P38479 (ABP1_SACEX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin-binding protein

Gene names

Name:

ABP1

Organism

Saccharomyces exiguus (Yeast)

Taxonomic identifier

34358 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kazachstania

Protein attributes

Sequence length	617 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be involved in the spatial organization of cell surface growth. An overproduction of ABP1 causes the assembly of the cortical actin skeleton at inappropriate sites on the cell surface, resulting in delocalized surface growth By similarity.
Subcellular location	Cytoplasm › cytoskeleton. Note: Cortical cytoskeleton.
Sequence similarities	Contains 1 ADF-H domain. Contains 1 SH3 domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Domain	Repeat SH3 domain
Ligand	Actin-binding
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 617	617	Actin-binding protein		PRO_0000064428
Regions
	Domain	7 – 136	130	ADF-H
	Repeat	202 – 211	10	1-1
	Repeat	444 – 453	10	1-2
	Repeat	495 – 510	16	2-1
	Repeat	523 – 538	16	2-2
	Domain	557 – 617	61	SH3
	Repeat	591 – 600	10	1-3
	Region	202 – 600	399	3 X 10 AA approximate repeats
	Region	495 – 538	44	2 X 16 AA repeats of E(7)-A-P-A-P-S-L-P-S-R
	Compositional bias	486 – 501	16	Poly-Glu
	Compositional bias	523 – 529	7	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	P38479 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 540A785191B65F85	FASTA	617	68,420
	10 20 30 40 50 60 MALEPIDATT HSRDIEQEYQ KVVRGTDNDT TWLIISPNTQ KEYLPSSTGS SFSDFLQSFD 70 80 90 100 110 120 ETKVEYGIAR VSPPGSDVGK IILVGWCPDS APMKTRASFA ANFGTIANSV LPGYHIQVTA 130 140 150 160 170 180 RDEDDLDEEE LLTKISNAAG ARYSIQAAGN SVPTSSASGS APVKKVFTPS LAKKESEPKK 190 200 210 220 230 240 SFVPPPVREE PVPVNVVKDN DADDWDEPEI KERNFETNPL SDNKPAYEPI GKIDLKKVIA 250 260 270 280 290 300 EETAKEDPRL INRIDPSADI AHLKQESKIH RDNDLDNLLK QEKTSSPAVG GTKPPLVNLI 310 320 330 340 350 360 FVEMIIVIRL YKVSRPEKSP AQLWAEKKMK QNQQSDSAQE EQKPVETKTE IEIGVDNSDE 370 380 390 400 410 420 MKIGDLKSRF EKLGAETETE PEPPVQWETD SIPTVVKPQT FGQPAANSKP ATQEVKKPFT 430 440 450 460 470 480 PSNIGQRLPG MHTETPEHEE EDNDDDWGED EDEPPKRNIP PPVMPARESA PQQPLPPRNT 490 500 510 520 530 540 EPEPVEEGEE EEEEEEEEEE EAPAPSLPSR NAAPEPEPEQ PQEEEEEEEA PAPSLPSRGS 550 560 570 580 590 600 VPPPPPQRAV EPEEPAAEAP WATAEYDYEA GEDNELTFAE NDKIINIEFV DDDWWLGELE 610 TTGQKGLFPS NYVVLGN

References

[1]	"Cloning and sequencing of a gene coding for an actin binding protein of Saccharomyces exiguus." Lange U., Steiner S., Grolig F., Wagner G., Philippsen P. Biochim. Biophys. Acta 1217:214-218(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CBS 379.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X73977 Genomic DNA. Translation: CAA52156.1.
PIR	S42719.
3D structure databases
ProteinModelPortal	P38479.
SMR	P38479. Positions 3-141, 559-617.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002108. Actin-bd_cofilin/tropomyosin. IPR000108. p67phox. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00241. Cofilin_ADF. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00499. P67PHOX. PR00452. SH3DOMAIN.
SMART	SM00102. ADF. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS51263. ADF_H. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABP1_SACEX

Accession

Primary (citable) accession number: P38479

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program