P38545 (RAN_PLAFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: GTP-binding nuclear protein Ran Alternative name(s): GTPase Ran Ras-like protein TC4
Organism	Plasmodium falciparum
Taxonomic identifier	5833 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Ran family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Nucleus
Ligand	GTP-binding Nucleotide-binding
Gene Ontology (GO)
Biological_process	intracellular protein transport Inferred from electronic annotation. Source: InterPro nucleocytoplasmic transport Inferred from electronic annotation. Source: InterPro small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 214	214	GTP-binding nuclear protein Ran		PRO_0000208714
Regions
	Nucleotide binding	16 – 23	8	GTP By similarity
	Nucleotide binding	64 – 68	5	GTP By similarity
	Nucleotide binding	121 – 124	4	GTP By similarity
Natural variations
	Natural variant	40	1	P → A in strain: IT04.
	Natural variant	196	1	E → G in strain: IT04.

Sequences

	Sequence		Length	Mass (Da)
	P38545 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 5CBF7739EF5D26C2	FASTA	214	24,875
	10 20 30 40 50 60 MDSQEYIPQY KLILVGDGGV GKTTFVKRHL TGEFEKKYIP TLGVEVHPLK FQTNFGKTQF 70 80 90 100 110 120 NVWDTAGQEK FGGLRDGYYI KSDCAIIMFD VSSRITYKNV PNWYRDITRV CETIPMVLVG 130 140 150 160 170 180 NKVDVKDRQV KSRQIQFHRK RNLQYYDLSA RSNYNFEKPF LWLARRLSNQ PNLVFVGEHA 190 200 210 KAPEFQIDLN IVREAEKELE QAAAVAIDEE DIEN

References

[1]	"Cloning and expression of a cDNA encoding the homologue of Ran/TC4 GTP-binding protein from Plasmodium falciparum." Dontfraid F.F., Chakrabarti D. Biochem. Biophys. Res. Commun. 201:423-429(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: DD2.
[2]	"Cloning and characterisation of a Plasmodium falciparum homologue of the Ran/TC4 signal transducing GTPase involved in cell cycle control." Sultan A., Richardson W., Alano P., Arnot D., Doerig C. Mol. Biochem. Parasitol. 65:331-338(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: IT04.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U06051 mRNA. Translation: AAA19587.1. X73954 Genomic DNA. Translation: CAA52140.1.
PIR	JC2374. S40121.
3D structure databases
ProteinModelPortal	P38545.
ModBase	Search...
Proteomic databases
PRIDE	P38545.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG1100.
Family and domain databases
InterPro	IPR002041. Ran_GTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00627. GTPRANTC4.
SMART	SM00176. RAN. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51418. RAN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RAN_PLAFA

Accession

Primary (citable) accession number: P38545

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)