Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcium-binding protein

Gene
N/A
Organism
Entamoeba histolytica
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Could play a role in the transduction of secondary messages on binding of calcium.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi10 – 21121Add
BLAST
Calcium bindingi46 – 57122Add
BLAST
Calcium bindingi85 – 96123Add
BLAST
Calcium bindingi117 – 128124Add
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein
Short name:
CABP
OrganismiEntamoeba histolytica
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 134134Calcium-binding proteinPRO_0000073470Add
BLAST

Interactioni

Subunit structurei

Trimer.1 Publication

Protein-protein interaction databases

STRINGi5759.rna_EHI_120900-1.

Structurei

Secondary structure

1
134
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 97Combined sources
Beta strandi14 – 163Combined sources
Helixi19 – 4527Combined sources
Beta strandi50 – 523Combined sources
Helixi55 – 617Combined sources
Turni62 – 654Combined sources
Helixi71 – 8414Combined sources
Beta strandi87 – 937Combined sources
Helixi94 – 1018Combined sources
Turni102 – 1043Combined sources
Helixi107 – 11711Combined sources
Beta strandi119 – 1257Combined sources
Helixi126 – 1338Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JFJNMR-A1-134[»]
1JFKNMR-A1-134[»]
2I18NMR-A71-134[»]
2M7KNMR-A1-66[»]
2M7MNMR-A1-66[»]
2M7NNMR-A1-134[»]
2NXQX-ray2.40A/B1-134[»]
3LI6X-ray2.50A/D/G/J1-66[»]
3PX1X-ray3.00A/B1-134[»]
3QJKX-ray3.00A/B1-134[»]
3ULGX-ray3.20A/B1-134[»]
ProteinModelPortaliP38505.
SMRiP38505. Positions 1-134.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38505.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 3232EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini33 – 6836EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini72 – 10736EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini104 – 13431EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38505-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEALFKEID VNGDGAVSYE EVKAFVSKKR AIKNEQLLQL IFKSIDADGN
60 70 80 90 100
GEIDQNEFAK FYGSIQGQDL SDDKIGLKVL YKLMDVDGDG KLTKEEVTSF
110 120 130
FKKHGIEKVA EQVMKADANG DGYITLEEFL EFSL
Length:134
Mass (Da):14,953
Last modified:December 7, 2004 - v2
Checksum:i27C8678ED3563B02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84155 mRNA. Translation: AAA29089.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84155 mRNA. Translation: AAA29089.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JFJNMR-A1-134[»]
1JFKNMR-A1-134[»]
2I18NMR-A71-134[»]
2M7KNMR-A1-66[»]
2M7MNMR-A1-66[»]
2M7NNMR-A1-134[»]
2NXQX-ray2.40A/B1-134[»]
3LI6X-ray2.50A/D/G/J1-66[»]
3PX1X-ray3.00A/B1-134[»]
3QJKX-ray3.00A/B1-134[»]
3ULGX-ray3.20A/B1-134[»]
ProteinModelPortaliP38505.
SMRiP38505. Positions 1-134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5759.rna_EHI_120900-1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.

Miscellaneous databases

EvolutionaryTraceiP38505.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequence analysis of a calcium-binding protein gene from a pathogenic strain of Entamoeba histolytica."
    Prasad J., Bhattacharya S., Bhattacharya A.
    Mol. Biochem. Parasitol. 52:137-140(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ATCC 30459 / HM-1:IMSS.
  2. "The calcium binding protein of Entamoeba histolytica: expression in Escherichia coli and immunochemical characterization."
    Prasad J., Bhattacharya S., Bhattacharya A.
    Cell. Mol. Biol. Res. 39:167-175(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  3. "NMR derived solution structure of an EF-hand calcium-binding protein from Entamoeba histolytica."
    Atreya H.S., Sahu S.C., Bhattacharya A., Chary K.V., Govil G.
    Biochemistry 40:14392-14403(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, SEQUENCE REVISION TO 131.
  4. "Crystal structure of calcium binding protein-1 from Entamoeba histolytica: a novel arrangement of EF hand motifs."
    Kumar S., Padhan N., Alam N., Gourinath S.
    Proteins 68:990-998(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEX WITH CALCIUM IONS, SUBUNIT.

Entry informationi

Entry nameiCALBP_ENTHI
AccessioniPrimary (citable) accession number: P38505
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: December 7, 2004
Last modified: December 9, 2015
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.