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Protein

Heat shock factor protein 2

Gene

HSF2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF2 shows constitutive DNA binding activity, even without heat shock.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi21 – 126106By similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of protein ubiquitination Source: AgBase
  • protein homotrimerization Source: AgBase
  • protein stabilization Source: AgBase
  • response to light stimulus Source: AgBase
  • response to organic cyclic compound Source: AgBase
  • response to organonitrogen compound Source: AgBase
  • response to sodium arsenite Source: AgBase
  • spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock factor protein 2
Short name:
HSF 2
Alternative name(s):
HSF 3B
HSTF 3B
Heat shock transcription factor 2
Short name:
HSTF 2
Gene namesi
Name:HSF2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Cytoplasmic during normal growth and moves to the nucleus upon activation.By similarity

GO - Cellular componenti

  • cytoplasm Source: AgBase
  • nuclear chromatin Source: AgBase
  • nucleus Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Heat shock factor protein 2PRO_0000124575Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP38530.
PRIDEiP38530.

Expressioni

Tissue specificityi

Expressed in most tissues with the exceptions of blood and liver.

Developmental stagei

Expressed during development.

Gene expression databases

BgeeiENSGALG00000014870.
ExpressionAtlasiP38530. baseline.

Interactioni

Subunit structurei

Homotrimer.

GO - Molecular functioni

  • protein homodimerization activity Source: AgBase

Protein-protein interaction databases

STRINGi9031.ENSGALP00000031100.

Structurei

3D structure databases

ProteinModelPortaliP38530.
SMRiP38530. Positions 18-124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 20674Hydrophobic repeat HR-A/BAdd
BLAST
Regioni390 – 41526Hydrophobic repeat HR-CAdd
BLAST

Sequence similaritiesi

Belongs to the HSF family.Curated

Phylogenomic databases

eggNOGiKOG0627. Eukaryota.
COG5169. LUCA.
HOGENOMiHOG000253917.
HOVERGENiHBG005999.
InParanoidiP38530.
OrthoDBiEOG091G087O.
PhylomeDBiP38530.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR027712. HSF2.
IPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR010542. Vert_HSTF_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 1 hit.
PTHR10015:SF185. PTHR10015:SF185. 1 hit.
PfamiPF00447. HSF_DNA-bind. 1 hit.
PF06546. Vert_HS_TF. 1 hit.
[Graphical view]
PRINTSiPR00056. HSFDOMAIN.
SMARTiSM00415. HSF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00434. HSF_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38530-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQEPQQQQP AQQPPPAGAG VPAFLSKLWA LVGEAPSNQL ITWSQNGQSF
60 70 80 90 100
LVLDEQRFAK EILPKYFKHN NMASFVRQLN MYGFRKVVHV DSGIVKLERD
110 120 130 140 150
GLVEFQHPYF KQGREDLLEH IKRKVSSSRP EENKISQEDL SKIISSAQKV
160 170 180 190 200
EIKQETIESR LSALKRENES LWREVAELRA KHLKQQQVIR KIVQFIVTLV
210 220 230 240 250
QNNQLVSLKR KRPLLLNTNG PTKSNVFQQI VKEPADNNNH VPLNRTEGLK
260 270 280 290 300
QREQISDDII IYDVTEDVAD EENTMVDEEN APITPETNED TTSDSSNCSR
310 320 330 340 350
SPDIVIVEDD NEEEYAPVIQ GDKSTESVAV SANDPLSPVS DSTSPLMSSA
360 370 380 390 400
VQLNNQSTLT AEDPVSMMDS ILNENGVISQ NINLLGKVEL LDYLDSIDCS
410 420 430 440 450
LEDFQAMLSG RQFSIDPDLL FDLFTSSVQM NPTDHIPNTK METKGIETTK
460 470 480 490 500
SNAGPAASQE TQVSKPKSDK QLIQYTAFPL LAFLDGNPGS TVESGSSATE
510 520 530 540 550
TPSSVDKPLE VDELLESSLD PEPTQSKLVR LEPLTEAEAS EATLFYLCEL
560
APAPMDTDMP FLDN
Length:564
Mass (Da):62,827
Last modified:October 1, 1994 - v1
Checksum:i3875ED4966ECF5C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06125 mRNA. Translation: AFP54344.1.
UniGeneiGga.2144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06125 mRNA. Translation: AFP54344.1.
UniGeneiGga.2144.

3D structure databases

ProteinModelPortaliP38530.
SMRiP38530. Positions 18-124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000031100.

Proteomic databases

PaxDbiP38530.
PRIDEiP38530.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0627. Eukaryota.
COG5169. LUCA.
HOGENOMiHOG000253917.
HOVERGENiHBG005999.
InParanoidiP38530.
OrthoDBiEOG091G087O.
PhylomeDBiP38530.

Miscellaneous databases

PROiP38530.

Gene expression databases

BgeeiENSGALG00000014870.
ExpressionAtlasiP38530. baseline.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR027712. HSF2.
IPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR010542. Vert_HSTF_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 1 hit.
PTHR10015:SF185. PTHR10015:SF185. 1 hit.
PfamiPF00447. HSF_DNA-bind. 1 hit.
PF06546. Vert_HS_TF. 1 hit.
[Graphical view]
PRINTSiPR00056. HSFDOMAIN.
SMARTiSM00415. HSF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00434. HSF_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSF2_CHICK
AccessioniPrimary (citable) accession number: P38530
Secondary accession number(s): I7FPS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.