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P38552

- LEG4_RAT

UniProt

P38552 - LEG4_RAT

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Protein

Galectin-4

Gene

Lgals4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Galectin that binds lactose and a related range of sugars.

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-4
Short name:
Gal-4
Alternative name(s):
L-36 lactose-binding protein
Short name:
L36LBP
Lactose-binding lectin 4
Gene namesi
Name:Lgals4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi3003. Lgals4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Galectin-4PRO_0000076937Add
BLAST

Proteomic databases

PaxDbiP38552.
PRIDEiP38552.

Expressioni

Tissue specificityi

Highly expressed in full-length form in small and large intestine and stomach but was not detected in other tissues including lung, liver, kidney and spleen.

Gene expression databases

GenevestigatoriP38552.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027603.

Structurei

3D structure databases

ProteinModelPortaliP38552.
SMRiP38552. Positions 13-159, 177-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 150132Galectin 1PROSITE-ProRule annotationAdd
BLAST
Domaini196 – 324129Galectin 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni257 – 2637Beta-galactoside bindingBy similarity

Domaini

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similaritiesi

Contains 2 galectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG264430.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiP38552.
KOiK10091.
OMAiFYEYGHR.
OrthoDBiEOG73Z2TM.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR015533. Galectin4/6.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF32. PTHR11346:SF32. 1 hit.
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38552-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYVPAPGYQ PTYNPTLPYK RPIPGGLSVG MSIYIQGIAK DNMRRFHVNF
60 70 80 90 100
AVGQDEGADI AFHFNPRFDG WDKVVFNTMQ SGQWGKEEKK KSMPFQKGHH
110 120 130 140 150
FELVFMVMSE HYKVVVNGTP FYEYGHRLPL QMVTHLQVDG DLELQSINFL
160 170 180 190 200
GGQPAASQYP GTMTIPAYPS AGYNPPQMNS LPVMAGPPIF NPPVPYVGTL
210 220 230 240 250
QGGLTARRTI IIKGYVLPTA KNLIINFKVG STGDIAFHMN PRIGDCVVRN
260 270 280 290 300
SYMNGSWGSE ERKIPYNPFG AGQFFDLSIR CGTDRFKVFA NGQHLFDFSH
310 320
RFQAFQRVDM LEIKGDITLS YVQI
Length:324
Mass (Da):36,347
Last modified:October 1, 1994 - v1
Checksum:i478024D7322AFE7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73553 mRNA. Translation: AAA41505.1.
PIRiA46631.
RefSeqiNP_037107.1. NM_012975.1.
UniGeneiRn.9656.

Genome annotation databases

EnsembliENSRNOT00000041205; ENSRNOP00000047505; ENSRNOG00000020338.
GeneIDi25474.
KEGGirno:25474.
UCSCiRGD:3003. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73553 mRNA. Translation: AAA41505.1 .
PIRi A46631.
RefSeqi NP_037107.1. NM_012975.1.
UniGenei Rn.9656.

3D structure databases

ProteinModelPortali P38552.
SMRi P38552. Positions 13-159, 177-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000027603.

Proteomic databases

PaxDbi P38552.
PRIDEi P38552.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000041205 ; ENSRNOP00000047505 ; ENSRNOG00000020338 .
GeneIDi 25474.
KEGGi rno:25474.
UCSCi RGD:3003. rat.

Organism-specific databases

CTDi 3960.
RGDi 3003. Lgals4.

Phylogenomic databases

eggNOGi NOG264430.
GeneTreei ENSGT00760000119105.
HOGENOMi HOG000290194.
HOVERGENi HBG002412.
InParanoidi P38552.
KOi K10091.
OMAi FYEYGHR.
OrthoDBi EOG73Z2TM.

Miscellaneous databases

NextBioi 606785.
PROi P38552.

Gene expression databases

Genevestigatori P38552.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR015533. Galectin4/6.
IPR001079. Galectin_CRD.
[Graphical view ]
PANTHERi PTHR11346:SF32. PTHR11346:SF32. 1 hit.
Pfami PF00337. Gal-bind_lectin. 2 hits.
[Graphical view ]
SMARTi SM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
PROSITEi PS51304. GALECTIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Soluble lactose-binding lectin from rat intestine with two different carbohydrate-binding domains in the same peptide chain."
    Oda Y., Herrmann J., Gitt M., Turck C.W., Burlingame A.L., Barondes S.H., Leffler H.
    J. Biol. Chem. 268:5929-5939(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  2. "Purification and characterization of the N-terminal domain of galectin-4 from rat small intestine."
    Tardy F., Deviller P., Louisot P., Martin A.
    FEBS Lett. 359:169-172(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 13-37 AND 44-66.

Entry informationi

Entry nameiLEG4_RAT
AccessioniPrimary (citable) accession number: P38552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3