P38565 (MUCB1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Integumentary mucin B.1 Alternative name(s): FIM-B.1
Organism	Xenopus laevis (African clawed frog)
Taxonomic identifier	8355 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	398 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Could be involved in defense against microbial infections. Protects the epithelia from external environment.
Subcellular location	Secreted.
Tissue specificity	Expressed and stored exclusively in mature mucous glands of the skin.
Post-translational modification	Extensively O-glycosylated.
Sequence similarities	Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 VWFC domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Repeat
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 398	›398	Integumentary mucin B.1		PRO_0000158961
Regions
	Repeat	‹1 – 7	›7	1
	Repeat	8 – 18	11	2
	Repeat	19 – 29	11	3
	Repeat	30 – 40	11	4
	Repeat	41 – 51	11	5
	Repeat	52 – 62	11	6
	Repeat	66 – 76	11	7
	Repeat	83 – 93	11	8
	Domain	169 – 234	66	VWFC
	Domain	301 – 392	92	CTCK
	Region	1 – 93	93	8 X 11 AA tandem repeats of G-E-S-T-P-A-P-S-E-T-T
Amino acid modifications
	Disulfide bond	301 ↔ 356		By similarity
	Disulfide bond	323 ↔ 370		By similarity
	Disulfide bond	332 ↔ 386		By similarity
	Disulfide bond	336 ↔ 388		By similarity
	Disulfide bond	? ↔ 391		By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P38565 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: C06C86A805A3C3A4	FASTA	398	42,101
	10 20 30 40 50 60 PAPSETTGES TPAPSETTGE STPAPSETTG ESTPAPSETT GESTPAPSET TGESTPAPSE 70 80 90 100 110 120 TTVPSGESTP APSETTVPSV PSGESTPAPS ETTELRIIPP EVSTVAVPVT TGQITPAVTT 130 140 150 160 170 180 EHSTEEILTL PPPVVGPVLP AKPTVDISKY TNTTTTKSTV PTTTIPPKAT CCGSSGESVQ 190 200 210 220 230 240 AGHMWQTGCD VCTCNGTSGK TQCAPRQCEK EIICKSDERR VLRKPGKSCC GYCEPLTCKH 250 260 270 280 290 300 NGTEYKLGAT FIDKSNPCIT YRCDASGLTV NVKSCPNEQV CSKSERTYDS DGCCFSCDTS 310 320 330 340 350 360 CKPVPATVGI QGEYDYQNEK TNCSANIIMA KCSGQCQHKL TYDTIDNKVV TKCRCCKADR 370 380 390 VEPRKAHLVC DNGKKKIYKY KHITSCKCTS CTAYNIRL

References

[1]	"An integumentary mucin (FIM-B.1) from Xenopus laevis homologous with von Willebrand factor." Probst J.C., Gertzen E.-M., Hoffmann W. Biochemistry 29:6240-6244(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	J02910 mRNA. Translation: AAA49711.1.
PIR	A35281.
UniGene	Xl.785.
3D structure databases
ProteinModelPortal	P38565.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Xenbase	XB-GENE-6252375. muc19.
Family and domain databases
InterPro	IPR006208. Cys_knot. IPR006207. Cys_knot_C. IPR001007. VWF_C. [Graphical view]
Pfam	PF00007. Cys_knot. 1 hit. [Graphical view]
SMART	SM00041. CT. 1 hit. SM00214. VWC. 2 hits. [Graphical view]
PROSITE	PS01185. CTCK_1. 1 hit. PS01225. CTCK_2. 1 hit. PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUCB1_XENLA

Accession

Primary (citable) accession number: P38565

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program