Reviewed, UniProtKB/Swiss-Prot P38445 (AVR2B_RAT)

Names and origin

Protein names

Recommended name:
    Activin receptor type-2B
    EC=2.7.11.30
Alternative name(s):
    Activin receptor type IIB
      Short name(s)=ACTR-IIB

Gene names

Name:	Acvr2b
Synonyms:	Actriib

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A By similarity.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 513	495	Activin receptor type-2B
Regions
	Topological domain	19 – 137	119	Extracellular Potential
	Transmembrane	138 – 158	21	Potential
	Topological domain	159 – 513	355	Cytoplasmic Potential
	Domain	190 – 481	292	Protein kinase
	Nucleotide binding	196 – 204	9	ATP By similarity
Sites
	Active site	322	1	Proton acceptor By similarity
	Binding site	217	1	ATP By similarity
Amino acid modifications
	Glycosylation	42	1	N-linked (GlcNAc...) Potential
	Glycosylation	65	1	N-linked (GlcNAc...) Potential
	Disulfide bond	29 ↔ 59		By similarity
	Disulfide bond	49 ↔ 77		By similarity
	Disulfide bond	84 ↔ 103		By similarity
	Disulfide bond	90 ↔ 102		By similarity
	Disulfide bond	104 ↔ 109		By similarity
Experimental info
	Sequence conflict	64	1	R → P in AAA40772. Ref.1
	Sequence conflict	64	1	R → P Ref.2
	Sequence conflict	255	1	Missing in AAH97358. Ref.2 Ref.3
	Sequence conflict	488	1	S → G in AAA40772. Ref.1
	Sequence conflict	488	1	S → G Ref.2
	Sequence conflict	501	1	V → S in AAA40772. Ref.1
	Sequence conflict	501	1	V → S Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P38445-1 [UniParc]. Last modified November 13, 2007. Version 3. Checksum: 765DB33F11C64CA7	FASTA	513	57,857
	10 20 30 40 50 60 MTAPWAALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY 70 80 90 100 110 120 ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEPG 130 140 150 160 170 180 GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS LIVLLAFWMY RHRKPPYGHV DIHEDPGPPP 190 200 210 220 230 240 PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDFVAVKIFP LQDKQSWQSE REIFSTPGMK 250 260 270 280 290 300 HENLLQFIAA EKRGCSNLEV ELWLITAFHD KGSLTDYLKG NIITWNELCH VAETMSRGLS 310 320 330 340 350 360 YLHEDVPWCR GEGHKPSIAH RDFKSKNVLL KSDLTAVLAD FGLAVRFEPG KPPGDTHGQV 370 380 390 400 410 420 GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELVSR CKAADGPVDE YMLPFEEEIG 430 440 450 460 470 480 QHPSLEELQE VVVHKKMRPT IKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEERVS 490 500 510 LIRRSVNSST SDCLVSLVTS VTNVDLLPKE SSI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel rat activin receptor." Legerski R., Zhou X., Dresback J., Eberspaecher H., McKinney S., Segarini P., de Crombrugghe B. Biochem. Biophys. Res. Commun. 183:672-679(1992) [PubMed: 1312838] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Expression of type II activin receptor genes in the male and female reproductive tissues of the rat." Feng Z.M., Madigan M.B., Chen C.L.C. Endocrinology 132:2593-2600(1993) [PubMed: 7916681] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions." Thompson T.B., Woodruff T.K., Jardetzky T.S. EMBO J. 22:1555-1566(2003) [PubMed: 12660162] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF 19-119 IN COMPLEX WITH HUMAN INHBA.

Cross-references

Sequence databases

EMBLGenBankDDBJ

L10640 mRNA. Translation: AAA40772.1.
BC097358 mRNA. Translation: AAH97358.1.

PIR

B49193.
JQ1484.

RefSeq

NP_113742.1.

UniGene

Rn.24240

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1NYS	X-ray	3.05	A/C	19-119	[»]
1NYU	X-ray	3.10	A/C	19-119	[»]

SMR

P38445. Positions 24-117.

ModBase

Search...

Genome annotation databases

Ensembl

ENSRNOG00000014477. Rattus norvegicus. [Contig view]

GeneID

25366.

KEGG

rno:25366.

Organism-specific databases

RGD

2028. Acvr2b.

GeneLynx

Search...

Phylogenomic databases

HOVERGEN

P38445.

Gene expression databases

ArrayExpress

P38445.

GermOnline

ENSRNOG00000014477. Rattus norvegicus.

Family and domain databases

InterPro

IPR000333. Activin_II_recpt.
IPR015768. Activin_II_recpt_C.
IPR000472. Activin_rcpt.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_bd_CS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
[Graphical view]

PANTHER

PTHR23255:SF10. Activin_II_recpt_C. 1 hit.

Pfam

PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]

PRINTS

PR00653. ACTIVIN2R.

ProDom

PD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

PROSITE

PS00107. PROTEIN_KINASE_ATP. False negative.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

BLOCKS

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Other Resources

ProtoNet

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Entry information

Entry name

AVR2B_RAT

Accession

Primary (citable) accession number: P38445
Secondary accession number(s): Q4V8J8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	November 13, 2007
Last modified:	July 22, 2008
This is version 81 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)