P38552 (LEG4_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galectin-4
Short name=Gal-4

Alternative name(s):
L-36 lactose-binding protein
Short name=L36LBP
Lactose-binding lectin 4

Gene names

Name:

Lgals4

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Galectin that binds lactose and a related range of sugars.
Subunit structure	Monomer.
Tissue specificity	Highly expressed in full-length form in small and large intestine and stomach but was not detected in other tissues including lung, liver, kidney and spleen.
Domain	Contains two homologous but distinct carbohydrate-binding domains.
Sequence similarities	Contains 2 galectin domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Lectin
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	Galectin-4		PRO_0000076937
Regions
	Domain	19 – 150	132	Galectin 1
	Domain	196 – 324	129	Galectin 2
	Region	257 – 263	7	Beta-galactoside binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	P38552 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 478024D7322AFE7B	FASTA	324	36,347
	10 20 30 40 50 60 MAYVPAPGYQ PTYNPTLPYK RPIPGGLSVG MSIYIQGIAK DNMRRFHVNF AVGQDEGADI 70 80 90 100 110 120 AFHFNPRFDG WDKVVFNTMQ SGQWGKEEKK KSMPFQKGHH FELVFMVMSE HYKVVVNGTP 130 140 150 160 170 180 FYEYGHRLPL QMVTHLQVDG DLELQSINFL GGQPAASQYP GTMTIPAYPS AGYNPPQMNS 190 200 210 220 230 240 LPVMAGPPIF NPPVPYVGTL QGGLTARRTI IIKGYVLPTA KNLIINFKVG STGDIAFHMN 250 260 270 280 290 300 PRIGDCVVRN SYMNGSWGSE ERKIPYNPFG AGQFFDLSIR CGTDRFKVFA NGQHLFDFSH 310 320 RFQAFQRVDM LEIKGDITLS YVQI

References

[1]	"Soluble lactose-binding lectin from rat intestine with two different carbohydrate-binding domains in the same peptide chain." Oda Y., Herrmann J., Gitt M., Turck C.W., Burlingame A.L., Barondes S.H., Leffler H. J. Biol. Chem. 268:5929-5939(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Intestine.
[2]	"Purification and characterization of the N-terminal domain of galectin-4 from rat small intestine." Tardy F., Deviller P., Louisot P., Martin A. FEBS Lett. 359:169-172(1995) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 13-37 AND 44-66.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M73553 mRNA. Translation: AAA41505.1.
IPI	IPI00211324.
PIR	A46631.
RefSeq	NP_037107.1. NM_012975.1.
UniGene	Rn.9656.
3D structure databases
ProteinModelPortal	P38552.
SMR	P38552. Positions 13-159, 177-324.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000027603.
Proteomic databases
PaxDb	P38552.
PRIDE	P38552.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000041205; ENSRNOP00000047505; ENSRNOG00000020338.
GeneID	25474.
KEGG	rno:25474.
UCSC	RGD:3003. rat.
Organism-specific databases
CTD	3960.
RGD	3003. Lgals4.
Phylogenomic databases
eggNOG	NOG264430.
GeneTree	ENSGT00690000101933.
HOGENOM	HOG000290194.
HOVERGEN	HBG002412.
KO	K10091.
Gene expression databases
ArrayExpress	P38552.
Genevestigator	P38552.
GermOnline	ENSRNOG00000020338. Rattus norvegicus.
Family and domain databases
Gene3D	2.60.120.200. 2 hits.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR015533. Galectin4/6. IPR001079. Galectin_CRD. [Graphical view]
PANTHER	PTHR11346:SF23. PTHR11346:SF23. 1 hit.
Pfam	PF00337. Gal-bind_lectin. 2 hits. [Graphical view]
SMART	SM00908. Gal-bind_lectin. 2 hits. SM00276. GLECT. 2 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 2 hits.
PROSITE	PS51304. GALECTIN. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	606785.

Entry information

Entry name

LEG4_RAT

Accession

Primary (citable) accession number: P38552

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	April 3, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program