Reviewed,
UniProtKB/Swiss-Prot P38551 (TGFR2_PIG)
Last modified
July 22, 2008.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: TGF-beta receptor type-2 EC=2.7.11.30 Alternative name(s): Transforming growth factor-beta receptor type II Short name=TGF-beta receptor type II TGF-beta type II receptor TbetaR-II TGFR-2 | ||
| Gene names |
| ||
| Organism | Sus scrofa (Pig) | ||
| Taxonomic identifier | 9823 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus |
Protein attributes
| Sequence length | 297 AA. |
| Sequence status | Fragment. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. |
| Catalytic activity | ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. |
| Cofactor | Magnesium or manganese By similarity. |
| Subunit structure | Binds to DAXX. Interacts with TCTEX1D4 By similarity. |
| Subcellular location | |
| Post-translational modification | Phosphorylated on a Ser/Thr residue in the cytoplasmic domain. |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal Transmembrane |
| Ligand | ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding |
| Molecular function | Kinase Receptor Serine/threonine-protein kinase Transferase |
| PTM | Glycoprotein Phosphoprotein |
Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||||
Molecule processing | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 23 | 23 | Potential | |||||||
| Chain | 24 – ›297 | ›274 | TGF-beta receptor type-2 | |||||||
Regions | ||||||||||
| Topological domain | 24 – 166 | 143 | Extracellular Potential | |||||||
| Transmembrane | 167 – 187 | 21 | Potential | |||||||
| Topological domain | 188 – ›297 | ›110 | Cytoplasmic Potential | |||||||
| Domain | 244 – ›297 | ›54 | Protein kinase | |||||||
| Nucleotide binding | 250 – 258 | 9 | ATP By similarity | |||||||
Sites | ||||||||||
| Binding site | 277 | 1 | ATP By similarity | |||||||
Amino acid modifications | ||||||||||
| Glycosylation | 70 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Glycosylation | 94 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Disulfide bond | 51 ↔ 84 | By similarity | ||||||||
| Disulfide bond | 54 ↔ 71 | By similarity | ||||||||
| Disulfide bond | 61 ↔ 67 | By similarity | ||||||||
| Disulfide bond | 77 ↔ 101 | By similarity | ||||||||
| Disulfide bond | 121 ↔ 136 | By similarity | ||||||||
| Disulfide bond | 138 ↔ 143 | By similarity | ||||||||
Experimental info | ||||||||||
| Non-terminal residue | 297 | 1 | ||||||||
Sequences
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References
| [1] | "Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase." Lin H.Y., Wang X.-F., Ng-Eaton E., Weinberg R.A., Lodish H.F. Cell 68:775-785(1992) [PubMed: 1310899] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. |
Cross-references
3D structure databases | |
|---|---|
| HSSP | HSSP built from PDB template 1KTZ based on UniProtKB P37173. |
| SMR | P38551. Positions 38-159. |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | P38551. |
Family and domain databases | |
| InterPro | IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR008271. Ser_thr_pkin_AS. IPR015769. TGF-beta_II_C. IPR015013. TGF_beta_receptor2. IPR001245. Tyr_pkinase. [Graphical view] |
| PANTHER | PTHR23255:SF11. TGF-beta_II_C. 1 hit. |
| Pfam | PF08917. ecTbetaR2. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. Partial match. [Graphical view] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | TGFR2_PIG | ||||||||
| Accession | Primary (citable) accession number: P38551 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


