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Protein

GrpE protein homolog, mitochondrial

Gene

MGE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of SSC1 to substrate proteins and the association of SSC1 with TIM44.1 Publication

GO - Molecular functioni

  • adenyl-nucleotide exchange factor activity Source: SGD
  • unfolded protein binding Source: GO_Central

GO - Biological processi

  • protein import into mitochondrial matrix Source: SGD
  • protein refolding Source: SGD
  • protein targeting to mitochondrion Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-33730-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Protein family/group databases

TCDBi3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog, mitochondrial
Gene namesi
Name:MGE1
Synonyms:GRPE, GRPE1, YGE1
Ordered Locus Names:YOR232W
ORF Names:O5099
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR232W.
SGDiS000005758. MGE1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial matrix Source: SGD
  • presequence translocase-associated import motor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000013046? – 228GrpE protein homolog, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

MaxQBiP38523.
PRIDEiP38523.

Interactioni

Subunit structurei

Component of the PAM complex, at least composed of SSC1 (mtHsp70), MGE1, TIM44, PAM16/TIM16, PAM17 and PAM18/TIM14. Interacts with SSQ1.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34625. 116 interactors.
DIPiDIP-775N.
IntActiP38523. 13 interactors.
MINTiMINT-493356.

Structurei

3D structure databases

ProteinModelPortaliP38523.
SMRiP38523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000005589.
HOGENOMiHOG000252083.
InParanoidiP38523.
KOiK03687.
OMAiYADFENY.
OrthoDBiEOG092C4MA6.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38523-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAFSAATVR ATTRKSFIPM APRTPFVTPS FTKNVGSMRR MRFYSDEAKS
60 70 80 90 100
EESKENNEDL TEEQSEIKKL ESQLSAKTKE ASELKDRLLR SVADFRNLQQ
110 120 130 140 150
VTKKDIQKAK DFALQKFAKD LLESVDNFGH ALNAFKEEDL QKSKEISDLY
160 170 180 190 200
TGVRMTRDVF ENTLRKHGIE KLDPLGEPFD PNKHEATFEL PQPDKEPGTV
210 220
FHVQQLGFTL NDRVIRPAKV GIVKGEEN
Length:228
Mass (Da):26,066
Last modified:October 1, 1994 - v1
Checksum:i816A5E26C648E613
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78350 Genomic DNA. Translation: CAA55145.1.
D26059 Genomic DNA. Translation: BAA05058.1.
U09565 Unassigned RNA. Translation: AAA19253.1.
Z75140 Genomic DNA. Translation: CAA99452.1.
BK006948 Genomic DNA. Translation: DAA11002.1.
PIRiS41760.
RefSeqiNP_014875.3. NM_001183651.3.

Genome annotation databases

EnsemblFungiiYOR232W; YOR232W; YOR232W.
GeneIDi854407.
KEGGisce:YOR232W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78350 Genomic DNA. Translation: CAA55145.1.
D26059 Genomic DNA. Translation: BAA05058.1.
U09565 Unassigned RNA. Translation: AAA19253.1.
Z75140 Genomic DNA. Translation: CAA99452.1.
BK006948 Genomic DNA. Translation: DAA11002.1.
PIRiS41760.
RefSeqiNP_014875.3. NM_001183651.3.

3D structure databases

ProteinModelPortaliP38523.
SMRiP38523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34625. 116 interactors.
DIPiDIP-775N.
IntActiP38523. 13 interactors.
MINTiMINT-493356.

Protein family/group databases

TCDBi3.A.8.1.1. the mitochondrial protein translocase (mpt) family.

Proteomic databases

MaxQBiP38523.
PRIDEiP38523.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR232W; YOR232W; YOR232W.
GeneIDi854407.
KEGGisce:YOR232W.

Organism-specific databases

EuPathDBiFungiDB:YOR232W.
SGDiS000005758. MGE1.

Phylogenomic databases

GeneTreeiENSGT00390000005589.
HOGENOMiHOG000252083.
InParanoidiP38523.
KOiK03687.
OMAiYADFENY.
OrthoDBiEOG092C4MA6.

Enzyme and pathway databases

BioCyciYEAST:G3O-33730-MONOMER.
ReactomeiR-SCE-1268020. Mitochondrial protein import.

Miscellaneous databases

PROiP38523.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRPE_YEAST
AccessioniPrimary (citable) accession number: P38523
Secondary accession number(s): D6W2T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.