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P38565

- MUCB1_XENLA

UniProt

P38565 - MUCB1_XENLA

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Protein

Integumentary mucin B.1

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Could be involved in defense against microbial infections. Protects the epithelia from external environment.

Names & Taxonomyi

Protein namesi
Recommended name:
Integumentary mucin B.1
Alternative name(s):
FIM-B.1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252375. muc19.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 398›398Integumentary mucin B.1PRO_0000158961Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 391PROSITE-ProRule annotation
Disulfide bondi301 ↔ 356PROSITE-ProRule annotation
Disulfide bondi323 ↔ 370PROSITE-ProRule annotation
Disulfide bondi332 ↔ 386PROSITE-ProRule annotation
Disulfide bondi336 ↔ 388PROSITE-ProRule annotation

Post-translational modificationi

Extensively O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed and stored exclusively in mature mucous glands of the skin.

Structurei

3D structure databases

ProteinModelPortaliP38565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati‹1 – 7›71
Repeati8 – 18112Add
BLAST
Repeati19 – 29113Add
BLAST
Repeati30 – 40114Add
BLAST
Repeati41 – 51115Add
BLAST
Repeati52 – 62116Add
BLAST
Repeati66 – 76117Add
BLAST
Repeati83 – 93118Add
BLAST
Domaini169 – 23466VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini301 – 39292CTCKPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 93938 X 11 AA tandem repeats of G-E-S-T-P-A-P-S-E-T-TAdd
BLAST

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
[Graphical view]
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P38565-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
PAPSETTGES TPAPSETTGE STPAPSETTG ESTPAPSETT GESTPAPSET
60 70 80 90 100
TGESTPAPSE TTVPSGESTP APSETTVPSV PSGESTPAPS ETTELRIIPP
110 120 130 140 150
EVSTVAVPVT TGQITPAVTT EHSTEEILTL PPPVVGPVLP AKPTVDISKY
160 170 180 190 200
TNTTTTKSTV PTTTIPPKAT CCGSSGESVQ AGHMWQTGCD VCTCNGTSGK
210 220 230 240 250
TQCAPRQCEK EIICKSDERR VLRKPGKSCC GYCEPLTCKH NGTEYKLGAT
260 270 280 290 300
FIDKSNPCIT YRCDASGLTV NVKSCPNEQV CSKSERTYDS DGCCFSCDTS
310 320 330 340 350
CKPVPATVGI QGEYDYQNEK TNCSANIIMA KCSGQCQHKL TYDTIDNKVV
360 370 380 390
TKCRCCKADR VEPRKAHLVC DNGKKKIYKY KHITSCKCTS CTAYNIRL
Length:398
Mass (Da):42,101
Last modified:October 1, 1994 - v1
Checksum:iC06C86A805A3C3A4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02910 mRNA. Translation: AAA49711.1.
PIRiA35281.
UniGeneiXl.785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02910 mRNA. Translation: AAA49711.1 .
PIRi A35281.
UniGenei Xl.785.

3D structure databases

ProteinModelPortali P38565.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Xenbasei XB-GENE-6252375. muc19.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00007. Cys_knot. 1 hit.
[Graphical view ]
SMARTi SM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
[Graphical view ]
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "An integumentary mucin (FIM-B.1) from Xenopus laevis homologous with von Willebrand factor."
    Probst J.C., Gertzen E.-M., Hoffmann W.
    Biochemistry 29:6240-6244(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiMUCB1_XENLA
AccessioniPrimary (citable) accession number: P38565
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3