Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Galectin-4

Gene

Lgals4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Galectin that binds lactose and a related range of sugars.

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-4
Short name:
Gal-4
Alternative name(s):
L-36 lactose-binding protein
Short name:
L36LBP
Lactose-binding lectin 4
Gene namesi
Name:Lgals4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3003. Lgals4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Galectin-4PRO_0000076937Add
BLAST

Proteomic databases

PaxDbiP38552.
PRIDEiP38552.

Expressioni

Tissue specificityi

Highly expressed in full-length form in small and large intestine and stomach but was not detected in other tissues including lung, liver, kidney and spleen.

Gene expression databases

GenevestigatoriP38552.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027603.

Structurei

3D structure databases

SMRiP38552. Positions 13-159, 177-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 150132Galectin 1PROSITE-ProRule annotationAdd
BLAST
Domaini196 – 324129Galectin 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni257 – 2637Beta-galactoside bindingBy similarity

Domaini

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similaritiesi

Contains 2 galectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG264430.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiP38552.
KOiK10091.
OMAiFYEYGHR.
OrthoDBiEOG73Z2TM.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR015533. Galectin4/6.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF32. PTHR11346:SF32. 1 hit.
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38552-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYVPAPGYQ PTYNPTLPYK RPIPGGLSVG MSIYIQGIAK DNMRRFHVNF
60 70 80 90 100
AVGQDEGADI AFHFNPRFDG WDKVVFNTMQ SGQWGKEEKK KSMPFQKGHH
110 120 130 140 150
FELVFMVMSE HYKVVVNGTP FYEYGHRLPL QMVTHLQVDG DLELQSINFL
160 170 180 190 200
GGQPAASQYP GTMTIPAYPS AGYNPPQMNS LPVMAGPPIF NPPVPYVGTL
210 220 230 240 250
QGGLTARRTI IIKGYVLPTA KNLIINFKVG STGDIAFHMN PRIGDCVVRN
260 270 280 290 300
SYMNGSWGSE ERKIPYNPFG AGQFFDLSIR CGTDRFKVFA NGQHLFDFSH
310 320
RFQAFQRVDM LEIKGDITLS YVQI
Length:324
Mass (Da):36,347
Last modified:September 30, 1994 - v1
Checksum:i478024D7322AFE7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73553 mRNA. Translation: AAA41505.1.
PIRiA46631.
RefSeqiNP_037107.1. NM_012975.1.
UniGeneiRn.9656.

Genome annotation databases

EnsembliENSRNOT00000041205; ENSRNOP00000047505; ENSRNOG00000020338.
GeneIDi25474.
KEGGirno:25474.
UCSCiRGD:3003. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73553 mRNA. Translation: AAA41505.1.
PIRiA46631.
RefSeqiNP_037107.1. NM_012975.1.
UniGeneiRn.9656.

3D structure databases

SMRiP38552. Positions 13-159, 177-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027603.

Proteomic databases

PaxDbiP38552.
PRIDEiP38552.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000041205; ENSRNOP00000047505; ENSRNOG00000020338.
GeneIDi25474.
KEGGirno:25474.
UCSCiRGD:3003. rat.

Organism-specific databases

CTDi3960.
RGDi3003. Lgals4.

Phylogenomic databases

eggNOGiNOG264430.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiP38552.
KOiK10091.
OMAiFYEYGHR.
OrthoDBiEOG73Z2TM.

Miscellaneous databases

NextBioi606785.
PROiP38552.

Gene expression databases

GenevestigatoriP38552.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR015533. Galectin4/6.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF32. PTHR11346:SF32. 1 hit.
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Soluble lactose-binding lectin from rat intestine with two different carbohydrate-binding domains in the same peptide chain."
    Oda Y., Herrmann J., Gitt M., Turck C.W., Burlingame A.L., Barondes S.H., Leffler H.
    J. Biol. Chem. 268:5929-5939(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  2. "Purification and characterization of the N-terminal domain of galectin-4 from rat small intestine."
    Tardy F., Deviller P., Louisot P., Martin A.
    FEBS Lett. 359:169-172(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 13-37 AND 44-66.

Entry informationi

Entry nameiLEG4_RAT
AccessioniPrimary (citable) accession number: P38552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 30, 1994
Last sequence update: September 30, 1994
Last modified: March 31, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.