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Protein

Creatinase

Gene
N/A
Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Creatine + H2O = sarcosine + urea.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2321

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Creatinase (EC:3.5.3.3)
Alternative name(s):
Creatine amidinohydrolase
OrganismiPseudomonas putida (Arthrobacter siderocapsulatus)
Taxonomic identifieri303 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793441 – 403CreatinaseAdd BLAST403

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1403
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 7Combined sources3
Helixi21 – 37Combined sources17
Beta strandi41 – 45Combined sources5
Helixi48 – 55Combined sources8
Beta strandi67 – 70Combined sources4
Beta strandi75 – 80Combined sources6
Helixi81 – 83Combined sources3
Helixi86 – 90Combined sources5
Beta strandi93 – 99Combined sources7
Helixi106 – 114Combined sources9
Beta strandi119 – 123Combined sources5
Turni125 – 127Combined sources3
Helixi130 – 139Combined sources10
Beta strandi144 – 147Combined sources4
Helixi149 – 156Combined sources8
Helixi161 – 184Combined sources24
Helixi191 – 209Combined sources19
Beta strandi219 – 224Combined sources6
Helixi225 – 229Combined sources5
Beta strandi235 – 237Combined sources3
Beta strandi245 – 251Combined sources7
Beta strandi261 – 268Combined sources8
Helixi272 – 291Combined sources20
Helixi298 – 311Combined sources14
Helixi315 – 317Combined sources3
Beta strandi327 – 330Combined sources4
Beta strandi354 – 357Combined sources4
Beta strandi360 – 363Combined sources4
Beta strandi371 – 374Combined sources4
Beta strandi376 – 382Combined sources7
Beta strandi385 – 388Combined sources4
Helixi396 – 399Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CHMX-ray1.90A/B2-402[»]
ProteinModelPortaliP38488.
SMRiP38488.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38488.

Family & Domainsi

Domaini

Each monomer has two clearly defined domains. The small N-terminal domain (AA 1-161) and the large domain (AA 162-403). Each of the two active sites is made by residues of the large domain of one monomer and some residues of the small domain of the other monomer.

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.350.10. 1 hit.
3.90.230.10. 1 hit.
InterProiIPR029149. Creatin/AminoP/Spt16_NTD.
IPR028980. Creatinase/Aminopeptidase_P_N.
IPR000587. Creatinase_N.
IPR000994. Pept_M24.
[Graphical view]
PfamiPF01321. Creatinase_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
[Graphical view]
SUPFAMiSSF53092. SSF53092. 1 hit.
SSF55920. SSF55920. 1 hit.

Sequencei

Sequence statusi: Complete.

P38488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQMPKTLRIR NGDKVRSTFS AQEYANRQAR LRAHLAAENI DAAIFTSYHN
60 70 80 90 100
INYYSDFLYC SFGRPYALVV TEDDVISISA NIDGGQPWRR TVGTDNIVYT
110 120 130 140 150
DWQRDNYFAA IQQALPKARR IGIEHDHLNL QNRDKLAARY PDAELVDVAA
160 170 180 190 200
ACMRMRMIKS AEEHVMIRHG ARIADIGGAA VVEALGDQVP EYEVALHATQ
210 220 230 240 250
AMVRAIADTF EDVELMDTWT WFQSGINTDG AHNPVTTRKV NKGDILSLNC
260 270 280 290 300
FPMIAGYYTA LERTLFLDHC SDDHLRLWQV NVEVHEAGLK LIKPGARCSD
310 320 330 340 350
IARELNEIFL KHDVLQYRTF GYGHSFGTLS HYYGREAGLE LREDIDTVLE
360 370 380 390 400
PGMVVSMEPM IMLPEGLPGA GGYREHDILI VNENGAENIT KFPYGPEKNI

IRK
Length:403
Mass (Da):45,537
Last modified:February 1, 1995 - v2
Checksum:i21C2CD808D017EE0
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CHMX-ray1.90A/B2-402[»]
ProteinModelPortaliP38488.
SMRiP38488.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP38488.

Family and domain databases

Gene3Di3.40.350.10. 1 hit.
3.90.230.10. 1 hit.
InterProiIPR029149. Creatin/AminoP/Spt16_NTD.
IPR028980. Creatinase/Aminopeptidase_P_N.
IPR000587. Creatinase_N.
IPR000994. Pept_M24.
[Graphical view]
PfamiPF01321. Creatinase_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
[Graphical view]
SUPFAMiSSF53092. SSF53092. 1 hit.
SSF55920. SSF55920. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCREA_PSEPU
AccessioniPrimary (citable) accession number: P38488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: February 1, 1995
Last modified: November 30, 2016
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.