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P38448 (ALKH_DICD3) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
KHG/KDPG aldolase

Including the following 2 domains:

  1. 4-hydroxy-2-oxoglutarate aldolase
    EC=4.1.3.16
    Alternative name(s):
    2-keto-4-hydroxyglutarate aldolase
    Short name=KHG-aldolase
  2. 2-dehydro-3-deoxy-phosphogluconate aldolase
    EC=4.1.2.14
    Alternative name(s):
    2-keto-3-deoxy-6-phosphogluconate aldolase
    Short name=KDPG-aldolase
    Phospho-2-dehydro-3-deoxygluconate aldolase
    Phospho-2-keto-3-deoxygluconate aldolase
Gene names
Name:eda
Synonyms:kdgA
Ordered Locus Names:Dda3937_03573
OrganismDickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) [Complete proteome] [HAMAP]
Taxonomic identifier198628 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

Pathway

Carbohydrate acid metabolism; 2-dehydro-3-deoxy-D-gluconate degradation; D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 2/2.

Carbohydrate metabolism; glyoxylate and dicarboxylate metabolism.

Subunit structure

Homotrimer By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the KHG/KDPG aldolase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Multifunctional enzyme
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function2-dehydro-3-deoxy-phosphogluconate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

4-hydroxy-2-oxoglutarate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213KHG/KDPG aldolase
PRO_0000201040

Sites

Active site451 By similarity
Active site491 By similarity
Active site1331Schiff-base intermediate with KHG or pyruvate By similarity

Sequences

Sequence LengthMass (Da)Tools
P38448 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 641A0D1015CD7413

FASTA21322,184
        10         20         30         40         50         60 
MKNWKTSAEQ ILTAGPVVPV IVINKLEHAV PMAKALVAGG VRVLELTLRT ECAVEAIRLI 

        70         80         90        100        110        120 
AQEVPDAIVG AGTVTNPQQL AEVTAAGAQF AISPGLTEPL LKAATEGTIP LIPGISTVSE 

       130        140        150        160        170        180 
LMLGMDYGLR EFKFFPAEAN GGVKALQAIA GPFGKIRFCP TGGISLKNYR DYLALKSVLC 

       190        200        210 
VGGSWLVPAD ALESGDYDRI TALAREAVAG ATA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X74866 Genomic DNA. Translation: CAA52859.1.
CP002038 Genomic DNA. Translation: ADM98359.1.
PIRS37054.
RefSeqYP_003882916.1. NC_014500.1.

3D structure databases

ProteinModelPortalP38448.
SMRP38448. Positions 1-211.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP38448.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADM98359; ADM98359; Dda3937_03573.
GeneID9733589.
KEGGddd:Dda3937_03573.
PATRIC42316624. VBIDicDad25310_2135.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000233114.
KOK01625.
OMAKFFPAEY.

Enzyme and pathway databases

BioCycDDAD198628:GHFQ-2204-MONOMER.
MetaCyc:MONOMER-15645.
UniPathwayUPA00227.
UPA00856; UER00829.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view]
PfamPF01081. Aldolase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01182. eda. 1 hit.
PROSITEPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALKH_DICD3
AccessionPrimary (citable) accession number: P38448
Secondary accession number(s): E0SB90
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 16, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways