P38548 (RAN_VICFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: GTP-binding nuclear protein Ran/TC4
Organism	Vicia faba (Broad bean) (Faba vulgaris)
Taxonomic identifier	3906 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Fabales › Fabaceae › Papilionoideae › Fabeae › Vicia

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Ran family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Nucleus
Ligand	GTP-binding Nucleotide-binding
Gene Ontology (GO)
Biological_process	intracellular protein transport Inferred from electronic annotation. Source: InterPro nucleocytoplasmic transport Inferred from electronic annotation. Source: InterPro small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	GTP-binding nuclear protein Ran/TC4		PRO_0000208727
Regions
	Nucleotide binding	20 – 27	8	GTP By similarity
	Nucleotide binding	68 – 72	5	GTP By similarity
	Nucleotide binding	125 – 128	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P38548 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 40C2C711F1C2DE63	FASTA	221	25,290
	10 20 30 40 50 60 MALPNQQTVD YPSFKLVIVG DGGTGKTTFV KRHLTGEFEK KYEPTIGVEV HPLDFFTNCG 70 80 90 100 110 120 KIRFYCWDTA GQEKFGGLRD GYYIHGQCAI IMFDVTARLT YKNVPTWHRD LCRVCENIPI 130 140 150 160 170 180 VLCGNKVDVK NRQVKAKQVT FHRKKNLQYY EISAKSNYNF EKPFLYLARK LAGDANLHFV 190 200 210 220 ESPALAPPEV QIDIALQQRH ENEILEAANQ PLPDDDDDAF E

References

[1]	"Sequence of a plant cDNA from Vicia faba encoding a novel Ran-related GTP-binding protein." Saalbach G., Christov V. Plant Mol. Biol. 24:969-972(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cotyledon.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z24678 mRNA. Translation: CAA80845.1.
PIR	S46498.
3D structure databases
ProteinModelPortal	P38548.
SMR	P38548. Positions 14-218.
ModBase	Search...
Proteomic databases
PRIDE	P38548.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR027417. P-loop_NTPase. IPR002041. Ran_GTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00627. GTPRANTC4.
SMART	SM00176. RAN. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51418. RAN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RAN_VICFA

Accession

Primary (citable) accession number: P38548

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	May 29, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program