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P38570 (ITAE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 143. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integrin alpha-E
Alternative name(s):
HML-1 antigen
Integrin alpha-IEL
Mucosal lymphocyte 1 antigen
CD_antigen=CD103
Gene names
Name:ITGAE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1179 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

Subunit structure

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

Induction

Integrin alpha-E/beta-7 is induced by TGFB1. Ref.6

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similarities

Belongs to the integrin alpha chain family.

Contains 7 FG-GAP repeats.

Contains 1 VWFA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Ref.1
Chain19 – 11791161Integrin alpha-E
PRO_0000016283
Chain19 – 177159Integrin alpha-E light chain
PRO_0000016284
Chain179 – 1177999Integrin alpha-E heavy chain
PRO_0000016285

Regions

Topological domain19 – 11241106Extracellular Potential
Transmembrane1125 – 114723Helical; Potential
Topological domain1148 – 117932Cytoplasmic Potential
Repeat22 – 7958FG-GAP 1
Repeat80 – 13859FG-GAP 2
Domain200 – 389190VWFA
Repeat390 – 44253FG-GAP 3
Repeat447 – 50155FG-GAP 4
Repeat502 – 56059FG-GAP 5
Repeat563 – 62765FG-GAP 6
Repeat631 – 69161FG-GAP 7
Calcium binding522 – 5309 Potential
Calcium binding586 – 5949 Potential
Calcium binding654 – 6629 Potential
Region145 – 19955X-domain (extra domain)
Motif1150 – 11545GFFKR motif
Compositional bias181 – 19818Glu-rich (acidic)

Amino acid modifications

Glycosylation491N-linked (GlcNAc...) Potential
Glycosylation2711N-linked (GlcNAc...) Potential
Glycosylation3211N-linked (GlcNAc...) Potential
Glycosylation4441N-linked (GlcNAc...) Potential
Glycosylation7261N-linked (GlcNAc...) Potential
Glycosylation7821N-linked (GlcNAc...) Potential
Glycosylation8571N-linked (GlcNAc...) Potential
Glycosylation9341N-linked (GlcNAc...) Potential
Glycosylation9541N-linked (GlcNAc...) Potential
Glycosylation10651N-linked (GlcNAc...) Potential
Glycosylation10961N-linked (GlcNAc...) Potential
Disulfide bond70 ↔ 79 By similarity
Disulfide bond126 ↔ 159 By similarity
Disulfide bond706 ↔ 762 By similarity
Disulfide bond823 ↔ 829 By similarity
Disulfide bond893 ↔ 907 By similarity
Disulfide bond1008 ↔ 1033 By similarity
Disulfide bond1041 ↔ 1057 By similarity

Natural variations

Natural variant3601D → E.
VAR_008884
Natural variant4771I → V. Ref.1 Ref.4
Corresponds to variant rs220479 [ dbSNP | Ensembl ].
VAR_054889
Natural variant4821R → Q. Ref.1 Ref.4
Corresponds to variant rs2272606 [ dbSNP | Ensembl ].
VAR_054890
Natural variant8921Q → H.
Corresponds to variant rs3744679 [ dbSNP | Ensembl ].
VAR_020037
Natural variant9501R → W. Ref.5
Corresponds to variant rs1716 [ dbSNP | Ensembl ].
VAR_034025
Natural variant10191V → A. Ref.1 Ref.4
Corresponds to variant rs2976230 [ dbSNP | Ensembl ].
VAR_054891
Natural variant10411C → S.
VAR_008885

Experimental info

Mutagenesis2081D → A: Loss of E-cadherin binding. Ref.7
Mutagenesis3161F → A: Loss of E-cadherin binding. Ref.7

Sequences

Sequence LengthMass (Da)Tools
P38570 [UniParc].

Last modified April 14, 2009. Version 3.
Checksum: 6645F8FFF9A0F045

FASTA1,179130,159
        10         20         30         40         50         60 
MWLFHTLLCI ASLALLAAFN VDVARPWLTP KGGAPFVLSS LLHQDPSTNQ TWLLVTSPRT 

        70         80         90        100        110        120 
KRTPGPLHRC SLVQDEILCH PVEHVPIPKG RHRGVTVVRS HHGVLICIQV LVRRPHSLSS 

       130        140        150        160        170        180 
ELTGTCSLLG PDLRPQAQAN FFDLENLLDP DARVDTGDCY SNKEGGGEDD VNTARQRRAL 

       190        200        210        220        230        240 
EKEEEEDKEE EEDEEEEEAG TEIAIILDGS GSIDPPDFQR AKDFISNMMR NFYEKCFECN 

       250        260        270        280        290        300 
FALVQYGGVI QTEFDLRDSQ DVMASLARVQ NITQVGSVTK TASAMQHVLD SIFTSSHGSR 

       310        320        330        340        350        360 
RKASKVMVVL TDGGIFEDPL NLTTVINSPK MQGVERFAIG VGEEFKSART ARELNLIASD 

       370        380        390        400        410        420 
PDETHAFKVT NYMALDGLLS KLRYNIISME GTVGDALHYQ LAQIGFSAQI LDERQVLLGA 

       430        440        450        460        470        480 
VGAFDWSGGA LLYDTRSRRG RFLNQTAAAA ADAEAAQYSY LGYAVAVLHK TCSLSYIAGA 

       490        500        510        520        530        540 
PRYKHHGAVF ELQKEGREAS FLPVLEGEQM GSYFGSELCP VDIDMDGSTD FLLVAAPFYH 

       550        560        570        580        590        600 
VHGEEGRVYV YRLSEQDGSF SLARILSGHP GFTNARFGFA MAAMGDLSQD KLTDVAIGAP 

