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P38535

- XYNX_CLOTM

UniProt

P38535 - XYNX_CLOTM

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Protein
Exoglucanase XynX
Gene
xynX
Organism
Clostridium thermocellum
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei347 – 3471Proton donor By similarity
Active sitei389 – 3891 By similarity
Active sitei452 – 4521Nucleophile By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. cellulose 1,4-beta-cellobiosidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiCBM22. Carbohydrate-Binding Module Family 22.
CBM9. Carbohydrate-Binding Module Family 9.
GH10. Glycoside Hydrolase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Exoglucanase XynX (EC:3.2.1.91)
Alternative name(s):
1,4-beta-cellobiohydrolase
Exocellobiohydrolase
Gene namesi
Name:xynX
OrganismiClostridium thermocellum
Taxonomic identifieri1515 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed prediction
Add
BLAST
Chaini31 – 10871057Exoglucanase XynX
PRO_0000007982Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP38535.
SMRiP38535. Positions 711-895.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 188152CBM-cenC
Add
BLAST
Domaini903 – 96664SLH 1
Add
BLAST
Domaini967 – 102559SLH 2
Add
BLAST
Domaini1028 – 108760SLH 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.1190. 2 hits.
3.20.20.80. 1 hit.
InterProiIPR010502. Carb-bd_dom_fam9.
IPR003305. CenC_carb-bd.
IPR008979. Galactose-bd-like.
IPR001000. Glyco_hydro_10.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR001119. S-layer_homology_dom.
[Graphical view]
PfamiPF02018. CBM_4_9. 1 hit.
PF06452. DUF1083. 2 hits.
PF00331. Glyco_hydro_10. 1 hit.
PF00395. SLH. 3 hits.
[Graphical view]
PRINTSiPR00134. GLHYDRLASE10.
SMARTiSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00591. GLYCOSYL_HYDROL_F10. 1 hit.
PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
PS51272. SLH. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38535-1 [UniParc]FASTAAdd to Basket

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MKNNLSKFVS IFTAFIMIFG TSLFFPHVSA FADDNNANLV SNGDFESGTI     50
DGWIKQGNPT LAATTEEAIG QYSMKVAGRT QTYEGPAYSF LGKMQKGQSY 100
NVSLKVRLVS GQNSSNPLIT VTMFREDDNG KHYDTIVWQK QVSEDSWTTV 150
NGTYTLDYTG TLKTLYMYVE SPDPTLEYYI DDVVVTPQNP IQVGEISNNQ 200
ITIQNDIPDL SSVFKDYFPI GVAVDPSRLN DTDPHAQLTA KHFNMLVAEN 250
AMKPESLQPT EGNFTFDNAD RIVDYAIAHN MKMRGHTLLW HNQVPDWFFQ 300
DPSDPTKPAS RDLLLQRLKT HITTVLDHFK TKYGAQNPII GWDVVNEVLD 350
DNGSLRNSKW LQIIGPDYIE KAFEYAHEAD PSMKLFINDY NIENNGVKTQ 400
AMYDLVKKLK SEGVPISGIG MQMHININSN IDNIKASIEK LASLGVEIQV 450
TELDMNMNGN VSNEALLKQA RLYKQLFDLF KAEKQYITAV VFWGVSDDVT 500
WLSKPNAPLL FDSKLQAKPA YWAIADPSKA IPDIQSAKAL EGSPTIGANV 550
DSSWKLVKPL YANTYVEGTV GATATVKSMW DTKNLYLLVQ VSDNTPSSND 600
GIEIFVDKND NKSTSYETDD EHYTIKSDGT GSSDITKYVT SNADGYIVQL 650
AIPIEDISPT LNDKIGLDVR LNDDKGSGSI DTVTVWNDYT NSQDTNTSYF 700
GDIVLSKPAQ VATAIYGTPV IDGKIDDIWN KVDAITTNTW VLGSDGATAT 750
AKMMWDDKYL YVLADVTDSN LNKSSVNPYE QDSVEVFVDQ NNDKTSYYES 800
DDGQYRVNYD NEQSFGGSTN SNGFKSATSL TQSGYIVEEA IPWTSITLLN 850
GTIIGFDLQV NDADENGKRT GIVTWCDPSG NSWQDTSGFG NLLLTGKPSG 900
VLKKSVTFND IKDNWAKDVI EVLASRHIVE GMTDTQYEPS KTVTRAEFTA 950
MILKLLNIKE EAYNGEFSDV KNGDWYANAI EAAYKAGIIE GDGKNMRPND 1000
SITREEMTSI AMRAYEMLTS YKEENIGATS FNDDKSISDW AKNVVANAAK 1050
LGIINGEPSN VFAPKGIATR AEAAAIIYGL LEKSNNL 1087
Length:1,087
Mass (Da):120,358
Last modified:October 1, 1994 - v1
Checksum:i88077FC27AC83F51
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M67438 Genomic DNA. Translation: AAA23227.1.
PIRiS41797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M67438 Genomic DNA. Translation: AAA23227.1 .
PIRi S41797.

3D structure databases

ProteinModelPortali P38535.
SMRi P38535. Positions 711-895.
ModBasei Search...

Protein family/group databases

CAZyi CBM22. Carbohydrate-Binding Module Family 22.
CBM9. Carbohydrate-Binding Module Family 9.
GH10. Glycoside Hydrolase Family 10.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.1190. 2 hits.
3.20.20.80. 1 hit.
InterProi IPR010502. Carb-bd_dom_fam9.
IPR003305. CenC_carb-bd.
IPR008979. Galactose-bd-like.
IPR001000. Glyco_hydro_10.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR001119. S-layer_homology_dom.
[Graphical view ]
Pfami PF02018. CBM_4_9. 1 hit.
PF06452. DUF1083. 2 hits.
PF00331. Glyco_hydro_10. 1 hit.
PF00395. SLH. 3 hits.
[Graphical view ]
PRINTSi PR00134. GLHYDRLASE10.
SMARTi SM00633. Glyco_10. 1 hit.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEi PS00591. GLYCOSYL_HYDROL_F10. 1 hit.
PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
PS51272. SLH. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Pack M.Y., Jung K.H.
    Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiXYNX_CLOTM
AccessioniPrimary (citable) accession number: P38535
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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