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Protein

Activin receptor type-2A

Gene

Acvr2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6.By similarity

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei219ATPPROSITE-ProRule annotation1
Active sitei322Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi198 – 206ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • activin binding Source: RGD
  • activin receptor activity, type II Source: RGD
  • ATP binding Source: UniProtKB-KW
  • BMP receptor activity Source: UniProtKB
  • inhibin binding Source: RGD
  • metal ion binding Source: UniProtKB-KW
  • receptor signaling protein serine/threonine kinase activity Source: InterPro
  • transmembrane receptor protein serine/threonine kinase activity Source: RGD

GO - Biological processi

  • BMP signaling pathway Source: UniProtKB
  • positive regulation of follicle-stimulating hormone secretion Source: RGD
  • protein phosphorylation Source: RGD
  • response to organic substance Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-2A (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IIA
Short name:
ACTR-IIA
Gene namesi
Name:Acvr2a
Synonyms:Actrii, Acvr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70911. Acvr2a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 135ExtracellularSequence analysisAdd BLAST116
Transmembranei136 – 161HelicalSequence analysisAdd BLAST26
Topological domaini162 – 513CytoplasmicSequence analysisAdd BLAST352

GO - Cellular componenti

  • activin receptor complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002440120 – 513Activin receptor type-2AAdd BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 60By similarity
Glycosylationi43N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi50 ↔ 78By similarity
Glycosylationi66N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi85 ↔ 104By similarity
Disulfide bondi91 ↔ 103By similarity
Disulfide bondi105 ↔ 110By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP38444.
PRIDEiP38444.

PTM databases

PhosphoSitePlusiP38444.

Interactioni

Subunit structurei

Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity).By similarity

GO - Molecular functioni

  • activin binding Source: RGD
  • inhibin binding Source: RGD

Protein-protein interaction databases

MINTiMINT-263218.
STRINGi10116.ENSRNOP00000007404.

Structurei

Secondary structure

1513
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni35 – 417
Beta strandi44 – 496
Beta strandi58 – 669
Beta strandi71 – 8010
Helixi83 – 853
Beta strandi90 – 934
Beta strandi99 – 1057
Helixi110 – 1123

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NYSX-ray3.05A/C34-112[»]
1NYUX-ray3.10A/C34-112[»]
ProteinModelPortaliP38444.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38444.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 485Protein kinasePROSITE-ProRule annotationAdd BLAST294

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3653. Eukaryota.
ENOG410XS2Z. LUCA.
HOGENOMiHOG000231495.
HOVERGENiHBG054502.
InParanoidiP38444.
KOiK04670.
PhylomeDBiP38444.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38444-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWERD RTNQTGVEPC
60 70 80 90 100
YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV
110 120 130 140 150
YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI
160 170 180 190 200
AGIVICAFWV YRHHMMAYPP VLVPTQDPGP PPPSPLLGLK PLQLLEVKAR
210 220 230 240 250
GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG MKHENILQFI
260 270 280 290 300
GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL
310 320 330 340 350
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG
360 370 380 390 400
KSGGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR
410 420 430 440 450
CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG
460 470 480 490 500
MAMLCETIEE CWDHDAEARL SAGCLGERIT QMQRLTNIIT TEDIVTVVTM
510
VTNVDFPPKE SSL
Length:513
Mass (Da):57,893
Last modified:October 1, 1994 - v1
Checksum:iCE3A8742EF91DD7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165M → K in AAB23958 (PubMed:7916681).Curated1
Sequence conflicti218V → I in AAB23958 (PubMed:7916681).Curated1
Sequence conflicti353G → A in AAB23958 (PubMed:7916681).Curated1
Sequence conflicti475L → V in AAB23958 (PubMed:7916681).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S48190 mRNA. Translation: AAB23958.1.
L10639 mRNA. Translation: AAA40674.1.
PIRiA49193.
S27258.
RefSeqiNP_113759.1. NM_031571.2.
UniGeneiRn.161783.

Genome annotation databases

GeneIDi29263.
KEGGirno:29263.
UCSCiRGD:70911. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S48190 mRNA. Translation: AAB23958.1.
L10639 mRNA. Translation: AAA40674.1.
PIRiA49193.
S27258.
RefSeqiNP_113759.1. NM_031571.2.
UniGeneiRn.161783.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NYSX-ray3.05A/C34-112[»]
1NYUX-ray3.10A/C34-112[»]
ProteinModelPortaliP38444.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-263218.
STRINGi10116.ENSRNOP00000007404.

PTM databases

PhosphoSitePlusiP38444.

Proteomic databases

PaxDbiP38444.
PRIDEiP38444.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29263.
KEGGirno:29263.
UCSCiRGD:70911. rat.

Organism-specific databases

CTDi92.
RGDi70911. Acvr2a.

Phylogenomic databases

eggNOGiKOG3653. Eukaryota.
ENOG410XS2Z. LUCA.
HOGENOMiHOG000231495.
HOVERGENiHBG054502.
InParanoidiP38444.
KOiK04670.
PhylomeDBiP38444.

Enzyme and pathway databases

BRENDAi2.7.10.2. 5301.

Miscellaneous databases

EvolutionaryTraceiP38444.
PROiP38444.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAVR2A_RAT
AccessioniPrimary (citable) accession number: P38444
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.