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Protein

GrpE protein homolog, mitochondrial

Gene

MGE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of SSC1 to substrate proteins and the association of SSC1 with TIM44.1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein import into mitochondrial matrix Source: SGD
  • protein refolding Source: SGD

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-33730-MONOMER

Protein family/group databases

TCDBi3.A.8.1.1 the mitochondrial protein translocase (mpt) family

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog, mitochondrial
Gene namesi
Name:MGE1
Synonyms:GRPE, GRPE1, YGE1
Ordered Locus Names:YOR232W
ORF Names:O5099
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR232W
SGDiS000005758 MGE1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000013046? – 228GrpE protein homolog, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

MaxQBiP38523
PaxDbiP38523
PRIDEiP38523

Interactioni

Subunit structurei

Component of the PAM complex, at least composed of SSC1 (mtHsp70), MGE1, TIM44, PAM16/TIM16, PAM17 and PAM18/TIM14. Interacts with SSQ1.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34625, 331 interactors
ComplexPortaliCPX-539 Mitochondrial inner membrane pre-sequence translocase complex
DIPiDIP-775N
IntActiP38523, 22 interactors
MINTiP38523
STRINGi4932.YOR232W

Structurei

3D structure databases

ProteinModelPortaliP38523
SMRiP38523
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000005589
HOGENOMiHOG000252083
InParanoidiP38523
KOiK03687
OMAiYAYEKIA
OrthoDBiEOG092C4MA6

Family and domain databases

CDDicd00446 GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151 GrpE, 1 hit
InterProiView protein in InterPro
IPR000740 GrpE
IPR013805 GrpE_coiled_coil
IPR009012 GrpE_head
PANTHERiPTHR21237 PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025 GrpE, 1 hit
PRINTSiPR00773 GRPEPROTEIN
SUPFAMiSSF51064 SSF51064, 1 hit
SSF58014 SSF58014, 1 hit
PROSITEiView protein in PROSITE
PS01071 GRPE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38523-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAFSAATVR ATTRKSFIPM APRTPFVTPS FTKNVGSMRR MRFYSDEAKS
60 70 80 90 100
EESKENNEDL TEEQSEIKKL ESQLSAKTKE ASELKDRLLR SVADFRNLQQ
110 120 130 140 150
VTKKDIQKAK DFALQKFAKD LLESVDNFGH ALNAFKEEDL QKSKEISDLY
160 170 180 190 200
TGVRMTRDVF ENTLRKHGIE KLDPLGEPFD PNKHEATFEL PQPDKEPGTV
210 220
FHVQQLGFTL NDRVIRPAKV GIVKGEEN
Length:228
Mass (Da):26,066
Last modified:October 1, 1994 - v1
Checksum:i816A5E26C648E613
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78350 Genomic DNA Translation: CAA55145.1
D26059 Genomic DNA Translation: BAA05058.1
U09565 Unassigned RNA Translation: AAA19253.1
Z75140 Genomic DNA Translation: CAA99452.1
BK006948 Genomic DNA Translation: DAA11002.1
PIRiS41760
RefSeqiNP_014875.3, NM_001183651.3

Genome annotation databases

EnsemblFungiiYOR232W; YOR232W; YOR232W
GeneIDi854407
KEGGisce:YOR232W

Similar proteinsi

Entry informationi

Entry nameiGRPE_YEAST
AccessioniPrimary (citable) accession number: P38523
Secondary accession number(s): D6W2T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 20, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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