Reviewed, UniProtKB/Swiss-Prot P38569 (PGM_ACEXY)

Names and origin

Protein names

Recommended name:
    Phosphoglucomutase
      Short name=PGM
    EC=5.4.2.2
Alternative name(s):
    Glucose phosphomutase

Gene names

Name:

celB

Organism

Acetobacter xylinus (Gluconacetobacter xylinus)

Taxonomic identifier

28448 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Gluconacetobacter

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme participates in both the breakdown and synthesis of glucose.
Catalytic activity	Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglucomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 555	555	Phosphoglucomutase		PRO_0000147807
Sites
	Active site	148	1	Phosphoserine intermediate By similarity
	Metal binding	148	1	Magnesium; via phosphate group By similarity
	Metal binding	306	1	Magnesium By similarity
	Metal binding	308	1	Magnesium By similarity
	Metal binding	310	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	P38569-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: C67D1475AD4A9E8D	FASTA	555	59,634
	10 20 30 40 50 60 MPSISPFAGK PVDPDRLVNI DALLDAYYTR KPDPAIATQR VAFGTSGHRG SSLTTSFNEN 70 80 90 100 110 120 HILSISQAIA DYRKGAGITG PLFIGIDTHA LSRPALKSAL EVFAANGVEV RIDAQDGYTP 130 140 150 160 170 180 TPVISHAILT YNRDRSSDLA DGVVITPSHN PPEDGGYKYN PPHGGPADTD ITKVVETAAN 190 200 210 220 230 240 DYMAKKMEGV KRVSFEDALK APTTKRHDYI TPYVDDLAAV VDMDVIRESG VSIGIDPLGG 250 260 270 280 290 300 AAVDYWQPII DKYGINATIV SKEVDPTFRF MTADWDGQIR MDCSSPYAMA RLVGMKDKFD 310 320 330 340 350 360 IAFANDTDAD RHGIVSGKYG LMNPNHYLAV AIEYLFNNRE NWNASAGVGK TVVSSSMIDR 370 380 390 400 410 420 VAKEIGRKLV EVPVGFKWFV DGLYNGTLGF GGEESAGASF LRRAGTVWST DKDGIILGLL 430 440 450 460 470 480 AAEITARTKR TPGAAYEDMT RRLGTPYYAR IDAPADPEQK AILKNLSPEQ IGMTELAGEP 490 500 510 520 530 540 ILSTLTNAPG NGAAIGGLKV SAKDGWFAAR PSGTENVYKI YAESFKSAAH LKAIQTEAQD 550 AISALFAKAA QKNAG

References

[1]	"Nucleotide sequence and expression analysis of the Acetobacter xylinum phosphoglucomutase gene." Brautaset T., Standal R., Fjaervik E., Valla S. Microbiology 140:1183-1188(1994) [PubMed: 8025683] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 23768 / NCIB 7029.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L24077 Genomic DNA. Translation: AAA21561.1.
PIR	I39487.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005852. PGlcMutase_a-D-Glc-sp. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 2 hits.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
TIGRFAMs	TIGR01132. pgm. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGM_ACEXY

Accession

Primary (citable) accession number: P38569

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)