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P38448

- ALKH_DICD3

UniProt

P38448 - ALKH_DICD3

Protein

KHG/KDPG aldolase

Gene

eda

Organism
Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
    2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei45 – 451PROSITE-ProRule annotation
    Active sitei49 – 491PROSITE-ProRule annotation
    Active sitei133 – 1331Schiff-base intermediate with KHG or pyruvatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC
    2. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciDDAD198628:GHFQ-2204-MONOMER.
    MetaCyc:MONOMER-15645.
    UniPathwayiUPA00227.
    UPA00856; UER00829.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KHG/KDPG aldolase
    Including the following 2 domains:
    4-hydroxy-2-oxoglutarate aldolase (EC:4.1.3.16)
    Alternative name(s):
    2-keto-4-hydroxyglutarate aldolase
    Short name:
    KHG-aldolase
    2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
    Alternative name(s):
    2-keto-3-deoxy-6-phosphogluconate aldolase
    Short name:
    KDPG-aldolase
    Phospho-2-dehydro-3-deoxygluconate aldolase
    Phospho-2-keto-3-deoxygluconate aldolase
    Gene namesi
    Name:eda
    Synonyms:kdgA
    Ordered Locus Names:Dda3937_03573
    OrganismiDickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
    Taxonomic identifieri198628 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya
    ProteomesiUP000006859: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213KHG/KDPG aldolasePRO_0000201040Add
    BLAST

    Proteomic databases

    PRIDEiP38448.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP38448.
    SMRiP38448. Positions 1-211.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the KHG/KDPG aldolase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000233114.
    KOiK01625.
    OMAiSWLVPND.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR000887. Aldlse_KDPG_KHG.
    IPR013785. Aldolase_TIM.
    [Graphical view]
    PfamiPF01081. Aldolase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01182. eda. 1 hit.
    PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
    PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38448-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNWKTSAEQ ILTAGPVVPV IVINKLEHAV PMAKALVAGG VRVLELTLRT    50
    ECAVEAIRLI AQEVPDAIVG AGTVTNPQQL AEVTAAGAQF AISPGLTEPL 100
    LKAATEGTIP LIPGISTVSE LMLGMDYGLR EFKFFPAEAN GGVKALQAIA 150
    GPFGKIRFCP TGGISLKNYR DYLALKSVLC VGGSWLVPAD ALESGDYDRI 200
    TALAREAVAG ATA 213
    Length:213
    Mass (Da):22,184
    Last modified:October 1, 1994 - v1
    Checksum:i641A0D1015CD7413
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74866 Genomic DNA. Translation: CAA52859.1.
    CP002038 Genomic DNA. Translation: ADM98359.1.
    PIRiS37054.
    RefSeqiYP_003882916.1. NC_014500.1.

    Genome annotation databases

    EnsemblBacteriaiADM98359; ADM98359; Dda3937_03573.
    GeneIDi9733589.
    KEGGiddd:Dda3937_03573.
    PATRICi42316624. VBIDicDad25310_2135.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74866 Genomic DNA. Translation: CAA52859.1 .
    CP002038 Genomic DNA. Translation: ADM98359.1 .
    PIRi S37054.
    RefSeqi YP_003882916.1. NC_014500.1.

    3D structure databases

    ProteinModelPortali P38448.
    SMRi P38448. Positions 1-211.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P38448.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADM98359 ; ADM98359 ; Dda3937_03573 .
    GeneIDi 9733589.
    KEGGi ddd:Dda3937_03573.
    PATRICi 42316624. VBIDicDad25310_2135.

    Phylogenomic databases

    HOGENOMi HOG000233114.
    KOi K01625.
    OMAi SWLVPND.

    Enzyme and pathway databases

    UniPathwayi UPA00227 .
    UPA00856 ; UER00829 .
    BioCyci DDAD198628:GHFQ-2204-MONOMER.
    MetaCyc:MONOMER-15645.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR000887. Aldlse_KDPG_KHG.
    IPR013785. Aldolase_TIM.
    [Graphical view ]
    Pfami PF01081. Aldolase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01182. eda. 1 hit.
    PROSITEi PS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
    PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of the Erwinia chrysanthemi region containing the kdgA and zwf genes."
      Hugouvieux-Cotte-Pattat N., Robert-Baudouy J.
      Mol. Microbiol. 11:67-75(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 3937.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 3937.

    Entry informationi

    Entry nameiALKH_DICD3
    AccessioniPrimary (citable) accession number: P38448
    Secondary accession number(s): E0SB90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3