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P38535

- XYNX_CLOTM

UniProt

P38535 - XYNX_CLOTM

Protein

Exoglucanase XynX

Gene

xynX

Organism
Clostridium thermocellum (Ruminiclostridium thermocellum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei347 – 3471Proton donorBy similarity
    Active sitei389 – 3891By similarity
    Active sitei452 – 4521NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. cellulose 1,4-beta-cellobiosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Protein family/group databases

    CAZyiCBM22. Carbohydrate-Binding Module Family 22.
    CBM9. Carbohydrate-Binding Module Family 9.
    GH10. Glycoside Hydrolase Family 10.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exoglucanase XynX (EC:3.2.1.91)
    Alternative name(s):
    1,4-beta-cellobiohydrolase
    Exocellobiohydrolase
    Gene namesi
    Name:xynX
    OrganismiClostridium thermocellum (Ruminiclostridium thermocellum)
    Taxonomic identifieri1515 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 10871057Exoglucanase XynXPRO_0000007982Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP38535.
    SMRiP38535. Positions 711-895.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 188152CBM-cenCAdd
    BLAST
    Domaini903 – 96664SLH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini967 – 102559SLH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1028 – 108760SLH 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 SLH (S-layer homology) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.1190. 2 hits.
    3.20.20.80. 1 hit.
    InterProiIPR010502. Carb-bd_dom_fam9.
    IPR003305. CenC_carb-bd.
    IPR008979. Galactose-bd-like.
    IPR001000. Glyco_hydro_10.
    IPR018087. Glyco_hydro_5_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR001119. S-layer_homology_dom.
    [Graphical view]
    PfamiPF02018. CBM_4_9. 1 hit.
    PF06452. DUF1083. 2 hits.
    PF00331. Glyco_hydro_10. 1 hit.
    PF00395. SLH. 3 hits.
    [Graphical view]
    PRINTSiPR00134. GLHYDRLASE10.
    SMARTiSM00633. Glyco_10. 1 hit.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEiPS00591. GLYCOSYL_HYDROL_F10. 1 hit.
    PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
    PS51272. SLH. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P38535-1 [UniParc]FASTAAdd to Basket

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    MKNNLSKFVS IFTAFIMIFG TSLFFPHVSA FADDNNANLV SNGDFESGTI     50
    DGWIKQGNPT LAATTEEAIG QYSMKVAGRT QTYEGPAYSF LGKMQKGQSY 100
    NVSLKVRLVS GQNSSNPLIT VTMFREDDNG KHYDTIVWQK QVSEDSWTTV 150
    NGTYTLDYTG TLKTLYMYVE SPDPTLEYYI DDVVVTPQNP IQVGEISNNQ 200
    ITIQNDIPDL SSVFKDYFPI GVAVDPSRLN DTDPHAQLTA KHFNMLVAEN 250
    AMKPESLQPT EGNFTFDNAD RIVDYAIAHN MKMRGHTLLW HNQVPDWFFQ 300
    DPSDPTKPAS RDLLLQRLKT HITTVLDHFK TKYGAQNPII GWDVVNEVLD 350
    DNGSLRNSKW LQIIGPDYIE KAFEYAHEAD PSMKLFINDY NIENNGVKTQ 400
    AMYDLVKKLK SEGVPISGIG MQMHININSN IDNIKASIEK LASLGVEIQV 450
    TELDMNMNGN VSNEALLKQA RLYKQLFDLF KAEKQYITAV VFWGVSDDVT 500
    WLSKPNAPLL FDSKLQAKPA YWAIADPSKA IPDIQSAKAL EGSPTIGANV 550
    DSSWKLVKPL YANTYVEGTV GATATVKSMW DTKNLYLLVQ VSDNTPSSND 600
    GIEIFVDKND NKSTSYETDD EHYTIKSDGT GSSDITKYVT SNADGYIVQL 650
    AIPIEDISPT LNDKIGLDVR LNDDKGSGSI DTVTVWNDYT NSQDTNTSYF 700
    GDIVLSKPAQ VATAIYGTPV IDGKIDDIWN KVDAITTNTW VLGSDGATAT 750
    AKMMWDDKYL YVLADVTDSN LNKSSVNPYE QDSVEVFVDQ NNDKTSYYES 800
    DDGQYRVNYD NEQSFGGSTN SNGFKSATSL TQSGYIVEEA IPWTSITLLN 850
    GTIIGFDLQV NDADENGKRT GIVTWCDPSG NSWQDTSGFG NLLLTGKPSG 900
    VLKKSVTFND IKDNWAKDVI EVLASRHIVE GMTDTQYEPS KTVTRAEFTA 950
    MILKLLNIKE EAYNGEFSDV KNGDWYANAI EAAYKAGIIE GDGKNMRPND 1000
    SITREEMTSI AMRAYEMLTS YKEENIGATS FNDDKSISDW AKNVVANAAK 1050
    LGIINGEPSN VFAPKGIATR AEAAAIIYGL LEKSNNL 1087
    Length:1,087
    Mass (Da):120,358
    Last modified:October 1, 1994 - v1
    Checksum:i88077FC27AC83F51
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M67438 Genomic DNA. Translation: AAA23227.1.
    PIRiS41797.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M67438 Genomic DNA. Translation: AAA23227.1 .
    PIRi S41797.

    3D structure databases

    ProteinModelPortali P38535.
    SMRi P38535. Positions 711-895.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi CBM22. Carbohydrate-Binding Module Family 22.
    CBM9. Carbohydrate-Binding Module Family 9.
    GH10. Glycoside Hydrolase Family 10.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.1190. 2 hits.
    3.20.20.80. 1 hit.
    InterProi IPR010502. Carb-bd_dom_fam9.
    IPR003305. CenC_carb-bd.
    IPR008979. Galactose-bd-like.
    IPR001000. Glyco_hydro_10.
    IPR018087. Glyco_hydro_5_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR001119. S-layer_homology_dom.
    [Graphical view ]
    Pfami PF02018. CBM_4_9. 1 hit.
    PF06452. DUF1083. 2 hits.
    PF00331. Glyco_hydro_10. 1 hit.
    PF00395. SLH. 3 hits.
    [Graphical view ]
    PRINTSi PR00134. GLHYDRLASE10.
    SMARTi SM00633. Glyco_10. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEi PS00591. GLYCOSYL_HYDROL_F10. 1 hit.
    PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
    PS51272. SLH. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Pack M.Y., Jung K.H.
      Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiXYNX_CLOTM
    AccessioniPrimary (citable) accession number: P38535
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3