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P38448

- ALKH_DICD3

UniProt

P38448 - ALKH_DICD3

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Protein

KHG/KDPG aldolase

Gene
eda, kdgA, Dda3937_03573
Organism
Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451 By similarity
Active sitei49 – 491 By similarity
Active sitei133 – 1331Schiff-base intermediate with KHG or pyruvate By similarity

GO - Molecular functioni

  1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC
  2. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciDDAD198628:GHFQ-2204-MONOMER.
MetaCyc:MONOMER-15645.
UniPathwayiUPA00227.
UPA00856; UER00829.

Names & Taxonomyi

Protein namesi
Recommended name:
KHG/KDPG aldolase
Including the following 2 domains:
4-hydroxy-2-oxoglutarate aldolase (EC:4.1.3.16)
Alternative name(s):
2-keto-4-hydroxyglutarate aldolase
Short name:
KHG-aldolase
2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
Alternative name(s):
2-keto-3-deoxy-6-phosphogluconate aldolase
Short name:
KDPG-aldolase
Phospho-2-dehydro-3-deoxygluconate aldolase
Phospho-2-keto-3-deoxygluconate aldolase
Gene namesi
Name:eda
Synonyms:kdgA
Ordered Locus Names:Dda3937_03573
OrganismiDickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Taxonomic identifieri198628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya
ProteomesiUP000006859: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213KHG/KDPG aldolasePRO_0000201040Add
BLAST

Proteomic databases

PRIDEiP38448.

Interactioni

Subunit structurei

Homotrimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP38448.
SMRiP38448. Positions 1-211.

Family & Domainsi

Sequence similaritiesi

Belongs to the KHG/KDPG aldolase family.

Phylogenomic databases

HOGENOMiHOG000233114.
KOiK01625.
OMAiSWLVPND.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view]
PfamiPF01081. Aldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01182. eda. 1 hit.
PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38448-1 [UniParc]FASTAAdd to Basket

« Hide

MKNWKTSAEQ ILTAGPVVPV IVINKLEHAV PMAKALVAGG VRVLELTLRT    50
ECAVEAIRLI AQEVPDAIVG AGTVTNPQQL AEVTAAGAQF AISPGLTEPL 100
LKAATEGTIP LIPGISTVSE LMLGMDYGLR EFKFFPAEAN GGVKALQAIA 150
GPFGKIRFCP TGGISLKNYR DYLALKSVLC VGGSWLVPAD ALESGDYDRI 200
TALAREAVAG ATA 213
Length:213
Mass (Da):22,184
Last modified:October 1, 1994 - v1
Checksum:i641A0D1015CD7413
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74866 Genomic DNA. Translation: CAA52859.1.
CP002038 Genomic DNA. Translation: ADM98359.1.
PIRiS37054.
RefSeqiYP_003882916.1. NC_014500.1.

Genome annotation databases

EnsemblBacteriaiADM98359; ADM98359; Dda3937_03573.
GeneIDi9733589.
KEGGiddd:Dda3937_03573.
PATRICi42316624. VBIDicDad25310_2135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74866 Genomic DNA. Translation: CAA52859.1 .
CP002038 Genomic DNA. Translation: ADM98359.1 .
PIRi S37054.
RefSeqi YP_003882916.1. NC_014500.1.

3D structure databases

ProteinModelPortali P38448.
SMRi P38448. Positions 1-211.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P38448.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADM98359 ; ADM98359 ; Dda3937_03573 .
GeneIDi 9733589.
KEGGi ddd:Dda3937_03573.
PATRICi 42316624. VBIDicDad25310_2135.

Phylogenomic databases

HOGENOMi HOG000233114.
KOi K01625.
OMAi SWLVPND.

Enzyme and pathway databases

UniPathwayi UPA00227 .
UPA00856 ; UER00829 .
BioCyci DDAD198628:GHFQ-2204-MONOMER.
MetaCyc:MONOMER-15645.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view ]
Pfami PF01081. Aldolase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01182. eda. 1 hit.
PROSITEi PS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of the Erwinia chrysanthemi region containing the kdgA and zwf genes."
    Hugouvieux-Cotte-Pattat N., Robert-Baudouy J.
    Mol. Microbiol. 11:67-75(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 3937.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 3937.

Entry informationi

Entry nameiALKH_DICD3
AccessioniPrimary (citable) accession number: P38448
Secondary accession number(s): E0SB90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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