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Protein

Heat shock factor protein 2

Gene

HSF2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF2 shows constitutive DNA binding activity, even without heat shock.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi21 – 126By similarityAdd BLAST106

GO - Molecular functioni

  • core promoter sequence-specific DNA binding Source: AgBase
  • DNA binding transcription factor activity Source: InterPro
  • protein homodimerization activity Source: AgBase

GO - Biological processi

  • negative regulation of protein ubiquitination Source: AgBase
  • protein homotrimerization Source: AgBase
  • protein stabilization Source: AgBase
  • regulation of transcription by RNA polymerase II Source: InterPro
  • response to light stimulus Source: AgBase
  • response to organic cyclic compound Source: AgBase
  • response to organonitrogen compound Source: AgBase
  • response to sodium arsenite Source: AgBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processStress response, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock factor protein 2
Short name:
HSF 2
Alternative name(s):
HSF 3B
HSTF 3B
Heat shock transcription factor 2
Short name:
HSTF 2
Gene namesi
Name:HSF2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001245751 – 564Heat shock factor protein 2Add BLAST564

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP38530

Expressioni

Tissue specificityi

Expressed in most tissues with the exceptions of blood and liver.

Developmental stagei

Expressed during development.

Gene expression databases

BgeeiENSGALG00000014870

Interactioni

Subunit structurei

Homotrimer.

GO - Molecular functioni

  • protein homodimerization activity Source: AgBase

Protein-protein interaction databases

STRINGi9031.ENSGALP00000031100

Structurei

3D structure databases

ProteinModelPortaliP38530
SMRiP38530
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 206Hydrophobic repeat HR-A/BAdd BLAST74
Regioni390 – 415Hydrophobic repeat HR-CAdd BLAST26

Sequence similaritiesi

Belongs to the HSF family.Curated

Phylogenomic databases

eggNOGiKOG0627 Eukaryota
COG5169 LUCA
HOGENOMiHOG000253917
HOVERGENiHBG005999
InParanoidiP38530
OrthoDBiEOG091G087O
PhylomeDBiP38530

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR027712 HSF2
IPR000232 HSF_DNA-bd
IPR027725 HSF_fam
IPR010542 Vert_HSTF_C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10015 PTHR10015, 1 hit
PTHR10015:SF185 PTHR10015:SF185, 1 hit
PfamiView protein in Pfam
PF00447 HSF_DNA-bind, 1 hit
PF06546 Vert_HS_TF, 1 hit
PRINTSiPR00056 HSFDOMAIN
SMARTiView protein in SMART
SM00415 HSF, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00434 HSF_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

P38530-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQEPQQQQP AQQPPPAGAG VPAFLSKLWA LVGEAPSNQL ITWSQNGQSF
60 70 80 90 100
LVLDEQRFAK EILPKYFKHN NMASFVRQLN MYGFRKVVHV DSGIVKLERD
110 120 130 140 150
GLVEFQHPYF KQGREDLLEH IKRKVSSSRP EENKISQEDL SKIISSAQKV
160 170 180 190 200
EIKQETIESR LSALKRENES LWREVAELRA KHLKQQQVIR KIVQFIVTLV
210 220 230 240 250
QNNQLVSLKR KRPLLLNTNG PTKSNVFQQI VKEPADNNNH VPLNRTEGLK
260 270 280 290 300
QREQISDDII IYDVTEDVAD EENTMVDEEN APITPETNED TTSDSSNCSR
310 320 330 340 350
SPDIVIVEDD NEEEYAPVIQ GDKSTESVAV SANDPLSPVS DSTSPLMSSA
360 370 380 390 400
VQLNNQSTLT AEDPVSMMDS ILNENGVISQ NINLLGKVEL LDYLDSIDCS
410 420 430 440 450
LEDFQAMLSG RQFSIDPDLL FDLFTSSVQM NPTDHIPNTK METKGIETTK
460 470 480 490 500
SNAGPAASQE TQVSKPKSDK QLIQYTAFPL LAFLDGNPGS TVESGSSATE
510 520 530 540 550
TPSSVDKPLE VDELLESSLD PEPTQSKLVR LEPLTEAEAS EATLFYLCEL
560
APAPMDTDMP FLDN
Length:564
Mass (Da):62,827
Last modified:October 1, 1994 - v1
Checksum:i3875ED4966ECF5C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06125 mRNA Translation: AFP54344.1
UniGeneiGga.2144

Similar proteinsi

Entry informationi

Entry nameiHSF2_CHICK
AccessioniPrimary (citable) accession number: P38530
Secondary accession number(s): I7FPS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health