ID   MUCB1_XENLA             Reviewed;         398 AA.
AC   P38565;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   22-FEB-2023, entry version 83.
DE   RecName: Full=Integumentary mucin B.1;
DE   AltName: Full=FIM-B.1;
DE   Flags: Fragment;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2207068; DOI=10.1021/bi00478a018;
RA   Probst J.C., Gertzen E.-M., Hoffmann W.;
RT   "An integumentary mucin (FIM-B.1) from Xenopus laevis homologous with von
RT   Willebrand factor.";
RL   Biochemistry 29:6240-6244(1990).
CC   -!- FUNCTION: Could be involved in defense against microbial infections.
CC       Protects the epithelia from external environment.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed and stored exclusively in mature mucous
CC       glands of the skin.
CC   -!- PTM: Extensively O-glycosylated.
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DR   EMBL; J02910; AAA49711.1; -; mRNA.
DR   PIR; A35281; A35281.
DR   AlphaFoldDB; P38565; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001007; VWF_dom.
DR   PANTHER; PTHR47246; MUCIN-19; 1.
DR   PANTHER; PTHR47246:SF1; MUCIN-19; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00041; CT; 1.
DR   SMART; SM00214; VWC; 2.
DR   SUPFAM; SSF57603; FnI-like domain; 1.
DR   PROSITE; PS01185; CTCK_1; 1.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS01208; VWFC_1; 1.
DR   PROSITE; PS50184; VWFC_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Repeat; Secreted.
FT   CHAIN           <1..398
FT                   /note="Integumentary mucin B.1"
FT                   /id="PRO_0000158961"
FT   REPEAT          <1..7
FT                   /note="1"
FT   REPEAT          8..18
FT                   /note="2"
FT   REPEAT          19..29
FT                   /note="3"
FT   REPEAT          30..40
FT                   /note="4"
FT   REPEAT          41..51
FT                   /note="5"
FT   REPEAT          52..62
FT                   /note="6"
FT   REPEAT          66..76
FT                   /note="7"
FT   REPEAT          83..93
FT                   /note="8"
FT   DOMAIN          169..234
FT                   /note="VWFC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT   DOMAIN          301..392
FT                   /note="CTCK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   REGION          1..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1..93
FT                   /note="8 X 11 AA tandem repeats of G-E-S-T-P-A-P-S-E-T-T"
FT   COMPBIAS        1..92
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        301..356
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        323..370
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        332..386
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        336..388
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        ?..391
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   NON_TER         1
SQ   SEQUENCE   398 AA;  42101 MW;  C06C86A805A3C3A4 CRC64;
     PAPSETTGES TPAPSETTGE STPAPSETTG ESTPAPSETT GESTPAPSET TGESTPAPSE
     TTVPSGESTP APSETTVPSV PSGESTPAPS ETTELRIIPP EVSTVAVPVT TGQITPAVTT
     EHSTEEILTL PPPVVGPVLP AKPTVDISKY TNTTTTKSTV PTTTIPPKAT CCGSSGESVQ
     AGHMWQTGCD VCTCNGTSGK TQCAPRQCEK EIICKSDERR VLRKPGKSCC GYCEPLTCKH
     NGTEYKLGAT FIDKSNPCIT YRCDASGLTV NVKSCPNEQV CSKSERTYDS DGCCFSCDTS
     CKPVPATVGI QGEYDYQNEK TNCSANIIMA KCSGQCQHKL TYDTIDNKVV TKCRCCKADR
     VEPRKAHLVC DNGKKKIYKY KHITSCKCTS CTAYNIRL
//