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P38448

- ALKH_DICD3

UniProt

P38448 - ALKH_DICD3

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Protein

KHG/KDPG aldolase

Gene

eda

Organism
Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451PROSITE-ProRule annotation
Active sitei49 – 491PROSITE-ProRule annotation
Active sitei133 – 1331Schiff-base intermediate with KHG or pyruvatePROSITE-ProRule annotation

GO - Molecular functioni

  1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC
  2. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciDDAD198628:GHFQ-2204-MONOMER.
MetaCyc:MONOMER-15645.
UniPathwayiUPA00227.
UPA00856; UER00829.

Names & Taxonomyi

Protein namesi
Recommended name:
KHG/KDPG aldolase
Including the following 2 domains:
4-hydroxy-2-oxoglutarate aldolase (EC:4.1.3.16)
Alternative name(s):
2-keto-4-hydroxyglutarate aldolase
Short name:
KHG-aldolase
2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
Alternative name(s):
2-keto-3-deoxy-6-phosphogluconate aldolase
Short name:
KDPG-aldolase
Phospho-2-dehydro-3-deoxygluconate aldolase
Phospho-2-keto-3-deoxygluconate aldolase
Gene namesi
Name:eda
Synonyms:kdgA
Ordered Locus Names:Dda3937_03573
OrganismiDickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Taxonomic identifieri198628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya
ProteomesiUP000006859: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213KHG/KDPG aldolasePRO_0000201040Add
BLAST

Proteomic databases

PRIDEiP38448.

Interactioni

Subunit structurei

Homotrimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP38448.
SMRiP38448. Positions 1-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KHG/KDPG aldolase family.Curated

Phylogenomic databases

HOGENOMiHOG000233114.
KOiK01625.
OMAiSWLVPND.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view]
PfamiPF01081. Aldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01182. eda. 1 hit.
PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38448-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNWKTSAEQ ILTAGPVVPV IVINKLEHAV PMAKALVAGG VRVLELTLRT
60 70 80 90 100
ECAVEAIRLI AQEVPDAIVG AGTVTNPQQL AEVTAAGAQF AISPGLTEPL
110 120 130 140 150
LKAATEGTIP LIPGISTVSE LMLGMDYGLR EFKFFPAEAN GGVKALQAIA
160 170 180 190 200
GPFGKIRFCP TGGISLKNYR DYLALKSVLC VGGSWLVPAD ALESGDYDRI
210
TALAREAVAG ATA
Length:213
Mass (Da):22,184
Last modified:October 1, 1994 - v1
Checksum:i641A0D1015CD7413
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74866 Genomic DNA. Translation: CAA52859.1.
CP002038 Genomic DNA. Translation: ADM98359.1.
PIRiS37054.
RefSeqiYP_003882916.1. NC_014500.1.

Genome annotation databases

EnsemblBacteriaiADM98359; ADM98359; Dda3937_03573.
GeneIDi9733589.
KEGGiddd:Dda3937_03573.
PATRICi42316624. VBIDicDad25310_2135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74866 Genomic DNA. Translation: CAA52859.1 .
CP002038 Genomic DNA. Translation: ADM98359.1 .
PIRi S37054.
RefSeqi YP_003882916.1. NC_014500.1.

3D structure databases

ProteinModelPortali P38448.
SMRi P38448. Positions 1-211.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P38448.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADM98359 ; ADM98359 ; Dda3937_03573 .
GeneIDi 9733589.
KEGGi ddd:Dda3937_03573.
PATRICi 42316624. VBIDicDad25310_2135.

Phylogenomic databases

HOGENOMi HOG000233114.
KOi K01625.
OMAi SWLVPND.

Enzyme and pathway databases

UniPathwayi UPA00227 .
UPA00856 ; UER00829 .
BioCyci DDAD198628:GHFQ-2204-MONOMER.
MetaCyc:MONOMER-15645.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view ]
Pfami PF01081. Aldolase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01182. eda. 1 hit.
PROSITEi PS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of the Erwinia chrysanthemi region containing the kdgA and zwf genes."
    Hugouvieux-Cotte-Pattat N., Robert-Baudouy J.
    Mol. Microbiol. 11:67-75(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 3937.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 3937.

Entry informationi

Entry nameiALKH_DICD3
AccessioniPrimary (citable) accession number: P38448
Secondary accession number(s): E0SB90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3