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Protein

Glutamine synthetase root isozyme 3

Gene

GLN4

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the flow of nitrogen into nitrogenous organic compounds.

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.3.1.2. 6752.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase root isozyme 3 (EC:6.3.1.2)
Alternative name(s):
GS112
Glutamate--ammonia ligase
Gene namesi
Name:GLN4
Synonyms:GS1-3
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi17151.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001531801 – 356Glutamine synthetase root isozyme 3Add BLAST356

Proteomic databases

PaxDbiP38561.
PRIDEiP38561.

Expressioni

Tissue specificityi

Found in all the tissues examined with higher expression found in tissues of the root.

Interactioni

Subunit structurei

Homooctamer.

Protein-protein interaction databases

STRINGi4577.GRMZM5G872068_P01.

Structurei

Secondary structure

1356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 8Combined sources5
Helixi12 – 14Combined sources3
Beta strandi19 – 26Combined sources8
Beta strandi33 – 42Combined sources10
Helixi47 – 49Combined sources3
Beta strandi53 – 56Combined sources4
Turni57 – 61Combined sources5
Beta strandi65 – 67Combined sources3
Beta strandi69 – 79Combined sources11
Turni81 – 83Combined sources3
Beta strandi88 – 95Combined sources8
Helixi107 – 115Combined sources9
Helixi117 – 122Combined sources6
Beta strandi125 – 136Combined sources12
Turni137 – 139Combined sources3
Beta strandi154 – 156Combined sources3
Turni163 – 165Combined sources3
Helixi169 – 182Combined sources14
Beta strandi186 – 191Combined sources6
Beta strandi197 – 206Combined sources10
Helixi208 – 228Combined sources21
Beta strandi230 – 233Combined sources4
Beta strandi236 – 239Combined sources4
Beta strandi241 – 243Combined sources3
Beta strandi247 – 253Combined sources7
Turni255 – 257Combined sources3
Helixi262 – 275Combined sources14
Helixi277 – 281Combined sources5
Helixi288 – 291Combined sources4
Beta strandi293 – 297Combined sources5
Beta strandi306 – 309Combined sources4
Beta strandi313 – 317Combined sources5
Helixi319 – 323Combined sources5
Beta strandi329 – 331Combined sources3
Helixi340 – 351Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D3AX-ray2.63A/B/C/D/E/F/G/H/I/J1-356[»]
2D3BX-ray3.50A/B/C/D/E/F/G/H/I/J1-356[»]
2D3CX-ray3.81A/B/C/D/E/F/G/H/I/J1-356[»]
ProteinModelPortaliP38561.
SMRiP38561.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38561.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiKOG0683. Eukaryota.
COG0174. LUCA.
HOGENOMiHOG000061500.
KOiK01915.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_b-grasp.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SMARTiSM01230. Gln-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38561-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACLTDLVNL NLSDTTEKII AEYIWIGGSG MDLRSKARTL SGPVTDPSKL
60 70 80 90 100
PKWNYDGSST GQAPGEDSEV ILYPQAIFKD PFRRGNNILV MCDCYTPAGE
110 120 130 140 150
PIPTNKRYNA AKIFSSPEVA AEEPWYGIEQ EYTLLQKDTN WPLGWPIGGF
160 170 180 190 200
PGPQGPYYCG IGAEKSFGRD IVDAHYKACL YAGINISGIN GEVMPGQWEF
210 220 230 240 250
QVGPSVGISS GDQVWVARYI LERITEIAGV VVTFDPKPIP GDWNGAGAHT
260 270 280 290 300
NYSTESMRKE GGYEVIKAAI EKLKLRHREH IAAYGEGNDG RLTGRHETAD
310 320 330 340 350
INTFSWGVAN RGASVRVGRE TEQNGKGYFE DRRPASNMDP YVVTSMIAET

TIIWKP
Length:356
Mass (Da):39,169
Last modified:October 1, 1994 - v1
Checksum:i0112DD32D5FB474C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15T → N in BAA03431 (Ref. 2) Curated1
Sequence conflicti289 – 290DG → ER in BAA03431 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65928 mRNA. Translation: CAA46721.1.
D14577 mRNA. Translation: BAA03431.1.
PIRiS39479.
RefSeqiNP_001105296.1. NM_001111826.1.
UniGeneiZm.66285.

Genome annotation databases

GeneIDi542214.
KEGGizma:542214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65928 mRNA. Translation: CAA46721.1.
D14577 mRNA. Translation: BAA03431.1.
PIRiS39479.
RefSeqiNP_001105296.1. NM_001111826.1.
UniGeneiZm.66285.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D3AX-ray2.63A/B/C/D/E/F/G/H/I/J1-356[»]
2D3BX-ray3.50A/B/C/D/E/F/G/H/I/J1-356[»]
2D3CX-ray3.81A/B/C/D/E/F/G/H/I/J1-356[»]
ProteinModelPortaliP38561.
SMRiP38561.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4577.GRMZM5G872068_P01.

Proteomic databases

PaxDbiP38561.
PRIDEiP38561.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi542214.
KEGGizma:542214.

Organism-specific databases

MaizeGDBi17151.

Phylogenomic databases

eggNOGiKOG0683. Eukaryota.
COG0174. LUCA.
HOGENOMiHOG000061500.
KOiK01915.

Enzyme and pathway databases

BRENDAi6.3.1.2. 6752.

Miscellaneous databases

EvolutionaryTraceiP38561.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_b-grasp.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SMARTiSM01230. Gln-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLNA3_MAIZE
AccessioniPrimary (citable) accession number: P38561
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.