Reviewed,
UniProtKB/Swiss-Prot P38438 (TGFR2_RAT)
Last modified
July 22, 2008.
Version 75.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: TGF-beta receptor type-2 EC=2.7.11.30 Alternative name(s): Transforming growth factor-beta receptor type II Short name=TGF-beta receptor type II TGF-beta type II receptor TbetaR-II TGFR-2 | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 567 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Acts as a signal transducer. Phosphorylates TGFBR1 upon binding to its ligand, TGF-beta. TGFBR1 in turn phosphorylates the cytoplasmic effectors of the pathway, known as SMADs. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. |
| Catalytic activity | ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. |
| Cofactor | Magnesium or manganese By similarity. |
| Subunit structure | Binds to DAXX. Interacts with TCTEX1D4 By similarity. |
| Subcellular location | |
| Post-translational modification | Phosphorylated on a Ser/Thr residue in the cytoplasmic domain. |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal Transmembrane |
| Ligand | ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding |
| Molecular function | Kinase Receptor Serine/threonine-protein kinase Transferase |
| PTM | Glycoprotein Phosphoprotein |
Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||||
Molecule processing | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 23 | 23 | Potential | |||||||
| Chain | 24 – 567 | 544 | TGF-beta receptor type-2 | |||||||
Regions | ||||||||||
| Topological domain | 24 – 166 | 143 | Extracellular Potential | |||||||
| Transmembrane | 167 – 187 | 21 | Potential | |||||||
| Topological domain | 188 – 567 | 380 | Cytoplasmic Potential | |||||||
| Domain | 244 – 546 | 303 | Protein kinase | |||||||
| Nucleotide binding | 250 – 258 | 9 | ATP By similarity | |||||||
Sites | ||||||||||
| Active site | 379 | 1 | Proton acceptor By similarity | |||||||
| Binding site | 277 | 1 | ATP By similarity | |||||||
Amino acid modifications | ||||||||||
| Modified residue | 548 | 1 | Phosphoserine By similarity | |||||||
| Glycosylation | 70 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Glycosylation | 94 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Disulfide bond | 51 ↔ 84 | By similarity | ||||||||
| Disulfide bond | 54 ↔ 71 | By similarity | ||||||||
| Disulfide bond | 61 ↔ 67 | By similarity | ||||||||
| Disulfide bond | 77 ↔ 101 | By similarity | ||||||||
| Disulfide bond | 121 ↔ 136 | By similarity | ||||||||
| Disulfide bond | 138 ↔ 143 | By similarity | ||||||||
Experimental info | ||||||||||
| Sequence conflict | 388 – 389 | 2 | KN → RS in AAB29352. Ref.2 | |||||||
| Sequence conflict | 403 | 1 | R → G Ref.2 | |||||||
| Sequence conflict | 405 | 1 | D → S Ref.2 | |||||||
| Sequence conflict | 477 | 1 | K → R in AAB29352. Ref.2 | |||||||
Sequences
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References
| [1] | "Molecular characterization of rat transforming growth factor-beta type II receptor." Tsuchida K., Lewis K.A., Mathews L.S., Vale W.W. Biochem. Biophys. Res. Commun. 191:790-795(1993) [PubMed: 8385453] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Pituitary. |
| [2] | "Rat mesangial cell hypertrophy in response to transforming growth factor-beta 1." Choi M.E., Kim E.G., Huang Q., Ballermann B.J. Kidney Int. 44:948-958(1993) [PubMed: 8264154] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| L09653 mRNA. Translation: AAA42237.1. S67770 mRNA. Translation: AAB29352.2. | |
| PIR | JN0459. |
| RefSeq | NP_112394.3. |
| UniGene | Rn.9954 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1M9Z based on UniProtKB P37173. |
| SMR | P38438. Positions 40-159. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSRNOG00000013265. Rattus norvegicus. [Contig view] |
| GeneID | 81810. |
| KEGG | rno:81810. |
Organism-specific databases | |
| RGD | 69651. Tgfbr2. |
Phylogenomic databases | |
| HOVERGEN | P38438. |
Gene expression databases | |
| ArrayExpress | P38438. |
| GermOnline | ENSRNOG00000013265. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR000333. Activin_II_recpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR015769. TGF-beta_II_C. IPR015013. TGF_beta_receptor2. IPR017194. TGFRII. [Graphical view] |
| PANTHER | PTHR23255:SF11. TGF-beta_II_C. 1 hit. |
| Pfam | PF08917. ecTbetaR2. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view] |
| PIRSF | PIRSF037393. TGFRII. 1 hit. |
| PRINTS | PR00653. ACTIVIN2R. |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | TGFR2_RAT | ||||||||
| Accession | Primary (citable) accession number: P38438 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


