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P38565

- MUCB1_XENLA

UniProt

P38565 - MUCB1_XENLA

Protein

Integumentary mucin B.1

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    • Comment

    Functioni

    Could be involved in defense against microbial infections. Protects the epithelia from external environment.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integumentary mucin B.1
    Alternative name(s):
    FIM-B.1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6252375. muc19.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 398›398Integumentary mucin B.1PRO_0000158961Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi? ↔ 391PROSITE-ProRule annotation
    Disulfide bondi301 ↔ 356PROSITE-ProRule annotation
    Disulfide bondi323 ↔ 370PROSITE-ProRule annotation
    Disulfide bondi332 ↔ 386PROSITE-ProRule annotation
    Disulfide bondi336 ↔ 388PROSITE-ProRule annotation

    Post-translational modificationi

    Extensively O-glycosylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed and stored exclusively in mature mucous glands of the skin.

    Structurei

    3D structure databases

    ProteinModelPortaliP38565.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati‹1 – 7›71
    Repeati8 – 18112Add
    BLAST
    Repeati19 – 29113Add
    BLAST
    Repeati30 – 40114Add
    BLAST
    Repeati41 – 51115Add
    BLAST
    Repeati52 – 62116Add
    BLAST
    Repeati66 – 76117Add
    BLAST
    Repeati83 – 93118Add
    BLAST
    Domaini169 – 23466VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini301 – 39292CTCKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 93938 X 11 AA tandem repeats of G-E-S-T-P-A-P-S-E-T-TAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00007. Cys_knot. 1 hit.
    [Graphical view]
    SMARTiSM00041. CT. 1 hit.
    SM00214. VWC. 2 hits.
    [Graphical view]
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P38565-1 [UniParc]FASTAAdd to Basket

    « Hide

    PAPSETTGES TPAPSETTGE STPAPSETTG ESTPAPSETT GESTPAPSET    50
    TGESTPAPSE TTVPSGESTP APSETTVPSV PSGESTPAPS ETTELRIIPP 100
    EVSTVAVPVT TGQITPAVTT EHSTEEILTL PPPVVGPVLP AKPTVDISKY 150
    TNTTTTKSTV PTTTIPPKAT CCGSSGESVQ AGHMWQTGCD VCTCNGTSGK 200
    TQCAPRQCEK EIICKSDERR VLRKPGKSCC GYCEPLTCKH NGTEYKLGAT 250
    FIDKSNPCIT YRCDASGLTV NVKSCPNEQV CSKSERTYDS DGCCFSCDTS 300
    CKPVPATVGI QGEYDYQNEK TNCSANIIMA KCSGQCQHKL TYDTIDNKVV 350
    TKCRCCKADR VEPRKAHLVC DNGKKKIYKY KHITSCKCTS CTAYNIRL 398
    Length:398
    Mass (Da):42,101
    Last modified:October 1, 1994 - v1
    Checksum:iC06C86A805A3C3A4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02910 mRNA. Translation: AAA49711.1.
    PIRiA35281.
    UniGeneiXl.785.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02910 mRNA. Translation: AAA49711.1 .
    PIRi A35281.
    UniGenei Xl.785.

    3D structure databases

    ProteinModelPortali P38565.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Xenbasei XB-GENE-6252375. muc19.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00007. Cys_knot. 1 hit.
    [Graphical view ]
    SMARTi SM00041. CT. 1 hit.
    SM00214. VWC. 2 hits.
    [Graphical view ]
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An integumentary mucin (FIM-B.1) from Xenopus laevis homologous with von Willebrand factor."
      Probst J.C., Gertzen E.-M., Hoffmann W.
      Biochemistry 29:6240-6244(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiMUCB1_XENLA
    AccessioniPrimary (citable) accession number: P38565
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3