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Protein

GTP-binding protein YPT31/YPT8

Gene

YPT31

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for protein transport in the secretory pathway. Probably involved in regulation of secretory vesicle formation at the trans-Golgi compartment. Plays a role in autophagy.4 Publications

Miscellaneous

Present with 5955 molecules/cell in log phase SD medium.1 Publication

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by the guanine nucleotide-exchange factor (GEF) TRAPP complex, and inactivated by GTPase-activating protein (GAP) GYP3.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTPBy similarity8
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • autophagy Source: UniProtKB-KW
  • early endosome to Golgi transport Source: SGD
  • exocytosis Source: SGD
  • protein transport Source: UniProtKB-KW
  • vesicle-mediated transport Source: SGD

Keywordsi

Biological processAutophagy, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30212-MONOMER
ReactomeiR-SCE-6798695 Neutrophil degranulation
R-SCE-8854214 TBC/RABGAPs
R-SCE-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein YPT31/YPT8
Alternative name(s):
Rab GTPase YPT31
Gene namesi
Name:YPT31
Synonyms:YPT8
Ordered Locus Names:YER031C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

EuPathDBiFungiDB:YER031C
SGDiS000000833 YPT31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001213232 – 223GTP-binding protein YPT31/YPT8Add BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Lipidationi222S-geranylgeranyl cysteineBy similarity1
Lipidationi223S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Prenylation

Proteomic databases

MaxQBiP38555
PaxDbiP38555
PRIDEiP38555

PTM databases

iPTMnetiP38555

Interactioni

Subunit structurei

Interacts with YIF1, YIP1, YIP3, YIP4 and YIP5. Interacts with TRS130.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36766, 300 interactors
DIPiDIP-2022N
IntActiP38555, 19 interactors
MINTiP38555
STRINGi4932.YER031C

Structurei

Secondary structure

1223
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 20Combined sources9
Helixi26 – 35Combined sources10
Beta strandi49 – 57Combined sources9
Beta strandi60 – 67Combined sources8
Turni70 – 76Combined sources7
Helixi80 – 82Combined sources3
Turni83 – 85Combined sources3
Beta strandi88 – 93Combined sources6
Helixi98 – 114Combined sources17
Beta strandi120 – 125Combined sources6
Helixi128 – 133Combined sources6
Helixi138 – 147Combined sources10
Beta strandi151 – 154Combined sources4
Helixi163 – 174Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CPJX-ray2.35B1-223[»]
ProteinModelPortaliP38555
SMRiP38555
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38555

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector regionCurated9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
InParanoidiP38555
KOiK07905
OMAiKHSTYES
OrthoDBiEOG092C5MDH

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEDYGYDY DLLFKIVLIG DSGVGKSNLL SRFTKNEFNM DSKSTIGVEF
60 70 80 90 100
ATRTLEIDGK RIKAQIWDTA GQERYRAITS AYYRGAVGAL IVYDISKSSS
110 120 130 140 150
YENCNHWLSE LRENADDNVA VGLIGNKSDL AHLRAVPTEE SKTFAQENQL
160 170 180 190 200
LFTETSALNS ENVDKAFEEL INTIYQKVSK HQMDLGDSSA NGNANGASAP
210 220
NGPTISLTPT PNENKKANGN NCC
Length:223
Mass (Da):24,469
Last modified:January 23, 2007 - v3
Checksum:iEC274E5873138D78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L17070 Genomic DNA Translation: AAA83385.1
X72833 Genomic DNA Translation: CAA51354.1
U18778 Genomic DNA Translation: AAB64564.1
BK006939 Genomic DNA Translation: DAA07684.1
PIRiS42679
RefSeqiNP_010948.1, NM_001178922.1

Genome annotation databases

EnsemblFungiiYER031C; YER031C; YER031C
GeneIDi856753
KEGGisce:YER031C

Similar proteinsi

Entry informationi

Entry nameiYPT31_YEAST
AccessioniPrimary (citable) accession number: P38555
Secondary accession number(s): D3DLT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

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