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Protein

Actin-binding protein

Gene

ABP1

Organism
Saccharomyces exiguus (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May be involved in the spatial organization of cell surface growth. An overproduction of ABP1 causes the assembly of the cortical actin skeleton at inappropriate sites on the cell surface, resulting in delocalized surface growth (By similarity).By similarity

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-binding protein
Gene namesi
Name:ABP1
OrganismiSaccharomyces exiguus (Yeast)
Taxonomic identifieri34358 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKazachstania

Subcellular locationi

Cytoplasmcytoskeleton
Note: Cortical cytoskeleton.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Actin-binding proteinPRO_0000064428Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP38479.
SMRiP38479. Positions 3-141, 559-617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 136130ADF-HPROSITE-ProRule annotationAdd
BLAST
Repeati202 – 211101-1
Repeati444 – 453101-2
Repeati495 – 510162-1Add
BLAST
Repeati523 – 538162-2Add
BLAST
Domaini557 – 61761SH3PROSITE-ProRule annotationAdd
BLAST
Repeati591 – 600101-3

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni202 – 6003993 X 10 AA approximate repeatsAdd
BLAST
Regioni495 – 538442 X 16 AA repeats of E(7)-A-P-A-P-S-L-P-S-RAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi486 – 50116Poly-GluAdd
BLAST
Compositional biasi523 – 5297Poly-Glu

Sequence similaritiesi

Contains 1 ADF-H domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00241. Cofilin_ADF. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00102. ADF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51263. ADF_H. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38479-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALEPIDATT HSRDIEQEYQ KVVRGTDNDT TWLIISPNTQ KEYLPSSTGS
60 70 80 90 100
SFSDFLQSFD ETKVEYGIAR VSPPGSDVGK IILVGWCPDS APMKTRASFA
110 120 130 140 150
ANFGTIANSV LPGYHIQVTA RDEDDLDEEE LLTKISNAAG ARYSIQAAGN
160 170 180 190 200
SVPTSSASGS APVKKVFTPS LAKKESEPKK SFVPPPVREE PVPVNVVKDN
210 220 230 240 250
DADDWDEPEI KERNFETNPL SDNKPAYEPI GKIDLKKVIA EETAKEDPRL
260 270 280 290 300
INRIDPSADI AHLKQESKIH RDNDLDNLLK QEKTSSPAVG GTKPPLVNLI
310 320 330 340 350
FVEMIIVIRL YKVSRPEKSP AQLWAEKKMK QNQQSDSAQE EQKPVETKTE
360 370 380 390 400
IEIGVDNSDE MKIGDLKSRF EKLGAETETE PEPPVQWETD SIPTVVKPQT
410 420 430 440 450
FGQPAANSKP ATQEVKKPFT PSNIGQRLPG MHTETPEHEE EDNDDDWGED
460 470 480 490 500
EDEPPKRNIP PPVMPARESA PQQPLPPRNT EPEPVEEGEE EEEEEEEEEE
510 520 530 540 550
EAPAPSLPSR NAAPEPEPEQ PQEEEEEEEA PAPSLPSRGS VPPPPPQRAV
560 570 580 590 600
EPEEPAAEAP WATAEYDYEA GEDNELTFAE NDKIINIEFV DDDWWLGELE
610
TTGQKGLFPS NYVVLGN
Length:617
Mass (Da):68,420
Last modified:October 1, 1994 - v1
Checksum:i540A785191B65F85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73977 Genomic DNA. Translation: CAA52156.1.
PIRiS42719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73977 Genomic DNA. Translation: CAA52156.1.
PIRiS42719.

3D structure databases

ProteinModelPortaliP38479.
SMRiP38479. Positions 3-141, 559-617.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00241. Cofilin_ADF. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00102. ADF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51263. ADF_H. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequencing of a gene coding for an actin binding protein of Saccharomyces exiguus."
    Lange U., Steiner S., Grolig F., Wagner G., Philippsen P.
    Biochim. Biophys. Acta 1217:214-218(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CBS 379.

Entry informationi

Entry nameiABP1_SACEX
AccessioniPrimary (citable) accession number: P38479
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: January 7, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.