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Protein

Integumentary mucin B.1

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Could be involved in defense against microbial infections. Protects the epithelia from external environment.

Names & Taxonomyi

Protein namesi
Recommended name:
Integumentary mucin B.1
Alternative name(s):
FIM-B.1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000158961‹1 – 398Integumentary mucin B.1Add BLAST›398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi? ↔ 391PROSITE-ProRule annotation
Disulfide bondi301 ↔ 356PROSITE-ProRule annotation
Disulfide bondi323 ↔ 370PROSITE-ProRule annotation
Disulfide bondi332 ↔ 386PROSITE-ProRule annotation
Disulfide bondi336 ↔ 388PROSITE-ProRule annotation

Post-translational modificationi

Extensively O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed and stored exclusively in mature mucous glands of the skin.

Structurei

3D structure databases

ProteinModelPortaliP38565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati‹1 – 71›7
Repeati8 – 182Add BLAST11
Repeati19 – 293Add BLAST11
Repeati30 – 404Add BLAST11
Repeati41 – 515Add BLAST11
Repeati52 – 626Add BLAST11
Repeati66 – 767Add BLAST11
Repeati83 – 938Add BLAST11
Domaini169 – 234VWFCPROSITE-ProRule annotationAdd BLAST66
Domaini301 – 392CTCKPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 938 X 11 AA tandem repeats of G-E-S-T-P-A-P-S-E-T-TAdd BLAST93

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
[Graphical view]
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P38565-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PAPSETTGES TPAPSETTGE STPAPSETTG ESTPAPSETT GESTPAPSET
60 70 80 90 100
TGESTPAPSE TTVPSGESTP APSETTVPSV PSGESTPAPS ETTELRIIPP
110 120 130 140 150
EVSTVAVPVT TGQITPAVTT EHSTEEILTL PPPVVGPVLP AKPTVDISKY
160 170 180 190 200
TNTTTTKSTV PTTTIPPKAT CCGSSGESVQ AGHMWQTGCD VCTCNGTSGK
210 220 230 240 250
TQCAPRQCEK EIICKSDERR VLRKPGKSCC GYCEPLTCKH NGTEYKLGAT
260 270 280 290 300
FIDKSNPCIT YRCDASGLTV NVKSCPNEQV CSKSERTYDS DGCCFSCDTS
310 320 330 340 350
CKPVPATVGI QGEYDYQNEK TNCSANIIMA KCSGQCQHKL TYDTIDNKVV
360 370 380 390
TKCRCCKADR VEPRKAHLVC DNGKKKIYKY KHITSCKCTS CTAYNIRL
Length:398
Mass (Da):42,101
Last modified:October 1, 1994 - v1
Checksum:iC06C86A805A3C3A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02910 mRNA. Translation: AAA49711.1.
PIRiA35281.
UniGeneiXl.785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02910 mRNA. Translation: AAA49711.1.
PIRiA35281.
UniGeneiXl.785.

3D structure databases

ProteinModelPortaliP38565.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
[Graphical view]
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUCB1_XENLA
AccessioniPrimary (citable) accession number: P38565
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 13, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.