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P38552

- LEG4_RAT

UniProt

P38552 - LEG4_RAT

Protein

Galectin-4

Gene

Lgals4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Galectin that binds lactose and a related range of sugars.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galectin-4
    Short name:
    Gal-4
    Alternative name(s):
    L-36 lactose-binding protein
    Short name:
    L36LBP
    Lactose-binding lectin 4
    Gene namesi
    Name:Lgals4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi3003. Lgals4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Galectin-4PRO_0000076937Add
    BLAST

    Proteomic databases

    PaxDbiP38552.
    PRIDEiP38552.

    Expressioni

    Tissue specificityi

    Highly expressed in full-length form in small and large intestine and stomach but was not detected in other tissues including lung, liver, kidney and spleen.

    Gene expression databases

    GenevestigatoriP38552.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000027603.

    Structurei

    3D structure databases

    ProteinModelPortaliP38552.
    SMRiP38552. Positions 13-159, 177-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 150132Galectin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini196 – 324129Galectin 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni257 – 2637Beta-galactoside bindingBy similarity

    Domaini

    Contains two homologous but distinct carbohydrate-binding domains.

    Sequence similaritiesi

    Contains 2 galectin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG264430.
    GeneTreeiENSGT00750000117327.
    HOGENOMiHOG000290194.
    HOVERGENiHBG002412.
    KOiK10091.
    OMAiFYEYGHR.
    OrthoDBiEOG73Z2TM.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR015533. Galectin4/6.
    IPR001079. Galectin_CRD.
    [Graphical view]
    PANTHERiPTHR11346:SF32. PTHR11346:SF32. 1 hit.
    PfamiPF00337. Gal-bind_lectin. 2 hits.
    [Graphical view]
    SMARTiSM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 2 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.
    PROSITEiPS51304. GALECTIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38552-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYVPAPGYQ PTYNPTLPYK RPIPGGLSVG MSIYIQGIAK DNMRRFHVNF    50
    AVGQDEGADI AFHFNPRFDG WDKVVFNTMQ SGQWGKEEKK KSMPFQKGHH 100
    FELVFMVMSE HYKVVVNGTP FYEYGHRLPL QMVTHLQVDG DLELQSINFL 150
    GGQPAASQYP GTMTIPAYPS AGYNPPQMNS LPVMAGPPIF NPPVPYVGTL 200
    QGGLTARRTI IIKGYVLPTA KNLIINFKVG STGDIAFHMN PRIGDCVVRN 250
    SYMNGSWGSE ERKIPYNPFG AGQFFDLSIR CGTDRFKVFA NGQHLFDFSH 300
    RFQAFQRVDM LEIKGDITLS YVQI 324
    Length:324
    Mass (Da):36,347
    Last modified:October 1, 1994 - v1
    Checksum:i478024D7322AFE7B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73553 mRNA. Translation: AAA41505.1.
    PIRiA46631.
    RefSeqiNP_037107.1. NM_012975.1.
    UniGeneiRn.9656.

    Genome annotation databases

    EnsembliENSRNOT00000041205; ENSRNOP00000047505; ENSRNOG00000020338.
    GeneIDi25474.
    KEGGirno:25474.
    UCSCiRGD:3003. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73553 mRNA. Translation: AAA41505.1 .
    PIRi A46631.
    RefSeqi NP_037107.1. NM_012975.1.
    UniGenei Rn.9656.

    3D structure databases

    ProteinModelPortali P38552.
    SMRi P38552. Positions 13-159, 177-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000027603.

    Proteomic databases

    PaxDbi P38552.
    PRIDEi P38552.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000041205 ; ENSRNOP00000047505 ; ENSRNOG00000020338 .
    GeneIDi 25474.
    KEGGi rno:25474.
    UCSCi RGD:3003. rat.

    Organism-specific databases

    CTDi 3960.
    RGDi 3003. Lgals4.

    Phylogenomic databases

    eggNOGi NOG264430.
    GeneTreei ENSGT00750000117327.
    HOGENOMi HOG000290194.
    HOVERGENi HBG002412.
    KOi K10091.
    OMAi FYEYGHR.
    OrthoDBi EOG73Z2TM.

    Miscellaneous databases

    NextBioi 606785.
    PROi P38552.

    Gene expression databases

    Genevestigatori P38552.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR015533. Galectin4/6.
    IPR001079. Galectin_CRD.
    [Graphical view ]
    PANTHERi PTHR11346:SF32. PTHR11346:SF32. 1 hit.
    Pfami PF00337. Gal-bind_lectin. 2 hits.
    [Graphical view ]
    SMARTi SM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    PROSITEi PS51304. GALECTIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Soluble lactose-binding lectin from rat intestine with two different carbohydrate-binding domains in the same peptide chain."
      Oda Y., Herrmann J., Gitt M., Turck C.W., Burlingame A.L., Barondes S.H., Leffler H.
      J. Biol. Chem. 268:5929-5939(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Intestine.
    2. "Purification and characterization of the N-terminal domain of galectin-4 from rat small intestine."
      Tardy F., Deviller P., Louisot P., Martin A.
      FEBS Lett. 359:169-172(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 13-37 AND 44-66.

    Entry informationi

    Entry nameiLEG4_RAT
    AccessioniPrimary (citable) accession number: P38552
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3