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P38444

- AVR2A_RAT

UniProt

P38444 - AVR2A_RAT

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Protein

Activin receptor type-2A

Gene

Acvr2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Magnesium or manganese.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei219 – 2191ATPPROSITE-ProRule annotation
Active sitei322 – 3221Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi198 – 2069ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. activin binding Source: RGD
  2. activin receptor activity, type II Source: RGD
  3. ATP binding Source: UniProtKB-KW
  4. inhibin binding Source: RGD
  5. metal ion binding Source: UniProtKB-KW
  6. receptor signaling protein serine/threonine kinase activity Source: InterPro
  7. transforming growth factor beta-activated receptor activity Source: InterPro
  8. transmembrane receptor protein serine/threonine kinase activity Source: RGD

GO - Biological processi

  1. activin receptor signaling pathway Source: GOC
  2. positive regulation of follicle-stimulating hormone secretion Source: RGD
  3. protein phosphorylation Source: RGD
  4. response to organic substance Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-2A (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IIA
Short name:
ACTR-IIA
Gene namesi
Name:Acvr2a
Synonyms:Actrii, Acvr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi70911. Acvr2a.

Subcellular locationi

GO - Cellular componenti

  1. activin receptor complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 513494Activin receptor type-2APRO_0000024401Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 60By similarity
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi50 ↔ 78By similarity
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi85 ↔ 104By similarity
Disulfide bondi91 ↔ 103By similarity
Disulfide bondi105 ↔ 110By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP38444.

Expressioni

Gene expression databases

GenevestigatoriP38444.

Interactioni

Subunit structurei

Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-263218.
STRINGi10116.ENSRNOP00000007404.

Structurei

Secondary structure

1
513
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni35 – 417
Beta strandi44 – 496
Beta strandi58 – 669
Beta strandi71 – 8010
Helixi83 – 853
Beta strandi90 – 934
Beta strandi99 – 1057
Helixi110 – 1123

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NYSX-ray3.05A/C34-112[»]
1NYUX-ray3.10A/C34-112[»]
ProteinModelPortaliP38444.
SMRiP38444. Positions 26-119, 192-484.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38444.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 135116ExtracellularSequence AnalysisAdd
BLAST
Topological domaini162 – 513352CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei136 – 16126HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini192 – 485294Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000231495.
HOVERGENiHBG054502.
InParanoidiP38444.
KOiK04670.
PhylomeDBiP38444.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38444-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWERD RTNQTGVEPC
60 70 80 90 100
YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV
110 120 130 140 150
YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI
160 170 180 190 200
AGIVICAFWV YRHHMMAYPP VLVPTQDPGP PPPSPLLGLK PLQLLEVKAR
210 220 230 240 250
GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG MKHENILQFI
260 270 280 290 300
GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL
310 320 330 340 350
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG
360 370 380 390 400
KSGGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR
410 420 430 440 450
CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG
460 470 480 490 500
MAMLCETIEE CWDHDAEARL SAGCLGERIT QMQRLTNIIT TEDIVTVVTM
510
VTNVDFPPKE SSL
Length:513
Mass (Da):57,893
Last modified:October 1, 1994 - v1
Checksum:iCE3A8742EF91DD7D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti165 – 1651M → K in AAB23958. (PubMed:7916681)Curated
Sequence conflicti218 – 2181V → I in AAB23958. (PubMed:7916681)Curated
Sequence conflicti353 – 3531G → A in AAB23958. (PubMed:7916681)Curated
Sequence conflicti475 – 4751L → V in AAB23958. (PubMed:7916681)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S48190 mRNA. Translation: AAB23958.1.
L10639 mRNA. Translation: AAA40674.1.
PIRiA49193.
S27258.
RefSeqiNP_113759.1. NM_031571.2.
UniGeneiRn.161783.

Genome annotation databases

GeneIDi29263.
KEGGirno:29263.
UCSCiRGD:70911. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S48190 mRNA. Translation: AAB23958.1 .
L10639 mRNA. Translation: AAA40674.1 .
PIRi A49193.
S27258.
RefSeqi NP_113759.1. NM_031571.2.
UniGenei Rn.161783.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NYS X-ray 3.05 A/C 34-112 [» ]
1NYU X-ray 3.10 A/C 34-112 [» ]
ProteinModelPortali P38444.
SMRi P38444. Positions 26-119, 192-484.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-263218.
STRINGi 10116.ENSRNOP00000007404.

Proteomic databases

PaxDbi P38444.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29263.
KEGGi rno:29263.
UCSCi RGD:70911. rat.

Organism-specific databases

CTDi 92.
RGDi 70911. Acvr2a.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000231495.
HOVERGENi HBG054502.
InParanoidi P38444.
KOi K04670.
PhylomeDBi P38444.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 5301.

Miscellaneous databases

EvolutionaryTracei P38444.
NextBioi 608592.
PROi P38444.

Gene expression databases

Genevestigatori P38444.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR00653. ACTIVIN2R.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. "Expression of type II activin receptor genes in the male and female reproductive tissues of the rat."
    Feng Z.M., Madigan M.B., Chen C.L.C.
    Endocrinology 132:2593-2600(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Testis.

Entry informationi

Entry nameiAVR2A_RAT
AccessioniPrimary (citable) accession number: P38444
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 1, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3