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P38444

- AVR2A_RAT

UniProt

P38444 - AVR2A_RAT

Protein

Activin receptor type-2A

Gene

Acvr2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei219 – 2191ATPPROSITE-ProRule annotation
    Active sitei322 – 3221Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi198 – 2069ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. activin binding Source: RGD
    2. activin receptor activity, type II Source: RGD
    3. ATP binding Source: UniProtKB-KW
    4. inhibin binding Source: RGD
    5. metal ion binding Source: UniProtKB-KW
    6. receptor signaling protein serine/threonine kinase activity Source: InterPro
    7. transforming growth factor beta-activated receptor activity Source: InterPro
    8. transmembrane receptor protein serine/threonine kinase activity Source: RGD

    GO - Biological processi

    1. activin receptor signaling pathway Source: GOC
    2. positive regulation of follicle-stimulating hormone secretion Source: RGD
    3. protein phosphorylation Source: RGD
    4. response to organic substance Source: RGD

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 5301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activin receptor type-2A (EC:2.7.11.30)
    Alternative name(s):
    Activin receptor type IIA
    Short name:
    ACTR-IIA
    Gene namesi
    Name:Acvr2a
    Synonyms:Actrii, Acvr2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi70911. Acvr2a.

    Subcellular locationi

    GO - Cellular componenti

    1. activin receptor complex Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 513494Activin receptor type-2APRO_0000024401Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 60By similarity
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi50 ↔ 78By similarity
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi85 ↔ 104By similarity
    Disulfide bondi91 ↔ 103By similarity
    Disulfide bondi105 ↔ 110By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP38444.

    Expressioni

    Gene expression databases

    GenevestigatoriP38444.

    Interactioni

    Subunit structurei

    Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 By similarity.By similarity

    Protein-protein interaction databases

    MINTiMINT-263218.
    STRINGi10116.ENSRNOP00000007404.

    Structurei

    Secondary structure

    1
    513
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni35 – 417
    Beta strandi44 – 496
    Beta strandi58 – 669
    Beta strandi71 – 8010
    Helixi83 – 853
    Beta strandi90 – 934
    Beta strandi99 – 1057
    Helixi110 – 1123

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1NYSX-ray3.05A/C34-112[»]
    1NYUX-ray3.10A/C34-112[»]
    ProteinModelPortaliP38444.
    SMRiP38444. Positions 26-119, 192-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP38444.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 135116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini162 – 513352CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei136 – 16126HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini192 – 485294Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000231495.
    HOVERGENiHBG054502.
    InParanoidiP38444.
    KOiK04670.
    PhylomeDBiP38444.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR00653. ACTIVIN2R.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P38444-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWERD RTNQTGVEPC    50
    YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV 100
    YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI 150
    AGIVICAFWV YRHHMMAYPP VLVPTQDPGP PPPSPLLGLK PLQLLEVKAR 200
    GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG MKHENILQFI 250
    GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300
    AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG 350
    KSGGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR 400
    CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG 450
    MAMLCETIEE CWDHDAEARL SAGCLGERIT QMQRLTNIIT TEDIVTVVTM 500
    VTNVDFPPKE SSL 513
    Length:513
    Mass (Da):57,893
    Last modified:October 1, 1994 - v1
    Checksum:iCE3A8742EF91DD7D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti165 – 1651M → K in AAB23958. (PubMed:7916681)Curated
    Sequence conflicti218 – 2181V → I in AAB23958. (PubMed:7916681)Curated
    Sequence conflicti353 – 3531G → A in AAB23958. (PubMed:7916681)Curated
    Sequence conflicti475 – 4751L → V in AAB23958. (PubMed:7916681)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S48190 mRNA. Translation: AAB23958.1.
    L10639 mRNA. Translation: AAA40674.1.
    PIRiA49193.
    S27258.
    RefSeqiNP_113759.1. NM_031571.2.
    UniGeneiRn.161783.

    Genome annotation databases

    GeneIDi29263.
    KEGGirno:29263.
    UCSCiRGD:70911. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S48190 mRNA. Translation: AAB23958.1 .
    L10639 mRNA. Translation: AAA40674.1 .
    PIRi A49193.
    S27258.
    RefSeqi NP_113759.1. NM_031571.2.
    UniGenei Rn.161783.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1NYS X-ray 3.05 A/C 34-112 [» ]
    1NYU X-ray 3.10 A/C 34-112 [» ]
    ProteinModelPortali P38444.
    SMRi P38444. Positions 26-119, 192-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-263218.
    STRINGi 10116.ENSRNOP00000007404.

    Proteomic databases

    PaxDbi P38444.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29263.
    KEGGi rno:29263.
    UCSCi RGD:70911. rat.

    Organism-specific databases

    CTDi 92.
    RGDi 70911. Acvr2a.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000231495.
    HOVERGENi HBG054502.
    InParanoidi P38444.
    KOi K04670.
    PhylomeDBi P38444.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 5301.

    Miscellaneous databases

    EvolutionaryTracei P38444.
    NextBioi 608592.
    PROi P38444.

    Gene expression databases

    Genevestigatori P38444.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00653. ACTIVIN2R.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    2. "Expression of type II activin receptor genes in the male and female reproductive tissues of the rat."
      Feng Z.M., Madigan M.B., Chen C.L.C.
      Endocrinology 132:2593-2600(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Testis.

    Entry informationi

    Entry nameiAVR2A_RAT
    AccessioniPrimary (citable) accession number: P38444
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3