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P38552 (LEG4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galectin-4

Short name=Gal-4
Alternative name(s):
L-36 lactose-binding protein
Short name=L36LBP
Lactose-binding lectin 4
Gene names
Name:Lgals4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Galectin that binds lactose and a related range of sugars.

Subunit structure

Monomer.

Tissue specificity

Highly expressed in full-length form in small and large intestine and stomach but was not detected in other tissues including lung, liver, kidney and spleen.

Domain

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similarities

Contains 2 galectin domains.

Ontologies

Keywords
   DomainRepeat
   LigandLectin
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Galectin-4
PRO_0000076937

Regions

Domain19 – 150132Galectin 1
Domain196 – 324129Galectin 2
Region257 – 2637Beta-galactoside binding By similarity

Sequences

Sequence LengthMass (Da)Tools
P38552 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 478024D7322AFE7B

FASTA32436,347
        10         20         30         40         50         60 
MAYVPAPGYQ PTYNPTLPYK RPIPGGLSVG MSIYIQGIAK DNMRRFHVNF AVGQDEGADI 

        70         80         90        100        110        120 
AFHFNPRFDG WDKVVFNTMQ SGQWGKEEKK KSMPFQKGHH FELVFMVMSE HYKVVVNGTP 

       130        140        150        160        170        180 
FYEYGHRLPL QMVTHLQVDG DLELQSINFL GGQPAASQYP GTMTIPAYPS AGYNPPQMNS 

       190        200        210        220        230        240 
LPVMAGPPIF NPPVPYVGTL QGGLTARRTI IIKGYVLPTA KNLIINFKVG STGDIAFHMN 

       250        260        270        280        290        300 
PRIGDCVVRN SYMNGSWGSE ERKIPYNPFG AGQFFDLSIR CGTDRFKVFA NGQHLFDFSH 

       310        320 
RFQAFQRVDM LEIKGDITLS YVQI 

« Hide

References

[1]"Soluble lactose-binding lectin from rat intestine with two different carbohydrate-binding domains in the same peptide chain."
Oda Y., Herrmann J., Gitt M., Turck C.W., Burlingame A.L., Barondes S.H., Leffler H.
J. Biol. Chem. 268:5929-5939(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Intestine.
[2]"Purification and characterization of the N-terminal domain of galectin-4 from rat small intestine."
Tardy F., Deviller P., Louisot P., Martin A.
FEBS Lett. 359:169-172(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 13-37 AND 44-66.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M73553 mRNA. Translation: AAA41505.1.
PIRA46631.
RefSeqNP_037107.1. NM_012975.1.
UniGeneRn.9656.

3D structure databases

ProteinModelPortalP38552.
SMRP38552. Positions 13-159, 177-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000027603.

Proteomic databases

PaxDbP38552.
PRIDEP38552.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000041205; ENSRNOP00000047505; ENSRNOG00000020338.
GeneID25474.
KEGGrno:25474.
UCSCRGD:3003. rat.

Organism-specific databases

CTD3960.
RGD3003. Lgals4.

Phylogenomic databases

eggNOGNOG264430.
GeneTreeENSGT00750000117327.
HOGENOMHOG000290194.
HOVERGENHBG002412.
KOK10091.
OMAFYEYGHR.
OrthoDBEOG73Z2TM.

Gene expression databases

GenevestigatorP38552.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR015533. Galectin4/6.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERPTHR11346:SF23. PTHR11346:SF23. 1 hit.
PfamPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 2 hits.
PROSITEPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio606785.
PROP38552.

Entry information

Entry nameLEG4_RAT
AccessionPrimary (citable) accession number: P38552
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families