       610        620        630        640        650        660 
LEGFGADDGA SFGSVYIYNG HWDGLSASPS QRIRASTVAP GLQYFGMSMA GGFDISGDGL 

       670        680        690        700        710        720 
ADITVGTLGQ AVVFRSRPVV RLKVSMAFTP SALPIGFNGV VNVRLCFEIS SVTTASESGL 

       730        740        750        760        770        780 
REALLNFTLD VDVGKQRRRL QCSDVRSCLG CLREWSSGSQ LCEDLLLMPT EGELCEEDCF 

       790        800        810        820        830        840 
SNASVKVSYQ LQTPEGQTDH PQPILDRYTE PFAIFQLPYE KACKNKLFCV AELQLATTVS 

       850        860        870        880        890        900 
QQELVVGLTK ELTLNINLTN SGEDSYMTSM ALNYPRNLQL KRMQKPPSPN IQCDDPQPVA 

       910        920        930        940        950        960 
SVLIMNCRIG HPVLKRSSAH VSVVWQLEEN AFPNRTADIT VTVTNSNERR SLANETHTLQ 

       970        980        990       1000       1010       1020 
FRHGFVAVLS KPSIMYVNTG QGLSHHKEFL FHVHGENLFG AEYQLQICVP TKLRGLQVVA 

      1030       1040       1050       1060       1070       1080 
VKKLTRTQAS TVCTWSQERA CAYSSVQHVE EWHSVSCVIA SDKENVTVAA EISWDHSEEL 

      1090       1100       1110       1120       1130       1140 
LKDVTELQIL GEISFNKSLY EGLNAENHRT KITVVFLKDE KYHSLPIIIK GSVGGLLVLI 

      1150       1160       1170 
VILVILFKCG FFKRKYQQLN LESIRKAQLK SENLLEEEN 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution."
Shaw S.K., Cepek K.L., Murphy E.A., Russell G.J., Brenner M.B., Parker C.M.
J. Biol. Chem. 269:6016-6025(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-38 AND 179-188, VARIANTS VAL-477; GLN-482 AND ALA-1019.
Tissue: Leukemia and Lymphocyte.
[2]Parker C.M.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 88-114.
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-477; GLN-482 AND ALA-1019.
[5]"The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion."
Touchman J.W., Anikster Y., Dietrich N.L., Maduro V.V.B., McDowell G., Shotelersuk V., Bouffard G.G., Beckstrom-Sternberg S.M., Gahl W.A., Green E.D.
Genome Res. 10:165-173(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-1179, VARIANT TRP-950.
Tissue: Fetal kidney.
[6]"A family of beta 7 integrins on human mucosal lymphocytes."
Parker C.M., Cepek K.L., Russell G.J., Shaw S.K., Posnett D.N., Schwarting R., Brenner M.B.
Proc. Natl. Acad. Sci. U.S.A. 89:1924-1928(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH INTEGRIN BETA-7, INDUCTION.
[7]"The role of alpha and beta chains in ligand recognition by beta 7 integrins."
Higgins J.M.G., Cernadas M., Tan K., Irie A., Wang J.-H., Takada Y., Brenner M.B.
J. Biol. Chem. 275:25652-25664(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS OF ASP-208 AND PHE-316.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L25851 mRNA. Translation: AAB59359.2.
AC116914 Genomic DNA. No translation available.
BC113436 mRNA. Translation: AAI13437.1.
BC117207 mRNA. Translation: AAI17208.1.
AF168787 Genomic DNA. Translation: AAF43107.1.
CCDSCCDS32531.1.
PIRA53213.
RefSeqNP_002199.3. NM_002208.4.
UniGeneHs.513867.

3D structure databases

ProteinModelPortalP38570.
SMRP38570. Positions 201-375, 395-1162.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109888. 4 interactions.
IntActP38570. 1 interaction.
MINTMINT-1397425.
STRING9606.ENSP00000263087.

PTM databases

PhosphoSiteP38570.

Polymorphism databases

DMDM226694184.

Proteomic databases

PaxDbP38570.
PRIDEP38570.

Protocols and materials databases

DNASU3682.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263087; ENSP00000263087; ENSG00000083457.
GeneID3682.
KEGGhsa:3682.
UCSCuc002fwo.4. human.

Organism-specific databases

CTD3682.
GeneCardsGC17M003617.
H-InvDBHIX0202464.
HGNCHGNC:6147. ITGAE.
HPACAB026461.
HPA036313.
HPA052147.
MIM604682. gene.
neXtProtNX_P38570.
PharmGKBPA29947.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG240019.
HOGENOMHOG000049185.
HOVERGENHBG006187.
InParanoidP38570.
KOK06524.
OMANHRTKIT.
OrthoDBEOG74TWXT.
PhylomeDBP38570.
TreeFamTF105391.

Enzyme and pathway databases

ReactomeREACT_118779. Extracellular matrix organization.

Gene expression databases

BgeeP38570.
CleanExHS_ITGAE.
GenevestigatorP38570.

Family and domain databases

InterProIPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamPF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 4 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF53300. SSF53300. 1 hit.
PROSITEPS51470. FG_GAP. 5 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSITGAE. human.
GeneWikiITGAE.
GenomeRNAi3682.
NextBio14411.
PROP38570.
SOURCESearch...

Entry information

Entry nameITAE_HUMAN
AccessionPrimary (citable) accession number: P38570
Secondary accession number(s): Q17RS6, Q9NZU9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: April 14, 2009
Last modified: July 9, 2014
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries