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P38565 (MUCB1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integumentary mucin B.1
Alternative name(s):
FIM-B.1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length398 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Could be involved in defense against microbial infections. Protects the epithelia from external environment.

Subcellular location

Secreted.

Tissue specificity

Expressed and stored exclusively in mature mucous glands of the skin.

Post-translational modification

Extensively O-glycosylated.

Sequence similarities

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 VWFC domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 398›398Integumentary mucin B.1
PRO_0000158961

Regions

Repeat‹1 – 7›71
Repeat8 – 18112
Repeat19 – 29113
Repeat30 – 40114
Repeat41 – 51115
Repeat52 – 62116
Repeat66 – 76117
Repeat83 – 93118
Domain169 – 23466VWFC
Domain301 – 39292CTCK
Region1 – 93938 X 11 AA tandem repeats of G-E-S-T-P-A-P-S-E-T-T

Amino acid modifications

Disulfide bond301 ↔ 356 By similarity
Disulfide bond323 ↔ 370 By similarity
Disulfide bond332 ↔ 386 By similarity
Disulfide bond336 ↔ 388 By similarity
Disulfide bond? ↔ 391 By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P38565 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: C06C86A805A3C3A4

FASTA39842,101
        10         20         30         40         50         60 
PAPSETTGES TPAPSETTGE STPAPSETTG ESTPAPSETT GESTPAPSET TGESTPAPSE 

        70         80         90        100        110        120 
TTVPSGESTP APSETTVPSV PSGESTPAPS ETTELRIIPP EVSTVAVPVT TGQITPAVTT 

       130        140        150        160        170        180 
EHSTEEILTL PPPVVGPVLP AKPTVDISKY TNTTTTKSTV PTTTIPPKAT CCGSSGESVQ 

       190        200        210        220        230        240 
AGHMWQTGCD VCTCNGTSGK TQCAPRQCEK EIICKSDERR VLRKPGKSCC GYCEPLTCKH 

       250        260        270        280        290        300 
NGTEYKLGAT FIDKSNPCIT YRCDASGLTV NVKSCPNEQV CSKSERTYDS DGCCFSCDTS 

       310        320        330        340        350        360 
CKPVPATVGI QGEYDYQNEK TNCSANIIMA KCSGQCQHKL TYDTIDNKVV TKCRCCKADR 

       370        380        390 
VEPRKAHLVC DNGKKKIYKY KHITSCKCTS CTAYNIRL 

« Hide

References

[1]"An integumentary mucin (FIM-B.1) from Xenopus laevis homologous with von Willebrand factor."
Probst J.C., Gertzen E.-M., Hoffmann W.
Biochemistry 29:6240-6244(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02910 mRNA. Translation: AAA49711.1.
PIRA35281.
UniGeneXl.785.

3D structure databases

ProteinModelPortalP38565.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

XenbaseXB-GENE-6252375. muc19.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR001007. VWF_C.
[Graphical view]
PfamPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTSM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
[Graphical view]
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUCB1_XENLA
AccessionPrimary (citable) accession number: P38565
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families