Reviewed, UniProtKB/Swiss-Prot P38551 (TGFR2_PIG)

Names and origin

Protein names

Recommended name:
    TGF-beta receptor type-2
    EC=2.7.11.30
Alternative name(s):
    Transforming growth factor-beta receptor type II
      Short name=TGF-beta receptor type II
    TGF-beta type II receptor
    TbetaR-II
    TGFR-2

Gene names

Name:

TGFBR2

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	297 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subunit structure	Binds to DAXX. Interacts with TCTEX1D4 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – ›297	›274	TGF-beta receptor type-2
Regions
	Topological domain	24 – 166	143	Extracellular Potential
	Transmembrane	167 – 187	21	Potential
	Topological domain	188 – ›297	›110	Cytoplasmic Potential
	Domain	244 – ›297	›54	Protein kinase
	Nucleotide binding	250 – 258	9	ATP By similarity
Sites
	Binding site	277	1	ATP By similarity
Amino acid modifications
	Glycosylation	70	1	N-linked (GlcNAc...) Potential
	Glycosylation	94	1	N-linked (GlcNAc...) Potential
	Disulfide bond	51 ↔ 84		By similarity
	Disulfide bond	54 ↔ 71		By similarity
	Disulfide bond	61 ↔ 67		By similarity
	Disulfide bond	77 ↔ 101		By similarity
	Disulfide bond	121 ↔ 136		By similarity
	Disulfide bond	138 ↔ 143		By similarity
Experimental info
	Non-terminal residue	297	1

Sequences

	Sequence		Length	Mass (Da)
	P38551-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: F9869D3079B66A15	FASTA	297	33,302
	10 20 30 40 50 60 MGRGLLGGLW PLHVVLWTRI ASTIPPHVPK SVNSDMMVTD SNGAVKLPQL CKFCDVRSST 70 80 90 100 110 120 CDNQKSCLSN CSITAICEKP QEVCVAVWRK NDENITIETV CDDPKIAYHG FVLDDAASSK 130 140 150 160 170 180 CIMKERKGSG ETFFMCSCSS DECNDHIIFS EEYATNNPDL LLVIFQVTGV SLLPPLGIAI 190 200 210 220 230 240 AVIITFYCYR VHRQQKLSPS WDSGKPRKLM EFSEHLAIIL EDDRSDISST CANNINHNTE 250 260 270 280 290 LLPIELDTLV GKGRFAEVYK AKLRQNTSEQ FETVAVKIFP YEEYASWKTE KDIFSDL

References

[1]	"Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase." Lin H.Y., Wang X.-F., Ng-Eaton E., Weinberg R.A., Lodish H.F. Cell 68:775-785(1992) [PubMed: 1310899] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

3D structure databases
HSSP	HSSP built from PDB template 1KTZ based on UniProtKB P37173.
SMR	P38551. Positions 38-159.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P38551.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR008271. Ser_thr_pkin_AS. IPR015769. TGF-beta_II_C. IPR015013. TGF_beta_receptor2. IPR001245. Tyr_pkinase. [Graphical view]
PANTHER	PTHR23255:SF11. TGF-beta_II_C. 1 hit.
Pfam	PF08917. ecTbetaR2. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. Partial match. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

TGFR2_PIG

Accession

Primary (citable) accession number: P38551

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	July 22, 2008
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)