Checksum:i6645F8FFF9A0F045
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti360 – 3601D → E.
    VAR_008884
    Natural varianti477 – 4771I → V.2 Publications
    Corresponds to variant rs220479 [ dbSNP | Ensembl ].
    VAR_054889
    Natural varianti482 – 4821R → Q.2 Publications
    Corresponds to variant rs2272606 [ dbSNP | Ensembl ].
    VAR_054890
    Natural varianti892 – 8921Q → H.
    Corresponds to variant rs3744679 [ dbSNP | Ensembl ].
    VAR_020037
    Natural varianti950 – 9501R → W.1 Publication
    Corresponds to variant rs1716 [ dbSNP | Ensembl ].
    VAR_034025
    Natural varianti1019 – 10191V → A.2 Publications
    Corresponds to variant rs2976230 [ dbSNP | Ensembl ].
    VAR_054891
    Natural varianti1041 – 10411C → S.
    VAR_008885

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25851 mRNA. Translation: AAB59359.2.
    AC116914 Genomic DNA. No translation available.
    BC113436 mRNA. Translation: AAI13437.1.
    BC117207 mRNA. Translation: AAI17208.1.
    AF168787 Genomic DNA. Translation: AAF43107.1.
    CCDSiCCDS32531.1.
    PIRiA53213.
    RefSeqiNP_002199.3. NM_002208.4.
    UniGeneiHs.513867.

    Genome annotation databases

    EnsembliENST00000263087; ENSP00000263087; ENSG00000083457.
    GeneIDi3682.
    KEGGihsa:3682.
    UCSCiuc002fwo.4. human.

    Polymorphism databases

    DMDMi226694184.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25851 mRNA. Translation: AAB59359.2 .
    AC116914 Genomic DNA. No translation available.
    BC113436 mRNA. Translation: AAI13437.1 .
    BC117207 mRNA. Translation: AAI17208.1 .
    AF168787 Genomic DNA. Translation: AAF43107.1 .
    CCDSi CCDS32531.1.
    PIRi A53213.
    RefSeqi NP_002199.3. NM_002208.4.
    UniGenei Hs.513867.

    3D structure databases

    ProteinModelPortali P38570.
    SMRi P38570. Positions 201-375, 395-1162.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109888. 4 interactions.
    IntActi P38570. 1 interaction.
    MINTi MINT-1397425.
    STRINGi 9606.ENSP00000263087.

    PTM databases

    PhosphoSitei P38570.

    Polymorphism databases

    DMDMi 226694184.

    Proteomic databases

    PaxDbi P38570.
    PRIDEi P38570.

    Protocols and materials databases

    DNASUi 3682.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263087 ; ENSP00000263087 ; ENSG00000083457 .
    GeneIDi 3682.
    KEGGi hsa:3682.
    UCSCi uc002fwo.4. human.

    Organism-specific databases

    CTDi 3682.
    GeneCardsi GC17M003617.
    H-InvDB HIX0202464.
    HGNCi HGNC:6147. ITGAE.
    HPAi CAB026461.
    HPA036313.
    HPA052147.
    MIMi 604682. gene.
    neXtProti NX_P38570.
    PharmGKBi PA29947.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240019.
    HOGENOMi HOG000049185.
    HOVERGENi HBG006187.
    InParanoidi P38570.
    KOi K06524.
    OMAi NHRTKIT.
    OrthoDBi EOG74TWXT.
    PhylomeDBi P38570.
    TreeFami TF105391.

    Enzyme and pathway databases

    Reactomei REACT_13552. Integrin cell surface interactions.

    Miscellaneous databases

    ChiTaRSi ITGAE. human.
    GeneWikii ITGAE.
    GenomeRNAii 3682.
    NextBioi 14411.
    PROi P38570.
    SOURCEi Search...

    Gene expression databases

    Bgeei P38570.
    CleanExi HS_ITGAE.
    Genevestigatori P38570.

    Family and domain databases

    InterProi IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 4 hits.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    PROSITEi PS51470. FG_GAP. 5 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution."
      Shaw S.K., Cepek K.L., Murphy E.A., Russell G.J., Brenner M.B., Parker C.M.
      J. Biol. Chem. 269:6016-6025(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-38 AND 179-188, VARIANTS VAL-477; GLN-482 AND ALA-1019.
      Tissue: Leukemia and Lymphocyte.
    2. Parker C.M.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 88-114.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-477; GLN-482 AND ALA-1019.
    5. "The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion."
      Touchman J.W., Anikster Y., Dietrich N.L., Maduro V.V.B., McDowell G., Shotelersuk V., Bouffard G.G., Beckstrom-Sternberg S.M., Gahl W.A., Green E.D.
      Genome Res. 10:165-173(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-1179, VARIANT TRP-950.
      Tissue: Fetal kidney.
    6. Cited for: INTERACTION WITH INTEGRIN BETA-7, INDUCTION.
    7. "The role of alpha and beta chains in ligand recognition by beta 7 integrins."
      Higgins J.M.G., Cernadas M., Tan K., Irie A., Wang J.-H., Takada Y., Brenner M.B.
      J. Biol. Chem. 275:25652-25664(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF ASP-208 AND PHE-316.

    Entry informationi

    Entry nameiITAE_HUMAN
    AccessioniPrimary (citable) accession number: P38570
    Secondary accession number(s): Q17RS6, Q9NZU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 145 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3