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Protein

Tubulin gamma-2 chain

Gene

TUBG2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.1 Publication
Gamma-tubulin complex is essential for the control of microtubular network remodeling in the course of initiation and development of giant-feeding cells, and for the successful reproduction of nematodes (e.g. Meloidogyne spp.) in their plant hosts.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 148GTPSequence analysis7

GO - Molecular functioni

GO - Biological processi

  • cellular localization Source: TAIR
  • cytokinesis by cell plate formation Source: TAIR
  • cytoplasmic microtubule organization Source: InterPro
  • leaf development Source: TAIR
  • microtubule nucleation Source: InterPro
  • response to nematode Source: UniProtKB
  • root hair cell tip growth Source: TAIR
  • stomatal complex morphogenesis Source: TAIR

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin gamma-2 chain
Alternative name(s):
Gamma-2-tubulin
Gene namesi
Name:TUBG2
Ordered Locus Names:At5g05620
ORF Names:MJJ3.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G05620
TAIRilocus:2166469 AT5G05620

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Disruption phenotypei

Alteration of the morphology of feeding site and failure of nematode life cycle completion.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000484461 – 474Tubulin gamma-2 chainAdd BLAST474

Proteomic databases

PaxDbiP38558
PRIDEiP38558

Expressioni

Inductioni

Up-regulated in galls upon nematode infection.1 Publication

Gene expression databases

ExpressionAtlasiP38558 baseline and differential
GenevisibleiP38558 AT

Interactioni

Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin and GCP proteins.1 Publication

Protein-protein interaction databases

BioGridi15724, 4 interactors
STRINGi3702.AT5G05620.1

Structurei

3D structure databases

ProteinModelPortaliP38558
SMRiP38558
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1374 Eukaryota
COG5023 LUCA
HOGENOMiHOG000165714
InParanoidiP38558
KOiK10389
OMAiRRESMFK
OrthoDBiEOG093607FQ
PhylomeDBiP38558

Family and domain databases

CDDicd02188 gamma_tubulin, 1 hit
Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002454 Gamma_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01164 GAMMATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

P38558-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPREIITLQV GQCGNQIGME FWKQLCLEHG ISKDGILEDF ATQGGDRKDV
60 70 80 90 100
FFYQADDQHY IPRALLIDLE PRVINGIQNG EYRNLYNHEN IFLSDHGGGA
110 120 130 140 150
GNNWASGYHQ GKGVEEEIMD MIDREADGSD SLEGFVLCHS IAGGTGSGMG
160 170 180 190 200
SYLLETLNDR YSKKLVQTYS VFPNQMETSD VVVQPYNSLL TLKRLTLNAD
210 220 230 240 250
CVVVLDNTAL NRIAVERLHL TNPTFAQTNS LVSTVMSAST TTLRYPGYMN
260 270 280 290 300
NDLVGLLASL IPTPRCHFLM TGYTPLTVER QANVIRKTTV LDVMRRLLQT
310 320 330 340 350
KNIMVSSYAR NKEASQAKYI SILNIIQGEV DPTQVHESLQ RIRERKLVNF
360 370 380 390 400
IDWGPASIQV ALSKKSPYVQ TSHRVSGLML ASHTSIRHLF SRCLSQYDKL
410 420 430 440 450
RKKQAFLDNY RKFPMFADND LSEFDESRDI IESLVDEYKA CESPDYIKWG
460 470
MEDPGQLMTG EGNASGVADP KLAF
Length:474
Mass (Da):53,277
Last modified:October 1, 1994 - v1
Checksum:i2986B84CBA57F429
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03990 Genomic DNA Translation: AAA20654.1
AB005237 Genomic DNA Translation: BAB09656.1
CP002688 Genomic DNA Translation: AED90900.1
BT030394 mRNA Translation: ABO45697.1
PIRiT50558
RefSeqiNP_196181.1, NM_120644.3
UniGeneiAt.50433

Genome annotation databases

EnsemblPlantsiAT5G05620.1; AT5G05620.1; AT5G05620
GeneIDi830445
GrameneiAT5G05620.1; AT5G05620.1; AT5G05620
KEGGiath:AT5G05620

Similar proteinsi

Entry informationi

Entry nameiTBG2_ARATH
AccessioniPrimary (citable) accession number: P38558
Secondary accession number(s): A4IJ36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health